Poly(ADP-ribose) glycohydrolase

A poly(ADP-ribose) glycohydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86W56]

EC 3.2.1.143

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzamide	Homo sapiens (human)	IC50	1,000.0000	1	1
adenosine diphosphate (hydroxymethyl)pyrrolidinediol	Homo sapiens (human)	IC50	0.1200	1	1

This protein enables 2 target(s):

Target	Category	Definition
poly(ADP-ribose) glycohydrolase activity	molecular function	Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. [EC:3.2.1.143]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 5 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear body	cellular component	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 5 target(s):

Target	Category	Definition
carbohydrate metabolic process	biological process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]
base-excision repair, gap-filling	biological process	Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. [ISBN:1550091131]
ATP generation from poly-ADP-D-ribose	biological process	The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. [PMID:27257257]
nucleotide-sugar metabolic process	biological process	The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [ISBN:0198506732]
regulation of DNA repair	biological process	Any process that modulates the frequency, rate or extent of DNA repair. [GOC:go_curators]