Page last updated: 2024-08-07 20:14:01
Histone deacetylase 8
[no definition available]
Synonyms
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quisinostat | Schistosoma mansoni | Kd | 0.0284 | 1 | 1 |
| pci 34051 | Schistosoma mansoni | Kd | 0.3670 | 1 | 1 |
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.Journal of medicinal chemistry, , Mar-24, Volume: 59, Issue:6, 2016
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.Journal of medicinal chemistry, , Mar-24, Volume: 59, Issue:6, 2016