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Adenosine deaminase
An adenosine deaminase that is encoded in the genome of cow. [OMA:P56658, PRO:DNx]
Synonyms
EC 3.5.4.4;
Adenosine aminohydrolase
Research
Bioassay Publications (28)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
Compounds (28)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine.Journal of medicinal chemistry, , Nov-21, Volume: 40, Issue:24, 1997
Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus.Journal of medicinal chemistry, , Feb-05, Volume: 36, Issue:3, 1993
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.Journal of medicinal chemistry, , Oct-25, Volume: 44, Issue:22, 2001
Synthesis and biological evaluation of 2-fluoro-8-azaadenosine and related compounds.Journal of medicinal chemistry, , Volume: 26, Issue:10, 1983
Azadideoxyadenosine: synthesis, enzymology, and anti-HIV activity.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents.Journal of medicinal chemistry, , Jun-17, Volume: 47, Issue:13, 2004
Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.Journal of medicinal chemistry, , Oct-24, Volume: 45, Issue:22, 2002
Synthesis and biological evaluation of purine-containing butenolides.Journal of medicinal chemistry, , May-24, Volume: 44, Issue:11, 2001
3'-Beta-ethynyl and 2'-deoxy-3'-beta-ethynyl adenosines: first 3'-beta-branched-adenosines substrates of adenosine deaminase.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 10, Issue:2, 2000
Design, synthesis, and structure-activity relationship of novel dinucleotide analogs as agents against herpes and human immunodeficiency viruses.Journal of medicinal chemistry, , Nov-10, Volume: 38, Issue:23, 1995
Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus.Journal of medicinal chemistry, , Feb-05, Volume: 36, Issue:3, 1993
Synthesis, structure, and biological activity of certain 2-deoxy-beta-D-ribo-hexopyranosyl nucleosides and nucleotides.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity.Journal of medicinal chemistry, , Volume: 28, Issue:11, 1985
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.Journal of medicinal chemistry, , Volume: 27, Issue:3, 1984
Synthesis and biological evaluation of 2-fluoro-8-azaadenosine and related compounds.Journal of medicinal chemistry, , Volume: 26, Issue:10, 1983
Inhibitors of adenosine deaminase. Studies in combining high-affinity enzyme-binding structural units. erythro-1,6-Dihydro-6-(hydroxymethyl)-9-(2-hydroxy-3-nonyl)purine and erythro-9-(2-hydroxy-3-nonyl)purine.Journal of medicinal chemistry, , Volume: 25, Issue:5, 1982
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles.Journal of medicinal chemistry, , Jan-07, Volume: 37, Issue:1, 1994
Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.Journal of medicinal chemistry, , Volume: 31, Issue:2, 1988
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.Journal of medicinal chemistry, , Volume: 27, Issue:3, 1984
Inhibitors of adenosine deaminase. Studies in combining high-affinity enzyme-binding structural units. erythro-1,6-Dihydro-6-(hydroxymethyl)-9-(2-hydroxy-3-nonyl)purine and erythro-9-(2-hydroxy-3-nonyl)purine.Journal of medicinal chemistry, , Volume: 25, Issue:5, 1982
Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2's-hydroxy-3's-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.Journal of medicinal chemistry, , Mar-26, Volume: 52, Issue:6, 2009
Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R-nonyl)adenine [(+)-EHNA].Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Adenosine deaminase inhibitors. Synthesis and biological evaluation of putative metabolites of (+)-erythro-9-(2S-hydroxy-3R-nonyl)adenine.Journal of medicinal chemistry, , Oct-28, Volume: 37, Issue:22, 1994
Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
Effect of a chemical modification on the hydrated adenosine intermediate produced by adenosine deaminase and a model reaction for a potential mechanism of action of 5-aminoimidazole ribonucleotide carboxylase.Journal of medicinal chemistry, , Oct-10, Volume: 40, Issue:21, 1997
Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.Journal of medicinal chemistry, , Volume: 34, Issue:3, 1991
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.Journal of medicinal chemistry, , Volume: 27, Issue:3, 1984
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles.Journal of medicinal chemistry, , Jan-07, Volume: 37, Issue:1, 1994
Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992