arborinine and Necrosis

The effects of arborinine, an alkaloid extracted from Erthela bahiensis and of rutin, a flavonoid obtained from Dimorphandra mollis (Benth.), Brazilian medicinal plants, on the viability and function of a murine B-cell hybridoma as a tumor model were investigated. The flavonoid rutin at 50 microM induced an increase in the number of apoptotic cells of one- to fivefold and reductions in cellular proliferation and monoclonal antibody production. Less but still significant necrosis was also induced by rutin under the same experimental conditions. On the other hand, the alkaloid arborinine exerted no significant effects on the studied parameters.

Topics: Acridines; Animals; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; Apoptosis; B-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Fabaceae; Hybridomas; Mice; Necrosis; Plant Extracts; Rutaceae; Rutin; Seeds