Proteins > Tubulin beta chain
Page last updated: 2024-08-07 15:34:49
Tubulin beta chain
[no definition available]
Synonyms
Beta-tubulin
Research
Bioassay Publications (58)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (1.72) | 18.7374 |
| 1990's | 1 (1.72) | 18.2507 |
| 2000's | 10 (17.24) | 29.6817 |
| 2010's | 38 (65.52) | 24.3611 |
| 2020's | 8 (13.79) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| nocodazole | Sus scrofa (pig) | IC50 | 0.7600 | 7 | 7 |
| vorinostat | Sus scrofa (pig) | IC50 | 1.5000 | 1 | 1 |
| colchicine | Sus scrofa (pig) | IC50 | 4.8445 | 26 | 26 |
| colchicine | Sus scrofa (pig) | Ki | 5.7500 | 1 | 1 |
| podophyllotoxin | Sus scrofa (pig) | IC50 | 0.6220 | 10 | 10 |
| podophyllotoxin | Sus scrofa (pig) | Ki | 2.1800 | 1 | 1 |
| vinblastine | Sus scrofa (pig) | IC50 | 1.1000 | 3 | 3 |
| 2-methoxyestradiol | Sus scrofa (pig) | IC50 | 2.2000 | 1 | 1 |
| phenoxazine | Sus scrofa (pig) | IC50 | 10.0000 | 1 | 1 |
| estrone-3-o-sulfamate | Sus scrofa (pig) | IC50 | 25.9000 | 1 | 1 |
| e 7010 | Sus scrofa (pig) | IC50 | 2.7900 | 1 | 1 |
| semaxinib | Sus scrofa (pig) | IC50 | 40.0000 | 1 | 1 |
| fosbretabulin | Sus scrofa (pig) | IC50 | 1.9428 | 25 | 25 |
| vinblastine sulfate | Sus scrofa (pig) | IC50 | 0.1300 | 7 | 7 |
| nsc 600032 | Sus scrofa (pig) | IC50 | 3.5000 | 1 | 1 |
| npi 2358 | Sus scrofa (pig) | IC50 | 1.8000 | 1 | 1 |
| 2-(2,6-diisopropylphenyl)-5-hydroxy-1h-isoindole-1,3-dione | Sus scrofa (pig) | IC50 | 6.9000 | 1 | 1 |
| tubulysin d | Sus scrofa (pig) | IC50 | 1.7000 | 1 | 1 |
| pci 34051 | Sus scrofa (pig) | IC50 | 0.3100 | 1 | 1 |
| (2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone | Sus scrofa (pig) | IC50 | 17.9000 | 1 | 1 |
| isoerianin | Sus scrofa (pig) | IC50 | 21.5000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| colchicine | Sus scrofa (pig) | Kd | 7.5000 | 2 | 2 |
| podophyllotoxin | Sus scrofa (pig) | Kd | 70.5000 | 1 | 1 |
| paclitaxel | Sus scrofa (pig) | EC50 | 0.5200 | 1 | 1 |
| fosbretabulin | Sus scrofa (pig) | EC50 | 0.0070 | 1 | 1 |
| npi 2358 | Sus scrofa (pig) | Kd | 1.0450 | 4 | 4 |
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
[no title available]
European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Design, synthesis, and bioevaluation of imidazo [1,2-a] pyrazine derivatives as tubulin polymerization inhibitors with potent anticancer activities.
Bioorganic & medicinal chemistry, , 12-15, Volume: 76, 2022
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities.
European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
Journal of medicinal chemistry, , 01-23, Volume: 63, Issue:2, 2020
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.
European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.
European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
ACS medicinal chemistry letters, , Feb-11, Volume: 7, Issue:2, 2016
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Journal of medicinal chemistry, , Dec-10, Volume: 58, Issue:23, 2015
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
Journal of medicinal chemistry, , Dec-27, Volume: 55, Issue:24, 2012
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.
Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.
Bioorganic & medicinal chemistry letters, , Nov-04, Volume: 12, Issue:21, 2002
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.
Journal of medicinal chemistry, , Volume: 23, Issue:5, 1980
European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Design, synthesis, and bioevaluation of imidazo [1,2-a] pyrazine derivatives as tubulin polymerization inhibitors with potent anticancer activities.
Bioorganic & medicinal chemistry, , 12-15, Volume: 76, 2022
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities.
European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
Journal of medicinal chemistry, , 01-23, Volume: 63, Issue:2, 2020
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.
European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.
European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.
ACS medicinal chemistry letters, , Feb-11, Volume: 7, Issue:2, 2016
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.
Journal of medicinal chemistry, , Dec-10, Volume: 58, Issue:23, 2015
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
Journal of medicinal chemistry, , Dec-27, Volume: 55, Issue:24, 2012
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.
Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.
Bioorganic & medicinal chemistry letters, , Nov-04, Volume: 12, Issue:21, 2002
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.
Journal of medicinal chemistry, , Volume: 23, Issue:5, 1980
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
Bioorganic & medicinal chemistry, , May-15, Volume: 16, Issue:10, 2008
Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications.
Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.
Journal of medicinal chemistry, , Volume: 23, Issue:5, 1980
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
Bioorganic & medicinal chemistry, , May-15, Volume: 16, Issue:10, 2008
Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications.
Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.
Journal of medicinal chemistry, , Volume: 23, Issue:5, 1980
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.
European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.
Bioorganic & medicinal chemistry letters, , Nov-04, Volume: 12, Issue:21, 2002
European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.
Bioorganic & medicinal chemistry letters, , Nov-04, Volume: 12, Issue:21, 2002
Synthesis and Biological Evaluation of a Biotinylated Paclitaxel With an Extra-Long Chain Spacer Arm.
ACS medicinal chemistry letters, , Sep-13, Volume: 3, Issue:9, 2012
ACS medicinal chemistry letters, , Sep-13, Volume: 3, Issue:9, 2012
Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis.
European journal of medicinal chemistry, , Oct-06, Volume: 85, 2014
European journal of medicinal chemistry, , Oct-06, Volume: 85, 2014
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents.
RSC medicinal chemistry, , Aug-18, Volume: 12, Issue:8, 2021
RSC medicinal chemistry, , Aug-18, Volume: 12, Issue:8, 2021
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005
[no title available]
European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents.
RSC medicinal chemistry, , Aug-18, Volume: 12, Issue:8, 2021
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.
European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
Journal of medicinal chemistry, , 01-24, Volume: 62, Issue:2, 2019
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.
European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available]
European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available]
European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.
European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.
European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability.
Bioorganic & medicinal chemistry letters, , 09-15, Volume: 26, Issue:18, 2016
Design, synthesis of phenstatin/isocombretastatin-oxindole conjugates as antimitotic agents.
Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.
Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 22, Issue:21, 2012
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
Journal of medicinal chemistry, , Mar-08, Volume: 55, Issue:5, 2012
Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.
Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 20, Issue:1, 2012
Synthesis and biological evaluation of phenstatin metabolites.
Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.
Bioorganic & medicinal chemistry, , Sep-15, Volume: 18, Issue:18, 2010
1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
Bioorganic & medicinal chemistry, , May-01, Volume: 16, Issue:9, 2008
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.
Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents.
RSC medicinal chemistry, , Aug-18, Volume: 12, Issue:8, 2021
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.
European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
Journal of medicinal chemistry, , 01-24, Volume: 62, Issue:2, 2019
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.
European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available]
European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available]
European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.
European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.
European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability.
Bioorganic & medicinal chemistry letters, , 09-15, Volume: 26, Issue:18, 2016
Design, synthesis of phenstatin/isocombretastatin-oxindole conjugates as antimitotic agents.
Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.
Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.
Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 22, Issue:21, 2012
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
Journal of medicinal chemistry, , Mar-08, Volume: 55, Issue:5, 2012
Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.
Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 20, Issue:1, 2012
Synthesis and biological evaluation of phenstatin metabolites.
Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.
Bioorganic & medicinal chemistry, , Sep-15, Volume: 18, Issue:18, 2010
1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
Bioorganic & medicinal chemistry, , May-01, Volume: 16, Issue:9, 2008
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 20, Issue:1, 2012
Bioorganic & medicinal chemistry, , Jan-01, Volume: 20, Issue:1, 2012
Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.
ACS medicinal chemistry letters, , Oct-09, Volume: 5, Issue:10, 2014
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin.
Bioorganic & medicinal chemistry, , May-01, Volume: 18, Issue:9, 2010
ACS medicinal chemistry letters, , Oct-09, Volume: 5, Issue:10, 2014
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin.
Bioorganic & medicinal chemistry, , May-01, Volume: 18, Issue:9, 2010
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
[no title available]
Journal of medicinal chemistry, , 06-24, Volume: 64, Issue:12, 2021
Journal of medicinal chemistry, , 06-24, Volume: 64, Issue:12, 2021
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.
Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013