Solute carrier family 22 member 3

A solute carrier family 22 member 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75751]

Synonyms

Extraneuronal monoamine transporter;
EMT;
Organic cation transporter 3

Research

Bioassay Publications (9)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (22.22)	18.2507
2000's	4 (44.44)	29.6817
2010's	3 (33.33)	24.3611
2020's	0 (0.00)	2.80

Compounds (36)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
histamine	Homo sapiens (human)	Ki	140.0000	1	1
bithionol	Homo sapiens (human)	IC50	5.5000	1	1
clonidine	Homo sapiens (human)	IC50	79.3000	1	1
clonidine	Homo sapiens (human)	Ki	373.0000	1	1
desipramine	Homo sapiens (human)	Ki	14.0000	1	1
guanidine	Homo sapiens (human)	IC50	2,200.0000	1	1
guanidine	Homo sapiens (human)	Ki	6,201.0000	1	1
imipramine	Homo sapiens (human)	Ki	42.0000	1	1
mitoxantrone	Homo sapiens (human)	IC50	60.5000	1	1
nifekalant	Homo sapiens (human)	IC50	146.0000	1	1
ondansetron	Homo sapiens (human)	IC50	17.4000	1	1
pantoprazole	Homo sapiens (human)	IC50	137.0000	1	1
pentamidine	Homo sapiens (human)	IC50	9.5000	1	1
phenoxybenzamine	Homo sapiens (human)	IC50	6.1300	1	1
prazosin	Homo sapiens (human)	IC50	12.6000	1	1
procainamide	Homo sapiens (human)	Ki	738.0000	1	1
imatinib	Homo sapiens (human)	IC50	25.5000	1	1
tetraethylammonium	Homo sapiens (human)	IC50	10,300.0000	1	1
tetraethylammonium	Homo sapiens (human)	Ki	1,372.0000	1	1
corticosterone	Homo sapiens (human)	IC50	0.9450	2	1
colchicine	Homo sapiens (human)	Ki	0.1200	1	1
phenylguanidine	Homo sapiens (human)	IC50	99.8000	1	1
1-methyl-4-phenylpyridinium	Homo sapiens (human)	Ki	54.0000	1	1
irinotecan	Homo sapiens (human)	IC50	74.6000	1	1
metiprenaline	Homo sapiens (human)	IC50	4.3800	1	1
ritonavir	Homo sapiens (human)	IC50	300.0000	1	1
s 1033	Homo sapiens (human)	IC50	0.5000	1	0
2-(4-chlorophenyl)guanidine	Homo sapiens (human)	IC50	2.8000	1	1
indinavir sulfate	Homo sapiens (human)	IC50	500.0000	1	1
penicillin v	Homo sapiens (human)	IC50	0.0900	1	1
famotidine	Homo sapiens (human)	IC50	10.7000	1	1
chlorhexidine	Homo sapiens (human)	IC50	0.4100	1	1
m-chlorophenylguanidine	Homo sapiens (human)	IC50	7.6000	1	1
pci 32765	Homo sapiens (human)	IC50	7.9000	1	0
cyanine 863	Homo sapiens (human)	IC50	1.7600	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
agmatine	Homo sapiens (human)	Km	2,500.0000	1	1
histamine	Homo sapiens (human)	Km	180.0000	1	1
1-methyl-4-phenylpyridinium	Homo sapiens (human)	Km	47.0000	1	1
norfentanyl	Homo sapiens (human)	Km	49.1000	1	1
hydromorphone	Homo sapiens (human)	Km	755.0000	1	1
methylnaltrexone	Homo sapiens (human)	Km	22.5000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
neurotransmitter transmembrane transporter activity	molecular function	Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
monoamine transmembrane transporter activity	molecular function	Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. [GOC:mah]
organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai]
organic cation transmembrane transporter activity	molecular function	Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
spermidine transmembrane transporter activity	molecular function	Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other. [GOC:ai, RHEA:35039]
quaternary ammonium group transmembrane transporter activity	molecular function	Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [ISBN:0198506732]
toxin transmembrane transporter activity	molecular function	Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [ISBN:0198506732]

Located In

This protein is located in 9 target(s):

Target	Category	Definition
nuclear outer membrane	cellular component	The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
endomembrane system	cellular component	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. [GOC:lh]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
mitochondrial membrane	cellular component	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. [GOC:mah, NIF_Subcellular:sao1045389829]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]

Involved In

This protein is involved in 24 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
neurotransmitter transport	biological process	The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]
serotonin transport	biological process	The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. [GOC:ai]
organic cation transport	biological process	The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. [GOC:ai]
quaternary ammonium group transport	biological process	The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [GOC:ai, ISBN:0198506732]
organic anion transport	biological process	The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]
monocarboxylic acid transport	biological process	The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
monoamine transport	biological process	The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
spermidine transport	biological process	The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc, ISBN:0198506732]
dopamine transport	biological process	The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. [GOC:ai]
norepinephrine transport	biological process	The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. [GOC:ai, ISBN:0198506732]
regulation of appetite	biological process	Any process which modulates appetite, the desire or physical craving for food. [GOC:add]
xenobiotic transport	biological process	The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]
epinephrine transport	biological process	The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jid]
histamine transport	biological process	The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]
serotonin uptake	biological process	The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. [GOC:ai]
histamine uptake	biological process	The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]
norepinephrine uptake	biological process	The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. [GOC:ai]
epinephrine uptake	biological process	The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:ai]
purine-containing compound transmembrane transport	biological process	The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof. [GOC:mah]
dopamine uptake	biological process	The directed movement of dopamine into a cell. [GOC:dph, GOC:tb]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
spermidine transmembrane transport	biological process	The process in which spermidine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:15637075]
cellular detoxification	biological process	Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. [GOC:vw]