Proteins > Palmitoleoyl-protein carboxylesterase NOTUM
Page last updated: 2024-08-07 10:24:33
Palmitoleoyl-protein carboxylesterase NOTUM
A protein notum that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6P988]
Synonyms
EC 3.1.1.98;
hNOTUM
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| theophylline | Homo sapiens (human) | Kd | 6,800.0000 | 1 | 1 |
| caffeine | Homo sapiens (human) | EC50 | 45.8000 | 1 | 1 |
| caffeine | Homo sapiens (human) | Kd | 85.0000 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| phospholipase C activity | molecular function | Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| palmitoleyl hydrolase activity | molecular function | Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate. [PMID:25731175] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| Wnt signaling pathway | biological process | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397] |
| negative regulation of Wnt signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. [GOC:dph, GOC:go_curators, GOC:tb] |
| protein depalmitoleylation | biological process | The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein. [PMID:25731175] |
| negative regulation of canonical Wnt signaling pathway | biological process | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:tb] |