Proteins > Histidine-rich protein PFHRP-II
Page last updated: 2024-08-07 15:40:00
Histidine-rich protein PFHRP-II
[no definition available]
Synonyms
Research
Bioassay Publications (15)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 14 (93.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (14)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quinacrine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 292.0000 | 1 | 1 |
| chloroquine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 396,967.5905 | 13 | 13 |
| clotrimazole | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 2,500,000.0000 | 1 | 1 |
| mefloquine hydrochloride | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 315.0000 | 1 | 1 |
| ursolic acid | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 20,000.0000 | 1 | 1 |
| chloroquine diphosphate | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5,900.0000 | 1 | 1 |
| 7-chloro-4-aminoquinoline | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 16.0000 | 1 | 1 |
| desethylchloroquine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 15.0000 | 1 | 1 |
| cryptolepine monohydrochloride | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1,720,000.0000 | 1 | 1 |
| quinidine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 325.0000 | 1 | 1 |
| quinine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 7,400,000.0000 | 1 | 1 |
| 2-tert-butylprimaquine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 2.9000 | 1 | 1 |
| amodiaquine hydrochloride | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 395,083.5000 | 2 | 2 |
| quinine sulfate | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 365.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| chloroquine | Plasmodium falciparum (malaria parasite P. falciparum) | Inhibition | 55.0000 | 1 | 1 |
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:8, 2007
Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:1, 2007
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 16, Issue:20, 2006
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 16, Issue:1, 2006
Probing the role of the covalent linkage of ferrocene into a chloroquine template.Journal of medicinal chemistry, , Jul-27, Volume: 49, Issue:15, 2006
Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.Journal of natural products, , Volume: 68, Issue:5, 2005
Design, synthesis and antimalarial activity of a glyoxylylhydrazone library.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.Journal of medicinal chemistry, , Nov-07, Volume: 45, Issue:23, 2002
Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines.Bioorganic & medicinal chemistry letters, , Aug-20, Volume: 11, Issue:16, 2001
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.Journal of medicinal chemistry, , Nov-04, Volume: 42, Issue:22, 1999