diethylnitrosamine has been researched along with Necrosis in 30 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The possible molecular mechanisms of Nano-selenium (nano-se) in attenuating hepatocellular carcinoma (HCC) was investigated in this study." | 7.80 | Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. ( Ahmed, HH; Hamza, AH; Khalil, WK, 2014) |
| "Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat." | 7.66 | Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. ( Farber, E; Sarma, DS; Ying, TS, 1981) |
| "Posttreatment with diethyldithiocarbamate (DEDTC) largely prevented the development of acute hepatocellular necrosis induced by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in male Fischer rats as monitored by the release of glutamate-pyruvate transaminase and sorbitol dehydrogenase into the serum and by histologic examination." | 7.66 | The sequential analysis of liver cell necrosis: inhibition of diethylnitrosamine- and dimethylnitrosamine-induced acute liver cell death by posttreatment with diethyldithiocarbamate. ( Farber, E; Sarma, DS; Ying, TS, 1980) |
| " Treatment with 2500 ppm ACI for 26 weeks after initiation with diethylnitrosamine increased the incidence and multiplicities of altered foci and adenomas in hepatocytes from WT mice; these effects were significantly reduced in CARKO mice." | 3.83 | Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. ( Ichimura, R; Inoue, K; Kodama, Y; Kuwata, K; Shibutani, M; Takahashi, M; Yoshida, M, 2016) |
| "The possible molecular mechanisms of Nano-selenium (nano-se) in attenuating hepatocellular carcinoma (HCC) was investigated in this study." | 3.80 | Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. ( Ahmed, HH; Hamza, AH; Khalil, WK, 2014) |
| "Diethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver." | 3.79 | Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. ( Başaran-Küçükgergin, C; Bingül, İ; Doğru-Abbasoğlu, S; Olgaç, V; Tekkeşin, MS; Uysal, M, 2013) |
| " Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes." | 3.77 | Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. ( Bailly-Maitre, B; Bard-Chapeau, EA; Ding, J; Fang, DD; Feng, GS; Han, T; Li, S; Poli, V; Princen, F; Varki, NM; Wang, H; Zhang, SS; Zhu, HH, 2011) |
| " Metallothionein (MT), an inducible metal-binding protein associated with tolerance to many metal including Cd, was not detected immunohistochemically in mouse liver tumors, even those undergoing Cd-induced necrosis, whereas the surrounding normal liver cells expressed high levels of MT after Cd exposure." | 3.69 | Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice. ( Cherian, MG; Diwan, BA; Goyer, RA; Moussa, M; Rehm, S; Waalkes, MP; Ward, JM, 1996) |
| " When administered 1 or 3 days after N-diethylnitrosamine initiation and partial hepatectomy, colchicine increased the mitotic index of regenerating hepatocytes at days 4-6 without evidence of liver cell necrosis." | 3.69 | Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicine-induced cell cycle disturbance in partially hepatectomized rats. ( Kobitsu, K; Konishi, Y; Mori, Y; Nakajima, Y; Nakano, H; Ohashi, K; Okajima, E; Takahashi, M; Tsujiuchi, T; Tsutsumi, M, 1996) |
| "Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat." | 3.66 | Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. ( Farber, E; Sarma, DS; Ying, TS, 1981) |
| "Posttreatment with diethyldithiocarbamate (DEDTC) largely prevented the development of acute hepatocellular necrosis induced by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in male Fischer rats as monitored by the release of glutamate-pyruvate transaminase and sorbitol dehydrogenase into the serum and by histologic examination." | 3.66 | The sequential analysis of liver cell necrosis: inhibition of diethylnitrosamine- and dimethylnitrosamine-induced acute liver cell death by posttreatment with diethyldithiocarbamate. ( Farber, E; Sarma, DS; Ying, TS, 1980) |
| " indica leaf extract (AAILE) was administered orally at a dosage of 100 μg/g body mass till the termination of experiment." | 1.40 | Azadirachta indica modulates electrical properties and type of cell death in NDEA-induced hepatic tumors. ( Bharati, S; Koul, A; Rishi, P, 2014) |
| " The chromosomal aberration evaluation revealed a discrete dose-response curve." | 1.37 | N-nitrosodiethylamine genotoxicity evaluation: a cytochrome P450 induction study in rat hepatocytes. ( Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Pinto, LF; Silva, IO, 2011) |
| "In contrast to vitamin E deficiency, which permitted the drug to exert stronger toxic effects, 20-fold supplementation with vitamin E did not provide additional protection against the lipoperoxidation and necrosis provoked by DEN (P < 0." | 1.30 | Effect of a necrogenic dose of diethylnitrosamine on vitamin E-deficient and vitamin E-supplemented rats. ( Chiarello, PG; Iglesias, AC; Jordao, AA; Moreno, F; Vannucchi, H; Zucoloto, S, 1998) |
| "The R16 males developed liver cancer and the R16 females developed breast cancer, there also were malignancies in other organs in some animals." | 1.28 | Genetic control of susceptibility to diethylnitrosamine and dimethylbenzanthracene carcinogenesis in rats. ( Gill, TJ; Kunz, HW; Melhem, MF, 1991) |
| " Furthermore, chronic administration of 0." | 1.27 | Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats. ( Denda, A; Emi, Y; Konishi, Y; Mikami, S; Nakae, D; Ohnishi, T; Takahashi, S; Yokose, Y, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (26.67) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 2 (6.67) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bingül, İ | 1 |
| Başaran-Küçükgergin, C | 1 |
| Tekkeşin, MS | 1 |
| Olgaç, V | 1 |
| Doğru-Abbasoğlu, S | 1 |
| Uysal, M | 1 |
| Aparicio-Bautista, DI | 1 |
| Pérez-Carreón, JI | 1 |
| Gutiérrez-Nájera, N | 1 |
| Reyes-Grajeda, JP | 1 |
| Arellanes-Robledo, J | 1 |
| Vásquez-Garzón, VR | 1 |
| Jiménez-García, MN | 1 |
| Villa-Treviño, S | 1 |
| Hong, EJ | 1 |
| Levasseur, MP | 1 |
| Dufour, CR | 1 |
| Perry, MC | 1 |
| Giguère, V | 1 |
| Bharati, S | 1 |
| Rishi, P | 1 |
| Koul, A | 1 |
| Poornima, K | 1 |
| Chella Perumal, P | 1 |
| Gopalakrishnan, VK | 1 |
| Ahmed, HH | 1 |
| Khalil, WK | 1 |
| Hamza, AH | 1 |
| Vatakuti, S | 1 |
| Pennings, JL | 1 |
| Gore, E | 1 |
| Olinga, P | 1 |
| Groothuis, GM | 1 |
| Kuwata, K | 1 |
| Inoue, K | 1 |
| Ichimura, R | 1 |
| Takahashi, M | 2 |
| Kodama, Y | 1 |
| Shibutani, M | 1 |
| Yoshida, M | 1 |
| Gamal-Eldeen, AM | 1 |
| Moustafa, D | 1 |
| El-Daly, SM | 1 |
| El-Hussieny, EA | 1 |
| Saleh, S | 1 |
| Khoobchandani, M | 1 |
| Bacon, KL | 1 |
| Gupta, S | 1 |
| Katti, K | 1 |
| Shukla, R | 1 |
| Katti, KV | 1 |
| Sakurai, T | 2 |
| He, G | 1 |
| Matsuzawa, A | 1 |
| Yu, GY | 1 |
| Maeda, S | 2 |
| Hardiman, G | 1 |
| Karin, M | 2 |
| Bard-Chapeau, EA | 1 |
| Li, S | 1 |
| Ding, J | 1 |
| Zhang, SS | 1 |
| Zhu, HH | 1 |
| Princen, F | 1 |
| Fang, DD | 1 |
| Han, T | 1 |
| Bailly-Maitre, B | 1 |
| Poli, V | 1 |
| Varki, NM | 1 |
| Wang, H | 1 |
| Feng, GS | 1 |
| Aiub, CA | 1 |
| Gadermaier, G | 1 |
| Silva, IO | 1 |
| Felzenszwalb, I | 1 |
| Pinto, LF | 1 |
| Ferreira, F | 1 |
| Eckl, P | 1 |
| Naugler, WE | 1 |
| Kim, S | 1 |
| Kim, K | 1 |
| Elsharkawy, AM | 1 |
| Ying, TS | 2 |
| Sarma, DS | 2 |
| Farber, E | 2 |
| Takahashi, S | 1 |
| Nakae, D | 2 |
| Yokose, Y | 1 |
| Emi, Y | 1 |
| Denda, A | 2 |
| Mikami, S | 1 |
| Ohnishi, T | 1 |
| Konishi, Y | 3 |
| Simon, K | 1 |
| Lapis, K | 1 |
| Goodwin, AE | 1 |
| Grizzle, JM | 1 |
| Waalkes, MP | 1 |
| Diwan, BA | 1 |
| Rehm, S | 1 |
| Ward, JM | 1 |
| Moussa, M | 1 |
| Cherian, MG | 1 |
| Goyer, RA | 1 |
| Columbano, A | 2 |
| Endoh, T | 1 |
| Noguchi, O | 1 |
| Hasegawa, K | 1 |
| Ledda-Columbano, GM | 2 |
| Zedda, AI | 1 |
| Ohashi, K | 1 |
| Tsutsumi, M | 1 |
| Tsujiuchi, T | 1 |
| Kobitsu, K | 1 |
| Okajima, E | 1 |
| Nakajima, Y | 1 |
| Nakano, H | 1 |
| Mori, Y | 1 |
| Chiarello, PG | 1 |
| Iglesias, AC | 1 |
| Zucoloto, S | 1 |
| Moreno, F | 1 |
| Jordao, AA | 1 |
| Vannucchi, H | 1 |
| Tessitore, L | 2 |
| Wang, GS | 1 |
| Eriksson, LC | 1 |
| Xia, L | 1 |
| Olsson, J | 1 |
| Stål, P | 1 |
| Chu, C | 1 |
| Mirvish, SS | 1 |
| Pani, P | 2 |
| Dianzani, MU | 1 |
| Melhem, MF | 1 |
| Kunz, HW | 1 |
| Gill, TJ | 1 |
| Coni, P | 1 |
| Liguori, C | 1 |
| Dragani, TA | 1 |
| Manenti, G | 1 |
| Della Porta, G | 1 |
| Daoust, R | 1 |
| Morais, R | 1 |
30 other studies available for diethylnitrosamine and Necrosis
| Article | Year |
|---|---|
Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Blueberry Plants; Cell Proliferation; Chemical and Dru | 2013 |
Comparative proteomic analysis of thiol proteins in the liver after oxidative stress induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; Antioxidants; Diethylnitrosamine; Liver; Male; Necrosis; Oxidative Stres | 2013 |
Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.
Topics: Animals; Blotting, Western; Carcinogenesis; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromat | 2013 |
Azadirachta indica modulates electrical properties and type of cell death in NDEA-induced hepatic tumors.
Topics: Animals; Apoptosis; Azadirachta; Diethylnitrosamine; Electrophysiological Phenomena; Liver Neoplasms | 2014 |
Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.
Topics: Alkylating Agents; Animals; Antimetabolites; Antioxidants; Bilirubin; Biomarkers; Carcinogens; Chemi | 2014 |
Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats.
Topics: Aldehyde Reductase; Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers; Carc | 2014 |
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis | 2016 |
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cell Transformation, Neoplastic | 2016 |
Photothermal therapy mediated by gum Arabic-conjugated gold nanoparticles suppresses liver preneoplastic lesions in mice.
Topics: Animals; Apoptosis; Cell Survival; Cell Transformation, Neoplastic; Diethylnitrosamine; Glutathione | 2016 |
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.
Topics: Animals; Antioxidants; Carcinogens; Cell Death; Cell Proliferation; Diethylnitrosamine; Enzyme Activ | 2008 |
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; Gene Express | 2011 |
N-nitrosodiethylamine genotoxicity evaluation: a cytochrome P450 induction study in rat hepatocytes.
Topics: Alkylating Agents; Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P- | 2011 |
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Estradiol; Female; Hepatocytes; Interleukin-6; Ku | 2007 |
Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.
Topics: Animals; Cell Division; Diethylnitrosamine; Ditiocarb; gamma-Glutamyltransferase; Hepatectomy; Histo | 1981 |
Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Benzamides; Diethylnitrosamine; DNA Repair; gamma-Glutamyltransferase; Liver; Liver Neoplas | 1984 |
The sequential analysis of liver cell necrosis: inhibition of diethylnitrosamine- and dimethylnitrosamine-induced acute liver cell death by posttreatment with diethyldithiocarbamate.
Topics: Animals; Carcinogens; Cell Survival; Diethylnitrosamine; Dimethylnitrosamine; Ditiocarb; Dose-Respon | 1980 |
Carcinogenesis studies on guppies.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Fishes; Liver Neoplasms; Liver Regeneration; Male; | 1984 |
Oncogene expression in hepatocytes of the fish Rivulus ocellatus marmoratus during the necrotic and regenerative phases of diethylnitrosamine toxicity.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; ErbB Receptors; Fishes; | 1994 |
Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice.
Topics: Animals; Antineoplastic Agents; Cadmium; Carcinoma, Hepatocellular; Diethylnitrosamine; Down-Regulat | 1996 |
Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogens; Cell Death; Cell Division; Diethylnitrosamine | 1996 |
Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicine-induced cell cycle disturbance in partially hepatectomized rats.
Topics: Animals; Carcinogens; Cell Cycle; Cell Division; Cocarcinogenesis; Colchicine; Diethylnitrosamine; g | 1996 |
Effect of a necrogenic dose of diethylnitrosamine on vitamin E-deficient and vitamin E-supplemented rats.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; Free Radicals; Gluta | 1998 |
Hepatocellular carcinoma is induced by a subnecrogenic dose of diethylnitrosamine in previously fasted-refed rats.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Dru | 1998 |
Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Carbon Tetrachloride; Carcinogens; Cell Division; Die | 1999 |
Effects of nine N-nitroso compounds on the specific radioactivity of liver proteins after injection of [14C]leucine into rats.
Topics: Animals; Cycloleucine; Diethylnitrosamine; Dimethylnitrosamine; Leucine; Liver; Liver Neoplasms; Mal | 1977 |
Mechanisms of the enhanced liver carcinogenesis by choline in female rats: delay in liver growth after partial hepatectomy and stimulation of 2-AAF mitoinhibition.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline; Diethylnitrosamine; DNA, Neoplasm; Drug Inte | 1992 |
Genetic control of susceptibility to diethylnitrosamine and dimethylbenzanthracene carcinogenesis in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diethylnitrosamine; Female; Genetic Predisposition to Dis | 1991 |
Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Ethylene Dibromide; gamma-Glutamyl | 1987 |
Enhancing effects of carbon tetrachloride in mouse hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms, | 1986 |
Degenerative changes, DNA synthesis and mitotic activity in rat liver following single exposure to diethylnitrosamine.
Topics: Animals; Cell Nucleus; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Histocytochemistry | 1986 |