Proteins > 5-hydroxytryptamine receptor 6
Page last updated: 2024-08-07 16:47:33
5-hydroxytryptamine receptor 6
A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406]
Synonyms
5-HT-6;
5-HT6;
Serotonin receptor 6
Research
Bioassay Publications (140)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (0.71) | 18.7374 |
| 1990's | 2 (1.43) | 18.2507 |
| 2000's | 50 (35.71) | 29.6817 |
| 2010's | 62 (44.29) | 24.3611 |
| 2020's | 25 (17.86) | 2.80 |
Compounds (158)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tryptamine | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| octoclothepine | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| 1-(1-naphthyl)piperazine | Homo sapiens (human) | Ki | 0.1080 | 3 | 3 |
| 1-(2-methoxyphenyl)piperazine | Homo sapiens (human) | Ki | 0.0012 | 1 | 1 |
| 1-(3-chlorophenyl)piperazine | Homo sapiens (human) | Ki | 2.0240 | 2 | 2 |
| 2-methyl-5-ht | Homo sapiens (human) | Ki | 0.1640 | 3 | 3 |
| 5-carboxamidotryptamine | Homo sapiens (human) | Ki | 0.8600 | 2 | 2 |
| methylbufotenin | Homo sapiens (human) | Ki | 0.0308 | 4 | 4 |
| 5-methoxytryptamine | Homo sapiens (human) | Ki | 0.0690 | 2 | 2 |
| amiodarone | Homo sapiens (human) | IC50 | 19.4410 | 1 | 0 |
| amiodarone | Homo sapiens (human) | Ki | 9.0260 | 1 | 0 |
| amitriptyline | Homo sapiens (human) | IC50 | 0.1400 | 1 | 0 |
| amitriptyline | Homo sapiens (human) | Ki | 0.0650 | 1 | 0 |
| amlodipine | Homo sapiens (human) | IC50 | 2.8980 | 1 | 0 |
| amlodipine | Homo sapiens (human) | Ki | 1.3460 | 1 | 0 |
| amoxapine | Homo sapiens (human) | IC50 | 0.0760 | 1 | 0 |
| amoxapine | Homo sapiens (human) | Ki | 0.0350 | 1 | 0 |
| astemizole | Homo sapiens (human) | IC50 | 3.2660 | 1 | 0 |
| astemizole | Homo sapiens (human) | Ki | 1.5160 | 1 | 0 |
| buspirone | Homo sapiens (human) | Ki | 0.0120 | 1 | 1 |
| carvedilol | Homo sapiens (human) | IC50 | 1.5190 | 1 | 0 |
| carvedilol | Homo sapiens (human) | Ki | 0.7050 | 1 | 0 |
| chlorpromazine | Homo sapiens (human) | IC50 | 0.0570 | 1 | 0 |
| chlorpromazine | Homo sapiens (human) | Ki | 0.0417 | 5 | 5 |
| clomiphene | Homo sapiens (human) | Ki | 1.9560 | 1 | 1 |
| clomipramine | Homo sapiens (human) | IC50 | 0.2450 | 1 | 0 |
| clomipramine | Homo sapiens (human) | Ki | 0.1130 | 2 | 1 |
| clotrimazole | Homo sapiens (human) | IC50 | 12.5430 | 1 | 0 |
| clotrimazole | Homo sapiens (human) | Ki | 5.8240 | 1 | 0 |
| cyproheptadine | Homo sapiens (human) | IC50 | 0.2810 | 1 | 0 |
| cyproheptadine | Homo sapiens (human) | Ki | 0.1300 | 1 | 0 |
| dapsone | Homo sapiens (human) | Ki | 0.1830 | 1 | 1 |
| dicyclomine | Homo sapiens (human) | IC50 | 3.0650 | 1 | 0 |
| dicyclomine | Homo sapiens (human) | Ki | 1.4230 | 1 | 0 |
| disulfiram | Homo sapiens (human) | IC50 | 16.0010 | 1 | 0 |
| disulfiram | Homo sapiens (human) | Ki | 7.4290 | 1 | 0 |
| doxepin | Homo sapiens (human) | IC50 | 0.3200 | 1 | 0 |
| doxepin | Homo sapiens (human) | Ki | 0.1270 | 2 | 1 |
| ebastine | Homo sapiens (human) | IC50 | 2.1974 | 1 | 0 |
| ebastine | Homo sapiens (human) | Ki | 1.0202 | 1 | 0 |
| econazole | Homo sapiens (human) | IC50 | 10.8990 | 1 | 0 |
| econazole | Homo sapiens (human) | Ki | 5.0600 | 1 | 0 |
| fluphenazine | Homo sapiens (human) | IC50 | 0.0520 | 1 | 0 |
| fluphenazine | Homo sapiens (human) | Ki | 0.0370 | 2 | 1 |
| fluoxetine | Homo sapiens (human) | IC50 | 1.6610 | 1 | 0 |
| fluoxetine | Homo sapiens (human) | Ki | 0.7710 | 1 | 0 |
| fluspirilene | Homo sapiens (human) | Ki | 1.1880 | 1 | 1 |
| flutamide | Homo sapiens (human) | IC50 | 17.8140 | 1 | 0 |
| flutamide | Homo sapiens (human) | Ki | 8.2710 | 1 | 0 |
| haloperidol | Homo sapiens (human) | Ki | 4.0277 | 3 | 3 |
| haloprogin | Homo sapiens (human) | IC50 | 4.0110 | 1 | 0 |
| haloprogin | Homo sapiens (human) | Ki | 1.8620 | 1 | 0 |
| imipramine | Homo sapiens (human) | Ki | 3.7300 | 1 | 3 |
| ketanserin | Homo sapiens (human) | Ki | 2.8000 | 1 | 1 |
| ketotifen | Homo sapiens (human) | IC50 | 1.1410 | 1 | 0 |
| ketotifen | Homo sapiens (human) | Ki | 0.5300 | 1 | 0 |
| loxapine | Homo sapiens (human) | Ki | 0.0325 | 2 | 2 |
| maprotiline | Homo sapiens (human) | IC50 | 0.8920 | 1 | 0 |
| maprotiline | Homo sapiens (human) | Ki | 0.4140 | 1 | 0 |
| methapyrilene | Homo sapiens (human) | IC50 | 3.0910 | 1 | 0 |
| methapyrilene | Homo sapiens (human) | Ki | 1.4350 | 1 | 0 |
| methiothepin | Homo sapiens (human) | IC50 | 0.0300 | 5 | 5 |
| methiothepin | Homo sapiens (human) | Ki | 0.0014 | 10 | 10 |
| mianserin | Homo sapiens (human) | IC50 | 0.0850 | 1 | 0 |
| mianserin | Homo sapiens (human) | Ki | 0.0475 | 2 | 1 |
| miconazole | Homo sapiens (human) | IC50 | 10.8870 | 1 | 0 |
| miconazole | Homo sapiens (human) | Ki | 5.0550 | 1 | 0 |
| mitotane | Homo sapiens (human) | IC50 | 1.4020 | 1 | 0 |
| mitotane | Homo sapiens (human) | Ki | 0.6510 | 1 | 0 |
| nortriptyline | Homo sapiens (human) | IC50 | 0.5540 | 1 | 0 |
| nortriptyline | Homo sapiens (human) | Ki | 0.2355 | 2 | 1 |
| orphenadrine | Homo sapiens (human) | IC50 | 1.1210 | 1 | 0 |
| orphenadrine | Homo sapiens (human) | Ki | 0.5210 | 1 | 0 |
| oxymetazoline | Homo sapiens (human) | IC50 | 1.6700 | 1 | 0 |
| oxymetazoline | Homo sapiens (human) | Ki | 0.7750 | 1 | 0 |
| prochlorperazine | Homo sapiens (human) | IC50 | 0.2670 | 1 | 0 |
| prochlorperazine | Homo sapiens (human) | Ki | 0.1240 | 1 | 0 |
| promazine | Homo sapiens (human) | IC50 | 0.2740 | 1 | 0 |
| promazine | Homo sapiens (human) | Ki | 0.1270 | 1 | 0 |
| promethazine | Homo sapiens (human) | IC50 | 2.4290 | 1 | 0 |
| promethazine | Homo sapiens (human) | Ki | 1.1280 | 1 | 0 |
| propafenone | Homo sapiens (human) | IC50 | 1.8630 | 1 | 0 |
| propafenone | Homo sapiens (human) | Ki | 0.8650 | 1 | 0 |
| propranolol | Homo sapiens (human) | IC50 | 4.0384 | 2 | 1 |
| propranolol | Homo sapiens (human) | Ki | 1.4230 | 1 | 0 |
| quetiapine | Homo sapiens (human) | Ki | 1.4000 | 1 | 1 |
| quipazine | Homo sapiens (human) | Ki | 3.6000 | 1 | 1 |
| raloxifene | Homo sapiens (human) | Ki | 0.7500 | 1 | 1 |
| risperidone | Homo sapiens (human) | Ki | 1.2124 | 8 | 8 |
| spiperone | Homo sapiens (human) | Ki | 1.5950 | 2 | 2 |
| sulfadimethoxine | Homo sapiens (human) | IC50 | 1.3390 | 1 | 0 |
| sulfadimethoxine | Homo sapiens (human) | Ki | 0.6220 | 1 | 0 |
| terfenadine | Homo sapiens (human) | IC50 | 1.3060 | 1 | 0 |
| terfenadine | Homo sapiens (human) | Ki | 0.6060 | 1 | 0 |
| thioridazine | Homo sapiens (human) | IC50 | 0.0710 | 1 | 0 |
| thioridazine | Homo sapiens (human) | Ki | 0.0520 | 2 | 1 |
| lysergic acid diethylamide | Homo sapiens (human) | Ki | 0.0066 | 2 | 2 |
| mepazine | Homo sapiens (human) | IC50 | 1.8370 | 1 | 0 |
| mepazine | Homo sapiens (human) | Ki | 0.8530 | 1 | 0 |
| bisphenol a | Homo sapiens (human) | IC50 | 5.4200 | 1 | 0 |
| bisphenol a | Homo sapiens (human) | Ki | 2.5160 | 1 | 0 |
| rotenone | Homo sapiens (human) | IC50 | 0.8700 | 1 | 0 |
| rotenone | Homo sapiens (human) | Ki | 0.4040 | 1 | 0 |
| ergotamine | Homo sapiens (human) | IC50 | 0.0020 | 1 | 0 |
| ergotamine | Homo sapiens (human) | Ki | 0.0009 | 1 | 0 |
| methylergonovine | Homo sapiens (human) | IC50 | 0.0025 | 1 | 0 |
| methylergonovine | Homo sapiens (human) | Ki | 0.0012 | 1 | 0 |
| dibenzothiazyl disulfide | Homo sapiens (human) | IC50 | 5.2760 | 1 | 0 |
| dibenzothiazyl disulfide | Homo sapiens (human) | Ki | 2.4500 | 1 | 0 |
| yohimbine | Homo sapiens (human) | IC50 | 1.6890 | 1 | 0 |
| yohimbine | Homo sapiens (human) | Ki | 0.7840 | 1 | 0 |
| indopan | Homo sapiens (human) | Ki | 0.9105 | 1 | 2 |
| dibenzepin | Homo sapiens (human) | Ki | 3.3000 | 1 | 1 |
| methysergide | Homo sapiens (human) | IC50 | 0.1620 | 1 | 0 |
| methysergide | Homo sapiens (human) | Ki | 0.0750 | 1 | 0 |
| 2-bromolysergic acid diethylamide | Homo sapiens (human) | Ki | 0.0170 | 1 | 1 |
| dihydroergotamine | Homo sapiens (human) | IC50 | 0.0032 | 1 | 0 |
| dihydroergotamine | Homo sapiens (human) | Ki | 0.0015 | 1 | 0 |
| pimozide | Homo sapiens (human) | Ki | 0.0710 | 1 | 1 |
| n-methyllaurotetanine | Homo sapiens (human) | Ki | 0.3060 | 1 | 1 |
| clemastine | Homo sapiens (human) | IC50 | 0.0770 | 1 | 0 |
| clemastine | Homo sapiens (human) | Ki | 0.0360 | 1 | 0 |
| metergoline | Homo sapiens (human) | IC50 | 0.0280 | 1 | 0 |
| metergoline | Homo sapiens (human) | Ki | 0.0130 | 1 | 0 |
| lisuride | Homo sapiens (human) | IC50 | 0.0120 | 1 | 0 |
| lisuride | Homo sapiens (human) | Ki | 0.0055 | 1 | 0 |
| bromocriptine | Homo sapiens (human) | IC50 | 0.0220 | 1 | 0 |
| bromocriptine | Homo sapiens (human) | Ki | 0.0300 | 2 | 1 |
| penfluridol | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| pergolide | Homo sapiens (human) | IC50 | 0.0390 | 1 | 0 |
| pergolide | Homo sapiens (human) | Ki | 0.0180 | 1 | 0 |
| ipsapirone | Homo sapiens (human) | Ki | 16.8000 | 1 | 1 |
| sertindole | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| aripiprazole | Homo sapiens (human) | Ki | 0.2648 | 6 | 6 |
| ziprasidone | Homo sapiens (human) | Ki | 0.0562 | 5 | 5 |
| mesulergine | Homo sapiens (human) | Ki | 0.7761 | 1 | 2 |
| ergocornine | Homo sapiens (human) | IC50 | 0.0150 | 1 | 0 |
| ergocornine | Homo sapiens (human) | Ki | 0.0071 | 1 | 0 |
| gr 127935 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| tryptoline | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole | Homo sapiens (human) | IC50 | 0.0790 | 1 | 1 |
| pramipexole | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| desloratadine | Homo sapiens (human) | IC50 | 2.1710 | 1 | 0 |
| desloratadine | Homo sapiens (human) | Ki | 1.0080 | 1 | 0 |
| alpha-ergocryptine | Homo sapiens (human) | IC50 | 0.0160 | 1 | 0 |
| alpha-ergocryptine | Homo sapiens (human) | Ki | 0.0076 | 1 | 0 |
| 3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole | Homo sapiens (human) | Ki | 0.0980 | 1 | 1 |
| harmalan | Homo sapiens (human) | Ki | 1.4500 | 1 | 1 |
| n-demethyllysergic acid diethylamide | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| nantenine, (+-)-isomer | Homo sapiens (human) | Ki | 0.2570 | 1 | 1 |
| maduramicin | Homo sapiens (human) | IC50 | 0.0017 | 1 | 0 |
| maduramicin | Homo sapiens (human) | Ki | 0.0008 | 1 | 0 |
| latrepirdine | Homo sapiens (human) | IC50 | 0.9800 | 3 | 3 |
| latrepirdine | Homo sapiens (human) | Ki | 0.0308 | 5 | 5 |
| sorafenib | Homo sapiens (human) | Ki | 6.2130 | 1 | 1 |
| 1-(benzenesulfonyl)indole | Homo sapiens (human) | Ki | 0.1590 | 1 | 1 |
| 1-methyl-6-methoxy-dihydro-beta-carboline | Homo sapiens (human) | Ki | 1.9300 | 1 | 1 |
| sb 243213 | Homo sapiens (human) | IC50 | 0.6670 | 1 | 1 |
| ergonovine | Homo sapiens (human) | IC50 | 0.0032 | 1 | 0 |
| ergonovine | Homo sapiens (human) | Ki | 0.0015 | 1 | 0 |
| dihydroergocristine monomesylate | Homo sapiens (human) | IC50 | 0.0420 | 1 | 0 |
| dihydroergocristine monomesylate | Homo sapiens (human) | Ki | 0.0190 | 1 | 0 |
| diethylstilbestrol | Homo sapiens (human) | IC50 | 12.8920 | 1 | 0 |
| diethylstilbestrol | Homo sapiens (human) | Ki | 5.9860 | 1 | 0 |
| chlorprothixene | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| 3,4,5-trimethoxycinnamic acid | Homo sapiens (human) | IC50 | 10.0000 | 2 | 4 |
| 2-(2,3-dihydroindol-1-yl)-N,N-dimethylethanamine | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| benztropine | Homo sapiens (human) | IC50 | 2.7880 | 1 | 0 |
| benztropine | Homo sapiens (human) | Ki | 1.2940 | 1 | 0 |
| enclomiphene | Homo sapiens (human) | IC50 | 1.5220 | 1 | 0 |
| enclomiphene | Homo sapiens (human) | Ki | 0.7070 | 1 | 0 |
| tamoxifen | Homo sapiens (human) | IC50 | 2.6790 | 1 | 0 |
| tamoxifen | Homo sapiens (human) | Ki | 1.1425 | 2 | 1 |
| toremifene | Homo sapiens (human) | Ki | 4.1250 | 1 | 1 |
| rasagiline | Homo sapiens (human) | Ki | 0.0014 | 1 | 1 |
| sb 258585 | Homo sapiens (human) | IC50 | 0.0190 | 1 | 1 |
| sb 258585 | Homo sapiens (human) | Ki | 0.0025 | 2 | 2 |
| bw 723c86 | Homo sapiens (human) | IC50 | 0.6414 | 1 | 0 |
| bw 723c86 | Homo sapiens (human) | Ki | 0.2978 | 1 | 0 |
| harmine | Homo sapiens (human) | Ki | 1.4800 | 1 | 1 |
| l 745870 | Homo sapiens (human) | Ki | 1.6562 | 1 | 1 |
| zuclopenthixol | Homo sapiens (human) | Ki | 0.1690 | 1 | 1 |
| ro 63-0563 | Homo sapiens (human) | Ki | 0.0585 | 10 | 11 |
| ro 4-6790 | Homo sapiens (human) | IC50 | 0.0263 | 1 | 1 |
| ro 4-6790 | Homo sapiens (human) | Ki | 0.0515 | 11 | 11 |
| sb 258719 | Homo sapiens (human) | Ki | 15.8489 | 1 | 1 |
| sb 271046 | Homo sapiens (human) | IC50 | 0.0020 | 1 | 1 |
| sb 271046 | Homo sapiens (human) | Ki | 0.0019 | 18 | 19 |
| sb 269970 | Homo sapiens (human) | Ki | 8.1548 | 2 | 2 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Homo sapiens (human) | IC50 | 0.0850 | 2 | 2 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Homo sapiens (human) | Ki | 0.0224 | 11 | 11 |
| 5-methoxy-2-phenyl-n,n-dimethyltryptamine | Homo sapiens (human) | Ki | 0.0307 | 6 | 6 |
| ms-245 | Homo sapiens (human) | Ki | 0.0042 | 23 | 24 |
| n-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide | Homo sapiens (human) | Ki | 0.0030 | 7 | 7 |
| sb 399885 | Homo sapiens (human) | IC50 | 0.0970 | 1 | 1 |
| sb 399885 | Homo sapiens (human) | Ki | 0.0007 | 5 | 5 |
| ro4368554 | Homo sapiens (human) | Ki | 0.0005 | 1 | 1 |
| 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine | Homo sapiens (human) | IC50 | 0.0032 | 1 | 1 |
| 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine | Homo sapiens (human) | Ki | 0.0010 | 4 | 4 |
| st 1936 | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| sb-656104-a | Homo sapiens (human) | Ki | 0.8511 | 1 | 1 |
| 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole | Homo sapiens (human) | IC50 | 0.0074 | 2 | 2 |
| way 181187 | Homo sapiens (human) | Ki | 0.1161 | 9 | 11 |
| gsk215083 | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| e-6801 | Homo sapiens (human) | Ki | 0.0462 | 7 | 7 |
| sb-649915 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| way-208466 | Homo sapiens (human) | Ki | 0.0048 | 4 | 4 |
| barettin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| sb 742457 | Homo sapiens (human) | IC50 | 0.0264 | 4 | 4 |
| sb 742457 | Homo sapiens (human) | Ki | 0.0013 | 12 | 13 |
| naluzotan | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| 4-(4-chlorophenyl)sulfonyl-5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-ethylsulfonylthiazole | Homo sapiens (human) | Ki | 0.1293 | 3 | 3 |
| af 353 | Homo sapiens (human) | Ki | 100,000.0000 | 1 | 1 |
| a 803467 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| sam-531 | Homo sapiens (human) | Ki | 0.0013 | 3 | 3 |
| sp 203 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| lu ae58054 | Homo sapiens (human) | IC50 | 0.5130 | 2 | 2 |
| lu ae58054 | Homo sapiens (human) | Ki | 0.0017 | 9 | 10 |
| e-55888 | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| pf 3246799 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| n-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide | Homo sapiens (human) | Ki | 1.5710 | 2 | 2 |
| n,n-diallyl-5-methoxytryptamine | Homo sapiens (human) | Ki | 2.5810 | 2 | 4 |
| clozapine | Homo sapiens (human) | IC50 | 0.0171 | 4 | 3 |
| clozapine | Homo sapiens (human) | Ki | 0.0170 | 17 | 19 |
| olanzapine | Homo sapiens (human) | IC50 | 0.0130 | 1 | 0 |
| olanzapine | Homo sapiens (human) | Ki | 0.0101 | 17 | 17 |
| methylaplysinopsin | Homo sapiens (human) | Ki | 1.7160 | 1 | 1 |
| aplysinopsin | Homo sapiens (human) | Ki | 8.7680 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
[no title available]European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 16, Issue:22, 2006
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.Bioorganic & medicinal chemistry letters, , Oct-16, Volume: 10, Issue:20, 2000
Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues.Journal of medicinal chemistry, , Volume: 21, Issue:8, 1978
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
[no title available],
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
[no title available]Journal of medicinal chemistry, , 09-09, Volume: 64, Issue:17, 2021
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).European journal of medicinal chemistry, , Apr-01, Volume: 191, 2020
[no title available]Bioorganic & medicinal chemistry letters, , 06-15, Volume: 28, Issue:11, 2018
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties.Chemical biology & drug design, , Volume: 89, Issue:3, 2017
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.Journal of medicinal chemistry, , 09-14, Volume: 60, Issue:17, 2017
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HTEuropean journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
[no title available],
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 40, 2021
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 30, Issue:20, 2020
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 40, 2021
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.European journal of medicinal chemistry, , Volume: 60, 2013
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Polypharmacology - foe or friend?Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.European journal of medicinal chemistry, , Jul-01, Volume: 173, 2019
Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents.Journal of enzyme inhibition and medicinal chemistry, , Volume: 25, Issue:1, 2010
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTEuropean journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 23, Issue:16, 2013
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.Journal of medicinal chemistry, , Jan-28, Volume: 42, Issue:2, 1999
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Aug-07, Volume: 10, Issue:15, 2000
5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.Journal of medicinal chemistry, , Jan-28, Volume: 42, Issue:2, 1999
[no title available]European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Aug-07, Volume: 10, Issue:15, 2000
5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.Journal of medicinal chemistry, , Jan-28, Volume: 42, Issue:2, 1999
[no title available]European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Synthesis and SAR of tolylamine 5-HT6 antagonists.Bioorganic & medicinal chemistry letters, , May-01, Volume: 19, Issue:9, 2009
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , May-20, Volume: 12, Issue:10, 2002
Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.Bioorganic & medicinal chemistry letters, , Nov-05, Volume: 11, Issue:21, 2001
6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Aug-07, Volume: 10, Issue:15, 2000
Discovery of G Protein-Biased Antagonists against 5-HTJournal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
Therapeutic Potential of 5-HT6 Receptor Agonists.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 15, Issue:19, 2005
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
Therapeutic Potential of 5-HT6 Receptor Agonists.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Therapeutic Potential of 5-HT6 Receptor Agonists.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT₆ receptor antagonists.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 22, Issue:22, 2012
Rigidized 1-aryl sulfonyl tryptamines: synthesis and pharmacological evaluation as 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 21, Issue:15, 2011
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.Journal of medicinal chemistry, , Feb-14, Volume: 51, Issue:3, 2008
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Interaction of chiral MS-245 analogs at h5-HT6 receptors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 15, Issue:15, 2005
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
N1-benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates.Bioorganic & medicinal chemistry letters, , Oct-06, Volume: 13, Issue:19, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.Bioorganic & medicinal chemistry letters, , Oct-16, Volume: 10, Issue:20, 2000
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).Bioorganic & medicinal chemistry letters, , Jan-08, Volume: 11, Issue:1, 2001
[no title available]Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
[no title available]European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-НТ6 receptors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Synthesis and in vivo evaluation of [O-methyl-11C] N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide as an imaging probe for 5-HT6 receptors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 19, Issue:17, 2011
Synthesis and pharmacological evaluation of aryl aminosulfonamide derivatives as potent 5-HT(6) receptor antagonists.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.Journal of medicinal chemistry, , Mar-27, Volume: 46, Issue:7, 2003
Therapeutic Potential of 5-HT6 Receptor Agonists.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 15, Issue:19, 2005
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Therapeutic Potential of 5-HT6 Receptor Agonists.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Pharmaceutical and medicinal significance of sulfur (SEuropean journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Therapeutic Potential of 5-HT6 Receptor Agonists.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Imidazopyridine-Based 5-HTJournal of medicinal chemistry, , 01-28, Volume: 64, Issue:2, 2021
[no title available]Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
[no title available]European journal of medicinal chemistry, , Dec-15, Volume: 208, 2020
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HTEuropean journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Pyrroloquinoline scaffold-based 5-HTBioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Novel non-sulfonamide 5-HTEuropean journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HTJournal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014
Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-НТ6 receptors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HTJournal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Novel difluoromethyl-containing 1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1H-indole scaffold as potent 5-HTBioorganic & medicinal chemistry, , 09-15, Volume: 70, 2022
[no title available]Bioorganic & medicinal chemistry, , 10-01, Volume: 71, 2022
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HTEuropean journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Novel non-sulfonamide 5-HTEuropean journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HTJournal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013
Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 40, 2021
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HTBioorganic & medicinal chemistry, , 08-01, Volume: 28, Issue:15, 2020
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Synthesis and evaluation of antidepressant-like activity of some 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.Chemical biology & drug design, , Volume: 85, Issue:3, 2015
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.Bioorganic & medicinal chemistry letters, , Oct-16, Volume: 10, Issue:20, 2000
[no title available],
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Chlorine substituents and linker topology as factors of 5-HTEuropean journal of medicinal chemistry, , Oct-01, Volume: 203, 2020
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEuropean journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
[no title available]European journal of medicinal chemistry, , May-15, Volume: 170, 2019
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEuropean journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
2-Aminoimidazole-based antagonists of the 5-HTEuropean journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HTEuropean journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
[no title available]ACS medicinal chemistry letters, , Apr-13, Volume: 8, Issue:4, 2017
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.Bioorganic & medicinal chemistry, , Jan-01, Volume: 23, Issue:1, 2015
SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
[no title available],
Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 40, 2021
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| histamine receptor activity | molecular function | Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| neurotransmitter receptor activity | molecular function | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling] |
| G protein-coupled serotonin receptor activity | molecular function | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cilium | cellular component | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| cerebral cortex cell migration | biological process | The orderly movement of cells from one site to another in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| positive regulation of TOR signaling | biological process | Any process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah] |
| G protein-coupled serotonin receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. [GOC:mah] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). [GOC:mah, GOC:signaling, ISBN:0815316194] |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194] |