carbon tetrachloride has been researched along with Necrosis in 284 studies
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated the role of Pin1 in carbon tetrachloride (CCl(4))-induced apoptosis and necrosis of hepatocytes during acute liver injury of mice." | 7.78 | Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice. ( Cho, BH; Jeong, YJ; Kim, JC; Park, BH; Risal, P, 2012) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 7.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver fibrosis in the rat." | 7.74 | Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. ( Clarke, CJ; Dare, T; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2007) |
| " The effect of central TRH on carbon tetrachloride (CCl(4))-induced acute hepatocellular necrosis was investigated in rats." | 7.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| " After N-acetylcysteine plus deferoxamine treatment, hepatocellular necrosis and inflammatory infiltration induced by carbon tetrachloride were greatly decreased." | 7.72 | Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. ( Andrades, M; Dal-Pizzol, F; Martins, MR; Menna-Barreto, S; Moreira, JC; Quevedo, J; Reinke, A; Ritter, C; Rocha, J, 2004) |
| "Administration of the radioprotective agent 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) at 3 or 6 hr after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 hr." | 7.69 | Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721). ( Castro, JA; de Castro, CR; Valles, EG, 1995) |
| "Fluphenazine (FP) treatment (50 mg/kg bw, ip in saline) 30 min before or 6 or 10 h after CCl4 administration (1 ml/kg ip in olive oil) significantly prevented the liver necrosis produced by the hepatotoxin at 24 h." | 7.69 | Late protective effects of the anticalmodulin drug fluphenazine on carbon tetrachloride-induced liver necrosis. ( Bernacchi, AS; Castro, GD; Castro, JA; de Ferreyra, EC; San Martin, MF, 1995) |
| "N-Acetyl cysteine (NAC) treatment 30 min before or 6 or 10 h after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 h." | 7.69 | N-acetyl cysteine is an early but also a late preventive agent against carbon tetrachloride-induced liver necrosis. ( Castro, JA; de Castro, CR; Valles, EG, 1994) |
| "A dose of diquat below the amount injurious to selenium-replete animals causes lipid peroxidation and massive liver necrosis in selenium-deficient rats." | 7.69 | Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. ( Awad, JA; Burk, RF; Cockell, KA; Hill, KE; Kato, T; Lyons, PR; Morrow, JD, 1995) |
| "Endothelial cell damage causes massive hepatic necrosis as a result of fibrin deposition in the hepatic sinusoids." | 7.69 | Use of prostaglandin I2 analog in treatment of massive hepatic necrosis associated with endothelial cell injury and diffuse sinusoidal fibrin deposition. ( Arai, M; Fujiwara, K; Hirata, K; Masaki, N; Matsui, A; Mochida, S; Nagoshi, S; Ohno, A; Tomiya, T; Yamaoka, M, 1995) |
| " In response to carbon tetrachloride (CCI4)-induced necrosis, an initial increase in the intensity of immunoreactivity was noted at 24 h following exposure to the toxin." | 7.68 | Intrahepatic distribution of transforming growth factor-alpha (TGF alpha) during liver regeneration following carbon tetrachloride-induced necrosis. ( Burr, AW; Burt, AD; Carpenter, MR; Gullick, WJ; Hines, JE, 1993) |
| "Arsenazo III (AIII) (100 mg/kg ip in saline) administration to Sprague-Dawley male rats 30 min before or 6 or 10 hr after CCl4 [1 ml/kg ip as a 20% (v/v) solution in olive oil] significantly prevented liver necrosis but not fatty liver caused by the hepatotoxin at 24 hr as demonstrated either by histology or by determination of isocitric acid dehydrogenase in plasma." | 7.68 | Prevention of CCl4-induced liver necrosis by the calcium chelator arsenazo III. ( Bernacchi, AS; Castro, JA; de Fenos, OM; de Ferreyra, EC; Villarruel, MC, 1993) |
| "Adenosine administration was tested in rats with carbon tetrachloride-induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin." | 7.68 | Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R; Suárez, J, 1990) |
| "Aspartic acid, cystine, methionine and tyrosine were protective against carbon tetrachloride (CCl4)-induced liver necrosis 24 h after its administration, when given 30 min before the hepatotoxin." | 7.66 | Prevention of carbon tetrachloride-induced liver necrosis by several amino acids. ( Castro, JA; De Fenos, OM; De Ferreyra, EC; De Toranzo, EG, 1983) |
| "Studies in the rat with hepatic necrosis induced by carbon tetrachloride showed that the abnormalities in one-stage coagulation tests and the increased catabolism of fibrinogen were similar to those found in man with acute viral or drug-induced hepatic necrosis." | 7.65 | Experimental hepatic necrosis: studies on coagulation abnormalities, plasma clearance, and organ distribution of 125I-labelled fibrinogen. ( Flute, PT; Pannell, G; Rake, MO; Shilkin, KB; Williams, R, 1973) |
| "Quinacrine (QUIN) is a well known inhibitor of PLA2." | 5.29 | Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis. ( Castro, JA; de Toranzo, EG; González Padrón, A, 1993) |
| "Cystamine post-treatment, therefore, does not appear to inhibit toxicant-induced influx of extracellular calcium into toxicant-damaged cells." | 5.27 | Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine. ( Gandolfi, AJ; MacDonald, JR; Sipes, IG, 1986) |
| "The mechanism of carbon tetrachloride (CCl4)-induced hepatotoxicity, especially necrosis and fatty liver, has long been a challenging subject of many researchers from various fields over the past 50 years." | 4.83 | [Learning toxicology from carbon tetrachloride-induced hepatotoxicity]. ( Masuda, Y, 2006) |
| "One of the principles of prevention and non-medicamentous treatment of liver diseases, including hepatitis of different etiology, is the normalization of the diet through the consumption of food with physiologically active ingredients, in particular betulin, which helps to eliminate the causes of metabolic and oxidative disorders within liver cells." | 4.31 | [Effects of triterpenoids in fatty products on liver condition of laboratory animals with acute toxic hepatitis]. ( Averyanova, EV; Chugunova, OV; Mazko, ON; Shkolnikova, MN, 2023) |
| " By establishing a simple method of discriminating between apoptosis and necrosis in the liver, we found that necrosis occurred prior to apoptosis at the onset of steatohepatitis in the choline-deficient, ethionine-supplemented (CDE) diet model." | 3.91 | Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis. ( Imai, H; Koumura, T; Matsuoka, M; Miyajima, A; Nakano, H; Nakasone, M; Okochi, H; Sakamoto, T; Tanaka, M; Tsuchiya, Y; Tsurusaki, S; Yuet-Yin Kok, C, 2019) |
| "This study demonstrates that hesperidin prevents experimental necrosis and fibrosis." | 3.80 | Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor. ( Muriel, P; Pérez-Vargas, JE; Segovia, J; Shibayama, M; Tsutsumi, V; Zarco, N, 2014) |
| " After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection." | 3.79 | TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013) |
| " In this study, we investigated the role of Pin1 in carbon tetrachloride (CCl(4))-induced apoptosis and necrosis of hepatocytes during acute liver injury of mice." | 3.78 | Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice. ( Cho, BH; Jeong, YJ; Kim, JC; Park, BH; Risal, P, 2012) |
| " Liver oxidative stress and inflammation were examined by detecting the liver malondialdehyde level and glutathione and superoxide dismutase activity, and serum tumour necrosis factor-alpha level, respectively." | 3.76 | Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice. ( Dong, W; Hao, X; Ren, X; Yan, F; Yang, L, 2010) |
| " This study determined the role of nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase deficiency in the development of hepatocellular necrosis, inflammation, and apoptosis in relation to fibrosis produced by chronic carbon tetrachloride (CCl(4)) administration." | 3.75 | Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. ( Aram, G; Liu, X; Mezey, E; Potter, JJ; Torbenson, MS; Wang, L, 2009) |
| " Here, we provided genetic evidence that mice lacking steroid receptor co-activator-3 (SRC-3) were protected against carbon tetrachloride (CCl4)-induced acute liver necrosis and chronic hepatic fibrosis." | 3.75 | Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. ( Chen, H; Li, X; Ma, X; Ning, G; Wang, S; Xu, J; Xu, L, 2009) |
| " Acute carbon tetrachloride (CCl(4)) toxicity was similar in wild-type (WT), PAR-1(-/-), and PAR-1(+/-) mice as judged by aminotransferase levels, area of liver necrosis, and liver peroxidation measured by Fourier-transformed infrared spectroscopy." | 3.74 | Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis. ( Bioulac-Sage, P; Costet, P; Cubel, G; Deleris, G; Dugot-Senant, N; Gillibert-Duplantier, J; Haurie, V; Petibois, C; Rosenbaum, J; Rullier, A; Taras, D, 2008) |
| "Carbon tetrachloride (CCl(4)) was used to induce liver fibrosis in the rat." | 3.74 | Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. ( Clarke, CJ; Dare, T; Munday, MR; Smyth, R; Turton, JA; York, MJ, 2007) |
| " As model toxic compounds lipopolysaccharide (LPS, inducing inflammation), paracetamol (necrosis), carbon tetrachloride (CCl(4), fibrosis and necrosis) and gliotoxin (apoptosis) were used." | 3.74 | Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. ( Bauerschmidt, S; Draaisma, AL; Elferink, MG; Groothuis, GM; Merema, MT; Olinga, P; Polman, J; Schoonen, WG, 2008) |
| " CCl4 administration resulted in hepatic necrosis and significant increases in plasma transaminase activities as well as hepatic malondialdehyde (MDA) and diene conjugate (DC) levels in the liver of rats." | 3.74 | Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. ( Cevikbaş, U; Koçak-Toker, N; Mehmetçik, G; Ozdemirler, G; Uysal, M, 2008) |
| " In this study, immunohistochemistry for DNase gamma was performed on paraffin sections of rodent liver in well-defined models of hepatocyte apoptosis induced by Fas antibody (Fas) or cycloheximide (CHX), and necrosis induced by lipopolysaccharide (LPS) or carbon tetrachloride (CCl4)." | 3.72 | Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes. ( Chiba, T; Higami, Y; Shimokawa, I; Shiokawa, D; Tanuma, S; To, K; Tsuchiya, T; Yamaza, H, 2004) |
| " MSCs were injected into renal arteries of healthy rats (labeled cells in four, unlabeled cells in two) and portal veins of rats treated with carbon tetrachloride to induce centrolobular liver necrosis (labeled cells and unlabeled cells in two each)." | 3.72 | In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver. ( Bos, C; Bulte, JW; Charbord, P; Combe, C; Delmas, Y; Desmoulière, A; Dubus, I; Grenier, N; Grosset, C; Hauger, O; Ivanovic, Z; Moonen, CT; Ripoche, J; Rosenbaum, J; Solanilla, A, 2004) |
| " The effect of central TRH on carbon tetrachloride (CCl(4))-induced acute hepatocellular necrosis was investigated in rats." | 3.72 | Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats. ( Makino, I; Nakamura, K; Sato, Y; Terano, A; Yoneda, M, 2003) |
| " After N-acetylcysteine plus deferoxamine treatment, hepatocellular necrosis and inflammatory infiltration induced by carbon tetrachloride were greatly decreased." | 3.72 | Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. ( Andrades, M; Dal-Pizzol, F; Martins, MR; Menna-Barreto, S; Moreira, JC; Quevedo, J; Reinke, A; Ritter, C; Rocha, J, 2004) |
| " In leptin-deficient mice, it was associated with exaggerated activation of NF-kappa B and STAT3 during the priming phase, abrogation of tumor necrosis factor (TNF) and interleukin (IL)-6 release at the time of G1/S transition, and failure of hepatocyte induction of cyclin D1 and cell cycle entry." | 3.72 | Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. ( Farrell, GC; Field, J; Leclercq, IA, 2003) |
| "Allyl-alcohol (AA) and carbon tetrachloride (CC14) are known to cause peritoneal and pericentral liver necrosis, respectively." | 3.70 | Pathological changes of hepatic artery and portal vein, after allyl-alcohol and carbon tetrachloride administration. An experimental study. ( Bastounis, E; Felekouras, E; Filis, K; Kourelis, T; Milonakis, M; Papalambros, E; Salakou, S; Sigala, F; Tepetes, K; Tsamandas, A, 2000) |
| " However, hepatic HGF levels were decreased despite an increased number of mitotic hepatocytes and increased or unchanged plasma HGF levels in rats given phenobarbital and in rats after dimethylnitrosamine intoxication, which can induce hepatic necrosis after apoptosis of hepatic stellate cells." | 3.70 | Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration. ( Fujiwara, K; Ogata, I; Tomiya, T, 1998) |
| "Reversible centrilobular to mid-zone necrosis and apoptosis occupying half the liver lobular area was evoked by carbon tetrachloride, and dimethylnitrosamine, respectively." | 3.70 | Biphasic effect of colchicine on acute liver injury induced by carbon tetrachloride or by dimethylnitrosamine in mice. ( Inoue, K; Mizuoka, H; Shikata, N; Takasu, M; Tsubura, A; Yang, J, 1999) |
| "Administration of the radioprotective agent 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721) at 3 or 6 hr after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 hr." | 3.69 | Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721). ( Castro, JA; de Castro, CR; Valles, EG, 1995) |
| "Methylenedioxybenzenes (MDBs) and structurally related alkenylbenzenes were compared for their effectiveness in preventing carbon tetrachloride (CCl4)-induced liver necrosis in mice." | 3.69 | The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes. ( O'Brien, PJ; Zhao, ZS, 1996) |
| "N-Acetyl cysteine (NAC) treatment 30 min before or 6 or 10 h after carbon tetrachloride (CCl4) administration significantly prevented the liver necrosis produced by the hepatotoxin at 24 h." | 3.69 | N-acetyl cysteine is an early but also a late preventive agent against carbon tetrachloride-induced liver necrosis. ( Castro, JA; de Castro, CR; Valles, EG, 1994) |
| " Hepatotoxic compounds such as CCl4, galactosamine and thioacetamide that cause hepatic necrosis and compounds such as hydrazine and ethionine that cause fatty liver all result in elevated urinary taurine levels in rats." | 3.69 | Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro. ( Timbrell, JA; Waterfield, CJ, 1996) |
| "Fluphenazine (FP) treatment (50 mg/kg bw, ip in saline) 30 min before or 6 or 10 h after CCl4 administration (1 ml/kg ip in olive oil) significantly prevented the liver necrosis produced by the hepatotoxin at 24 h." | 3.69 | Late protective effects of the anticalmodulin drug fluphenazine on carbon tetrachloride-induced liver necrosis. ( Bernacchi, AS; Castro, GD; Castro, JA; de Ferreyra, EC; San Martin, MF, 1995) |
| "Endothelial cell damage causes massive hepatic necrosis as a result of fibrin deposition in the hepatic sinusoids." | 3.69 | Use of prostaglandin I2 analog in treatment of massive hepatic necrosis associated with endothelial cell injury and diffuse sinusoidal fibrin deposition. ( Arai, M; Fujiwara, K; Hirata, K; Masaki, N; Matsui, A; Mochida, S; Nagoshi, S; Ohno, A; Tomiya, T; Yamaoka, M, 1995) |
| "A dose of diquat below the amount injurious to selenium-replete animals causes lipid peroxidation and massive liver necrosis in selenium-deficient rats." | 3.69 | Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. ( Awad, JA; Burk, RF; Cockell, KA; Hill, KE; Kato, T; Lyons, PR; Morrow, JD, 1995) |
| "Arsenazo III (AIII) (100 mg/kg ip in saline) administration to Sprague-Dawley male rats 30 min before or 6 or 10 hr after CCl4 [1 ml/kg ip as a 20% (v/v) solution in olive oil] significantly prevented liver necrosis but not fatty liver caused by the hepatotoxin at 24 hr as demonstrated either by histology or by determination of isocitric acid dehydrogenase in plasma." | 3.68 | Prevention of CCl4-induced liver necrosis by the calcium chelator arsenazo III. ( Bernacchi, AS; Castro, JA; de Fenos, OM; de Ferreyra, EC; Villarruel, MC, 1993) |
| "Hepatic necrosis produced by carbon tetrachloride (0." | 3.68 | Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine. ( Harbison, RD; James, RC; Roberts, SM; Seng, JE, 1991) |
| "Liver necrosis was produced in rats by administering 3 doses of a mixture of carbon tetrachloride + olive oil, 2 ml/kg, ip." | 3.68 | Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats. ( Garg, KN; Mehrotra, GC; Singh, J, 1990) |
| " However, cytokeratin dimers and high-molecular-weight cytokeratin polymers were detected in liver tissue with histological evidence of coagulative necrosis induced by ischemia or carbon tetrachloride." | 3.68 | Cross-linked cytokeratin polypeptides in liver and hepatoma cells: possible association with the process of cell degeneration and death. ( Chiu, JF; Fukuda, K; Kojiro, M, 1993) |
| "Adenosine administration was tested in rats with carbon tetrachloride-induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin." | 3.68 | Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. ( Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R; Suárez, J, 1990) |
| " In response to carbon tetrachloride (CCI4)-induced necrosis, an initial increase in the intensity of immunoreactivity was noted at 24 h following exposure to the toxin." | 3.68 | Intrahepatic distribution of transforming growth factor-alpha (TGF alpha) during liver regeneration following carbon tetrachloride-induced necrosis. ( Burr, AW; Burt, AD; Carpenter, MR; Gullick, WJ; Hines, JE, 1993) |
| " Centrilobular necrosis and marked elevation of serum glutamic-pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) activities were induced by carbon tetrachloride (0." | 3.67 | Potentiation of carbon tetrachloride hepatotoxicity by hypoxia. ( Shibayama, Y, 1986) |
| "The ability of 14 serum biochemical assays to predict the presence of hepatic necrosis induced by carbon tetrachloride (CCl4) (centrilobular necrosis), allyl alcohol (periportal necrosis), and 1-napththylisothiocyanate (ANIT) (biliary duct necrosis) was evaluated in rats." | 3.67 | Evaluating toxin-induced hepatic injury in rats by laboratory results and discriminant analysis. ( Carakostas, MC; Church, GE; Cleghorn, BL; Gossett, KA, 1986) |
| "Aspartic acid, cystine, methionine and tyrosine were protective against carbon tetrachloride (CCl4)-induced liver necrosis 24 h after its administration, when given 30 min before the hepatotoxin." | 3.66 | Prevention of carbon tetrachloride-induced liver necrosis by several amino acids. ( Castro, JA; De Fenos, OM; De Ferreyra, EC; De Toranzo, EG, 1983) |
| "Studies in the rat with hepatic necrosis induced by carbon tetrachloride showed that the abnormalities in one-stage coagulation tests and the increased catabolism of fibrinogen were similar to those found in man with acute viral or drug-induced hepatic necrosis." | 3.65 | Experimental hepatic necrosis: studies on coagulation abnormalities, plasma clearance, and organ distribution of 125I-labelled fibrinogen. ( Flute, PT; Pannell, G; Rake, MO; Shilkin, KB; Williams, R, 1973) |
| "Our findings suggest MLT may prevent liver fibrosis by inhibiting necroptosis-associated inflammatory signaling." | 1.42 | Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis. ( Choi, HS; Kang, JW; Lee, SM, 2015) |
| " Liver function tests and histopathological evaluation were carried out at the end of dosing using standards kits." | 1.39 | Hepatoprotective effect of herbal drug on CCl(4) induced liver damage. ( Feroz, Z; Khan, RA, 2013) |
| " To address this issue, we induced liver fibrosis by carbon tetrachloride (CCl(4)) chronic administration to 8-week- and 15-month-old mice." | 1.37 | Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response. ( Abdoun, E; Collin de l'Hortet, A; Cosson, C; Fromenty, B; Gilgenkrantz, H; Guidotti, JE; Mahrouf-Yorgov, M; Mitchell, C; Slama, A, 2011) |
| "Toxic hepatitis was induced by a single carbon tetrachloride injection in Gas6 deficient (Gas6(-/-)) mice and liver recovery was compared with wild-type animals." | 1.35 | Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. ( Brouillet, A; Chobert, MN; Deveaux, V; Lafdil, F; Laperche, Y; Mavier, P; Nakano, T; Zafrani, ES, 2009) |
| "Methyl palmitate (MP) is an effective Kupffer cell inhibitor." | 1.35 | Methyl palmitate prevents CCl(4)-induced liver fibrosis. ( Galicia-Moreno, M; Moreno, MG; Muriel, P; Reyes-Gordillo, K; Rodríguez-Rivera, A; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P, 2008) |
| "Fulminant hepatitis or acute liver failure (ALF), initiated by viral infection or hepatic toxin, is a devastating medical complication without effective therapeutic treatment." | 1.35 | Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure. ( Han, YP; Yan, C; Zhou, L, 2008) |
| "Liver necrosis was induced by administering a single intraperitoneal (i." | 1.34 | Protective effects of tungstophosphoric acid and sodium tungstate on chemically induced liver necrosis in wistar rats. ( Antić-Stanković, J; Kotur-Stevuljević, J; Milenković, M; Stefanović, A; Topić, A; Uskoković-Marković, S, 2007) |
| "Carbon tetrachloride treatment 24 h prior to a challenging dose of carbon tetrachloride or acetaminophen decreased the resulting hepatotoxicity both in male and female mice as determined by histopathological examination and increases in serum enzyme activities." | 1.34 | Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone. ( Jung, YS; Kim, SY; Kim, YC; Park, JH; Yim, HK, 2007) |
| "Carbon tetrachloride (CCl(4)) is a well-known model compound for producing chemical hepatic injury." | 1.34 | A proteomic method for analysis of CYP450s protein expression changes in carbon tetrachloride induced male rat liver microsomes. ( Fan, G; Jia, N; Liu, X; Qian, L; Qian, X; Wen, J; Wu, Y, 2007) |
| "Curcumin treatment (200 mg/kg, p." | 1.34 | Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. ( Moreno, MG; Muriel, P; Reyes-Gordillo, K; Segovia, J; Shibayama, M; Vergara, P, 2007) |
| "Retrorsine has no effect on mouse hepatocyte proliferation." | 1.33 | Effects of retrorsine on mouse hepatocyte proliferation after liver injury. ( Chu, JX; Liu, AL; Wang, Q; Zhou, XF, 2006) |
| " With repetitive dosing CCl(4) can be used to induce bridging hepatic fibrosis (4 wk of twice-weekly dosing), cirrhosis (8 wk of twice-weekly dosing) and advanced micronodular cirrhosis (12 wk of twice-weekly dosing)." | 1.33 | Modeling liver fibrosis in rodents. ( Constandinou, C; Henderson, N; Iredale, JP, 2005) |
| "Liver-necrosis was observed in CCl(4)-injected rats without pretreatment of flaxseed extract." | 1.31 | Protective effect of a lignan-containing flaxseed extract against CCl(4)-induced hepatic injury. ( Arikawa, J; Endoh, D; Hayashi, M; Kon, Y; Okui, T; Ozawa, S; Yamato, O, 2002) |
| " Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFalpha for potential therapeutic use." | 1.31 | The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity. ( Blazka, ME; Bruccoleri, A; Gallucci, RM; Luster, MI; Matheson, JM; Simeonova, PP; Yucesoy, B, 2000) |
| " A differentiation of the intensity of toxic effects was found dependent on the time of the day at which animals were administered the xenobiotic." | 1.31 | Circadian variations in hepatotoxicity of carbon tetrachloride in mice. ( Piotrowski, JK; Skrzypińska-Gawrysiak, M; Sporny, S, 2000) |
| " Tissue dosimetry at the pharmacokinetic and pharmacodynamic levels is achievable with simple and complex, but chemically defined, mixtures." | 1.29 | Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment. ( Benjamin, SA; el-Masri, HA; Thomas, RS; Yang, RS, 1995) |
| "Quinacrine (QUIN) is a well known inhibitor of PLA2." | 1.29 | Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis. ( Castro, JA; de Toranzo, EG; González Padrón, A, 1993) |
| " TCBM, like CT, reduces the hepatic level of GSH-S-transferase, increasing the amount of DBE available for cytochrome P450-dependent metabolism, with the production of toxic metabolites." | 1.28 | In vivo studies on halogen compound interactions. IV. Interaction among different halogen derivatives with and without synergistic action on liver toxicity. ( Aragno, M; Danni, O; Tamagno, E; Ugazio, G, 1992) |
| " Comparable results were obtained in vivo where supplementation with alpha-tocopherol 15 h before CCl4 dosing induced a partial or complete protection against the drug's necrogenic effect, depending on the concentration of the haloalkane used." | 1.28 | In vivo and in vitro evidence concerning the role of lipid peroxidation in the mechanism of hepatocyte death due to carbon tetrachloride. ( Albano, E; Biasi, F; Chiarpotto, E; Corongiu, FP; Dianzani, MU; Marinari, UM; Parola, M; Poli, G; Pronzato, MA, 1991) |
| " Modifying the toxicity with PM, together with a low dose of CCl4, helped to minimize secondary effects of CCl4, to clarify the sequence of toxic events, and to assess the sensitivity of some standard tests of hepatotoxicity." | 1.27 | Correlations between common tests for assessment of liver damage: indices of the hepatoprotective activity of promethazine in carbon tetrachloride hepatotoxicity. ( Cheeseman, KH; Reddrop, CJ; Slater, TF, 1983) |
| "Carbon tetrachloride was injected s." | 1.27 | Strain differences in mice in carbon tetrachloride-induced liver injury. ( Bhathal, PS; Mackay, IR; Rose, NR; Whittingham, S, 1983) |
| "The taurine pretreatment had no effect on the metabolism of 14CCl4 in hepatic microsomes and antioxidant content in the liver, but significantly enhanced the CCl4-induced increase in hepatic Ca++ content." | 1.27 | Pretreatment with taurine facilitates hepatic lipid peroxide formation associated with carbon tetrachloride intoxication. ( Kuriyama, K; Nakashima, T; Takino, T, 1983) |
| "Post-treatment with methoxsalen must be given early and is only partially effective in mice." | 1.27 | The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice. ( Amouyal, G; Carrion-Pavlov, Y; Degott, C; Descatoire, V; Geneve, J; Labbe, G; Larrey, D; Letteron, P; Pessayre, D; Tinel, M, 1987) |
| " The results from the multiple-dose studies showed a similar relationship except that with 20 mg/kg X d the concentrations of SGOT and SGPT decayed to control values after 14 d of dosing whereas the percentage of hepatocytes in S phase remained markedly elevated (greater than 10 X control)." | 1.27 | Relationship between hepatotoxicity and induction of replicative DNA synthesis following single or multiple doses of carbon tetrachloride. ( Doolittle, DJ; Muller, G; Scribner, HE, 1987) |
| "Cystamine post-treatment, therefore, does not appear to inhibit toxicant-induced influx of extracellular calcium into toxicant-damaged cells." | 1.27 | Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine. ( Gandolfi, AJ; MacDonald, JR; Sipes, IG, 1986) |
| "This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h." | 1.27 | A predictable pathophysiological model of porcine hepatic failure. ( Alp, MH; Hickman, R, 1986) |
| "Sodium propionate (3 mmol/kg) was injected IV into 6 healthy sheep before and after they were given carbon tetrachloride (20% CCl4 in mineral oil; 0." | 1.27 | Propionate loading test for liver function during experimental liver necrosis in sheep. ( Bruss, ML; Gröhn, Y; Lindberg, LA, 1985) |
| "Dipyridamole was effective from 1 hr before through 6 hrs after the oral administration of CCl4." | 1.26 | Decrease of carbon tetrachloride liver toxicity in rats given dipyridamole. ( Kast, A; Nishikawa, J; Yabe, T, 1982) |
| "Treatment with cycloheximide and a hepatotoxic dose of CCl4 (well tolerated in normal animals) is acutely toxic in animals bearing the Ehrlich ascites tumour." | 1.26 | The effect of cycloheximide and carbon tetrachloride in Ehrlich ascites tumour-bearing mice. ( Parry, EW, 1980) |
| " The result suggests that the acquired resistance to a toxic dose of furylfuramide is due to the acceleration of detoxication of the drug." | 1.26 | Development of resistance to hepatotoxic effect of furylfuramide by pretreatment with its subnecrotic doses and carbon tetrachloride. ( Horiuchi, T; Ohtsubo, K; Saito, M, 1978) |
| "A single intraperitoneal dose of carbon tetrachloride (CCl4), from 0-004 to 0-5 ml/kg, protected male mice against the toxic effects of dimethylnitrosamine (DMN)." | 1.25 | Protection by carbon tetrachloride against the toxic effects of dimethylnitrosamine in mice. ( Lawson, TA; Pound, AW, 1975) |
| " Prior dosing with phenobarbitone augments CCl4 toxicity only in the adult and the newborn but the foetus continues to be resistant." | 1.25 | Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine. ( Chopra, P; Das, PK; Dhar, A; Nayak, NC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 116 (40.85) | 18.7374 |
| 1990's | 60 (21.13) | 18.2507 |
| 2000's | 57 (20.07) | 29.6817 |
| 2010's | 47 (16.55) | 24.3611 |
| 2020's | 4 (1.41) | 2.80 |
| Authors | Studies |
|---|---|
| Averyanova, EV | 1 |
| Shkolnikova, MN | 1 |
| Chugunova, OV | 1 |
| Mazko, ON | 1 |
| Xu, P | 2 |
| Yao, J | 1 |
| Ji, J | 1 |
| Shi, H | 2 |
| Jiao, Y | 1 |
| Hao, S | 1 |
| Chen, D | 1 |
| Yang, S | 1 |
| Chen, Y | 1 |
| Wang, L | 3 |
| Wang, T | 1 |
| Yang, C | 1 |
| Yang, H | 1 |
| Li, SQ | 1 |
| Wang, SL | 1 |
| Song, Y | 1 |
| Cheng, WG | 1 |
| Wang, Y | 4 |
| Zhang, BB | 1 |
| Wang, DM | 1 |
| Wang, YL | 1 |
| Lee, J | 1 |
| Kim, SR | 1 |
| Lee, C | 1 |
| Jun, YI | 1 |
| Bae, S | 1 |
| Yoon, YJ | 1 |
| Kim, OY | 1 |
| Gho, YS | 1 |
| Esrefoglu, M | 1 |
| Cetin, A | 1 |
| Taslidere, E | 1 |
| Elbe, H | 1 |
| Ates, B | 1 |
| Tok, OE | 1 |
| Aydin, MS | 1 |
| Wu, YJ | 1 |
| Wu, YC | 1 |
| Chen, IF | 1 |
| Wu, YL | 1 |
| Chuang, CW | 1 |
| Huang, HH | 1 |
| Kuo, SM | 1 |
| Jia, Y | 1 |
| Wang, F | 1 |
| Guo, Q | 1 |
| Li, M | 1 |
| Zhang, Z | 1 |
| Jiang, S | 1 |
| Jin, H | 1 |
| Chen, A | 1 |
| Tan, S | 1 |
| Zhang, F | 1 |
| Shao, J | 1 |
| Zheng, S | 1 |
| Guo, J | 1 |
| Luo, Y | 1 |
| Yin, F | 1 |
| Huo, X | 1 |
| Niu, G | 1 |
| Song, M | 1 |
| Chen, S | 1 |
| Zhang, X | 1 |
| Tsurusaki, S | 1 |
| Tsuchiya, Y | 1 |
| Koumura, T | 1 |
| Nakasone, M | 1 |
| Sakamoto, T | 1 |
| Matsuoka, M | 1 |
| Imai, H | 1 |
| Yuet-Yin Kok, C | 1 |
| Okochi, H | 1 |
| Nakano, H | 1 |
| Miyajima, A | 1 |
| Tanaka, M | 1 |
| Hugenholtz, GC | 1 |
| Meijers, JC | 1 |
| Adelmeijer, J | 1 |
| Porte, RJ | 1 |
| Lisman, T | 1 |
| Gruttadauria, S | 1 |
| Grosso, G | 1 |
| Pagano, D | 1 |
| Biondi, A | 1 |
| Echeverri, GJ | 1 |
| Seria, E | 1 |
| Pietrosi, G | 1 |
| Liotta, R | 1 |
| Basile, F | 1 |
| Gridelli, B | 1 |
| Dong, W | 2 |
| Lv, B | 1 |
| Wei, F | 1 |
| Yang, L | 2 |
| Chan, CC | 1 |
| Lee, KC | 1 |
| Huang, YH | 1 |
| Chou, CK | 1 |
| Lin, HC | 1 |
| Lee, FY | 1 |
| Mochizuki, A | 1 |
| Pace, A | 1 |
| Rockwell, CE | 1 |
| Roth, KJ | 1 |
| Chow, A | 1 |
| O'Brien, KM | 1 |
| Albee, R | 1 |
| Kelly, K | 1 |
| Towery, K | 1 |
| Luyendyk, JP | 1 |
| Copple, BL | 1 |
| Baligar, NS | 1 |
| Aladakatti, RH | 1 |
| Ahmed, M | 1 |
| Hiremath, MB | 1 |
| Jia, R | 1 |
| Cao, LP | 1 |
| Du, JL | 1 |
| Wang, JH | 2 |
| Liu, YJ | 1 |
| Jeney, G | 1 |
| Yin, GJ | 1 |
| Castroneves, LA | 1 |
| Jugo, RH | 1 |
| Maynard, MA | 1 |
| Lee, JS | 1 |
| Wassner, AJ | 1 |
| Dorfman, D | 1 |
| Bronson, RT | 1 |
| Ukomadu, C | 1 |
| Agoston, AT | 1 |
| Ding, L | 1 |
| Luongo, C | 1 |
| Guo, C | 1 |
| Song, H | 1 |
| Demchev, V | 1 |
| Lee, NY | 1 |
| Feldman, HA | 1 |
| Vella, KR | 1 |
| Peake, RW | 1 |
| Hartigan, C | 1 |
| Kellogg, MD | 1 |
| Desai, A | 1 |
| Salvatore, D | 1 |
| Dentice, M | 1 |
| Huang, SA | 1 |
| Pérez-Vargas, JE | 1 |
| Zarco, N | 1 |
| Shibayama, M | 4 |
| Segovia, J | 3 |
| Tsutsumi, V | 3 |
| Muriel, P | 4 |
| Cresci, GA | 1 |
| Allende, D | 1 |
| McMullen, MR | 1 |
| Nagy, LE | 1 |
| Choi, HS | 1 |
| Kang, JW | 1 |
| Lee, SM | 1 |
| Liu, J | 2 |
| Zhang, QY | 1 |
| Yu, LM | 1 |
| Liu, B | 1 |
| Li, MY | 1 |
| Zhu, RZ | 1 |
| Zhao, X | 1 |
| Qian, Y | 1 |
| Li, GJ | 1 |
| Tan, J | 1 |
| Sachdeva, M | 1 |
| Chadha, R | 1 |
| Kumar, A | 1 |
| Karan, M | 1 |
| Singh, T | 1 |
| Dhingra, S | 1 |
| Go, J | 1 |
| Kim, JE | 1 |
| Koh, EK | 1 |
| Song, SH | 1 |
| Sung, JE | 1 |
| Lee, HA | 1 |
| Lee, YH | 1 |
| Lim, Y | 1 |
| Hong, JT | 1 |
| Hwang, DY | 1 |
| Choudhury, ST | 1 |
| Das, N | 1 |
| Ghosh, S | 1 |
| Ghosh, D | 1 |
| Chakraborty, S | 1 |
| Ali, N | 1 |
| Zhan, YY | 1 |
| Tian, X | 1 |
| Feng, SX | 1 |
| Xue, L | 1 |
| Tian, LP | 1 |
| Xing, X | 1 |
| Deng, X | 1 |
| Shi, J | 1 |
| Zhang, M | 1 |
| Sun, G | 1 |
| Tang, S | 1 |
| Huang, Q | 1 |
| Sun, X | 1 |
| Hamid, M | 1 |
| Liu, D | 1 |
| Abdulrahim, Y | 1 |
| Khan, A | 1 |
| Qian, G | 1 |
| Huang, K | 1 |
| Yan, C | 1 |
| Zhou, L | 1 |
| Han, YP | 1 |
| Mehmetçik, G | 1 |
| Ozdemirler, G | 1 |
| Koçak-Toker, N | 1 |
| Cevikbaş, U | 1 |
| Uysal, M | 1 |
| Etim, O | 1 |
| Akpan, E | 1 |
| Usoh, I | 1 |
| Rodríguez-Rivera, A | 1 |
| Galicia-Moreno, M | 1 |
| Reyes-Gordillo, K | 2 |
| Vergara, P | 2 |
| Moreno, MG | 2 |
| Das, BK | 1 |
| Bepary, S | 1 |
| Datta, BK | 1 |
| Chowdhury, AA | 1 |
| Ali, MS | 1 |
| Rouf, AS | 1 |
| Poyrazoglu, OK | 1 |
| Bahcecioglu, IH | 1 |
| Ataseven, H | 1 |
| Metin, K | 1 |
| Dagli, AF | 1 |
| Yalniz, M | 1 |
| Ustundag, B | 1 |
| Aram, G | 1 |
| Potter, JJ | 1 |
| Liu, X | 2 |
| Torbenson, MS | 1 |
| Mezey, E | 1 |
| Salam, OM | 1 |
| Sleem, AA | 1 |
| Omara, EA | 1 |
| Hassan, NS | 1 |
| Mochizuki, M | 1 |
| Shimizu, S | 1 |
| Urasoko, Y | 1 |
| Umeshita, K | 1 |
| Kamata, T | 1 |
| Kitazawa, T | 1 |
| Nakamura, D | 1 |
| Nishihata, Y | 1 |
| Ohishi, T | 1 |
| Edamoto, H | 1 |
| Lafdil, F | 1 |
| Chobert, MN | 1 |
| Deveaux, V | 1 |
| Zafrani, ES | 1 |
| Mavier, P | 1 |
| Nakano, T | 1 |
| Laperche, Y | 1 |
| Brouillet, A | 1 |
| Ma, X | 1 |
| Xu, L | 2 |
| Wang, S | 1 |
| Chen, H | 1 |
| Xu, J | 1 |
| Li, X | 1 |
| Ning, G | 1 |
| Hsu, CC | 1 |
| Hsu, CL | 1 |
| Tsai, SE | 1 |
| Fu, TY | 1 |
| Yen, GC | 1 |
| Park, CM | 1 |
| Youn, HJ | 1 |
| Chang, HK | 1 |
| Song, YS | 1 |
| Allman, M | 1 |
| Gaskin, L | 1 |
| Rivera, CA | 1 |
| Yan, F | 1 |
| Ren, X | 1 |
| Hao, X | 1 |
| Best, DH | 1 |
| Coleman, WB | 1 |
| Amat, N | 1 |
| Upur, H | 1 |
| Blazeković, B | 1 |
| Lu, B | 1 |
| Yin, L | 1 |
| Peng, J | 1 |
| ESCHENBRENNER, AB | 1 |
| MILLER, E | 1 |
| Liu, Q | 1 |
| Kong, B | 1 |
| Li, G | 1 |
| Liu, N | 2 |
| Xia, X | 1 |
| Weng, H | 1 |
| Li, H | 1 |
| Dooley, S | 1 |
| Mahrouf-Yorgov, M | 1 |
| Collin de l'Hortet, A | 1 |
| Cosson, C | 1 |
| Slama, A | 1 |
| Abdoun, E | 1 |
| Guidotti, JE | 1 |
| Fromenty, B | 1 |
| Mitchell, C | 1 |
| Gilgenkrantz, H | 1 |
| Kalaskar, MG | 1 |
| Surana, SJ | 1 |
| Cetin, E | 1 |
| Kanbur, M | 1 |
| Cetin, N | 1 |
| Eraslan, G | 1 |
| Atasever, A | 1 |
| Sahreen, S | 1 |
| Khan, MR | 1 |
| Khan, RA | 2 |
| Cha, JY | 1 |
| Ahn, HY | 1 |
| Moon, HI | 1 |
| Jeong, YK | 1 |
| Cho, YS | 1 |
| Rivera, H | 1 |
| Morales-Ríos, MS | 1 |
| Bautista, W | 1 |
| Pérez-Álvarez, V | 1 |
| Li, J | 1 |
| Gao, J | 1 |
| Yan, D | 1 |
| Yuan, Y | 1 |
| Sah, S | 1 |
| Satyal, U | 1 |
| Liu, M | 1 |
| Han, W | 1 |
| Yu, Y | 1 |
| Yang, X | 1 |
| Greenhaw, J | 1 |
| Shi, Q | 1 |
| Su, Z | 1 |
| Qian, F | 1 |
| Davis, K | 1 |
| Mendrick, DL | 1 |
| Salminen, WF | 1 |
| Xiao, J | 1 |
| Liong, EC | 1 |
| Ching, YP | 1 |
| Chang, RC | 1 |
| So, KF | 1 |
| Fung, ML | 1 |
| Tipoe, GL | 1 |
| Risal, P | 1 |
| Park, BH | 1 |
| Cho, BH | 1 |
| Kim, JC | 1 |
| Jeong, YJ | 1 |
| Bravo, E | 1 |
| D'Amore, E | 1 |
| Ciaffoni, F | 1 |
| Mammola, CL | 1 |
| Jiang, L | 1 |
| Huang, J | 1 |
| Tang, H | 1 |
| Zhang, L | 1 |
| Wang, YD | 1 |
| Chen, WD | 1 |
| Wang, X | 1 |
| Lou, G | 1 |
| Lin, M | 1 |
| Forman, BM | 1 |
| Huang, W | 1 |
| Feroz, Z | 1 |
| Kakegawa, T | 1 |
| Ise, H | 1 |
| Sugihara, N | 1 |
| Nikaido, T | 1 |
| Negishi, N | 1 |
| Akaike, T | 1 |
| Tanaka, E | 1 |
| Endoh, D | 1 |
| Okui, T | 1 |
| Ozawa, S | 1 |
| Yamato, O | 1 |
| Kon, Y | 1 |
| Arikawa, J | 1 |
| Hayashi, M | 1 |
| Zim, MC | 1 |
| Silveira, TR | 1 |
| Schwartsmann, G | 1 |
| Cerski, T | 1 |
| Motta, A | 1 |
| Otsuka, T | 1 |
| Takagi, H | 1 |
| Horiguchi, N | 1 |
| Toyoda, M | 1 |
| Sato, K | 1 |
| Takayama, H | 1 |
| Mori, M | 1 |
| Davidson, AJ | 1 |
| Zon, LI | 1 |
| LeCouter, J | 1 |
| Moritz, DR | 1 |
| Li, B | 1 |
| Phillips, GL | 1 |
| Liang, XH | 1 |
| Gerber, HP | 1 |
| Hillan, KJ | 1 |
| Ferrara, N | 1 |
| Leclercq, IA | 1 |
| Field, J | 1 |
| Farrell, GC | 1 |
| Kwon, YH | 1 |
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| COLTORTI, M | 2 |
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| AUZEPY, P | 1 |
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| Quevedo, J | 1 |
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| Dal-Pizzol, F | 1 |
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| Delmas, Y | 1 |
| Desmoulière, A | 1 |
| Solanilla, A | 1 |
| Hauger, O | 1 |
| Grosset, C | 1 |
| Dubus, I | 1 |
| Ivanovic, Z | 1 |
| Rosenbaum, J | 2 |
| Charbord, P | 1 |
| Combe, C | 1 |
| Bulte, JW | 1 |
| Moonen, CT | 1 |
| Ripoche, J | 1 |
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| Asoh, S | 1 |
| Mori, T | 1 |
| Nagai, S | 1 |
| Yamagata, K | 1 |
| Nishimaki, K | 1 |
| Miyato, Y | 1 |
| Shidara, Y | 1 |
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| Bansal, MB | 1 |
| Kovalovich, K | 1 |
| Gupta, R | 1 |
| Li, W | 1 |
| Agarwal, A | 1 |
| Radbill, B | 1 |
| Alvarez, CE | 1 |
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| Fiel, MI | 1 |
| Friedman, SL | 1 |
| Taub, RA | 1 |
| Constandinou, C | 1 |
| Henderson, N | 1 |
| Iredale, JP | 1 |
| Zhou, XF | 1 |
| Wang, Q | 1 |
| Chu, JX | 1 |
| Liu, AL | 1 |
| Roy, CK | 1 |
| Kamath, JV | 2 |
| Asad, M | 2 |
| Noyan, T | 1 |
| Kömüroğlu, U | 1 |
| Bayram, I | 1 |
| Sekeroğlu, MR | 1 |
| Y, J | 1 |
| Masuda, Y | 3 |
| Qiu, J | 1 |
| Liu, Z | 1 |
| Da, L | 1 |
| Li, Y | 1 |
| Xuan, H | 1 |
| Lin, Q | 1 |
| Li, F | 1 |
| Li, Z | 2 |
| Zhao, M | 1 |
| Todriya, TV | 1 |
| Nikolaeva, TL | 1 |
| Wang, CY | 1 |
| Ma, FL | 1 |
| Liu, JT | 1 |
| Tian, JW | 1 |
| Fu, FH | 1 |
| Xu, D | 1 |
| Wu, Y | 2 |
| Liao, ZX | 1 |
| Wang, H | 1 |
| Anselmi, K | 1 |
| Stolz, DB | 1 |
| Nalesnik, M | 1 |
| Watkins, SC | 1 |
| Kamath, R | 1 |
| Gandhi, CR | 1 |
| Song, JY | 1 |
| Li, L | 1 |
| Ahn, JB | 1 |
| Park, JG | 1 |
| Jo, JS | 1 |
| Park, DH | 1 |
| Jang, HK | 1 |
| Jang, JJ | 1 |
| Lee, MJ | 1 |
| Jia, N | 1 |
| Wen, J | 1 |
| Qian, L | 1 |
| Qian, X | 1 |
| Fan, G | 1 |
| Kim, YC | 1 |
| Yim, HK | 1 |
| Jung, YS | 1 |
| Park, JH | 1 |
| Kim, SY | 1 |
| Naugler, WE | 1 |
| Sakurai, T | 1 |
| Kim, S | 1 |
| Maeda, S | 1 |
| Kim, K | 1 |
| Elsharkawy, AM | 1 |
| Karin, M | 1 |
| Uskoković-Marković, S | 1 |
| Milenković, M | 1 |
| Topić, A | 1 |
| Kotur-Stevuljević, J | 1 |
| Stefanović, A | 1 |
| Antić-Stanković, J | 1 |
| Guo, TT | 1 |
| Xu, HL | 1 |
| Zhang, LX | 1 |
| Zhang, JP | 1 |
| Guo, YF | 1 |
| Gu, JW | 1 |
| He, PM | 1 |
| Smyth, R | 1 |
| Munday, MR | 1 |
| York, MJ | 1 |
| Clarke, CJ | 1 |
| Dare, T | 1 |
| Turton, JA | 1 |
| Rullier, A | 1 |
| Gillibert-Duplantier, J | 1 |
| Costet, P | 1 |
| Cubel, G | 1 |
| Haurie, V | 1 |
| Petibois, C | 1 |
| Taras, D | 1 |
| Dugot-Senant, N | 1 |
| Deleris, G | 1 |
| Bioulac-Sage, P | 1 |
| Tran, TT | 1 |
| Groben, P | 1 |
| Pisetsky, DS | 1 |
| Elferink, MG | 1 |
| Olinga, P | 1 |
| Draaisma, AL | 1 |
| Merema, MT | 1 |
| Bauerschmidt, S | 1 |
| Polman, J | 1 |
| Schoonen, WG | 1 |
| Groothuis, GM | 1 |
| Alexander, NM | 1 |
| Scheig, R | 1 |
| Klatskin, G | 1 |
| Leonard, TB | 1 |
| Neptun, DA | 1 |
| Popp, JA | 1 |
| Farber, JL | 4 |
| Gerson, RJ | 1 |
| Nakashima, T | 1 |
| Takino, T | 1 |
| Kuriyama, K | 1 |
| Bhathal, PS | 2 |
| Rose, NR | 2 |
| Mackay, IR | 2 |
| Whittingham, S | 1 |
| Mehrotra, R | 1 |
| Nath, P | 1 |
| Pandey, R | 1 |
| Chaturvedi, R | 1 |
| Reddrop, CJ | 1 |
| Cheeseman, KH | 1 |
| Biesel, KW | 1 |
| Ehrinpreis, MN | 1 |
| de Ferreyra, EC | 13 |
| de Fenos, OM | 12 |
| Castro, JA | 21 |
| Ghoshal, AK | 1 |
| Mullen, B | 1 |
| Medline, A | 1 |
| Farber, E | 1 |
| De Toranzo, EG | 4 |
| Matsubara, T | 1 |
| Mori, S | 1 |
| Touchi, A | 1 |
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5 reviews available for carbon tetrachloride and Necrosis
| Article | Year |
|---|---|
[Learning toxicology from carbon tetrachloride-induced hepatotoxicity].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fatty Liver; Hepatocytes; Lip | 2006 |
Mechanisms of cell injury with hepatotoxic chemicals.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1984 |
Calcium and the mechanisms of liver necrosis.
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Membrane; Chemical and Drug Induced Liver Injury; Galac | 1982 |
Sinusoidal intercellular adhesion molecule-1 up-regulation precedes the accumulation of leukocyte function antigen-1-positive cells and tissue necrosis in a model of carbontetrachloride-induced acute rat liver injury.
Topics: Acute Disease; Animals; Carbon Tetrachloride; Cell Separation; Chemical and Drug Induced Liver Injur | 1998 |
The biochemical pathology of toxic cell death.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Carbon Tetrachloride; Cell Membrane; Cell Membra | 1985 |
279 other studies available for carbon tetrachloride and Necrosis
| Article | Year |
|---|---|
[Effects of triterpenoids in fatty products on liver condition of laboratory animals with acute toxic hepatitis].
Topics: Alkaline Phosphatase; Animals; Animals, Laboratory; Antioxidants; Carbon Tetrachloride; Chemical and | 2023 |
Deficiency of apoptosis-stimulating protein 2 of p53 protects mice from acute hepatic injury induced by CCl
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Carbon Tetrachlori | 2019 |
Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2020 |
Comparison of the Effects of Intraperitoneal Injection with Carbon Tetrachloride on Acute Liver Toxicity in Male and Female Kunming Mice.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 2021 |
Extracellular vesicles from in vivo liver tissue accelerate recovery of liver necrosis induced by carbon tetrachloride.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Disease Models, Animal; Extracellular | 2021 |
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi | 2017 |
Reparative Effects of Astaxanthin-Hyaluronan Nanoaggregates against Retrorsine-CCl₄-Induced Liver Fibrosis and Necrosis.
Topics: Animals; Carbon Tetrachloride; Hyaluronic Acid; Liver Cirrhosis; Liver Diseases; Male; Necrosis; Pyr | 2018 |
Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Hepatic Stellate | 2018 |
Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice.
Topics: Animals; Apoptosis; Becaplermin; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Fibr | 2019 |
Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chromans; Cytokines; Diet; Ethionine; Ferroptosis; Hepatit | 2019 |
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Ca | 2013 |
Marrow-derived mesenchymal stem cells restore biochemical markers of acute liver injury in experimental model.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Biomarkers; Bone M | 2013 |
Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced chronic injury in rats.
Topics: Alanine Transaminase; Animals; Aprotinin; Aspartate Aminotransferases; Carbon Tetrachloride; Chemica | 2013 |
Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury.
Topics: Alanine Transaminase; Aldehydes; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransf | 2014 |
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Gene Dele | 2014 |
Hepatoprotective activity of the neem-based constituent azadirachtin-A in carbon tetrachloride intoxicated Wistar rats.
Topics: Animals; Azadirachta; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Limonins | 2014 |
Effects of carbon tetrachloride on oxidative stress, inflammatory response and hepatocyte apoptosis in common carp (Cyprinus carpio).
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carps; Cell Survival; Cytokines; Gene Expression Regulatio | 2014 |
Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; Iodide P | 2014 |
Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-β and connective tissue growth factor.
Topics: Animals; Antioxidants; Blotting, Western; Carbon Tetrachloride; Connective Tissue Growth Factor; Dis | 2014 |
Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl₄-induced injury.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Complemen | 2015 |
Melatonin attenuates carbon tetrachloride-induced liver fibrosis via inhibition of necroptosis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Hepatocytes; HMGB1 Protein; Interleukin-1alpha; Interleuki | 2015 |
Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Carbon Tetrachloride; Cell Proliferation; | 2015 |
Preventive effects of the polysaccharide of Larimichthys crocea swim bladder on carbon tetrachloride (CCl4)-induced hepatic damage.
Topics: Animal Structures; Animals; Biological Products; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 2015 |
Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug | 2015 |
Protective Effect of Gallotannin-Enriched Extract Isolated from Galla Rhois against CCl₄-Induced Hepatotoxicity in ICR Mice.
Topics: Animals; Antioxidants; Aphids; Apoptosis; Apoptosis Regulatory Proteins; Biological Products; Biomar | 2016 |
Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride-mediated oxidative hepatocellular damage in rat model.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curc | 2016 |
Protective effects of seed melon extract on CCl
Topics: Actins; Animals; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 2016 |
The chronic hepatotoxicity assessment of the herbal formula Zishen Yutai pill.
Topics: Administration, Oral; Alanine Transaminase; Animals; Biomarkers; Body Weight; Carbon Tetrachloride; | 2017 |
Inactivation of Kupffer Cells by Selenizing Astragalus Polysaccharides Prevents CCl
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astragalus propinquus; Carbon Tetr | 2017 |
Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure.
Topics: Animals; Carbon Tetrachloride; Caspase 3; Chemical and Drug Induced Liver Injury; Collagen Type IV; | 2008 |
Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress.
Topics: Administration, Oral; Antioxidants; Ascorbic Acid; Carbon Tetrachloride; Cynara scolymus; Glutathion | 2008 |
Hepatotoxicity of carbon tetrachloride: protective effect of Gongronema latifolium.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 2008 |
Methyl palmitate prevents CCl(4)-induced liver fibrosis.
Topics: Animals; Biotransformation; Blotting, Western; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 2008 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
Effect of unfiltered coffee on carbon tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 2008 |
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Disease Models, Animal; Hepato | 2009 |
Hepatoprotective effects of misoprostol and silymarin on carbon tetrachloride-induced hepatic damage in rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Dose-Response Relationsh | 2009 |
Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats.
Topics: Animals; Animals, Suckling; Blood Chemical Analysis; Blotting, Western; Carbon Tetrachloride; Carbon | 2009 |
Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice.
Topics: Acute Disease; Animals; Axl Receptor Tyrosine Kinase; Carbon Tetrachloride; Cell Proliferation; Chem | 2009 |
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferati | 2009 |
Protective effect of Millettia reticulata Benth against CCl(4)-induced hepatic damage and inflammatory action in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2009 |
TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon | 2010 |
CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.
Topics: Alanine Transaminase; Animals; Biomarkers; Blotting, Western; Carbon Tetrachloride; Chemical and Dru | 2010 |
Recombinant bovine pancreatic trypsin inhibitor protects the liver from carbon tetrachloride-induced acute injury in mice.
Topics: Animals; Aprotinin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Rela | 2010 |
Liver regeneration by small hepatocyte-like progenitor cells after necrotic injury by carbon tetrachloride in retrorsine-exposed rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatectomy; Hepatocytes; Liv | 2010 |
In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Artemisia absinthium; Asparta | 2010 |
Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Computational Biology; Diosge | 2011 |
Liver necrosis and the induction of carbon tetrachloride hepatomas in strain A mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Liver; Liver Diseases; Liver Neoplasms; Mi | 1946 |
Hepatoprotective and antioxidant effects of porcine plasma protein hydrolysates on carbon tetrachloride-induced liver damage in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Bloo | 2011 |
Inflammation does not always kill hepatocytes during liver damage.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, An | 2011 |
Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response.
Topics: Aging; Animals; Carbon Tetrachloride; Cell Proliferation; Chronic Disease; Disease Susceptibility; H | 2011 |
Free radical scavenging and hepatoprotective potential of Ficus microcarpa L. fil. bark extracts.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Ficus; Free Radical Scavengers; Liver; Male; Mice | 2011 |
Hepatoprotective effect of ghrelin on carbon tetrachloride-induced acute liver injury in rats.
Topics: Animals; Blood Glucose; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Cyto | 2011 |
Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat.
Topics: Animals; Antioxidants; Apocynaceae; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hy | 2011 |
Effect of fermented Angelicae gigantis Radix on carbon tetrachloride-induced hepatotoxicity and oxidative stress in rats.
Topics: Adipose Tissue, White; Angelica; Animals; Body Weight; Carbon Tetrachloride; Chemical and Drug Induc | 2012 |
A novel fluorinated stilbene exerts hepatoprotective properties in CCl(4)-induced acute liver damage.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cho | 2011 |
Neutralization of chemokine CXCL14 (BRAK) expression reduces CCl4 induced liver injury and steatosis in mice.
Topics: Animals; Antibodies, Neutralizing; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induc | 2011 |
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bio | 2012 |
Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemica | 2012 |
Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Hepatoc | 2012 |
Evaluation of the spontaneous reversibility of carbon tetrachloride-induced liver cirrhosis in rabbits.
Topics: Animals; Body Weight; Carbon Tetrachloride; Fibrosis; Image Processing, Computer-Assisted; Liver; Li | 2012 |
Metabonomic analysis reveals the CCl4-induced systems alterations for multiple rat organs.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Carbon Tetrachlorid | 2012 |
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice.
Topics: Analysis of Variance; Animals; Bile Acids and Salts; Carbon Tetrachloride; Chemical and Drug Induced | 2012 |
Hepatoprotective effect of herbal drug on CCl(4) induced liver damage.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Biomarkers; Carbon Tetrachloride; Ch | 2013 |
Soluble asialoglycoprotein receptors reflect the apoptosis of hepatocytes.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Asialoglycoprotein Receptor; Asialoglycoproteins; Carbon | 2002 |
Protective effect of a lignan-containing flaxseed extract against CCl(4)-induced hepatic injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA Damage; Drug Administrati | 2002 |
Potentiation of carbon tetrachloride hepatotoxicity by pentosan polysulfate in rats.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Enzyme Inhibitors; Liver Cirrhosis, Experimental; Mal | 2002 |
CCl4-induced acute liver injury in mice is inhibited by hepatocyte growth factor overexpression but stimulated by NK2 overexpression.
Topics: Alanine Transaminase; Animals; Blotting, Northern; Carbon Tetrachloride; Cell Division; DNA, Complem | 2002 |
Biomedicine. Love, honor, and protect (your liver).
Topics: Animals; Carbon Tetrachloride; Cell Communication; Cell Division; Chemical and Drug Induced Liver In | 2003 |
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2003 |
Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury.
Topics: Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver Injury; Cyclin D1; Fat | 2003 |
The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury.
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Caspases; Cell Cycle; Cell Cycle Pro | 2003 |
Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Carbon Tetrachloride; Che | 2003 |
[Behavior of the phosphoglyceromutase activity of blood in experimental carbon tetrachloride necrosis of the liver].
Topics: Carbon Tetrachloride; Intramolecular Transferases; Liver Diseases; Necrosis; Phosphoglycerate Mutase | 1956 |
[Behavior of the phosphoglyceromutase activity of blood in experimental carbon tetrachloride necrosis of the liver].
Topics: Carbon Tetrachloride; Intramolecular Transferases; Liver Diseases; Necrosis; Phosphoglycerate Mutase | 1956 |
[Behavior of the phosphoglyceromutase activity of blood in experimental carbon tetrachloride necrosis of the liver].
Topics: Carbon Tetrachloride; Intramolecular Transferases; Liver Diseases; Necrosis; Phosphoglycerate Mutase | 1956 |
[Behavior of the phosphoglyceromutase activity of blood in experimental carbon tetrachloride necrosis of the liver].
Topics: Carbon Tetrachloride; Intramolecular Transferases; Liver Diseases; Necrosis; Phosphoglycerate Mutase | 1956 |
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical | 2003 |
[Study of the hepatic release of vitamin B12 labeled by cobalt 60 in the course of experimental necrosis due to carbon tetrachloride].
Topics: Carbon Tetrachloride; Cobalt; Corrinoids; Liver Diseases; Necrosis; Vitamin B 12 | 1959 |
THE EFFECT OF CARBON TETRACHLORIDE ON HEPATIC LIPID METABOLISM.
Topics: Acetates; Alanine Transaminase; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 1964 |
[THE EFFECT OF DIFFERENT SUBSTANCES ON ACUTE CARBON TETRACHLORIDE NECROSIS OF THE RAT LIVER].
Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poi | 1965 |
HEPATIC AND SERUM CHANGES FOLLOWING REPEATED ADMINISTRATION OF SMALL AMOUNTS OF CARBON TETRACHLORIDE TO SHEEP.
Topics: Animals; Aspartate Aminotransferases; Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 1965 |
PROTECTION PROVIDED AGAINST CARBON TETRACHLORIDE AND THIOACETAMIDE POISONING BY STROPHANTHIN-G.
Topics: Amides; Bilirubin; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Ch | 1965 |
A NOTE ON THE RELATIVE TOXIC ACTIVITIES OF TETRACHLOROMETHANE AND TRICHLORO-FLUORO-METHANE ON THE RAT.
Topics: Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1965 |
The regulation of liver regeneration by the plasmin/alpha 2-antiplasmin system.
Topics: alpha-2-Antiplasmin; Animals; Carbon Tetrachloride; Cell Division; Chemical and Drug Induced Liver I | 2004 |
Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes.
Topics: Animals; Antibodies; Apoptosis; Carbon Tetrachloride; DNA Fragmentation; Endodeoxyribonucleases; fas | 2004 |
The effectiveness of auriculoacupoint treatment for artificially induced acute hepatic injury in dogs.
Topics: Acupuncture Points; Acupuncture Therapy; Alanine Transaminase; Animals; Aspartate Aminotransferases; | 2004 |
Intravital staining of damaged liver cells; the use of dyes in the study of necrosis and repair following acute chemical injury.
Topics: Carbon Tetrachloride; Coloring Agents; Liver; Liver Diseases; Necrosis; Staining and Labeling | 1950 |
Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Cholagogues and Choleretics; Drugs, Chinese Herbal; | 2004 |
Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Carbon Tetrachloride; Deferoxamine; Hydrocarbons; Inflammatio | 2004 |
In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver.
Topics: Adipocytes; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Cell Survival; | 2004 |
Zonal necrosis prevented by transduction of the artificial anti-death FNK protein.
Topics: Adenosine Triphosphate; Carbon Tetrachloride; Caspase Inhibitors; Dexamethasone; Ethanol; Humans; Li | 2005 |
Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
Topics: Acute Disease; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enz | 2005 |
Modeling liver fibrosis in rodents.
Topics: Actins; Animals; Animals, Genetically Modified; Apoptosis; Azo Compounds; Carbon Tetrachloride; Colo | 2005 |
Effects of retrorsine on mouse hepatocyte proliferation after liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Hepatocytes; Immunohistochemistry; Ki-67 Antigen; | 2006 |
Hepatoprotective activity of Psidium guajava Linn. leaf extract.
Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2006 |
Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice.
Topics: Animals; Antioxidants; Apoptosis; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver In | 2006 |
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug | 2006 |
Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Blotting, Western; Carbon Tet | 2007 |
Regeneration of the liver in mice treated with a mixture of hepatotoxins in delayed periods after bone marrow transplantation.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Female; | 2006 |
Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Caffeic Acids; Carbon Tetr | 2007 |
Protective effect of verapamil on multiple hepatotoxic factors-induced liver fibrosis in rats.
Topics: Actins; Alanine Transaminase; Animals; Carbon Tetrachloride; Collagen; Dietary Fats; Disease Models, | 2007 |
Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biom | 2007 |
Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: exacerbation by caspase and serine protease inhibition.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Caspase 3; Caspase Inhibitors; Cell Survival; Cytochromes | 2007 |
Acute liver toxicity by carbon tetrachloride in HSP70 knock out mice.
Topics: Acute Disease; Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 2007 |
A proteomic method for analysis of CYP450s protein expression changes in carbon tetrachloride induced male rat liver microsomes.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; | 2007 |
Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Animals; Biotransformation; Carbon Tetrachloride; Chemical | 2007 |
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Estradiol; Female; Hepatocytes; Interleukin-6; Ku | 2007 |
Protective effects of tungstophosphoric acid and sodium tungstate on chemically induced liver necrosis in wistar rats.
Topics: Acute Disease; Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Disease Models, An | 2007 |
In vivo protective effect of Porphyra yezoensis polysaccharide against carbon tetrachloride induced hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chem | 2007 |
Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Carbon Tetrachloride; Chemic | 2007 |
Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
Topics: Animals; Carbon Tetrachloride; Cell Hypoxia; Chemokine CCL2; Chemotaxis, Leukocyte; Collagen Type I; | 2008 |
The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis.
Topics: Acetaminophen; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; DNA; Female; L-Lactate Dehydrog | 2008 |
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Down-Regulation; Fibrosis; Forecasting; Gli | 2008 |
Effects of L-asparagine and related compounds on the hepatic fatty infiltration and necrosis induced by ethionine and carbon tetrachloride.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Tetrachloride; Chromatography, Gas; Ethionine; Fatty Acid | 1967 |
Serum gamma glutamyl transferase as a specific indicator of bile duct lesions in the rat liver.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Alkaline Phosphatase; Animals; Bile Acids and Salts; | 1984 |
Pretreatment with taurine facilitates hepatic lipid peroxide formation associated with carbon tetrachloride intoxication.
Topics: Animals; Calcium; Carbon Tetrachloride; Iron; Lipid Peroxides; Liver; Male; Microsomes, Liver; NADP; | 1983 |
Strain differences in mice in carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Glycocholic Acid; Liv | 1983 |
Histological & ultrastructural alterations in the livers of albino rats after prolonged administration of paracetamol.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; | 1983 |
Correlations between common tests for assessment of liver damage: indices of the hepatoprotective activity of promethazine in carbon tetrachloride hepatotoxicity.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Fatty Liver; Lipid Metabolism; Lipid Peroxides; Liv | 1983 |
Genetics of carbon tetrachloride-induced liver injury in mice. II. Multigenic regulation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Genotype; Glycocholic | 1984 |
Late preventive effects of phenylmethylsulfonyl-fluoride on carbon tetrachloride-induced liver necrosis.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1984 |
Sequential analysis of hepatic carcinogenesis. Regeneration of liver after carbon tetrachloride-induced liver necrosis when hepatocyte proliferation is inhibited by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Liver; Liver Neoplasms; Liver R | 1983 |
Prevention of carbon tetrachloride-induced liver necrosis by several amino acids.
Topics: Amino Acids; Animals; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Isocit | 1983 |
Carbon tetrachloride-induced hepatotoxicity in rats: evidence for different susceptibilities of rat liver lobes.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cytochrome P-450 E | 1983 |
Effect of 3 amino 1,2,4 triazole administration on the early CCl4-induced ultrastructural alterations in rat liver.
Topics: Amitrole; Animals; Carbon Tetrachloride; Endoplasmic Reticulum; Liver; Male; Microscopy, Electron; M | 1982 |
Decrease of carbon tetrachloride liver toxicity in rats given dipyridamole.
Topics: 1-Propanol; Animals; Body Temperature; Carbon Tetrachloride; Dipyridamole; Dose-Response Relationshi | 1982 |
Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis.
Topics: Calcium; Carbon Tetrachloride; Cell Membrane; Cell Survival; Cell Transformation, Viral; Homeostasis | 1982 |
Histochemical and ultrastructural studies of hepatic fibrogenesis; its initiation and the effect of dexamethasone in rats.
Topics: Animals; Carbon Tetrachloride; Dexamethasone; Histocytochemistry; Liver; Male; Microscopy, Electron; | 1982 |
Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Carb | 1981 |
Studies on the prevention of CCl4 induced liver necrosis by agents having effects on cell membrane.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Membrane; | 1980 |
Serum bile acid concentration in some experimental liver lesions of rat.
Topics: Alanine Transaminase; Aniline Compounds; Animals; Bile Acids and Salts; Bile Ducts; Carbon Tetrachlo | 1980 |
The effect of cycloheximide and carbon tetrachloride in Ehrlich ascites tumour-bearing mice.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Ehrlich Tumor; Chemical and Drug Induced Liver Injury; Cyc | 1980 |
Effect of carbon tetrachloride intoxication and ethanol ingestion on interferon production in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1994 |
Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health.
Topics: Animals; Animals, Newborn; Calcium; Carbon Tetrachloride; Cell Division; Chlordecone; Colchicine; Dr | 1994 |
Differential staining of DNA strand breaks in dying cells by non-radioactive in situ nick translation.
Topics: Acid Phosphatase; Animals; Apoptosis; Carbon Tetrachloride; Cell Nucleus; DNA Damage; DNA Nucleotidy | 1995 |
Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.
Topics: Animals; Carbon Tetrachloride; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Liver; Mic | 1995 |
Cross-linked cytokeratin polypeptides in liver and hepatoma cells: possible association with the process of cell degeneration and death.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Ischemia; Keratins; Liver; Liver Circulation; Liver Ne | 1993 |
Resiliency to amplification of carbon tetrachloride hepatotoxicity by chlordecone during postnatal development in rats.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chlordecone; Cytochrome P-450 Enzyme S | 1993 |
Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury.
Topics: Animals; Blotting, Northern; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; F | 1995 |
In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note.
Topics: Animals; Apoptosis; Autolysis; Carbon Tetrachloride; Cell Death; DNA; DNA Damage; Female; Genetic Te | 1995 |
Use of prostaglandin I2 analog in treatment of massive hepatic necrosis associated with endothelial cell injury and diffuse sinusoidal fibrin deposition.
Topics: Animals; Antithrombin III; Capillaries; Carbon Tetrachloride; Cells, Cultured; Dimethylnitrosamine; | 1995 |
Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P.
Topics: Animals; Carbon Tetrachloride; Dinoprost; Diquat; Dose-Response Relationship, Drug; Lipid Peroxidati | 1995 |
Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin.
Topics: Amino Acid Sequence; Animals; Bile Ducts; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 1993 |
Inhibition of carbon tetrachloride-induced liver injury by liposomes containing vitamin E.
Topics: Animals; Antioxidants; Carbocyanines; Carbon Tetrachloride; Dose-Response Relationship, Drug; Female | 1994 |
Nicotinamide late protective effects against carbon tetrachloride-induced liver necrosis.
Topics: Animals; Carbon Tetrachloride; Lipid Peroxidation; Liver; Male; Necrosis; Niacinamide; Rats; Rats, S | 1994 |
Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). II. Recovery from the acute, CCl4-induced liver damage.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Glycine; Imino Acids; Liver; Male; Metabolic Clear | 1993 |
N-acetyl cysteine is an early but also a late preventive agent against carbon tetrachloride-induced liver necrosis.
Topics: Acetylcysteine; Animals; Carbon Tetrachloride; Lipid Peroxidation; Liver; Male; Microsomes, Liver; N | 1994 |
Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis.
Topics: Animals; Body Temperature; Calcium; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug In | 1993 |
Experimental toxic liver damage and hepatic plasma clearance of 99mTc-mebrofenin (iminodiacetate derivative). I. Early, acute CCl4-induced liver damage in rabbits.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Glycine; Imino A | 1993 |
Carbon tetrachloride-induced cell death in perfused livers from phenobarbital-pretreated rats under hypoxic conditions and various ionic milieu. Further evidence for calcium-dependent irreversible changes.
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Death; Cell Hypoxia; Cytochrome P-450 Enzyme System; El | 1993 |
Intrahepatic distribution of transforming growth factor-alpha (TGF alpha) during liver regeneration following carbon tetrachloride-induced necrosis.
Topics: Animals; Antibodies, Monoclonal; Carbon Tetrachloride; Cell Division; Immunoenzyme Techniques; Liver | 1993 |
Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Death; Chromatin; DNA; Isc | 1993 |
Effect of hepatoprotective ayurvedic drugs on lipolytic activities during CCl4 induced acute hepatic injury in albino rats.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; India; Lipase; Liver; Liver D | 1993 |
Prevention of CCl4-induced liver necrosis by the calcium chelator arsenazo III.
Topics: Animals; Arsenazo III; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Glutathione; I | 1993 |
Late protective effects of the anticalmodulin drug fluphenazine on carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature Regulation; Calmodulin; Carbon Tetrachloride; Chemical and Drug Induced Li | 1995 |
Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment.
Topics: Animals; Carbon Tetrachloride; Chlordecone; Drug Interactions; Hazardous Substances; Humans; Liver; | 1995 |
Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogens; Cell Death; Cell Division; Diethylnitrosamine | 1996 |
Hepatoprotective effects of emodin from Ventilago leiocarpa.
Topics: Acetates; Analysis of Variance; Animals; Carbon Tetrachloride; Chemical Fractionation; Chloroform; E | 1996 |
Protective effect of celosian, an acidic polysaccharide, on chemically and immunologically induced liver injuries.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzymes; Galactosa | 1996 |
The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Liver; Male; Mice; Mice | 1996 |
Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Clenbute | 1996 |
Radioprotectors as late preventive agents against carbon tetrachloride induced liver necrosis: protection by 2-(3-aminopropylamino) ethylphosphorothioic acid (WR2721).
Topics: Alkaline Phosphatase; Amifostine; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Inj | 1995 |
Sequence requirements for alpha-fetoprotein gene expression during liver regeneration.
Topics: alpha-Fetoproteins; Animals; Carbon Tetrachloride; Enhancer Elements, Genetic; Fetus; Gene Expressio | 1995 |
alpha-Tocopheryl hemisuccinate administration increases rat liver subcellular alpha-tocopherol levels and protects against carbon tetrachloride-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1997 |
Time courses of hepatic injuries induced by chloroform and by carbon tetrachloride: comparison of biochemical and histopathological changes.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1997 |
Glutathione pretreatment lessens the acute liver injury induced by carbon tetrachloride.
Topics: Animals; Biomarkers; Blotting, Northern; Carbon Tetrachloride; Erythrocytes; Glutathione; Liver; Mal | 1997 |
Spatial and temporal dynamics of hepatic stellate cell activation during oxidant-stress-induced fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Collagen; Free Radicals; Heme Oxygenase (Decyclizing); Immunohistoche | 1998 |
The recovering effect of betaine on carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Animals; Betaine; Carbon Tetrachloride; Cell Nucleus; Chemical and Drug Induce | 1998 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal | 1998 |
Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.
Topics: Animals; Biliary Tract; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 1998 |
Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cell Movement; Chemical and Drug Induced Liver Injury; | 1998 |
Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague-Dawley rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Carbon Tetrachloride; Cel | 1998 |
Experimental studies on the stem cell concept of liver regeneration. II.
Topics: Animals; Bromodeoxyuridine; Carbon Tetrachloride; Cell Count; Cell Differentiation; Cell Division; F | 1999 |
Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Carbon Tetrachloride; Carcinogens; Cell Division; Die | 1999 |
4-Hydroxynonenal and malondialdehyde hepatic protein adducts in rats treated with carbon tetrachloride: immunochemical detection and lobular localization.
Topics: Alanine Transaminase; Aldehydes; Alkylation; Animals; Blotting, Western; Carbon Tetrachloride; Fatty | 1999 |
Biphasic effect of colchicine on acute liver injury induced by carbon tetrachloride or by dimethylnitrosamine in mice.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; bcl-X Protein; Carbon Tetrach | 1999 |
Pathological changes of hepatic artery and portal vein, after allyl-alcohol and carbon tetrachloride administration. An experimental study.
Topics: Animals; Carbon Tetrachloride; Hepatic Artery; Liver; Liver Regeneration; Male; Necrosis; Portal Vei | 2000 |
Circadian variations in hepatotoxicity of carbon tetrachloride in mice.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Circadian Rhythm; Liver; Male; Mice; Mice, Inbr | 2000 |
The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injur | 2000 |
Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver.
Topics: Animals; Apoptosis; Ascorbic Acid; Carbon Tetrachloride; Caspase 3; Caspases; Chemical and Drug Indu | 2001 |
Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.
Topics: Actins; Animals; Carbon Tetrachloride; Cells, Cultured; Collagen Type I; Dose-Response Relationship, | 2002 |
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 1975 |
[Change in the mitotic activity of hepatocytes and resorption of necrotic areas in the formation of liver cirrhosis].
Topics: Animals; Carbon Tetrachloride; Iodized Oil; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Mi | 1976 |
Protection by propylthiouracil against carbon tetrachloride-induced liver damage.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1976 |
Relationship between lysosomal damage, fatty infiltration and hepatocellular necrosis in the course of acute liver injury induced by carbon tetrachloride in the rat.
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1975 |
The mechanism of necrotic tissue removal in mouse liver following CCl4-induced injury.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cycloheximide; Eosinophils; L | 1979 |
Histopathology of skin, liver, and kidney after epicutaneous administration of five industrial solvents to guinea pigs.
Topics: Administration, Topical; Animals; Carbon Tetrachloride; Ethylene Chlorohydrin; Guinea Pigs; Hexanes; | 1979 |
Carbon tetrachloride activation, lipid peroxidation and liver necrosis in different strains of mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Lipid Me | 1978 |
Mechanism of chloramphenicol prevention of carbon tetrachloride-induced liver damage.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Chloramphenicol; Lipid Metabolism; Liver; Male; Mic | 1978 |
Development of resistance to hepatotoxic effect of furylfuramide by pretreatment with its subnecrotic doses and carbon tetrachloride.
Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Carbon Tetrachloride; | 1978 |
Radioimmunoassay of plasma ligandin: a sensitive index of experimental hepatocellular necrosis.
Topics: Animals; Aspartate Aminotransferases; Blood Specimen Collection; Carbon Tetrachloride; Carbon Tetrac | 1978 |
Studies on mobilization of Kupffer cells in mice. I. The effect of carbon tetrachloride-induced liver necrosis.
Topics: Animals; Carbon Tetrachloride; Cell Movement; Kupffer Cells; Liver; Liver Regeneration; Male; Mice; | 1978 |
Studies on the role of protein syntheis in cell injury by toxic agents: I. Effect of cycloheximide administration on several factors modulating carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cycloheximi | 1977 |
Histochemical studies on the liver of Heteropneustes fossilis treated with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cell Count; Cell Nucleus; DNA; Fishes; Liver; Liver Cirrhosis, Experi | 1976 |
[Relationship between cell division and function. Resistance of the liver to toxic effect of CCL4 after partial hepatectomy].
Topics: Animals; Biotransformation; Carbon Tetrachloride; Cell Division; Hepatectomy; Liver; Liver Regenerat | 1976 |
Protection by carbon tetrachloride against the toxic effects of dimethylnitrosamine in mice.
Topics: Animals; Carbon Tetrachloride; Dimethylnitrosamine; Lethal Dose 50; Liver; Male; Mice; Microsomes, L | 1975 |
Manganese induced hepatic lesions in carbon tetrachloride pretreated rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease | 1975 |
Pharmacological and pathological studies on hepatic protective crude drugs from Taiwan (V): The effects of Bombax malabarica and Scutellaria rivularis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1992 |
Effects of the prostaglandin E2 analogue enprostil on the carbon tetrachloride-induced necrosis of liver cells in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Dinoprostone; E | 1992 |
Prostaglandin E1 cytoprotection against CCl4-induced necrosis in isolated rat liver cells.
Topics: Alprostadil; Animals; Carbon Tetrachloride; In Vitro Techniques; Liver; Male; Misoprostol; Necrosis; | 1992 |
Prolonged reduction of hepatocyte proliferative ability in rats after a single treatment with carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Division; Fem | 1992 |
In vivo studies on halogen compound interactions. III. Effect of carbon tetrachloride plus 1,2-dichloroethane on liver necrosis and fatty accumulation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Combinations; | 1992 |
In vivo studies on halogen compound interactions. IV. Interaction among different halogen derivatives with and without synergistic action on liver toxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromotrichloromethane; Carbon Tetrachlor | 1992 |
Prevention of carbon tetrachloride-induced liver necrosis by the chelator alizarin sodium sulfonate.
Topics: Animals; Anthraquinones; Body Temperature; Calcium; Carbon Tetrachloride; Chelating Agents; Chemical | 1992 |
Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enzyme Induction; Extracellul | 1991 |
Different effects of carbon tetrachloride on carcinogen-induced hepatocellular carcinoma and normal liver of the rat: lowered lipid peroxidation and accelerated necrosis in cancer.
Topics: Animals; Ascorbic Acid; Azo Compounds; Carbon Tetrachloride; Fatty Acids; Fatty Liver; Lipid Peroxid | 1991 |
The production of hepatic cirrhosis in rats.
Topics: Animals; Body Weight; Carbon Tetrachloride; Fibrosis; Hyperplasia; Hypertrophy; Liver; Liver Cirrhos | 1991 |
In vivo and in vitro evidence concerning the role of lipid peroxidation in the mechanism of hepatocyte death due to carbon tetrachloride.
Topics: Animals; Calcium Chloride; Carbon Tetrachloride; Cell Survival; Lipid Peroxidation; Liver; Male; Mal | 1991 |
Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clonidine; | 1991 |
[Cell damage and phospholipid metabolism in drug-induced oxidative injury].
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Membrane; Free Radicals; Lipid Peroxides; Liver; Necros | 1991 |
Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats.
Topics: Animals; Aspartic Acid; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutamates; Li | 1990 |
Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats.
Topics: Adenine Nucleotides; Adenosine; Animals; Carbon Tetrachloride; Collagen; Fibrosis; Liver; Liver Cirr | 1990 |
The diagnostic usefulness of isocitrate dehydrogenase (ICDH) in the marmoset (Callithrix jacchus).
Topics: Alanine Transaminase; Amino Acid Oxidoreductases; Animals; Aspartate Aminotransferases; Callithrix; | 1989 |
[Protective effects of the pollen of Codonopsis pilosula (Franch.) Nannf. on liver lesions at the ultrastructural level].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Fibrosis; Liver; Male | 1989 |
Further studies on the mechanism of the late protective effects of phenylmethylsulfonyl fluoride on carbon tetrachloride-induced liver necrosis.
Topics: Administration, Oral; Animals; Body Temperature; Calcium; Carbon Radioisotopes; Carbon Tetrachloride | 1989 |
Liver cell necrosis and regeneration following injections of carbon tetrachloride. Effects of the thyrotropin-releasing hormone and somatostatin.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Regeneration; Male; Mice; Necrosis; Organ Size; Somatost | 1989 |
Late preventive effects against carbon tetrachloride-induced liver necrosis of the calcium chelating agent Calcion.
Topics: Animals; Body Temperature; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chelating | 1989 |
Collagen production in fat-storing cells after carbon tetrachloride intoxication in the rat. Immunoelectron microscopic observation of type I, type III collagens, and prolyl hydroxylase.
Topics: Animals; Carbon Tetrachloride; Collagen; Immunoenzyme Techniques; Immunohistochemistry; Liver; Liver | 1988 |
Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Ethylene Dibromide; gamma-Glutamyl | 1987 |
Structural and functional changes after the administration of tetrachlormethane in the liver of rats fed on diets with different protein contents.
Topics: Animals; Carbon Tetrachloride; Dietary Proteins; DNA; Liver; Liver Regeneration; Male; Necrosis; Rat | 1987 |
Late preventive effects of trifluoperazine on carbon tetrachloride-induced hepatic necrosis.
Topics: Animals; Body Temperature; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Liv | 1986 |
Evaluating toxin-induced hepatic injury in rats by laboratory results and discriminant analysis.
Topics: 1-Naphthylisothiocyanate; 1-Propanol; 5'-Nucleotidase; Alanine Transaminase; Animals; Carbon Tetrach | 1986 |
In vivo studies on halogen compound interactions. I. Effects of carbon tetrachloride plus 1,2-dibromoethane on liver necrosis.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Ethylene Dibromide; Glutathione; Hydrocarbons, Bromin | 1988 |
The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1987 |
Potentiating effects of phenobarbitone on the induction of cirrhosis in rats by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Female; Liver; Liver Cirrhosis, Experimental; Necrosi | 1988 |
Effects of epidermal growth factor, glucagon and insulin on the hepatocytes after experimental liver cell necrosis. In vivo studies with monoclonal anti-bromo-deoxyuridine staining.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Epidermal Growth Factor; | 1988 |
Hepatotoxicity of carbon tetrachloride after chronic ethanol consumption.
Topics: Alanine Transaminase; Alcoholism; Animals; Aspartate Aminotransferases; Body Weight; Carbon Tetrachl | 1988 |
Protection against carbon tetrachloride hepatotoxicity by 5,10-dihydroindeno[1,2-b]indole, a potent inhibitor of lipid peroxidation.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Chemical and Drug Induced | 1988 |
Development of paracetamol induced hepatocellular tolerance in albino rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Drug Tolerance; Liver; Necrosis; Rats; Rats, Inbred St | 1988 |
[Morphologic study of CCl4-induced liver necrosis in rats and its treatment with a "hepatitis No. III" decoction].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; | 1988 |
Protection by dimethylsulfoxide against acetaminophen-induced hepatic, but not respiratory toxicity in the mouse.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Dimethyl Sulfoxide; Female; Free Radicals; Glutathione | 1988 |
Effect of tryptophan on toxic cirrhosis induced by intermittent carbon tetrachloride intoxication in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride; Female; Liver; Liver Cirrhosis, Experimental; Necrosis; | 1988 |
The role of CCl4 biotransformation in the activation of hepatocyte phospholipase C in vivo and in vitro.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Enzyme Activation; Liver; Male; Necrosis; Rats; Ra | 1988 |
Relationship between hepatotoxicity and induction of replicative DNA synthesis following single or multiple doses of carbon tetrachloride.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; DNA; DNA Repair; D | 1987 |
Enhancing effects of carbon tetrachloride in mouse hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms, | 1986 |
Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine.
Topics: Administration, Oral; Alanine Transaminase; Animals; Calcium; Carbon Tetrachloride; Cystamine; DNA; | 1986 |
Possible effects of muramyl dipeptide on liver cell membranes.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Carbon Tetrachloride; Cell Membrane; Cell Survival; Hist | 1986 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hep | 1986 |
Desmin-containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury.
Topics: Animals; Carbon Tetrachloride; Desmin; Liver; Male; Necrosis; Rats; Rats, Inbred Strains; Time Facto | 1986 |
Potentiation of carbon tetrachloride hepatotoxicity by hypoxia.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1986 |
Changes in prolinase and prolidase activity during CCl4 administration inducing liver cytolysis and fibrosis in rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Dipeptidases; Fibr | 1987 |
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.
Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug I | 1986 |
Patterns of structural change in DNA during tissue necrosis indicated by benzoylated DEAE-cellulose chromatography.
Topics: Animals; Carbon Tetrachloride; Chromatography, DEAE-Cellulose; DNA; DNA, Single-Stranded; Female; Li | 1985 |
Propionate loading test for liver function during experimental liver necrosis in sheep.
Topics: Animals; Blood Glucose; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Glucon | 1985 |
Influence of cold environment on hepatic changes produced by repeated doses of carbon tetrachloride.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Carbon Tetrachloride | 1972 |
Functional structure of the cirrhotic rat liver.
Topics: Animals; Bile Ducts; Capillaries; Carbon Tetrachloride; Cell Nucleus; Cytoplasm; Freeze Drying; Incl | 1974 |
The liver-pathogenic role of spleen suspension of rats treated with carbon tetrachloride.
Topics: Animals; Antibodies; Carbon Tetrachloride; Fatty Liver; Female; Freund's Adjuvant; Liver; Liver Tran | 1973 |
Gamma-glutamyl transpeptidase: a clinical and experimental study.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Carbon | 1972 |
[Etiology of necrotic changes in organs of fattened geese. II. Attempts at infecting geese with S. necrogenes and prophylactic action of chlorocycline Polfa and deworming with carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Fusobacterium Infections; Geese; Liver; Liver Diseases; Necrosis; Nem | 1974 |
Sulfaguanidine protection of mouse liver from carbon tetrachloride-induced necrosis.
Topics: Aniline Compounds; Animals; Autoradiography; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 1973 |
Hepatocellular tolerance to carbon tetrachloride induced injury in the rat: a study of its nature and possible mode of evolution.
Topics: Animals; Biopsy; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liv | 1974 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; | 1971 |
The different susceptibility of rat liver lobes to carbon tetrachloride and dimethylnitrosamine.
Topics: Animals; Carbon Tetrachloride; Dose-Response Relationship, Drug; Injections; Injections, Intraperito | 1974 |
Time course of protection by N'N--diphenyl-p-phenylendiamine (DPPD) against carbon tetrachloride hepatotoxicy.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1974 |
[Effect of a second CCl 4 -intoxication on CCl 4 -damaged mouse liver].
Topics: Animals; Autoradiography; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Nucleus; Chemic | 1972 |
Pyrazole blockade of carbon tetrachloride activation and liver necrosis.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In | 1972 |
Pituitary necrosis induced by intrasellar injections of hexadimethrine-bromide.
Topics: Animals; Carbon Tetrachloride; Dimethylamines; Hydrocarbons, Halogenated; Hypopituitarism; Injection | 1972 |
Experimental hepatic necrosis: studies on coagulation abnormalities, plasma clearance, and organ distribution of 125I-labelled fibrinogen.
Topics: Animals; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagulation Tests; Body Weight; | 1973 |
Role of cytochrome P-450 in carbon tetrachloride activation and CCl 4-induced necrosis. Effect of inhibitors of heme synthesis. I. 3-Amino-1,2,4 triazole.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enz | 1973 |
Decreased toxicity of dimethylnitrosamine in rats after treatment with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylamines; DNA; Kidney; | 1973 |
[Morphological results of combined action of carbon tetrachloride and heightened room temperature in a short-time animal experiment].
Topics: Adrenal Glands; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response | 1973 |
Liver regeneration and uraemia.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; Lectins; Liver; Liver Re | 1973 |
Characterization of rat liver subcellular membranes. Demonstration of membrane-specific autoantigens.
Topics: Animals; Antigens; Autoantigens; Carbon Tetrachloride; Cell Fractionation; Cell Membrane; Cell Nucle | 1974 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1974 |
In-vivo nuclear localisation of human antinuclear antibodies in mice with carbon tetrachloride- and thioacetamide-induced hepatic necrosis.
Topics: Amides; Animals; Antibodies, Antinuclear; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 1970 |
Phagocytic activity in experimental liver injury.
Topics: Animals; Carbon Tetrachloride; Cell Division; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; M | 1968 |
Modification of chronic carbon tetrachloride hepatic injury by N,N'-diphenyl-p-phenylenediamine.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Necrosis; P | 1968 |
The role of triglyceride accumulation and of necrosis in the hemodynamic responses of the isolated perfused rat liver after administration of carbon tetrachloride.
Topics: Acetates; Amides; Animals; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; C | 1969 |
[Iron of the subcellular fractions of liver tissue. 3. Effect of promethazine on hepatocellular changes in carbon tetrachloride poisoning].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Iron; Liver; Necrosis; Promethazine; | 1972 |
Prevention by cystamine of liver necrosis and early biochemical alterations induced by carbon tetrachloride.
Topics: Administration, Oral; Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning | 1972 |
"In vivo" microscopic study of the response of the hepatic microvascular system to carbon tetrachloride poisoning.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Adhesion; Inflammation; Injectio | 1971 |
[Comparative studies on the induction of chronic hepatitis in the rat].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; Diabetes Mel | 1971 |
[Patterns of rat liver damage following intrasplenic injection of differentially dispersed carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1971 |
Effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Injections, Intraperi | 1970 |
[The influence of norepinephrine on the hepatotoxicity of carbon tetrachloride and allyl alcohol].
Topics: Alanine Transaminase; Alcohols; Alkenes; Allyl Compounds; Animals; Aspartate Aminotransferases; Carb | 1970 |
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi | 1971 |
Protection by reserpine of carbon tetrachloride-induced hepatic necrosis.
Topics: Animals; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Histocytoche | 1968 |
Portal hypertension in acute experimental veno-occlusive disease of the liver in rats.
Topics: Anesthesia, Inhalation; Animals; Blood Pressure Determination; Carbon Tetrachloride; Chemical and Dr | 1969 |
Cytotoxicity of carbon tetrachloride as measured by loss of cellular enzymes to surrounding medium.
Topics: Carbon Tetrachloride; Culture Techniques; Enzymes; Laryngeal Neoplasms; Liver; Necrosis; Toxins, Bio | 1965 |
Fatty cirrhosis in the rat.
Topics: Animals; Autoradiography; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Choline; Fats; | 1966 |
Adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and its prevention.
Topics: Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Carbon Tetrachloride; Female; Hepatectomy; Mety | 1966 |