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Alpha-1B adrenergic receptor
A protein that is a translation product of the ADRA1B gene in Mesocricetus auratus. [PRO:DNx, UniProtKB:P18841]
Synonyms
Alpha-1B adrenoreceptor;
Alpha-1B adrenoceptor
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (15)
Drugs with Inhibition Measurements
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.Journal of medicinal chemistry, , Jun-03, Volume: 47, Issue:12, 2004
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
Discovery of novel α₁-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.Journal of medicinal chemistry, , Jun-03, Volume: 47, Issue:12, 2004
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.Journal of medicinal chemistry, , Jun-03, Volume: 47, Issue:12, 2004
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003