Ras guanyl-releasing protein 3

A Ras guanyl-releasing protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV61]

Calcium and DAG-regulated guanine nucleotide exchange factor III;
Guanine nucleotide exchange factor for Rap1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tetradecanoylphorbol acetate	Homo sapiens (human)	EC50	0.0820	1	1

This protein enables 7 target(s):

Target	Category	Definition
guanyl-nucleotide exchange factor activity	molecular function	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
GTPase activator activity	molecular function	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
kinase binding	molecular function	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]
diacylglycerol binding	molecular function	Binding to a diacylglycerol, a diester of glycerol and two fatty acids. [GOC:ma]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 1 target(s):

Target	Category	Definition
guanyl-nucleotide exchange factor complex	cellular component	A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. [GOC:mah]

This protein is involved in 3 target(s):

Target	Category	Definition
MAPK cascade	biological process	An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267]
small GTPase-mediated signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase relays a signal. [GOC:mah]
Ras protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]