Page last updated: 2024-08-07 13:12:30

Translocator protein

[no definition available]

Synonyms

Mitochondrial benzodiazepine receptor;
PKBS;
Peripheral-type benzodiazepine receptor;
PBR

Research

Bioassay Publications (21)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (4.76)18.2507
2000's8 (38.10)29.6817
2010's9 (42.86)24.3611
2020's3 (14.29)2.80

Compounds (34)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pk 11195Homo sapiens (human)IC500.164533
pk 11195Homo sapiens (human)Ki0.020677
clonazepamHomo sapiens (human)IC50555,904.000011
nordazepamHomo sapiens (human)IC50106,414.000011
diazepamHomo sapiens (human)IC50123,595.000011
flunitrazepamHomo sapiens (human)IC50263,027.000011
lorazepamHomo sapiens (human)IC50285,759.000011
nitrazepamHomo sapiens (human)IC50100,000.000011
cm 7116Homo sapiens (human)IC50500,035.000011
oxazepamHomo sapiens (human)IC5055,590.400011
temazepamHomo sapiens (human)IC5062,517.300011
chlordesmethyldiazepamHomo sapiens (human)IC50555,904.000011
halazepamHomo sapiens (human)IC5010,864.300011
alpidemHomo sapiens (human)IC500.007911
alpidemHomo sapiens (human)Ki0.000522
n-desmethylflunitrazepamHomo sapiens (human)IC5025,003.500011
7-aminonitrazepamHomo sapiens (human)IC502,588.210011
ro 20-1815Homo sapiens (human)IC5015,381.500011
dx 9065Homo sapiens (human)IC500.070012
dx 9065Homo sapiens (human)Ki21.000011
ro 11-6893Homo sapiens (human)IC50142,889.000011
n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamideHomo sapiens (human)Ki0.003211
7-aminoclonazepamHomo sapiens (human)IC5013,335.200011
ro 5-3438Homo sapiens (human)IC5071,449.600011
n-desmethylflunitrazepamHomo sapiens (human)IC50666,807.000011
ro 05-4082Homo sapiens (human)IC50454,988.000011
ac-5216Homo sapiens (human)Ki0.018922
cb 34Homo sapiens (human)Ki0.000411
n-(2-methoxybenzyl)-n-(4-phenoxypyridin-3-yl)acetamideHomo sapiens (human)Ki0.002511
daa 1106Homo sapiens (human)IC500.000311
daa 1106Homo sapiens (human)Ki0.000233
naluzotanHomo sapiens (human)Ki2.000011
dpa-713Homo sapiens (human)Ki0.046288
a 803467Homo sapiens (human)IC502.000011
n-fluoroacetyl-n-(2,5-dimethoxybenzyl)-2-phenoxyanilineHomo sapiens (human)Ki0.001011
MS-417Homo sapiens (human)IC500.400011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pk 11195Homo sapiens (human)Kd0.008133
ro 5-4864Homo sapiens (human)Kd0.003622
n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamideHomo sapiens (human)Kd0.004011
cb 34Homo sapiens (human)EC500.337011
ssr180575Homo sapiens (human)Kd0.003124

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pk 11195Homo sapiens (human)Activity0.000611
ro 5-4864Homo sapiens (human)Activity0.007312

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
androgen bindingmolecular functionBinding to an androgen, a male sex hormone. [GOC:jl]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
benzodiazepine receptor activitymolecular functionCombining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. [GOC:jl]
cholesterol bindingmolecular functionBinding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]
transmembrane transporter bindingmolecular functionBinding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
cholesterol transfer activitymolecular functionRemoves cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
mitochondrioncellular componentA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial outer membranecellular componentThe outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
intracellular membrane-bounded organellecellular componentOrganized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Involved In

This protein is involved in 39 target(s):

TargetCategoryDefinition
protein targeting to mitochondrionbiological processThe process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. [GOC:mcc, ISBN:0716731363]
C21-steroid hormone biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]
heme biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. [GOC:jl, PMID:11788607]
monoatomic anion transportbiological processThe directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. [GOC:ai]
chloride transportbiological processThe directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
steroid metabolic processbiological processThe chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
glial cell migrationbiological processThe orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. [GOC:jl, GOC:mtg_sensu]
response to xenobiotic stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
response to manganese ionbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. [GOC:sm]
response to vitamin B1biological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus. [GOC:pz]
peripheral nervous system axon regenerationbiological processThe regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury. [GOC:ef]
sterol transportbiological processThe directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:ai]
adrenal gland developmentbiological processThe process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. [GOC:dgh]
negative regulation of protein ubiquitinationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
regulation of cholesterol transportbiological processAny process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
response to progesteronebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. [GOC:sl]
negative regulation of tumor necrosis factor productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120]
response to testosteronebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:sl]
regulation of cell population proliferationbiological processAny process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
cholesterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
positive regulation of apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of nitric oxide biosynthetic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. [GOC:go_curators]
behavioral response to painbiological processAny process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid]
regulation of steroid biosynthetic processbiological processAny process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:ai]
positive regulation of mitochondrial depolarizationbiological processAny process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]
positive regulation of calcium ion transportbiological processAny process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
contact inhibitionbiological processThe series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation. [GOC:dph, PMID:17376520]
positive regulation of glial cell proliferationbiological processAny process that activates or increases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]
negative regulation of glial cell proliferationbiological processAny process that stops or decreases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]
positive regulation of programmed necrotic cell deathbiological processAny process that increases the frequency, rate or extent of programmed necrotic cell death. [GOC:aruk, GOC:rph, PMID:27258785]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
cellular response to zinc ionbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. [GOC:mah]
cellular hypotonic responsebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. [GOC:mah]
maintenance of protein location in mitochondrionbiological processAny process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere. [GOC:mah]
negative regulation of mitophagybiological processAny process that stops, prevents or reduces the frequency, rate or extent of mitophagy. [GOC:TermGenie]
negative regulation of ATP metabolic processbiological processAny process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. [GO_REF:0000058, GOC:TermGenie, PMID:20695849]
response to acetylcholinebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
positive regulation of reactive oxygen species metabolic processbiological processAny process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]
negative regulation of corticosterone secretionbiological processAny process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion. [GOC:sl]