Proteins > Type-2 angiotensin II receptor
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Type-2 angiotensin II receptor
An angiotensin II receptor 2 that is encoded in the genome of rat. [OMA:P35351, PRO:DNx]
Synonyms
Angiotensin II type-2 receptor;
AT2
Research
Bioassay Publications (23)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 15 (65.22) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
Compounds (30)
Drugs with Potency Measurements
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| losartan | Rattus norvegicus (Norway rat) | IC50 | 28.0030 | 8 | 8 |
| losartan | Rattus norvegicus (Norway rat) | Ki | 0.0316 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | Ki | 0.5000 | 1 | 1 |
| mirtazapine | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 1 | 1 |
| piperoxan | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| thioflavin t | Rattus norvegicus (Norway rat) | Ki | 6.5000 | 1 | 2 |
| exp3174 | Rattus norvegicus (Norway rat) | IC50 | 33.3358 | 3 | 3 |
| exp7711 | Rattus norvegicus (Norway rat) | IC50 | 1.7650 | 2 | 2 |
| bibs 39 | Rattus norvegicus (Norway rat) | Ki | 0.0290 | 1 | 1 |
| bibs 222 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| up 269-6 | Rattus norvegicus (Norway rat) | Ki | 79.2000 | 1 | 1 |
| mk 996 | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| chrysamine g | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| angiotensin ii | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| angiotensin ii | Rattus norvegicus (Norway rat) | Ki | 0.0019 | 1 | 1 |
| l 158809 | Rattus norvegicus (Norway rat) | IC50 | 16.0004 | 5 | 5 |
| eprosartan | Rattus norvegicus (Norway rat) | IC50 | 0.1217 | 2 | 3 |
| pd 123319 | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| lisinopril | Rattus norvegicus (Norway rat) | IC50 | 0.0012 | 1 | 1 |
| enalapril | Rattus norvegicus (Norway rat) | IC50 | 1.2000 | 1 | 1 |
| enalaprilat anhydrous | Rattus norvegicus (Norway rat) | IC50 | 0.0012 | 1 | 1 |
| angiotensin ii, 1-sar-5-ile-8-ala- | Rattus norvegicus (Norway rat) | IC50 | 0.0051 | 1 | 1 |
| l 162313 | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 1 |
| exp-3179 | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| ema400 | Rattus norvegicus (Norway rat) | IC50 | 0.0752 | 1 | 1 |
| angiotensin amide | Rattus norvegicus (Norway rat) | Ki | 0.0055 | 1 | 1 |
| losartan potassium | Rattus norvegicus (Norway rat) | IC50 | 0.0082 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| saralasin | Rattus norvegicus (Norway rat) | Kd | 0.0002 | 2 | 3 |
4-(Heteroarylthio)-2-biphenylyltetrazoles as nonpeptide angiotensin II antagonists.Journal of medicinal chemistry, , Nov-10, Volume: 38, Issue:23, 1995
Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.Journal of medicinal chemistry, , Nov-25, Volume: 37, Issue:24, 1994
Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high oral bioavailability.Journal of medicinal chemistry, , Sep-16, Volume: 37, Issue:19, 1994
Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.Journal of medicinal chemistry, , Jan-08, Volume: 36, Issue:1, 1993
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.Journal of medicinal chemistry, , Volume: 27, Issue:4, 1984
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.Journal of medicinal chemistry, , Aug-19, Volume: 37, Issue:17, 1994
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.Journal of medicinal chemistry, , Nov-25, Volume: 37, Issue:24, 1994
Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.Journal of medicinal chemistry, , Jan-08, Volume: 36, Issue:1, 1993
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.Journal of medicinal chemistry, , Volume: 34, Issue:8, 1991
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.Journal of medicinal chemistry, , May-27, Volume: 37, Issue:11, 1994
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.Journal of medicinal chemistry, , Nov-25, Volume: 37, Issue:24, 1994
(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993
Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles.Journal of medicinal chemistry, , Dec-24, Volume: 36, Issue:26, 1993