Proteins > Rap guanine nucleotide exchange factor 4
Page last updated: 2024-08-08 00:06:35

Rap guanine nucleotide exchange factor 4

A Rap guanine nucleotide exchange factor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WZA2]

Synonyms

Exchange factor directly activated by cAMP 2;
Exchange protein directly activated by cAMP 2;
EPAC 2;
cAMP-regulated guanine nucleotide exchange factor II;
cAMP-GEFII

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (518)

Drugs with Potency Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
cysteine sulfinic acidHomo sapiens (human)Potency17.782810
pentachlorophenolHomo sapiens (human)Potency10.000010
1-aminobenzotriazoleHomo sapiens (human)Potency112.202010
bay-k-8644Homo sapiens (human)Potency44.964710
benzbromaroneHomo sapiens (human)Potency10.000010
butylbenzyl phthalateHomo sapiens (human)Potency25.118910
bay h 4502Homo sapiens (human)Potency22.387210
celecoxibHomo sapiens (human)Potency44.668410
chlorpyrifosHomo sapiens (human)Potency11.220210
clofoctolHomo sapiens (human)Potency19.952610
clotrimazoleHomo sapiens (human)Potency14.125410
diazinonHomo sapiens (human)Potency22.387210
dibutyl phthalateHomo sapiens (human)Potency31.622810
dichlorophenHomo sapiens (human)Potency79.432810
dipyridamoleHomo sapiens (human)Potency84.218020
disulfotonHomo sapiens (human)Potency22.387210
efavirenzHomo sapiens (human)Potency31.622810
famprofazoneHomo sapiens (human)Potency39.810710
felodipineHomo sapiens (human)Potency44.668410
guaiazuleneHomo sapiens (human)Potency79.432810
hexachloropheneHomo sapiens (human)Potency31.622810
iopanoic acidHomo sapiens (human)Potency70.794610
isoconazoleHomo sapiens (human)Potency25.118910
celanideHomo sapiens (human)Potency100.663620
lauric acidHomo sapiens (human)Potency44.668410
ly 171883Homo sapiens (human)Potency15.848910
methoxychlorHomo sapiens (human)Potency44.668410
MeticraneHomo sapiens (human)Potency63.095710
miconazoleHomo sapiens (human)Potency39.810710
mitotaneHomo sapiens (human)Potency79.432810
nabumetoneHomo sapiens (human)Potency28.183810
niclosamideHomo sapiens (human)Potency79.432810
nimodipineHomo sapiens (human)Potency56.234110
nitrendipineHomo sapiens (human)Potency44.668410
ns 1619Homo sapiens (human)Potency56.234110
perphenazineHomo sapiens (human)Potency35.481310
phenolphthaleinHomo sapiens (human)Potency44.668410
moxonidineHomo sapiens (human)Potency100.000010
pinacidilHomo sapiens (human)Potency100.000010
prochlorperazineHomo sapiens (human)Potency12.589310
ritanserinHomo sapiens (human)Potency39.810710
testosterone propionateHomo sapiens (human)Potency79.432810
tetrabromobisphenol aHomo sapiens (human)Potency35.481310
9,10-phenanthrenequinoneHomo sapiens (human)Potency50.118710
diisobutyl phthalateHomo sapiens (human)Potency39.810710
n,n'-diethylcarbanilideHomo sapiens (human)Potency35.481310
acriflavine chlorideHomo sapiens (human)Potency61.193620
1-naphthylphenylamineHomo sapiens (human)Potency39.810710
6-phenyl-1,3,5-triazine-2,4-diamineHomo sapiens (human)Potency2.818410
pyronineHomo sapiens (human)Potency28.183810
phenidoneHomo sapiens (human)Potency39.810710
2,4-d n-butyl esterHomo sapiens (human)Potency22.387210
fentichlorHomo sapiens (human)Potency35.481310
o-aminoazotolueneHomo sapiens (human)Potency50.118710
cloropheneHomo sapiens (human)Potency50.118710
3-tert-butyl-4-hydroxyanisoleHomo sapiens (human)Potency79.432810
di-n-propylphthalateHomo sapiens (human)Potency35.481310
diallyl phthalateHomo sapiens (human)Potency28.183810
2,4-dihydroxybenzophenoneHomo sapiens (human)Potency78.117120
2-Phenylethyl 2-aminobenzoateHomo sapiens (human)Potency44.668410
neozoneHomo sapiens (human)Potency8.912510
sterogenolHomo sapiens (human)Potency50.118710
1,4-dimethoxybenzeneHomo sapiens (human)Potency12.589310
benz(c)acridineHomo sapiens (human)Potency44.668410
2,3-dimercaptosuccinic acidHomo sapiens (human)Potency3.162310
ostholHomo sapiens (human)Potency50.118710
flavanoneHomo sapiens (human)Potency56.234110
oleanolic acidHomo sapiens (human)Potency22.387210
dibromsalicilHomo sapiens (human)Potency44.668410
evernic acidHomo sapiens (human)Potency44.668410
chlorotrianiseneHomo sapiens (human)Potency4.466810
pentabromophenolHomo sapiens (human)Potency19.952610
dicarbethoxydihydrocollidineHomo sapiens (human)Potency112.202010
2-amino-5-chlorobenzophenoneHomo sapiens (human)Potency70.794610
estradiol valerateHomo sapiens (human)Potency28.183810
rimantadine hydrochlorideHomo sapiens (human)Potency28.183810
digoxigeninHomo sapiens (human)Potency10.000010
4-octylphenolHomo sapiens (human)Potency44.668410
7-hydroxychlorpromazineHomo sapiens (human)Potency22.387210
4-(octyloxy)benzoic acidHomo sapiens (human)Potency56.234110
3-aminofluorantheneHomo sapiens (human)Potency77.037920
2-amino-2',5-dichlorobenzophenoneHomo sapiens (human)Potency56.234110
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexaneHomo sapiens (human)Potency17.782810
cladribineHomo sapiens (human)Potency39.810710
aseanostatin p5Homo sapiens (human)Potency44.668410
LSM-22634Homo sapiens (human)Potency3.162310
6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazineHomo sapiens (human)Potency69.905420
2-bromo-N-phenylbenzamideHomo sapiens (human)Potency89.125110
fenamiphosHomo sapiens (human)Potency50.118710
rafoxanideHomo sapiens (human)Potency39.810710
pbde 99Homo sapiens (human)Potency11.220210
2,4,5,2',4',5'-hexachlorobiphenylHomo sapiens (human)Potency3.981110
isovelleralHomo sapiens (human)Potency56.234110
lonidamineHomo sapiens (human)Potency6.309610
NanaomycinHomo sapiens (human)Potency89.125110
closantelHomo sapiens (human)Potency50.118710
s-2678Homo sapiens (human)Potency89.125110
butoconazole nitrateHomo sapiens (human)Potency3.548110
triclabendazoleHomo sapiens (human)Potency56.234110
lovastatinHomo sapiens (human)Potency35.481310
chaetochrominHomo sapiens (human)Potency89.125110
bambuterol hydrochlorideHomo sapiens (human)Potency11.220210
quinpirole hydrochlorideHomo sapiens (human)Potency3.162310
clopidogrelHomo sapiens (human)Potency79.432810
topotecan hydrochlorideHomo sapiens (human)Potency33.129020
Eugenyl benzoateHomo sapiens (human)Potency15.848910
daunorubicin hydrochlorideHomo sapiens (human)Potency100.000010
ursolic acidHomo sapiens (human)Potency50.118710
betulinic acidHomo sapiens (human)Potency100.000010
diacetylfluoresceinHomo sapiens (human)Potency69.905420
n-acetylaspartic acidHomo sapiens (human)Potency2.818410
sulconazole, mononitrate, (+-)-isomerHomo sapiens (human)Potency50.118710
physodic acidHomo sapiens (human)Potency15.848910
repaglinideHomo sapiens (human)Potency35.481310
toxoflavinHomo sapiens (human)Potency63.095710
tangeretinHomo sapiens (human)Potency31.622810
miconazole nitrateHomo sapiens (human)Potency50.118710
econazole nitrateHomo sapiens (human)Potency15.848910
bithionol sulfoxideHomo sapiens (human)Potency37.685810
cresolphthaleinHomo sapiens (human)Potency79.432810
naphthyl phenyl ketoneHomo sapiens (human)Potency12.589310
magnololHomo sapiens (human)Potency50.118710
honokiolHomo sapiens (human)Potency50.118710
coumarin 153Homo sapiens (human)Potency44.668410
berberrubineHomo sapiens (human)Potency89.125110
methyl fluorone blackHomo sapiens (human)Potency32.310520
1,10-phenanthroline-5,6-dioneHomo sapiens (human)Potency3.642620
lobaric acidHomo sapiens (human)Potency50.118710
stictic acidHomo sapiens (human)Potency56.234110
oxazolidin-2-oneHomo sapiens (human)Potency39.810710
n-benzylmaleimideHomo sapiens (human)Potency39.810710
2-phenylisatogenHomo sapiens (human)Potency17.782810
1-pyrenebutyrateHomo sapiens (human)Potency35.481310
4-phenyl-1,2,4-triazoline-3,5-dioneHomo sapiens (human)Potency2.818410
2-butyl-6-(butylamino)-1h-benzo(de)isoquinoline-1,3(2h)-dioneHomo sapiens (human)Potency67.740620
pc-796Homo sapiens (human)Potency25.118910
sennoside BHomo sapiens (human)Potency89.125110
prochlorperazine edisylate saltHomo sapiens (human)Potency14.125410
nimustineHomo sapiens (human)Potency89.125110
totarolHomo sapiens (human)Potency56.234110
coumarin 7Homo sapiens (human)Potency89.125110
diffractaic acidHomo sapiens (human)Potency19.952610
osajinHomo sapiens (human)Potency11.220210
2,2',4,4'-tetrabromodiphenyl etherHomo sapiens (human)Potency12.589310
4-chloro-3-(2,4-dihydroxyphenylazo)-2-hydroxybenzene-1-sulfonic acidHomo sapiens (human)Potency56.234110
6-methoxyflavanoneHomo sapiens (human)Potency50.118710
2-(3'-methoxy-4'-hydroxybenzylidene)cyclopentene-1,3-dioneHomo sapiens (human)Potency84.367910
n-benzoyl-l-phenylalaninolHomo sapiens (human)Potency25.118910
wr 159412Homo sapiens (human)Potency56.234110
karanjinHomo sapiens (human)Potency7.943310
4'-methoxyflavanoneHomo sapiens (human)Potency79.432810
cl 218872Homo sapiens (human)Potency100.000010
carboxyamido-triazoleHomo sapiens (human)Potency37.685810
pterosin bHomo sapiens (human)Potency100.000010
3,5-bis(trifluoromethyl)benzyl n-acetyltryptophanHomo sapiens (human)Potency44.668410
teomorfolinHomo sapiens (human)Potency39.810710
12-phenyllauric acidHomo sapiens (human)Potency56.234110
schizandrin aHomo sapiens (human)Potency79.432810
tetrahydroharmineHomo sapiens (human)Potency39.810710
epiberberineHomo sapiens (human)Potency125.892010
8-(4-benzenesulfonylamino)quinolineHomo sapiens (human)Potency19.952610
f 1459Homo sapiens (human)Potency14.125410
sb 216763Homo sapiens (human)Potency100.000010
moracin mHomo sapiens (human)Potency39.810710
glucuronolactoneHomo sapiens (human)Potency3.162310
1,1,3,3-tetraphenylureaHomo sapiens (human)Potency50.118710
1-benzothiophen-2-yl-(4-dimethylaminophenyl)methanolHomo sapiens (human)Potency50.118710
raubasineHomo sapiens (human)Potency35.481310
oxolamine citrateHomo sapiens (human)Potency3.162310
diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylateHomo sapiens (human)Potency44.668410
acetic acid (4-acetyloxy-6,7-dimethyl-5,8-dihydronaphthalen-1-yl) esterHomo sapiens (human)Potency19.952610
nsc228155Homo sapiens (human)Potency56.234110
1-(benzenesulfonyl)indoleHomo sapiens (human)Potency50.118710
nsc-260594Homo sapiens (human)Potency25.285520
1-(2,6-dichlorophenyl)-3-(6-methyl-3-pyridinyl)ureaHomo sapiens (human)Potency14.125410
[4-(4-hydroxyphenyl)phenyl]-phenylmethanoneHomo sapiens (human)Potency100.000010
1,3(2h,4h)-isoquinolinedioneHomo sapiens (human)Potency42.284110
graveolineHomo sapiens (human)Potency3.162310
4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acidHomo sapiens (human)Potency50.118710
nsc668394Homo sapiens (human)Potency79.432810
nsc354961Homo sapiens (human)Potency44.668410
saquinavirHomo sapiens (human)Potency15.848910
[(1S,2R,3S,4S,6R,7R,8R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetateHomo sapiens (human)Potency19.952610
doxorubicin hydrochlorideHomo sapiens (human)Potency11.220210
resveratrolHomo sapiens (human)Potency19.952610
oleic acidHomo sapiens (human)Potency19.952610
t0901317Homo sapiens (human)Potency44.668410
1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dioneHomo sapiens (human)Potency29.903320
meso-dihydroguaiaretic acidHomo sapiens (human)Potency79.432810
1-methoxyphaseollidinHomo sapiens (human)Potency31.622810
2-[(4-nitrophenyl)methylthio]-1,3-benzoxazoleHomo sapiens (human)Potency35.481310
8-isopentenylnaringeninHomo sapiens (human)Potency50.118710
1-[(4-fluoro-1-naphthalenyl)sulfonyl]piperidineHomo sapiens (human)Potency94.562620
2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazolineHomo sapiens (human)Potency31.622810
N-benzylquinazolin-4-amineHomo sapiens (human)Potency89.125110
7-chloro-5,10-dihydrothieno[3,4-b][1,5]benzodiazepin-4-oneHomo sapiens (human)Potency100.000010
idarubicin hydrochlorideHomo sapiens (human)Potency100.663620
2-[[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid butyl esterHomo sapiens (human)Potency22.387210
(1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanolHomo sapiens (human)Potency50.118710
2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4h-chromeneHomo sapiens (human)Potency89.125110
5-[4-morpholinyl(oxo)methyl]-2-pyranoneHomo sapiens (human)Potency28.183810
2-cyano-N-(3-methoxypropyl)-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetamideHomo sapiens (human)Potency100.000010
2-cyano-N-(2-furanylmethyl)-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetamideHomo sapiens (human)Potency79.432810
2-cyano-2-[3-[4-(phenylmethyl)-1-piperazinyl]-2-quinoxalinyl]acetic acid 2-methoxyethyl esterHomo sapiens (human)Potency89.125110
2-cyano-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetic acid cyclohexyl esterHomo sapiens (human)Potency57.457020
2-cyano-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetic acid hexyl esterHomo sapiens (human)Potency19.952610
(2S)-4-methyl-2-[[oxo-(1,2,3,4-tetrahydronaphthalen-1-ylamino)methyl]amino]pentanoic acid methyl esterHomo sapiens (human)Potency39.810710
4,8-dimethyl-3-(phenylmethyl)-7-(2H-tetrazol-5-ylmethoxy)-1-benzopyran-2-oneHomo sapiens (human)Potency112.202010
Glyceryl lactopalmitateHomo sapiens (human)Potency10.610120
2-(1,3-dimethyl-2,4,6-trioxo-5,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)-N-(2-methoxyphenyl)acetamideHomo sapiens (human)Potency39.810710
dienestrolHomo sapiens (human)Potency50.118710
3,3',4,5'-tetrahydroxystilbeneHomo sapiens (human)Potency50.118710
N-(3-acetamidophenyl)-4-methoxybenzamideHomo sapiens (human)Potency79.432810
1-(2,4-dimethylphenyl)-4-(1-piperidinylsulfonyl)piperazineHomo sapiens (human)Potency2.818410
5-[2-[(4-chlorophenyl)thio]-1-oxoethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid methyl esterHomo sapiens (human)Potency89.125110
4-[[[2-(4-fluorophenyl)ethylamino]-sulfanylidenemethyl]amino]benzoic acid ethyl esterHomo sapiens (human)Potency11.220210
Ethyl 4-acetyl-3-methyl-5-(methylthio)thiophene-2-carboxylateHomo sapiens (human)Potency7.943310
N-(2,5-dimethylphenyl)-2-benzofurancarboxamideHomo sapiens (human)Potency39.810710
4-methyl-2-(2-naphthalenyl)-1-phthalazinoneHomo sapiens (human)Potency39.810710
6-methyl-4-(trifluoromethyl)-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-oneHomo sapiens (human)Potency100.000010
3-[2-(4-methyl-2-propan-2-ylphenoxy)ethyl]-1H-benzimidazole-2-thioneHomo sapiens (human)Potency44.668410
4-methyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)benzenesulfonamideHomo sapiens (human)Potency100.000010
2-(dichloromethyl)-4-(ethylthio)-6-phenyl-1,3,5-triazineHomo sapiens (human)Potency44.668410
2-(3-cyano-4,5,6-trimethyl-1H-pyridin-2-ylidene)propanedinitrileHomo sapiens (human)Potency39.810710
N-(3-acetamidophenyl)-2-chlorobenzamideHomo sapiens (human)Potency89.125110
1-ethyl-2-[(4-methylphenoxy)methyl]benzimidazoleHomo sapiens (human)Potency89.125110
2-(2,4-dimethylphenyl)-5-benzotriazolamineHomo sapiens (human)Potency50.118710
N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamideHomo sapiens (human)Potency125.892010
2-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]indene-1,3-dioneHomo sapiens (human)Potency89.125110
4,5-dimethylcyclopenta[c]quinolizine-1,2-dicarboxylic acid dimethyl esterHomo sapiens (human)Potency50.118710
2-[(7-ethyl-[1,3]dioxolo[4,5-g]quinolin-6-yl)thio]acetic acid propan-2-yl esterHomo sapiens (human)Potency82.851420
1-(2-methyl-6-propan-2-ylphenyl)-5-phenyltetrazoleHomo sapiens (human)Potency31.622810
2-(2-chlorophenyl)-5-(2-methylpropylamino)-4-oxazolecarbonitrileHomo sapiens (human)Potency63.095710
2-(2-methylphenoxy)-N-[2-(methylthio)phenyl]acetamideHomo sapiens (human)Potency35.481310
1,6-dimethyl-3-(2-pyridinyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dioneHomo sapiens (human)Potency71.912420
4-ethoxy-N-(4-fluorophenyl)-2,3-dimethylbenzenesulfonamideHomo sapiens (human)Potency70.794610
2-(2-fluorophenyl)-5-(4-methyl-1-piperidinyl)-4-oxazolecarbonitrileHomo sapiens (human)Potency56.234110
1,3-dimethyl-8-(4-phenyl-1-piperazinyl)-7H-purine-2,6-dioneHomo sapiens (human)Potency28.183810
2-(2-methylphenoxy)-N-[2-(4-methyl-1-piperidinyl)phenyl]acetamideHomo sapiens (human)Potency31.622810
2-(2,3-dimethylphenoxy)-N-(2-oxo-1-benzopyran-6-yl)acetamideHomo sapiens (human)Potency112.202010
2-[[[(5-chloro-2-pyridinyl)amino]-oxomethyl]amino]benzoic acid methyl esterHomo sapiens (human)Potency100.000010
4-[methyl-(4-thiophen-2-yl-2-thiazolyl)amino]phenolHomo sapiens (human)Potency50.118710
2,2-dimethyl-N-[[2-(4-methyl-1-piperidinyl)anilino]-sulfanylidenemethyl]propanamideHomo sapiens (human)Potency100.000010
umi-77Homo sapiens (human)Potency12.589310
3-amino-N-(2-fluorophenyl)-6-(phenylmethyl)-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinecarboxamideHomo sapiens (human)Potency89.716420
[3-amino-6-thiophen-2-yl-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinyl]-cyclopropylmethanoneHomo sapiens (human)Potency95.817420
1-methyl-N-(2-naphthalenyl)-5-benzotriazolecarboxamideHomo sapiens (human)Potency25.118910
N-(3-benzamidophenyl)-1,3-benzodioxole-5-carboxamideHomo sapiens (human)Potency31.622810
2-(1,3-benzodioxol-5-yl)-N-[(2-ethoxyphenyl)methyl]-N-(2-pyridinylmethyl)ethanamineHomo sapiens (human)Potency10.000010
N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamideHomo sapiens (human)Potency89.125110
4-methoxy-N-[5-(4-methoxyphenyl)-4-(4-nitrophenyl)-2-thiazolyl]benzamideHomo sapiens (human)Potency72.334220
N-[3-(1,3-benzothiazol-2-ylthio)-4-hydroxyphenyl]-4-chlorobenzenesulfonamideHomo sapiens (human)Potency89.125110
(4-chlorophenyl)-(5-hydroxy-2-methyl-4,6-dinitro-3-benzofuranyl)methanoneHomo sapiens (human)Potency44.668410
4-[[3-[(2-chlorophenyl)methyl]-5-cyclopropyl-7-triazolo[4,5-d]pyrimidinyl]amino]-N,N-dimethylbenzenesulfonamideHomo sapiens (human)Potency35.481310
[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-thiophen-2-ylmethanoneHomo sapiens (human)Potency89.125110
4-chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamideHomo sapiens (human)Potency100.000010
4-(2,6-dimethylphenoxy)-5-methoxy-2-(2-pyridinyl)pyrimidineHomo sapiens (human)Potency14.125410
2-[2-(2,4-dichloro-5-propan-2-yloxyanilino)-2-oxoethyl]sulfinyl-N-[3-(trifluoromethyl)phenyl]acetamideHomo sapiens (human)Potency56.234110
4-(4-methyl-1-piperazinyl)-2,6-diphenyl-5-pyrimidinecarbonitrileHomo sapiens (human)Potency100.000010
4-[4-(2,4-dichlorophenyl)-2-thiazolyl]benzoic acidHomo sapiens (human)Potency79.432810
2-[1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-3-indolyl]acetic acid methyl esterHomo sapiens (human)Potency125.892010
3-amino-N-(4-methylphenyl)-5-(methylthio)-1,2,4-triazole-4-carboxamideHomo sapiens (human)Potency3.548110
5-methoxy-4-[(2-methoxyphenyl)thio]-2-phenylpyrimidineHomo sapiens (human)Potency25.118910
N-(4-bromo-2,6-dimethylphenyl)-2-methoxybenzamideHomo sapiens (human)Potency14.125410
epalrestatHomo sapiens (human)Potency56.234110
3-(5,8-dinitro-1,3-dioxo-2-benzo[de]isoquinolinyl)benzoic acidHomo sapiens (human)Potency50.118710
1-[2-[(4-methyl-2-oxo-1-benzopyran-7-yl)oxy]-1-oxoethyl]-4-phenyl-4-piperidinecarboxylic acidHomo sapiens (human)Potency14.125410
chlorogenic acidHomo sapiens (human)Potency39.810710
2-butoxy-3-phenyl-4-quinazolinoneHomo sapiens (human)Potency79.432810
5-tert-butyl-3-(4-chlorophenyl)-N-(2-pyridinylmethyl)-7-pyrazolo[1,5-a]pyrimidinamineHomo sapiens (human)Potency50.118710
5-hydroxy-2-[(phenylthio)methyl]-3-benzofurancarboxylic acid ethyl esterHomo sapiens (human)Potency70.794610
2-[[2-[(2-fluorophenyl)methoxy]-3-methoxyphenyl]methylamino]phenolHomo sapiens (human)Potency50.118710
N-bis(2-fluorophenoxy)phosphoryl-3,4-dimethylanilineHomo sapiens (human)Potency50.118710
N,N-dibutyl-2-(pyridin-4-yl)quinazolin-4-amineHomo sapiens (human)Potency50.118710
1-[2-(2-amino-3-cyano-1-pyrrolo[3,2-b]quinoxalinyl)ethyl]-3-phenylureaHomo sapiens (human)Potency31.622810
2-[[4-(2-ethoxyanilino)-6-(4-ethoxyanilino)-2-pyrimidinyl]methylidene]propanedinitrileHomo sapiens (human)Potency31.622810
N-[3-(benzenesulfonyl)-1-cyclohexyl-2-pyrrolo[3,2-b]quinoxalinyl]benzenesulfonamideHomo sapiens (human)Potency89.125110
7-chloro-2-methyl-4-(4-methylphenyl)sulfonylthiazolo[5,4-b]indoleHomo sapiens (human)Potency28.183810
2,4-dibromo-6-[(3-quinolinylamino)methyl]phenolHomo sapiens (human)Potency50.118710
1-[1-naphthalenyl(oxo)methyl]-3-indolecarboxylic acid methyl esterHomo sapiens (human)Potency8.912510
4-(4-chlorophenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl esterHomo sapiens (human)Potency11.220210
3-[(2-propoxyphenyl)methyl]-1,3-benzoxazol-2-oneHomo sapiens (human)Potency22.387210
N-[(2-furanylmethylamino)-oxomethyl]-2-[4-(4-hydroxyphenyl)-1-piperazinyl]acetamideHomo sapiens (human)Potency112.202010
6-(4-bromophenyl)-3-methyl-1-[2-(2H-tetrazol-5-yl)ethyl]-4-(trifluoromethyl)pyrazolo[3,4-b]pyridineHomo sapiens (human)Potency31.622810
[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-(2-ethoxy-3-pyridinyl)methanoneHomo sapiens (human)Potency50.118710
N-[(4-methoxyphenyl)methyl]-2-methyl-4,9-dioxo-3-benzo[f]benzofurancarboxamideHomo sapiens (human)Potency7.079510
1-(4-bromo-2-chlorophenyl)-3-(3-methyl-2-pyridinyl)thioureaHomo sapiens (human)Potency11.220210
2-butoxy-7-hydroxy-9-fluorenoneHomo sapiens (human)Potency50.118710
4-(3-hydroxyphenyl)-1-(thiophen-2-ylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl esterHomo sapiens (human)Potency50.118710
2-[[5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-4-oxo-2-phenyl-1-benzopyran-7-yl]oxy]acetic acid tert-butyl esterHomo sapiens (human)Potency44.668410
4E2RCatHomo sapiens (human)Potency56.234110
N-[2-(2-phenylphenoxy)ethyl]-2-furancarboxamideHomo sapiens (human)Potency22.387210
3-[[(4-tert-butylphenyl)-oxomethyl]amino]-1H-1,2,4-triazole-5-carboxylic acid methyl esterHomo sapiens (human)Potency100.000010
cyclohexanecarboxylic acid [2-oxo-2-[4-(1-piperidinyl)anilino]ethyl] esterHomo sapiens (human)Potency75.505420
2-[(5-chloro-2-thiophenyl)sulfonylamino]-N-(2-methoxy-5-methylphenyl)benzamideHomo sapiens (human)Potency31.622810
4-(1H-indol-3-yl)butanoic acid [2-(4-amino-1,3-dimethyl-2,6-dioxo-5-pyrimidinyl)-2-oxoethyl] esterHomo sapiens (human)Potency11.220210
2-(4-methoxyphenyl)-5-(2-methylpropylthio)-1,3,4-oxadiazoleHomo sapiens (human)Potency79.432810
2-chloro-N-[3-[(2-chlorophenyl)methyl]-2-thiazolylidene]acetamideHomo sapiens (human)Potency25.118910
2-[(3-acetyl-5-oxo-4H-imidazol-2-yl)thio]-N-(4-methyl-5-phenyl-2-thiazolyl)-N-prop-2-enylacetamideHomo sapiens (human)Potency56.234110
2-[[2-[(2-hydroxyphenyl)-oxomethoxy]-1-oxoethyl]amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid methyl esterHomo sapiens (human)Potency25.118910
4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]-1H-quinolin-2-oneHomo sapiens (human)Potency14.125410
N-(1,3-benzodioxol-5-yl)-2-chloro-N-[(2-prop-2-enoxyphenyl)methyl]acetamideHomo sapiens (human)Potency12.589310
2-chloro-3-pyridinecarboxylic acid [2-(4-ethylphenyl)-2-oxoethyl] esterHomo sapiens (human)Potency89.125110
5-(3,4-dimethoxyphenyl)-2-methyl-4-(4-methyl-1-piperidinyl)thieno[2,3-d]pyrimidineHomo sapiens (human)Potency50.118710
N-(4-tert-butyl-2-thiazolyl)-6-quinoxalinecarboxamideHomo sapiens (human)Potency112.202010
5-methyl-4-(4-methylphenyl)-2-[[2-[(1-methyl-5-tetrazolyl)thio]-1-oxoethyl]amino]-3-thiophenecarboxylic acid ethyl esterHomo sapiens (human)Potency79.432810
2-(4-methyl-1-piperidinyl)-N-[2-(phenylthio)phenyl]acetamideHomo sapiens (human)Potency56.234110
3-(tert-butylsulfamoyl)-4-phenyl-5-(trifluoromethyl)-2-thiophenecarboxylic acid methyl esterHomo sapiens (human)Potency44.668410
4-chlorobenzoic acid [3-cyano-6-(3-methoxyphenyl)-2-pyridinyl] esterHomo sapiens (human)Potency6.309610
4-oxo-2-(trifluoromethyl)-1H-thieno[3,4-b]pyridine-7-carboxylic acid methyl esterHomo sapiens (human)Potency7.943310
N-[(2-chloro-6-phenoxyphenyl)methyl]benzenesulfonamideHomo sapiens (human)Potency100.000010
4-acetamidobenzenesulfonic acid [2-(1-piperidinyl)phenyl] esterHomo sapiens (human)Potency44.668410
5-tert-butyl-N-[5-(dimethylsulfamoyl)-2-methylphenyl]-2-(phenylmethyl)-3-pyrazolecarboxamideHomo sapiens (human)Potency31.622810
4-fluoro-N-[2-(1-piperidinyl)phenyl]benzenesulfonamideHomo sapiens (human)Potency12.589310
2-fluoro-N-[2,2,2-trichloro-1-[[(4-methoxy-2-nitroanilino)-sulfanylidenemethyl]amino]ethyl]acetamideHomo sapiens (human)Potency89.125110
3-[4-(4-chlorophenyl)-1-piperazinyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dioneHomo sapiens (human)Potency50.118710
1-hexadecyl-3-methylimidazolium bromideHomo sapiens (human)Potency70.794610
6-(2-chlorophenyl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid 2-methylpropyl esterHomo sapiens (human)Potency56.234110
1-[1-(2,3-dihydro-1,4-benzodioxin-3-yl)ethyl]-3-phenylthioureaHomo sapiens (human)Potency70.794610
[(2S)-1,3-dimethyl-3'-nitro-1'-spiro[cyclohepta[d]imidazol-3-ium-2,4'-cyclohexa-2,5-diene]ylidene]-dioxidoammoniumHomo sapiens (human)Potency100.000010
N-(3-bicyclo[2.2.1]heptanyl)-3-bromo-4-methoxybenzenesulfonamideHomo sapiens (human)Potency50.118710
5-bromo-3-hydroxy-3-(4-methyl-1-piperidinyl)-1H-indol-2-oneHomo sapiens (human)Potency28.183810
1,3,8-trimethyl-5,10-diphenylpyrimido[1,2]pyrrolo[4,5-b]pyridazine-2,4-dioneHomo sapiens (human)Potency50.118710
eskazineHomo sapiens (human)Potency39.810710
N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]acetamideHomo sapiens (human)Potency35.481310
N-[(5-chloro-8-hydroxy-7-quinolinyl)-(4-methoxyphenyl)methyl]acetamideHomo sapiens (human)Potency44.668410
2-(3-hydroxyphenyl)-6-(1-piperidinyl)benzo[de]isoquinoline-1,3-dioneHomo sapiens (human)Potency89.716420
N-[3-(4-chlorophenyl)-2-methyl-3H-1,5-benzodiazepin-4-yl]benzamideHomo sapiens (human)Potency39.810710
2-[[[4-[[2-(4-chloro-2-methylphenoxy)-1-oxopropyl]amino]phenyl]-oxomethyl]amino]benzoic acidHomo sapiens (human)Potency50.118710
2-(1,3-benzothiazol-2-ylamino)-5-spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]oneHomo sapiens (human)Potency125.892010
1-(4-morpholinyl)-2-(4-phenylphenoxy)-1-propanoneHomo sapiens (human)Potency79.432810
[3-(2-hydroxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-phenylmethanoneHomo sapiens (human)Potency44.668410
1-[(4-tert-butylphenyl)methyl]-4-(4-nitrophenyl)imidazoleHomo sapiens (human)Potency89.125110
1-(2-furanyl)-3-(phenylthio)-3-thiophen-2-yl-1-propanoneHomo sapiens (human)Potency44.668410
2-cyano-N-(phenylmethyl)-2-[3-(1-pyrrolidinyl)-2-quinoxalinyl]acetamideHomo sapiens (human)Potency64.467920
(4As,6aS,6bR,10S,12aR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acidHomo sapiens (human)Potency39.810710
1-(4-nitrophenyl)sulfonyl-2-benzimidazolamineHomo sapiens (human)Potency89.125110
trimethoprimHomo sapiens (human)Potency70.794610
n-(2-naphthalene)sulfonyl-dl-tryptophanHomo sapiens (human)Potency22.387210
9-hydroxyiminofluorene-2,7-disulfonamideHomo sapiens (human)Potency39.810710
2-[[2,2,2-trichloro-1-[(2-methyl-1-oxopropyl)amino]ethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl esterHomo sapiens (human)Potency79.432810
2-(2-bromophenyl)-2,3-dihydro-1H-perimidineHomo sapiens (human)Potency44.668410
2-furanyl-[3-hydroxy-3-(trifluoromethyl)-3a,4,5,6,7,8-hexahydrocyclohepta[c]pyrazol-2-yl]methanoneHomo sapiens (human)Potency79.432810
9-chloro-6-methylindolo[3,2-b]quinoxalineHomo sapiens (human)Potency89.125110
5-methyl-1-[3-(2-methylphenoxy)propyl]indole-2,3-dioneHomo sapiens (human)Potency70.794610
9-(2-ethoxy-3-methoxyphenyl)-3,6,8,9-tetrahydro-2H-[1,4]dioxino[2,3-g]quinolin-7-oneHomo sapiens (human)Potency70.794610
1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dioneHomo sapiens (human)Potency2.818410
2-[[2-(1-benzotriazolyl)-1-oxoethyl]-(3-pyridinyl)amino]-2-(4-chlorophenyl)-N-(2-methoxyethyl)acetamideHomo sapiens (human)Potency112.202010
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-1-(2-methyl-2,3-dihydroindol-1-yl)ethanoneHomo sapiens (human)Potency89.125110
6-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamineHomo sapiens (human)Potency15.848910
N-(2-furanylmethyl)-6-(3-methoxyphenyl)-N-methyl-4-quinazolinamineHomo sapiens (human)Potency31.622810
6-(2-chlorophenyl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamineHomo sapiens (human)Potency19.952610
4-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]-2-methyl-5-furo[3,2-b]pyrrolecarboxylic acid methyl esterHomo sapiens (human)Potency50.118710
4-hydroxy-1-[1-oxo-2-(phenylmethoxycarbonylamino)propyl]-2-pyrrolidinecarboxylic acidHomo sapiens (human)Potency100.000010
3,4-dihydro-2H-quinolin-1-yl-(7-methoxy-4,5-dihydrobenzo[g][1,2]benzoxazol-3-yl)methanoneHomo sapiens (human)Potency17.782810
4,5-dihydrobenzo[g][1,2]benzoxazol-3-yl(3,4-dihydro-2H-quinolin-1-yl)methanoneHomo sapiens (human)Potency44.668410
3-[[oxo(2-quinoxalinyl)methyl]amino]benzoic acid ethyl esterHomo sapiens (human)Potency100.000010
N-[2-(2-ethyl-1-piperidinyl)ethyl]-2-[(2-methyl-1,3-benzothiazol-6-yl)sulfonylamino]acetamideHomo sapiens (human)Potency39.810710
1-[[1-(2-methoxyanilino)-4-isoquinolinyl]-oxomethyl]-4-piperidinecarboxamideHomo sapiens (human)Potency8.912510
N-cyclopentyl-4-(3,4-dimethoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinamineHomo sapiens (human)Potency63.095710
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] esterHomo sapiens (human)Potency79.432810
gw 7647Homo sapiens (human)Potency56.234110
N-[4-[2-(2-ethyl-1-oxobutyl)-3-phenyl-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamideHomo sapiens (human)Potency14.125410
2-methyl-N'-[2-[(5-methyl-4-phenyl-1,2,4-triazol-3-yl)thio]-1-oxoethyl]benzohydrazideHomo sapiens (human)Potency79.432810
1-[(3-chlorophenyl)methyl]-N-methyl-N-(phenylmethyl)-3-piperidinecarboxamideHomo sapiens (human)Potency89.125110
(S)-4',5,7-Trihydroxy-6-prenylflavanoneHomo sapiens (human)Potency35.481310
7,8-Dihydroxy-3,7-dimethyl-6-oxo-7,8-dihydro-6H-isochromene-5-carbaldehydeHomo sapiens (human)Potency75.059420
1-[2-[(4-chlorophenyl)thio]ethyl]-3-(4-methylphenyl)thioureaHomo sapiens (human)Potency2.818410
3-[(4-ethylphenoxy)methyl]-4-(6-methylheptan-2-yl)-1H-1,2,4-triazole-5-thioneHomo sapiens (human)Potency17.782810
1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazoleHomo sapiens (human)Potency79.432810
2-[(4-amino-7-tert-butyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)thio]acetic acidHomo sapiens (human)Potency39.810710
N-[3-fluoro-4-(4-phenyl-1-piperazinyl)phenyl]-2-(4-morpholinyl)acetamideHomo sapiens (human)Potency100.000010
2-hydroxy-2-pentyl-N'-phenylheptanehydrazideHomo sapiens (human)Potency112.202010
4-chloro-N-[3-(3-methyl-1-piperidinyl)-1,4-dioxo-2-naphthalenyl]benzenesulfonamideHomo sapiens (human)Potency100.000010
2-Chloro-1-[5-(3,4-dimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-oneHomo sapiens (human)Potency39.810710
5-[3-(3,5-dimethyl-1,2,4-triazol-1-yl)-2-hydroxypropoxy]-2-methyl-1-(phenylmethyl)-3-indolecarboxylic acid ethyl esterHomo sapiens (human)Potency50.118710
3-(3,4-dimethylphenyl)sulfonyl-2-imino-1-prop-2-enyl-5-dipyrido[1,2-e-4',3'-f]pyrimidinoneHomo sapiens (human)Potency94.562620
1-(Chloroacetyl)-5-[4-(difluoromethoxy)-3-methoxyphenyl]-3-thien-2-yl-4,5-dihydro-1H-pyrazoleHomo sapiens (human)Potency39.810710
or486Homo sapiens (human)Potency56.234110
2-(1H-benzimidazol-2-yl)-5-methyl-4-(phenylmethyl)-4H-pyrazol-3-oneHomo sapiens (human)Potency79.432810
4-[(2-chloro-6-fluorophenyl)-oxomethyl]-7-methyl-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-oneHomo sapiens (human)Potency63.095710
(5,7-dibromo-2-benzofuranyl)-(3,5-dimethyl-1-piperidinyl)methanoneHomo sapiens (human)Potency50.118710
2-(1,3-benzoxazol-2-ylthio)-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanoneHomo sapiens (human)Potency89.125110
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-2-(3-pyridinyl)ethyl]-2-thiophenesulfonamideHomo sapiens (human)Potency31.622810
2-[(6-methyl-4-spiro[3,4-dihydro-2H-1-benzopyran-2,1'-cyclopentane]yl)thio]-N-(2-phenylethyl)acetamideHomo sapiens (human)Potency35.481310
4-(1-phenylethyl)-3-(5-propyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneHomo sapiens (human)Potency112.202010
N,6-dimethyl-2-[[[4-[(2-methyl-1-piperidinyl)sulfonyl]phenyl]-oxomethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamideHomo sapiens (human)Potency64.992420
2-(5-bromo-2-thiophenyl)-N-(4-methyl-1-piperazinyl)-4-quinolinecarboxamideHomo sapiens (human)Potency89.125110
1-pyrrolidinyl-[1-[(2,3,4-trimethoxyphenyl)methyl]-3-piperidinyl]methanoneHomo sapiens (human)Potency89.125110
N-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-4-oxo-1-benzopyran-2-carboxamideHomo sapiens (human)Potency2.818410
2-[(2,2-dichloro-3,3-dimethylcyclopropyl)methylthio]-1H-benzimidazoleHomo sapiens (human)Potency56.234110
jhw 015Homo sapiens (human)Potency7.943310
2-[4-(dimethylamino)phenyl]azobenzoic acid [2-(1-azepanyl)-2-oxoethyl] esterHomo sapiens (human)Potency79.432810
2-(4-chlorophenyl)-3-methyl-N-(2-thiazolyl)butanamideHomo sapiens (human)Potency8.912510
5-bromo-N-[2-(2-methyl-1-indolyl)ethyl]-2-furancarboxamideHomo sapiens (human)Potency100.000010
1-(5-nitro-2-thiophenyl)piperidineHomo sapiens (human)Potency63.095710
2-[[2-(2-amino-4-oxo-5-thiazolyl)-1-oxoethyl]amino]-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl esterHomo sapiens (human)Potency50.118710
N2-(2-furanylmethyl)-5-nitro-6-(1-pyrrolidinyl)pyrimidine-2,4-diamineHomo sapiens (human)Potency39.810710
5-methyl-4-(3-phenoxyphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-6-carboxylic acid ethyl esterHomo sapiens (human)Potency50.118710
acetic acid [2-[2-acetyl-3-(4-methoxyphenyl)-3,4-dihydropyrazol-5-yl]phenyl] esterHomo sapiens (human)Potency31.622810
2-Chloro-1-[3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanoneHomo sapiens (human)Potency19.952610
2-[2-(2-chlorophenyl)-1-benzimidazolyl]-N-(2,6-diethylphenyl)acetamideHomo sapiens (human)Potency8.912510
LSM-1925Homo sapiens (human)Potency12.589310
isovitexinHomo sapiens (human)Potency79.432810
N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamideHomo sapiens (human)Potency79.432810
N-(5-methyl-3-isoxazolyl)-2-(4-propan-2-yloxyphenyl)-4-quinolinecarboxamideHomo sapiens (human)Potency100.000010
2-(4-benzoyl-1-piperazinyl)-N-(2-phenylphenyl)propanamideHomo sapiens (human)Potency28.183810
3-(1-methyl-2-benzimidazolyl)-1-(3-methylphenyl)-2-pyrrolo[3,2-b]quinoxalinamineHomo sapiens (human)Potency112.202010
5-nitro-N-[(4-propan-2-ylphenyl)methyl]-2-pyridinamineHomo sapiens (human)Potency28.183810
2-Chloro-1-[5-(furan-2-yl)-3-(5-methylfuran-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-oneHomo sapiens (human)Potency50.118710
4-[1-(2,4-dichlorophenyl)-2-nitroethyl]-5-(2-hydroxyphenyl)-1,2-dihydropyrazol-3-oneHomo sapiens (human)Potency79.432810
2-amino-4-(4-chlorophenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carboxylic acid ethyl esterHomo sapiens (human)Potency50.118710
5,6-dimethyl-1-octyl-4-benzimidazolamineHomo sapiens (human)Potency50.118710
4-tert-butyl-N-[3-[4-[3-[[(4-tert-butylphenyl)-oxomethyl]amino]propyl]-1-piperazinyl]propyl]benzamideHomo sapiens (human)Potency79.432810
2-nitro-4-[(6-nitro-4-quinolinyl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamideHomo sapiens (human)Potency50.118710
myricetinHomo sapiens (human)Potency8.912510
Licarin AHomo sapiens (human)Potency39.810710
ellagic acidHomo sapiens (human)Potency19.952610
isotretinoinHomo sapiens (human)Potency79.432810
irsogladineHomo sapiens (human)Potency39.810710
terbinafine hydrochlorideHomo sapiens (human)Potency89.125110
n-oleoylethanolamineHomo sapiens (human)Potency89.125110
acitretinHomo sapiens (human)Potency10.000010
3-[(5-chloro-2-pyridinyl)amino]-2-(2-pyridinyl)-3H-isoindol-1-oneHomo sapiens (human)Potency44.668410
3-[[2-(2-furanylmethyl)-3-oxo-1H-isoindol-1-yl]amino]benzoic acid ethyl esterHomo sapiens (human)Potency70.794610
3,4-dihydro-1H-isoquinolin-2-yl-(4-ethyl-5-thieno[3,2-b]pyrrolyl)methanoneHomo sapiens (human)Potency19.622220
2-[6-[(5-chloro-2-methoxyphenyl)sulfamoyl]-2-oxo-1,3-benzoxazol-3-yl]acetic acid ethyl esterHomo sapiens (human)Potency89.125110
4-[[[1-(1H-imidazol-5-ylsulfonyl)-3-piperidinyl]-oxomethyl]amino]benzoic acid ethyl esterHomo sapiens (human)Potency22.387210
3-(2-ethoxyanilino)-2-(2-furanylmethyl)-3H-isoindol-1-oneHomo sapiens (human)Potency15.848910
su 6656Homo sapiens (human)Potency19.952610
8-geranyloxypsoralenHomo sapiens (human)Potency79.432810
Squamatic acidHomo sapiens (human)Potency39.810710
semaxinibHomo sapiens (human)Potency84.218020
thunberginol bHomo sapiens (human)Potency56.234110
semilicoisoflavone bHomo sapiens (human)Potency2.818410
[(10R,13S,17R)-17-Ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetateHomo sapiens (human)Potency28.183810
methylbenzethonium chlorideHomo sapiens (human)Potency15.848910
quinaldine redHomo sapiens (human)Potency79.432810
metochalconeHomo sapiens (human)Potency17.782810
6-[(4-fluorophenyl)methyl]-5,7-dimethyl-2H-pyrrolo[3,4-d]pyridazin-1-oneHomo sapiens (human)Potency10.472620
3-amino-5-(4-bromophenyl)-4-pyridazinecarbonitrileHomo sapiens (human)Potency89.125110
hesperidinHomo sapiens (human)Potency3.162310
homatropine hydrobromide, (endo-(+-)-isomer)Homo sapiens (human)Potency70.794610
sclerotiorinHomo sapiens (human)Potency8.912510
columbianadinHomo sapiens (human)Potency56.234110
o-geranylsinapyl alcoholHomo sapiens (human)Potency39.810710
kolavenic acidHomo sapiens (human)Potency31.622810
N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(2-methylphenoxy)acetamideHomo sapiens (human)Potency70.794610
fluphenazineHomo sapiens (human)Potency44.668410
l-165041Homo sapiens (human)Potency12.589310
2-[[6-[(5-chloro-2,4-dimethoxyanilino)-oxomethyl]-1,2,3,4-tetrahydroacridin-9-yl]thio]acetic acidHomo sapiens (human)Potency79.432810
[4-(phenylmethyl)-2,3-dihydro-1,4-benzothiazin-6-yl]-(1-piperidinyl)methanoneHomo sapiens (human)Potency35.481310
6-ethyl-8-methyl-N-(3-pyridinylmethyl)-3-benzo[b][1,4]benzothiazepinecarboxamideHomo sapiens (human)Potency50.118710
corosolic acidHomo sapiens (human)Potency89.125110
4-[3-(3-methylanilino)-2-imidazo[1,2-a]pyrimidinyl]phenolHomo sapiens (human)Potency22.387210
chlorhexidineHomo sapiens (human)Potency100.000010
lissamine rhodamine bHomo sapiens (human)Potency100.663620
pimaric acidHomo sapiens (human)Potency44.668410
emergilHomo sapiens (human)Potency35.481310
((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1h-inden-5-yl)oxy)acetic acid, (+)-isomerHomo sapiens (human)Potency44.668410
macelignanHomo sapiens (human)Potency31.622810
5-methoxy-8,8-dimethyl-2-phenyl-4H,8H-pyrano[2,3-h]chromen-4-oneHomo sapiens (human)Potency56.234110
2-(4-chlorophenyl)-1,2-benzothiazol-3-oneHomo sapiens (human)Potency44.668410
10-isobutyryloxy-8,9-epoxythymol isobutyrateHomo sapiens (human)Potency10.000010
2-(4-butan-2-ylanilino)-3-pyridinecarbonitrileHomo sapiens (human)Potency10.000010
4-methoxybenzoic acid [2-(4-bromophenyl)-4-oxo-3-quinazolinyl] esterHomo sapiens (human)Potency17.782810
chlorhexidine hydrochlorideHomo sapiens (human)Potency100.000010
malyngamide AHomo sapiens (human)Potency25.118910
3,6-diamino-10-methylacridinium chloride hydrochlorideHomo sapiens (human)Potency89.716420
2-[(2-chloro-4-nitroanilino)methyl]-6-methoxyphenolHomo sapiens (human)Potency56.234110
(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid prop-2-enyl esterHomo sapiens (human)Potency35.481310
(2S)-4-methyl-2-[[oxo-[5-[oxo-[(phenylmethyl)amino]methyl]-1H-imidazol-4-yl]methyl]amino]pentanoic acid (phenylmethyl) esterHomo sapiens (human)Potency56.234110
(2R,4S)-4-cyclohexyl-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-carboxamideHomo sapiens (human)Potency44.668410
(3S,4aR,6aR,6bR,8aS,11S,12aS,14bS)-11-(hydroxymethyl)-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-3,14-diolHomo sapiens (human)Potency25.118910
3-(4-methylphenyl)-5-oxo-8-thiazolo[2,3-b]quinazolinecarboxamideHomo sapiens (human)Potency100.000010
(2R,4S)-6,6-dimethoxy-1-phenylmethoxyhexane-2,4-diolHomo sapiens (human)Potency89.125110
3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanoneHomo sapiens (human)Potency50.118710
3-(1,3-benzodioxol-5-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanoneHomo sapiens (human)Potency31.622810
(3R,3aS,7R,7aS)-7-methyl-3-(2-naphthalenyl)-2-(phenylmethyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-oneHomo sapiens (human)Potency39.810710
2-[(1R)-1-carboxy-2-(1-naphthalenyl)ethyl]-1,3-dioxo-5-isoindolecarboxylic acidHomo sapiens (human)Potency89.125110
6-(3,5-dimethyl-4-isoxazolyl)-N-[(2-ethoxyphenyl)methyl]-4-quinazolinamineHomo sapiens (human)Potency15.848910
amorfrutin aHomo sapiens (human)Potency35.481310
N-[3-(3,5-dimethyl-1-piperidinyl)propyl]-2-(1-piperidinyl)-1,3-benzothiazole-6-carboxamideHomo sapiens (human)Potency2.818410
3-[1-[[1-(4-methylphenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-oneHomo sapiens (human)Potency39.810710
3-[1-[[1-(4-chlorophenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-oneHomo sapiens (human)Potency8.912510
4'-epichaetoviridin AHomo sapiens (human)Potency50.118710
meclofenamate sodium anhydrousHomo sapiens (human)Potency50.118710
cefmetazole sodiumHomo sapiens (human)Potency2.511910
cyclic amp, monosodium saltHomo sapiens (human)Potency13.534620
cefamandole nafateHomo sapiens (human)Potency8.912510
acid blue 129Homo sapiens (human)Potency89.125110
leu-ser-glu-ala-leuHomo sapiens (human)Potency89.125110
2-[[2-(phenoxymethyl)-4-quinazolinyl]thio]acetic acid methyl esterHomo sapiens (human)Potency63.095710
[5-[(3,4-difluorophenoxy)methyl]-3-isoxazolyl]-(3-propoxy-1-piperidinyl)methanoneHomo sapiens (human)Potency89.125110
N,3-dimethyl-5-propyl-N-(2-thiazolylmethyl)-2-benzofurancarboxamideHomo sapiens (human)Potency56.234110
2-(2,6-dimethylphenoxy)-N-[2-(1-piperidinyl)phenyl]acetamideHomo sapiens (human)Potency10.000010
(1S,2R,4As,9aS)-1-[(Z)-5-hydroxy-3-(hydroxymethyl)pent-3-enyl]-6-(hydroxymethyl)-1,2-dimethyl-3,4a,5,8,9,9a-hexahydro-2H-benzo[7]annulen-4-oneHomo sapiens (human)Potency79.432810
LSM-1873Homo sapiens (human)Potency89.125110
LSM-1315Homo sapiens (human)Potency39.810710
2-(trifluoromethylsulfonyl)-6,11-dihydro-5H-dibenzo[1,3-e-1',2'-f][7]annulen-11-olHomo sapiens (human)Potency50.118710
5-(2-chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidineHomo sapiens (human)Potency89.125110
N-[(5-fluoro-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamideHomo sapiens (human)Potency22.387210
4-[[[(2S,3S)-10-[[cyclopropyl(oxo)methyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl-methylamino]methyl]benzoic acidHomo sapiens (human)Potency28.183810
1-[(2R,3R)-2-[[benzenesulfonyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-3-[4-(trifluoromethyl)phenyl]ureaHomo sapiens (human)Potency3.548110
2-[[1-[(3-bromophenyl)methyl]-3-indolyl]sulfonyl]-N-(5-methyl-3-isoxazolyl)acetamideHomo sapiens (human)Potency100.000010
N-[(5-bromo-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamideHomo sapiens (human)Potency31.622810
N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamideHomo sapiens (human)Potency22.387210
2-[5-[(3,4-dichlorophenyl)methylthio]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]pyridineHomo sapiens (human)Potency56.234110
5-(2,5-dichlorophenyl)-N-(2,6-dimethoxyphenyl)-2-furancarboxamideHomo sapiens (human)Potency50.118710
N-(2,6-dimethylphenyl)-5-(4-methyl-3-thiophenyl)-2-furancarboxamideHomo sapiens (human)Potency22.387210
(3,4-dimethoxyphenyl)-[1-(2-phenylethyl)-3-piperidinyl]methanoneHomo sapiens (human)Potency89.125110
sphaeropsidin aHomo sapiens (human)Potency14.125410
lfm a13Homo sapiens (human)Potency70.794610
1-ethyl-4-hydroxy-2-oxo-N'-(1-oxodecyl)-3-quinolinecarbohydrazideHomo sapiens (human)Potency63.095710
8-bromocyclic gmp, sodium saltHomo sapiens (human)Potency5.623410
galloflavinHomo sapiens (human)Potency25.118910
4-[[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acidHomo sapiens (human)Potency89.125110

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
esi-05Homo sapiens (human)IC500.450022

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
guanyl-nucleotide exchange factor activitymolecular functionStimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
cAMP bindingmolecular functionBinding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]
protein-macromolecule adaptor activitymolecular functionThe binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
small GTPase bindingmolecular functionBinding to a small monomeric GTPase. [GOC:mah, PMID:27218782]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
hippocampal mossy fiber to CA3 synapsecellular componentOne of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 9 target(s):

TargetCategoryDefinition
adaptive immune responsebiological processAn immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
adenylate cyclase-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
calcium-ion regulated exocytosisbiological processThe release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. [GOC:go_curators]
regulation of exocytosisbiological processAny process that modulates the frequency, rate or extent of exocytosis. [GOC:go_curators]
insulin secretionbiological processThe regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. [GOC:mah, ISBN:0198506732]
positive regulation of insulin secretionbiological processAny process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]
regulation of synaptic vesicle cyclebiological processAny process that modulates the frequency, rate or extent of the synaptic vesicle cycle. [GOC:dos]
Ras protein signal transductionbiological processAn intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]