Page last updated: 2024-08-07 21:12:56
Aurora kinase A
An aurora kinase A that is encoded in the genome of mouse. [OMA:P97477, PRO:DNx]
Synonyms
EC 2.7.11.1;
Aurora 2;
Aurora family kinase 1;
Aurora/IPL1-related kinase 1;
ARK-1;
Aurora-related kinase 1;
Ipl1- and aurora-related kinase 1;
Serine/threonine-protein kinase 6;
Serine/threonine-protein kinase Ayk1;
S
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| vx680 | Mus musculus (house mouse) | IC50 | 0.0006 | 1 | 1 |
| zm 447439 | Mus musculus (house mouse) | IC50 | 0.0390 | 1 | 1 |
| mln8054 | Mus musculus (house mouse) | IC50 | 0.0085 | 6 | 6 |
| mln8054 | Mus musculus (house mouse) | Ki | 0.0070 | 1 | 1 |
| mln 8237 | Mus musculus (house mouse) | IC50 | 0.0010 | 1 | 1 |
| mln 8237 | Mus musculus (house mouse) | Ki | 0.0003 | 1 | 1 |
| sns 314 | Mus musculus (house mouse) | IC50 | 0.0200 | 1 | 2 |
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors.Bioorganic & medicinal chemistry, , 01-01, Volume: 27, Issue:1, 2019
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.ACS medicinal chemistry letters, , Jun-11, Volume: 6, Issue:6, 2015
Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.Journal of medicinal chemistry, , Sep-13, Volume: 55, Issue:17, 2012
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.Proceedings of the National Academy of Sciences of the United States of America, , Mar-06, Volume: 104, Issue:10, 2007