A phospholipase D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14939]
PLD 2;
hPLD2;
EC 3.1.4.4;
Choline phosphatase 2;
PLD1C;
Phosphatidylcholine-hydrolyzing phospholipase D2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-NA-PP1 | Homo sapiens (human) | IC50 | 0.3870 | 1 | 3 |
| raloxifene | Homo sapiens (human) | IC50 | 7.6000 | 3 | 4 |
| 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol | Homo sapiens (human) | IC50 | 37.0220 | 2 | 2 |
| halopemide | Homo sapiens (human) | IC50 | 1.5367 | 6 | 6 |
| afimoxifene | Homo sapiens (human) | IC50 | 13.2500 | 1 | 2 |
| 5-fluoro-2-indolyldeschlorohalopemide | Homo sapiens (human) | IC50 | 0.0795 | 4 | 6 |
| N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide | Homo sapiens (human) | IC50 | 0.2323 | 5 | 7 |
| vu0155069 | Homo sapiens (human) | IC50 | 1.3665 | 4 | 4 |
| ml298 | Homo sapiens (human) | IC50 | 5.2662 | 3 | 4 |
| ml299 | Homo sapiens (human) | IC50 | 0.0283 | 3 | 4 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| phospholipase D activity | molecular function | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. [EC:3.1.4.4] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| phosphatidylinositol binding | molecular function | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417] |
| N-acylphosphatidylethanolamine-specific phospholipase D activity | molecular function | Catalysis of the reaction: H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine (NAE) + H+. [PMID:14634025, PMID:15878693, RHEA:33159] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| presynapse | cellular component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| plasma membrane region | cellular component | A membrane that is a (regional) part of the plasma membrane. [GOC:dos] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| phosphatidic acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [ISBN:0198506732] |
| cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah] |
| small GTPase-mediated signal transduction | biological process | An intracellular signaling cassette in which a small monomeric GTPase relays a signal. [GOC:mah] |
| synaptic vesicle recycling | biological process | The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563] |
| Fc-gamma receptor signaling pathway involved in phagocytosis | biological process | An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GOC:phg, PMID:12488490, PMID:15466916] |
| phospholipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| regulation of vesicle-mediated transport | biological process | Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. [GOC:dph, GOC:tb] |