Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

A peroxisomal N(1)-acetyl-spermine/spermidine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QHF9]

EC 1.5.3.13;
Polyamine oxidase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n(1)-acetylspermidine	Homo sapiens (human)	Ki	1,370.0000	1	1
n-acetylputrescine	Homo sapiens (human)	Ki	800.0000	1	1
7-(n-(3-aminopropyl)amino)heptan-2-one	Homo sapiens (human)	Ki	0.1800	1	1
n-acetyl-1,6-diaminohexane	Homo sapiens (human)	Ki	31.0000	1	1
chlorhexidine	Homo sapiens (human)	Ki	0.3250	1	2

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n(8)-acetylspermidine	Homo sapiens (human)	Km	11.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
polyamine oxidase activity	molecular function	Catalysis of the oxidative degradation or interconversion of polyamines. [PMID:1567380]
N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	molecular function	Catalysis of the reaction: H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine. [RHEA:25868]
spermine:oxygen oxidoreductase (spermidine-forming) activity	molecular function	Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine. [RHEA:25804]
spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity	molecular function	Catalysis of the reaction: H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine. [RHEA:25808]
N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	molecular function	Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine. [RHEA:25800]
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	molecular function	Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine. [RHEA:25812]

This protein is located in 2 target(s):

Target	Category	Definition
peroxisomal matrix	cellular component	The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. [GOC:curators, ISBN:0815316194]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 5 target(s):

Target	Category	Definition
putrescine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine. [GOC:go_curators, ISBN:0198506732]
putrescine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. [GOC:ai]
spermidine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]
spermine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [PMID:12141946]
positive regulation of spermidine biosynthetic process	biological process	Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process. [GOC:pm, GOC:TermGenie]