Proteins > 5-hydroxytryptamine receptor 3B
Page last updated: 2024-08-07 17:27:07
5-hydroxytryptamine receptor 3B
A 5-hydroxytryptamine receptor 3B that is encoded in the genome of rat. [OMA:Q9JJ16, PRO:DNx]
Synonyms
5-HT3-B;
5-HT3B;
Serotonin receptor 3B
Research
Bioassay Publications (50)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 6 (12.00) | 18.7374 |
| 1990's | 34 (68.00) | 18.2507 |
| 2000's | 10 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (90)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| ondansetron | Rattus norvegicus (Norway rat) | Kd | 0.0020 | 1 | 1 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| zacopride | Rattus norvegicus (Norway rat) | Kd | 0.0008 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| bemesetron | Rattus norvegicus (Norway rat) | Kd | 0.0158 | 1 | 1 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.Journal of medicinal chemistry, , Feb-27, Volume: 46, Issue:5, 2003
Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.Journal of medicinal chemistry, , Apr-29, Volume: 37, Issue:9, 1994
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Serotonin receptor affinity of cathinone and related analogues.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.Journal of medicinal chemistry, , May-06, Volume: 42, Issue:9, 1999
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.Journal of medicinal chemistry, , Feb-26, Volume: 41, Issue:5, 1998
Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.Journal of medicinal chemistry, , Feb-14, Volume: 40, Issue:4, 1997
Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.Journal of medicinal chemistry, , Oct-10, Volume: 40, Issue:21, 1997
5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives.Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
5-HT3 receptor antagonists. 1. New quinoline derivatives.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.Journal of medicinal chemistry, , Feb-27, Volume: 46, Issue:5, 2003
A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors.Bioorganic & medicinal chemistry letters, , Jun-16, Volume: 8, Issue:12, 1998
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.Journal of medicinal chemistry, , Oct-10, Volume: 40, Issue:21, 1997
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.Journal of medicinal chemistry, , Apr-29, Volume: 37, Issue:9, 1994
5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives.Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
5-HT3 receptor antagonists. 1. New quinoline derivatives.Journal of medicinal chemistry, , Dec-25, Volume: 35, Issue:26, 1992
Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl)ureas.Journal of medicinal chemistry, , May-01, Volume: 35, Issue:9, 1992
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.Journal of medicinal chemistry, , May-06, Volume: 42, Issue:9, 1999
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.Journal of medicinal chemistry, , Feb-26, Volume: 41, Issue:5, 1998
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.Journal of medicinal chemistry, , May-06, Volume: 42, Issue:9, 1999
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.Journal of medicinal chemistry, , Feb-26, Volume: 41, Issue:5, 1998
5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
Arylpiperazines with serotonin-3 antagonist activity: a comparative molecular field analysis.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.Journal of medicinal chemistry, , Feb-14, Volume: 40, Issue:4, 1997
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl)ureas.Journal of medicinal chemistry, , May-01, Volume: 35, Issue:9, 1992
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.Journal of medicinal chemistry, , Mar-06, Volume: 35, Issue:5, 1992
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.Journal of medicinal chemistry, , Feb-27, Volume: 46, Issue:5, 2003
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.Journal of medicinal chemistry, , Apr-17, Volume: 35, Issue:8, 1992
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.Journal of medicinal chemistry, , Feb-14, Volume: 40, Issue:4, 1997
Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.Journal of medicinal chemistry, , Oct-10, Volume: 40, Issue:21, 1997
Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.Journal of medicinal chemistry, , Oct-21, Volume: 42, Issue:21, 1999
Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl)ureas.Journal of medicinal chemistry, , May-01, Volume: 35, Issue:9, 1992
Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists.Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.Journal of medicinal chemistry, , Volume: 33, Issue:6, 1990
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.Journal of medicinal chemistry, , Volume: 33, Issue:12, 1990
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985