Amoxicillin is a penicillin-based antibiotic widely used to treat bacterial infections. It is a semi-synthetic derivative of penicillin V, synthesized by attaching an amino group to the penicillin molecule. Amoxicillin is effective against a broad spectrum of bacteria, including those that cause ear infections, respiratory infections, skin infections, and urinary tract infections. Its mechanism of action involves inhibiting the formation of peptidoglycans, essential components of bacterial cell walls. This leads to cell wall weakening and ultimately cell lysis. Amoxicillin is commonly prescribed due to its high bioavailability, good oral absorption, and relatively long half-life. It is often studied to understand its efficacy against specific bacterial strains, evaluate its safety and side effects, and explore potential drug interactions. Amoxicillin's importance lies in its ability to effectively treat a wide range of infections, making it a crucial tool in public health and medical practice.'
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 33613 |
| CHEMBL ID | 1082 |
| CHEBI ID | 2676 |
| CHEBI ID | 53712 |
| SCHEMBL ID | 3427 |
| MeSH ID | M0001009 |
| Synonym |
|---|
| AC-12263 |
| topramoxin |
| damoxy |
| CHEMBL1082 |
| amoxyke |
| largopen |
| moksilin |
| atoksilin |
| remoxil |
| promoxil |
| amoxicillin (as trihydrate) |
| amoxicillinum trihydricum |
| demoksil |
| amoxicillinum |
| amoxicilina |
| 6beta-[(2r)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid |
| CHEBI:2676 , |
| amoxycilin |
| BRD-K55044200-001-03-9 |
| amoxicillin crystalline |
| BPBIO1_000499 |
| PRESTWICK_713 |
| PRESTWICK3_000357 |
| BSPBIO_000453 |
| PRESTWICK2_000357 |
| NCGC00179554-01 |
| amoxicillin (inn) |
| D07452 |
| amoxicillin (tn) |
| unicillin |
| moxal |
| nsc-277174 |
| histocillin |
| p-hydroxyampicillin |
| flemoxin |
| amoclen |
| d-2-amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid |
| 26787-78-0 |
| amoxicillin |
| C06827 |
| amoxicillin anhydrous |
| amoxycillin |
| (2s,5r,6r)-6-[[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino (4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2s-[2.alpha.,5.alpha.,6.beta.(s*)]]- |
| nsc277174 |
| amox |
| 6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid |
| ax |
| amoxicillin (anhydrous) |
| alpha-amino-p-hydroxybenzylpenicillin |
| (2s,5r,6r)-6-{[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| DB01060 |
| sawamox pm |
| 6-(d-(-)-alpha-amino-p-hydroxyphenylacetamido)penicillanic acid |
| amoxiden |
| imacillin |
| amopenixin |
| delacillin |
| blp 1410 |
| ro 10-8756 |
| cemoxin |
| nsc 277174 |
| d-(-)-alpha-amino-p-hydroxybenzylpenicillin |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2r)-amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, (2s,5r,6r)- |
| efpenix |
| 4-thia-1-azobicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, (2s-(2alpha,5alpha,6beta(s)))- |
| bristamox |
| hsdb 3204 |
| bl-p 1410 |
| anemolin |
| piramox |
| metifarma capsules |
| hiconcil |
| amoxicillin pediatric |
| amoxivet |
| amoxicilina [inn-spanish] |
| amolin |
| amoxicilline [inn-french] |
| (-)-6-(2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0)heptane-2-carboxylic acid |
| vetramox |
| amoxicillinum [inn-latin] |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-, d- |
| metafarma capsules |
| amoxi-mast |
| 6-(d-(-)-p-hydroxy-alpha-aminobenzyl)penicillin |
| sumox |
| einecs 248-003-8 |
| brl-2333 |
| amoxi |
| amopen |
| amoxicilline |
| aspenil |
| d-amoxicillin |
| smr000058707 |
| MLS000028632 |
| SPBIO_002374 |
| PRESTWICK1_000357 |
| PRESTWICK0_000357 |
| moxatag |
| MLS002222248 |
| amoxicillanyl |
| CHEBI:53712 , |
| HMS1569G15 |
| HMS2096G15 |
| HMS3259P17 |
| tox21_111302_1 |
| tox21_111302 |
| dtxcid1017044 |
| dtxsid3037044 , |
| amoxi-tabs |
| bdbm50350464 |
| amoxi-inject |
| HMS2231K23 |
| unii-9em05410q9 |
| apo-amoxi |
| ospamox |
| amoxicillin [inn] |
| 9em05410q9 , |
| amoxicaps |
| ec 248-003-8 |
| amoxicillin anhydrous [hsdb] |
| (2s,5r,6r)-6-((r)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-(2s-(2.alpha.,5.alpha.,6.beta.(s*)))- |
| amoxicillin [who-dd] |
| amoxicillin [mart.] |
| amoxicillin [mi] |
| EPITOPE ID:116054 |
| EPITOPE ID:114241 |
| S3015 |
| LSQZJLSUYDQPKJ-NJBDSQKTSA-N |
| CCG-220357 |
| HY-B0467A |
| NC00670 |
| SCHEMBL3427 |
| (2s,5r,6r)-6-[(2r)-2-amino-2-(4-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| AKOS025395540 |
| amoxicillin, potency: >=900 mug per mg |
| sr-01000721886 |
| SR-01000721886-2 |
| (2s,5r,6r)-6-((r)-2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| notoginsenoside-fe |
| HMS3713G15 |
| DS-3835 |
| Q201928 |
| EN300-118704 |
| BRD-K55044200-001-15-3 |
| gtpl10895 |
| co-amoxiclav (amoxicillin + clavulanic acid) |
| A877139 |
| (2s,5r,6r)-6-((r)-2-amino-2-(4-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid |
| amoxicillin (usp impurity) |
| amoxicillin (mart.) |
| 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-(2s-(2alpha,5alpha,6beta(s*)))- |
| j01ca04 |
| amoxicillin trihydrate (ep monograph) |
| (2s,5r,6r)-6-(((2r)-2-amino-2-(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid |
| amoxicillinum (latin) |
| amoxicillina |
| 6beta-((2r)-2-amino-2-(4-hydroxyphenyl)acetamido)-2,2-dimethylpenam-3alpha-carboxylic acid |
| amoxicillin (usp monograph) |
| amoxicillin trihydrate (mart.) |
| Z1515385072 |
Amoxicillin (AMX) is a broad-spectrum antibiotic used to treat a variety of gram-positive and gram-negative infections. Amoxicillin induces harmful effects to nature via bioaccumulation and persistence in the environment if discharged untreated into water bodies. The amoxicillin index is a recently proposed metric to assess first-line antibiotic prescribing to children.
Oral amoxicillin has an excellent primary response rate and complete cure rate for PD-related peritonitis episodes caused by Enterococcus species. Amoxicillin, which has a bactericidal effect on H. coli, has a slow metabolism rate in humans.
Amoxicillin has become a major antimicrobial substance in pig medicine for the treatment and control of severe, systemic infections such as Streptococcus suis. Amoxicillin use has been reported to be associated with developmental defects on enamel surfaces.
Amoxicillin was found to increase stool Alistipes, Odoribacter and Stomatobaculum species while significantly depleting Holdemanella and Anaeroplasma. Amoxicillin could either activate polymorphonuclear neutrophils NADPH-oxidase or cause its activation by a membrane effect. Mean amoxicillin dose was lower in patients with TDM than those without TDM.
Amoxicillin treatment led to a 'reversal' of the majority of gene pathways implicated in disease response. Amoxicillin-clavulanate treatment is beneficial in terms of resolution of non-severe exacerbations of bronchiectasis in children.
71 patients, aged 20-83, with a history of an adverse reaction to amoxicillin were retrospectively analysed. Amoxicillin was found safe in 22, cefuroxime - in 21 and macrolide - in 19 patients. Algal bioassays indicate that, in the range of concentrations from 50 ng/L to 50 mg/L, am Toxicillin is not toxic toward eucariotic organisms.
The blood level and the basic pharmacokinetic parameters (kel, Cop, T 1/2, AUC) of amoxicillin trihydrate were studied following its oral application to albino rats with experimentally injured kidneys (potassium chromate) and liver (tetrachloromethane) Pharmacokinetics parameters for vonoprazan, amoxicilline, and levofloxacin were also evaluated.
The double-blind, randomized, phase III clinical trial was carried out in two parallel groups to assess the efficacy of ebrotidine. It was used to evaluate the efficacy and economics of different proton pump inhibitors (PPIs) combined with bismuth quadruple regimens for Helicobacter pylori (Hp) eradication.
Amoxicillin depends on passive diffusion and a saturable 'pump' mechanism that produces variable serum concentrations of the antibacterial agent. The hydrogel formulation increases the bioavailability of drugs by ∼18% compared to that with aqueous amoxicillin formulation.
160 children with an average age of 9 years (range 6-15) affected by acute bacterial tonsillitis, were selected and assigned. The amoxicillin dosage was 20 mg/kg/day either bid or qd. Dosed fish were harvested after fo fo.
| Role | Description |
|---|---|
| antibacterial drug | A drug used to treat or prevent bacterial infections. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| penicillin | Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6. |
| penicillin allergen | Any penicillin which causes the onset of an allergic reaction. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| Male infertility | 0 | 3 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 1.4125 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 35.4813 | 0.0447 | 17.8581 | 100.0000 | AID485294 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.6228 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| AR protein | Homo sapiens (human) | Potency | 0.0017 | 0.0002 | 21.2231 | 8,912.5098 | AID743042 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 2.2387 | 0.7079 | 12.1943 | 39.8107 | AID720542 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 33.4915 | 0.0002 | 29.3054 | 16,493.5996 | AID743080 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 50.1187 | 0.4256 | 12.0591 | 28.1838 | AID504891 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 58.6829 | 0.1000 | 28.9256 | 213.3130 | AID588591; AID720502 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 44.6684 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.4125 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.4125 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.4125 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 0.0316 | 22.3146 | 100.0000 | AID588579 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.6315 | 4.4531 | 9.3000 | AID1473740 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.2000 | 5.6774 | 10.0000 | AID1473741 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.4000 | 2.7500 | 8.6000 | AID1209456 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 711.0000 | 0.1100 | 7.1903 | 10.0000 | AID1209455; AID1449628; AID1473738 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 (µMol) | 50.0000 | 0.0000 | 2.8005 | 10.0000 | AID1210069 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | Ki | 10,000.0000 | 0.1800 | 3.3933 | 9.8000 | AID681115 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 (µMol) | 50.0000 | 0.0120 | 2.5312 | 9.4700 | AID1210069 |
| Solute carrier family 15 member 2 | Homo sapiens (human) | Ki | 428.2900 | 0.7943 | 4.2210 | 8.0000 | AID612540 |
| Solute carrier family 15 member 2 | Rattus norvegicus (Norway rat) | Ki | 304.5000 | 3.0000 | 6.4778 | 8.5000 | AID681114; AID681347 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 2.4100 | 6.3433 | 10.0000 | AID1473739 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Beta-lactamase | Citrobacter gillenii | Km | 84.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| Beta-lactamase | Aeromonas caviae | Km | 207.0000 | 7.0000 | 7.0000 | 7.0000 | AID374363 |
| Beta-lactamase | Shouchella clausii | Km | 22.0000 | 0.0100 | 3.0050 | 6.0000 | AID373209 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 5.2000 | 3.2000 | 5.8250 | 10.0000 | AID562754 |
| Beta-lactamase SHV-1 | Klebsiella pneumoniae | Km | 31.0000 | 4.2000 | 4.2500 | 4.3000 | AID519746; AID519983 |
| Beta-lactamase | Pseudomonas aeruginosa PAO1 | Km | 20.0000 | 0.5000 | 4.2444 | 8.0000 | AID546426 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Km | 84.0000 | 10.0000 | 10.0000 | 10.0000 | AID285442 |
| B2 metallo-beta-lactamase | Chryseobacterium indologenes | Km | 85.0000 | 3.0000 | 3.0000 | 3.0000 | AID562337 |
| Beta-lactamase | Salmonella enterica subsp. enterica serovar Westhampton | Km | 40.0000 | 10.0000 | 10.0000 | 10.0000 | AID556340 |
| Beta-lactamase | Klebsiella pneumoniae | Km | 10.0000 | 5.0000 | 7.1667 | 10.0000 | AID519982 |
| Beta-lactamase | Pseudomonas luteola | Km | 20.0000 | 7.0000 | 7.5000 | 8.0000 | AID495635 |
| Beta-lactamase | Pseudomonas aeruginosa | Km | 30.0000 | 0.5000 | 2.7500 | 5.0000 | AID546429 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID558591 | Antimicrobial activity against Streptococcus pneumoniae 3 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID285259 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-29 and ESBL by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID573954 | Antibacterial activity against Enterobacter cloacae El3799 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID351629 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID534085 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID548252 | Antibacterial activity against beta-lactamase SHV or TEM ESBL-producing Enterobacteriaceae assessed as percent susceptible isolates by twofold dilution method in presence of beta-lactamase inhibitor clavulanate | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. |
| AID21711 | Solubility at a pH of 2.0; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID351621 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1161166 | Antimicrobial activity against Staphylococcus aureus isolate Ealing 23 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID531618 | Antimicrobial activity against Escherichia coli JM109 harboring pE1MD plasmid expressing beta-lactamase SHV-56 by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID573602 | Antibacterial activity against Fusobacterium varium by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID87962 | Minimum inhibitory concentration against Helicobacter pylori under acidic conditions at pH 6.0 | 2001 | Journal of medicinal chemistry, Dec-06, Volume: 44, Issue:25 | 3-(Arylacetylamino)-N-methylbenzamides: a novel class of selective anti-Helicobacter pylori agents. |
| AID434282 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID434483 | Antimicrobial activity against Streptococcus pneumoniae WT3 infected in iv dosed Chinchilla lanigera assessed as bacterial growth after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID531484 | Antibacterial activity against Bacteroides vulgatus isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID377029 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by disk diffusion assay | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. |
| AID531676 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid containing OXA-58-3 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID278572 | Antimicrobial activity against Streptococcus pyogenes ATCC 19615 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID520420 | Antimicrobial activity against trimethoprim-sulfamethoxazole-resistant Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID521489 | Antibacterial activity against Escherichia coli DH10B expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID1161182 | Antimicrobial activity against Staphylococcus aureus isolate 306 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID285271 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM1 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID495806 | Antimicrobial activity against Providencia stuartii 6858 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID519982 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID542060 | Antibacterial activity against Klebsiella pneumoniae expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID323660 | Antibacterial activity against Peptostreptococcus stomatis | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antimicrobial susceptibilities of Peptostreptococcus anaerobius and the newly described Peptostreptococcus stomatis isolated from various human sources. |
| AID325445 | Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID542065 | Antibacterial activity against Klebsiella pneumoniae A expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID1347486 | Antibacterial activity against Streptococcus pyogenes assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID1546191 | Antimicrobial activity against Escherichia coli assessed as zone of inhibition at 250 ug/ml after 24 hrs by disk diffusion method | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID494625 | Antibacterial activity against Staphylococcus aureus 887 expressing beta-lactamase | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams. |
| AID444051 | Total clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID520970 | Antibacterial activity against Escherichia coli harboring pNGR plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID434287 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 235 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID144210 | Antimicrobial activity was measured against Neisseria meningitidis organism; range is between (0.05-0.1). | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID278333 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-15986 infected Swiss mouse lung at 15 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID532221 | Antibacterial activity against macrolide-lincosamide-streptogramin B-positive, beta-lactamase-positive, methicillin-resistant Staphylococcus aureus isolate 6 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID557719 | Antimicrobial activity in Fusobacterium mortiferum by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID326531 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis 309 challenged with 10 times ID90 bacterial size inoculum in Wistar rat assessed as infection at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID558587 | Antimicrobial activity against Streptococcus pneumoniae 19A by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1230218 | Antibacterial activity against Enterococcus faecalis N518 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID294965 | Antibacterial activity against Escherichia coli ATCC 23556 after 24 hrs by serial dilution method | 2007 | European journal of medicinal chemistry, Oct, Volume: 42, Issue:10 | Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. |
| AID519735 | Antibacterial activity against Escherichia coli DH5alpha with deltaampC by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID1161184 | Antimicrobial activity against Staphylococcus aureus isolate 929003 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1246784 | Antibacterial activity against Pseudomonas aeruginosa at 10 ug/disk after 24 hrs by agar plate disk diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID575087 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID519005 | Antimicrobial activity against Escherichia coli HB101 expressing recombinant plasmid encoded TEM-149 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID478873 | Antibacterial activity against Escherichia coli ATCC 25922 after overnight incubation by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9 | Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams. |
| AID558326 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1962 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID21264 | Effective permeability measured in human. | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID495918 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-19 by Etest in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID543820 | Antimicrobial activity against Borrelia spielmanii isolate PMew after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1228004 | Bactericidal activity against Helicobacter pylori J99 assessed as compound concentration causing reduction in viable colony-forming units pre-incubated for 2 hrs followed by incubation at 37 degC under microaerophilic conditions for 72 hrs | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers. |
| AID1270911 | Antibacterial activity against Bacillus subtilis ATCC 6633 by broth microdilution method | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp. |
| AID521353 | Antimicrobial activity against Streptococcus pneumoniae isolate k-421 obtained from ear of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID573761 | Antibacterial activity against Klebsiella oxytoca isolate Ko238 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID557499 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID574028 | Antibacterial activity against beta-lactamase producing Peptostreptococcus anaerobius assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID564542 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID495924 | Antimicrobial activity in Escherichia coli J53 strain in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID573748 | Antibacterial activity against Klebsiella pneumoniae isolate Kp4614 in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID574957 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID520421 | Antimicrobial activity against macrolide-susceptible Streptococcus sp. 'group A' by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID351640 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1.5 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID519748 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID557739 | Antimicrobial activity in Peptoniphilus asaccharolyticus by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID518723 | Antimicrobial activity against Pseudomonas stutzeri clinical isolate expressing beta-lactamase DIM-1 by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID87950 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 115 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID278857 | Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID156431 | The compound was tested against Penicillinase (TEM) and its stability towards beta-lactamase relative to cephaloridine was evaluated | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID519746 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID278573 | Antimicrobial activity against Rhodococcus equi ATCC 6939 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID533876 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID573613 | Antibacterial activity against Fusobacterium necrophorum assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID532019 | Antibacterial activity against macrolide-lincosamide-streptogramin B-positive, beta-lactamase-positive, methicillin-resistant Staphylococcus aureus ATCC 43300 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID529468 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, SHV-12 and Oxa-9 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID434271 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as Vmax at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID278288 | T>MIC in leukopenic mouse with renal failure at 7 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID573554 | Antibacterial activity against Bacteroides fragilis assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1577947 | Antimicrobial activity against Pseudomonas aeruginosa KW799 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID1525351 | Antibacterial activity against Pseudomonas aeruginosa PA4 after 20 hrs under iron-deficient medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID495923 | Antimicrobial activity in Escherichia coli TOP10 strain in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID1533858 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3411 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID520400 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID573754 | Antibacterial activity against Klebsiella pneumoniae isolate Kp211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID402032 | Antimicrobial activity against Helicobacter pylori TPH30 after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID520877 | Antibacterial activity against Achromobacter xylosoxidans MER by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID684232 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate cpu0446 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID592681 | Apparent permeability across human Caco2 cell membrane after 2 hrs by LC-MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8 | QSAR-based permeability model for drug-like compounds. |
| AID87929 | Antibacterial activity against Helicobacter pylori HP007 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID531437 | Antibacterial activity against Streptococcus pneumoniae serotype 3 assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID637614 | Antibacterial activity against Xanthomonas oryzae after 24 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID558603 | Antimicrobial activity against Streptococcus pneumoniae isolate 37 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID469300 | Ratio of compound to grisofulvin activity against Geotrichum candidum at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID264471 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID528604 | Antimicrobial activity against Escherichia coli J53 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID569356 | Antibacterial activity against Moraxella catarrhalis 1502 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1819811 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID469303 | Antibacterial activity against Bacillus subtilis at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID279187 | Ratio of kcat to Km of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID1916814 | Antibacterial activity against Pseudomonas aeruginosa NCIM 2036 assessed as bacterial growth inhibition incubated for 8 hrs by absorbance based assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery. |
| AID481441 | Aqueous diffusivity at 37C | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID573788 | Antibacterial activity against Prevotella bivia by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID557266 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae 2527 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID562817 | Antimicrobial activity against Escherichia coli DH5[alpha] in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID573560 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID543283 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID325160 | Antimicrobial activity against Escherichia coli pB1000 expressing ROB1 beta lactamase | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID557471 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae 1077 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID529609 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID557441 | Antimicrobial activity in Prevotella buccae by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID285269 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM28 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID325448 | Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID562751 | Antimicrobial activity against Escherichia coli DH5alpha harboring pBC-CTX-M-71 plasmid by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID521484 | Antibacterial activity against Escherichia coli harboring pBC633 plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID521470 | Antimicrobial activity against Escherichia coli S2 expressing penicillinase TEM-1 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID531479 | Antibacterial activity against Bacteroides eggerthii isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID531483 | Antibacterial activity against Bacteroides caccae isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID522054 | Antimicrobial activity against Escherichia coli isolate J53 harboring pL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID87933 | Antibacterial activity against Helicobacter pylori HP022 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID557965 | Antimicrobial activity in Clostridium difficile by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID557977 | Antimicrobial activity in Clostridium ramosum by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID529469 | Antimicrobial activity against Escherichia coli J53 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID519983 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID524248 | Antimicrobial activity against Escherichia coli DH5alpha in presence of 2 ug/ml clavulanic acid beta-lactamase inhibitor | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID528611 | Antimicrobial activity against Escherichia coli TOP10 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID533874 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID562736 | Antimicrobial activity against Klebsiella pneumoniae AH24-270 expressing blaCTX-M-71 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID434464 | Unbound plasma clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID543276 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID67862 | Tested for inhibition of visible growth of Enterobacter aerogenes | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID560492 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-2 producing Escherichia coli MC4100 harboring plasmid AC-cmy2 by microdilution method in presence of 2 ug/ml clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID402029 | Antimicrobial activity against Helicobacter pylori Sa-1 isolate after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID558582 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID373052 | Antimicrobial activity against Escherichia coli DH10B carrying pJIM2246 expressing Bacillus clausii NR beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID406623 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID495637 | Antimicrobial activity against Pseudomonas luteola LAM expressing blaLUT-1 at 2:1 ratio of compound to clavulanic acid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID1126564 | Antimicrobial activity against Staphylococcus aureus MTCC 96 at 200 ug/ml after 24 hrs by cup plate method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs. |
| AID574007 | Antibacterial activity against beta-lactamase producing Clostridium perfringens assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID531478 | Antibacterial activity against Bacteroides merdae isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1438616 | Antibacterial activity against Enterococcus faecium isolate 015205261801 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID50983 | Compound was evaluated for antimicrobial activity against Clostridium perfringens | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID557711 | Antimicrobial activity in Fusobacterium nucleatum by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID521143 | Antibacterial activity against extracellular Listeria monocytogenes EGDe at four times of MIC by time-kill study | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. |
| AID1161150 | Antimicrobial activity against Enterococcus faecalis Isolate 1 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID494627 | Antibacterial activity against Staphylococcus aureus COL expressing beta-lactamase | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams. |
| AID569350 | Antibacterial activity against Staphylococcus aureus WCUH29 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1438610 | Antibacterial activity against Listeria monocytogenes isolate 015170199001 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID373056 | Antimicrobial activity against Bacillus clausii NR expressing beta-lactamase BCL1 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID548235 | Antibacterial activity against beta-lactamase CTX-M ESBL-producing Enterobacteriaceae by twofold dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. |
| AID87939 | In vitro minimum inhibitory concentration against growth of Helicobacter pylori ATCC 43504. | 1998 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16 | Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents. |
| AID1347490 | Antibacterial activity against Pseudomonas aeruginosa assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID114724 | Tested for the antimicrobial activity against Streptococcus pneumoniae (D815) in mice, perorally | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID544571 | Antimicrobial activity against Escherichia coli DH5[alpha] by microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID481439 | Absolute bioavailability in human | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID529465 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone B expressing beta-lactamase Oxa-48, TEM-1, CTX-M-15 and Oxa-1 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID1230223 | Antibacterial activity against Enterococcus faecium N507 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID565676 | Antimicrobial activity against beta-lactamase negative ampicillin-susceptible Haemophilus influenzae harboring fst1 mutant gene by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID557486 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1916811 | Antibacterial activity against Staphylococcus aureus NCIM 2010 assessed as bacterial growth inhibition incubated for 8 hrs by absorbance based assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery. |
| AID519066 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID560122 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG4 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID278335 | Effect on survival of Swiss mouse infected with penicillin-resistant Streptococcus pneumoniae P-54988 at 15 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID531477 | Antibacterial activity against Bacteroides stercoris isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID558604 | Antimicrobial activity against Streptococcus pneumoniae isolate 1055 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID495810 | Antimicrobial activity against Escherichia coli harbouring plasmid BK-CMV expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID567474 | Antimicrobial activity against gBLPACR-1 Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID557735 | Antimicrobial activity in Peptostreptococcus anaerobius by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID521152 | Antibacterial activity against intracellular Listeria monocytogenes EGDe infected in bone marrow-derived BALB/c mouse macrophage assessed as prevention of bacterial release and spread of infection by preventing macrophage lysis after 24 hrs | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. |
| AID206177 | Tested for inhibition of visible growth of Staphylococcus aureus | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID573727 | Antibacterial activity against Klebsiella pneumoniae isolate Kp1945 harboring IncL/M plasmid, blaIMP-4-qacG2-aacA4-catB3 and dfrA12-orfF-aadA2 arrays by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID571685 | Antimicrobial activity against ESBL producing Escherichia coli isolated from patient bloodstream assessed as resistant isolate by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. |
| AID374368 | Ratio of Kcat to Km of Acinetobacter baumannii AC-54/97 metallo-beta-lactamase IMP-2 expressed in Escherichia coli DH5alpha | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID234038 | Therapeutic efficacy at an oral dose of 0.032 mg/kg in mouse; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID395156 | Antibacterial activity against Staphylococcus aureus GIORGIO after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID521681 | Antimicrobial activity against Escherichia coli S5 expressing extended-spectrum beta-lactamase TEM-116 in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID278298 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse lung at 15 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1161190 | Antimicrobial activity against Staphylococcus aureus isolate NEQAS 4158 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID562409 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID530346 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M plasmid carrying blaCTX-M-15 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID373058 | Antimicrobial activity against Escherichia coli DH10B carrying pJIM2246 expressing Bacillus clausii NR beta-lactamase BCL1 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID1438607 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID156202 | Binding to POPC (palmitoyl-oleolyl-phosphatidyl-choline) liposomes using biosensor system | 2000 | Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11 | SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans. |
| AID535343 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID557727 | Antimicrobial activity in Finegoldia magna by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID325154 | Antimicrobial activity against Haemophilus parasuis BB 1021 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID543424 | Antimicrobial activity against Escherichia coli XL-1 Blue transconjugant harboring beta-lactamase CTX-M-64 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID1126568 | Antimicrobial activity against Escherichia coli ESS 2231 at 200 ug/ml after 24 hrs by cup plate method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs. |
| AID565668 | Antimicrobial activity against beta-lactamase positive (amoxicillin)clavulanate-resistant Haemophilus influenzae by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID1694323 | Antibacterial activity against Staphylococcus aureus 209P assessed as bacterial growth inhibition in Mueller-Hinton broth 2 measured every 24 hrs for 5 days by serial dilution method | 2021 | Bioorganic & medicinal chemistry, 02-15, Volume: 32 | Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. |
| AID341106 | Antibacterial activity against metallo-beta-lactamase VIM12 expressing Escherichia coli 28 isolate from decubitus ulcer infection patient by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID351215 | fCmax in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID285267 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM29 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID529616 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID530345 | Antimicrobial activity against Escherichia coli BicA expressing blaTEM-1, blaCTX-M-15 and qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID557504 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID559817 | Antimicrobial activity against Enterobacter cloacae CHE-2 harboring blaGES-5 and blaSHV-5 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID434469 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID425865 | Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID1246796 | Antibacterial activity against Salmonella typhi after 24 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID574046 | Antibacterial activity against beta-lactamase producing Peptoniphilus asaccharolyticus assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID565680 | Antimicrobial activity against beta-lactamase negative ampicillin-susceptible Haemophilus influenzae harboring fst1 mutant gene assessed as susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID1245569 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Deprotometalation-iodolysis and computed CH acidity of 1,2,3- and 1,2,4-triazoles. Application to the synthesis of resveratrol analogues. |
| AID678717 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID562360 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID543821 | Antimicrobial activity against Borrelia spielmanii isolate PSig2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID394497 | Antimicrobial activity against Escherichia coli MC4100 harboring pBCSK plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID469301 | Antibacterial activity against Staphylococcus aureus at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID434465 | Unbound plasma clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573770 | Antibacterial activity against Citrobacter amalonaticus Ca3927 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID434456 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID543272 | Antimicrobial activity against Streptococcus pneumoniae 72521 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID91481 | Binding constant against human serum albumin (HSA) | 2001 | Journal of medicinal chemistry, Dec-06, Volume: 44, Issue:25 | Cheminformatic models to predict binding affinities to human serum albumin. |
| AID573756 | Antibacterial activity against Klebsiella pneumoniae isolate Kp266 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID573738 | Antibacterial activity against Klebsiella pneumoniae isolate Kp38045 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID555662 | Antimicrobial activity against Salmonella enterica serotype Westhampton isolate 04CEB8273SAL expressing CTX-M-53 gene by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID573729 | Antibacterial activity against Enterobacter cloacae isolate El3280 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1659472 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as induction of changes in mass spectral profile of bacteria 1 times MIC uM by MALDI-TOF MS analysis | 2020 | Journal of medicinal chemistry, 08-27, Volume: 63, Issue:16 | Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening. |
| AID573826 | Antibacterial activity against beta-lactamase producing Clostridium perfringens by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID529627 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID495655 | Antimicrobial activity against Pseudomonas aeruginosa 51170 expressing beta-lactamase BEL-1 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID557743 | Antimicrobial activity in Anaerococcus tetradius by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID560114 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69-V49 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID575949 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID495811 | Antimicrobial activity against Escherichia coli 138 expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID1228003 | Bactericidal activity against Helicobacter pylori J99 assessed as reduction in viable colony-forming units pre-incubated for 2 hrs followed by incubation at 37 degC under microaerophilic conditions for 72 hrs | 2015 | Journal of natural products, Apr-24, Volume: 78, Issue:4 | Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers. |
| AID522018 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pPR containing beta-lactamase and TEM-101 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID543824 | Antimicrobial activity against Borrelia spielmanii isolate PJes after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID549203 | Antimicrobial activity against Pseudomonas aeruginosa after 24 hrs by ELISA | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. |
| AID511289 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-1 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID678712 | Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID369640 | Antibacterial activity against Acinetobacter baumannii A clone expressing carbapenemase-encoding blaOXA-40 gene by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID558327 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P285 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID556017 | Antibacterial activity against Helicobacter pylori harboring gyrA mutant gene infected in human assessed as bacterial eradication rate after 7 days | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation. |
| AID559821 | Antimicrobial activity against Pseudomonas aeruginosa PU21 harboring pCHE-A plasmid expressing blaGES-5 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID197987 | In vitro minimum inhibitory activity against Staphylococcus aureus WCUH29 strain | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID519734 | Antibacterial activity against Escherichia coli DH5alpha with deltaampC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID424322 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID543829 | Antimicrobial activity against Borrelia spielmanii isolate TIsar3 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID519638 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2320 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID557487 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID422495 | Antimicrobial activity against Escherichia coli BL21 (DE3) harboring pAT514 by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID481442 | Transcellular permeability at pH 6.5 calculated from in vitro P app values in Caco-2 and/or MDCK cells | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID511288 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-13 plasmid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID40353 | Relative stability towards beta-lactamase was determined in Bacillus fragilis FP784 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID562756 | Ratio of Kcat to Km for Klebsiella pneumoniae AH24-270 CTX-M-71 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID533880 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID555285 | Antibacterial activity against atlA-deficient Enterococcus faecalis JH2-2 assessed as decrease in decrease in bacterial count at 2 ug/ml after 24 hrs by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID557421 | Antimicrobial activity in Bacteroides vulgatus by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID558337 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1650 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1546154 | Antifungal activity against Aspergillus fumigatus assessed as zone of inhibition at 30 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID584844 | Antimicrobial activity against Escherichia coli DH10B by agar dilution method in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID522062 | Antimicrobial activity against Escherichia coli isolate J53 harboring pCF containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID534084 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID684237 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis isolate cpu0347 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID519204 | Antibacterial activity against Streptococcus pneumoniae assessed as resistant isolates by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID559859 | Antimicrobial activity against Streptococcus agalactiae clinical isolates by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections. |
| AID297186 | Antibacterial activity against multidrug resistant Staphylococcus aureus 49589 | 2007 | Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17 | Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms. |
| AID561099 | Antibacterial activity against Pasteurella multocida ATCC 43137 by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID558636 | Antimicrobial activity against Streptococcus pneumoniae 5 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID564531 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid with entire blaAmpC gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID535063 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pOXA-58-6 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID541856 | Antimicrobial activity against florfenicol-resistant Edwardsiella ictaluri M07-1 by microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. |
| AID351644 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID326271 | Activity of Escherichia coli K12 beta-lactamase CARB1 relative to penicillin G | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID278570 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID531428 | Antibacterial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID434480 | Terminal half life in Chinchilla lanigera at 15 mg/kg, iv | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573604 | Antibacterial activity against Fusobacterium mortiferum by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID595734 | Antimicrobial activity against Bacillus megaterium after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID444050 | Fraction unbound in human plasma | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID557699 | Antimicrobial activity in Prevotella loescheii by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID521999 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp6A expressing beta-lactamase OXA-48 and TEM-150 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID519004 | Antimicrobial activity against Serratia marcescens isolate CT-118 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID558607 | Antimicrobial activity against Streptococcus pneumoniae isolate 1384 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID559826 | Antimicrobial activity against Escherichia coli J53 by agar dilution in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID536467 | Antimicrobial activity against Salmonella typhi at 100 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID599618 | Antibacterial activity against Shigella dysenteriae isolate 3 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID558616 | Antimicrobial activity against Streptococcus pneumoniae isolate 2880 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID520422 | Antimicrobial activity against macrolide-resistant Streptococcus sp. 'group A' by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID520402 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID536464 | Antimicrobial activity against Bacillus subtilis at 100 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID557515 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID612540 | Binding affinity to human PepT2 in SKTP cells | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. |
| AID87936 | Antibacterial activity was evaluated against Helicobacter pylori (9005). | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID351634 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID567317 | Antimicrobial activity against Proteus mirabilis TUM4660 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID540952 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pA172 plasmid expressing cephalosporinase CMY-31 by agar dilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID546426 | Activity at Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID64384 | MIC required to inhibit 90% of the growth of Enterococcus faecium (n = 10) | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID1230224 | Antibacterial activity against Enterococcus faecium N733 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID351214 | Cmax in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID562613 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557437 | Antimicrobial activity in Prevotella bivia by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID521144 | Antibacterial activity against extracellular Listeria monocytogenes EGDe at 400 times of MIC by time-kill study | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. |
| AID543411 | Antimicrobial activity against Shigella sonnei UIH-1 expressing beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID544978 | Antimicrobial activity against Klebsiella pneumoniae 52OmpA2 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1533863 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 757 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID519007 | Antimicrobial activity against Escherichia coli HB101 expressing plasmid encoded TEM-149 T182M mutant by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID544422 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1533870 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 358 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID340734 | Antimicrobial activity against Escherichia coli HB101 harboring pBC-SK plasmid assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID1230231 | Antibacterial activity against Listeria monocytogenes CIP 103575 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID264470 | Antibacterial activity against Enterococcus spp | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID425864 | Antimicrobial activity against Carnobacterium divergens CIP101029 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID681115 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID543285 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID559644 | Antimicrobial activity against Extended-spectrum beta-lactamase producing Escherichia coli clinical isolate assessed as resistant isolate in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Molecular characteristics of travel-related extended-spectrum-beta-lactamase-producing Escherichia coli isolates from the Calgary Health Region. |
| AID521490 | Antibacterial activity against Escherichia coli harboring pCOL plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID543825 | Antimicrobial activity against Borrelia spielmanii isolate PAnz after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1126566 | Antimicrobial activity against Pseudomonas aeruginosa MTCC 1688 at 200 ug/ml after 24 hrs by cup plate method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs. |
| AID372619 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-1 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID543428 | Antimicrobial activity against Escherichia coli XL-1 Blue harboring plasmid CL1920 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID561105 | Antibacterial activity against Pasteurella multocida BB1039 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID557751 | Antimicrobial activity in Lactobacillus by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1634996 | Hemolytic activity in human type RBC after 1 hr | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID520876 | Antibacterial activity against Achromobacter xylosoxidans CIP69598 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID574044 | Antibacterial activity against beta-lactamase producing Peptoniphilus asaccharolyticus by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID434459 | Unbound plasma clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID575098 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID573762 | Antibacterial activity against Klebsiella pneumoniae isolate Kp204 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID533877 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID1916832 | Antibacterial activity against Staphylococcus aureus NCIM 2010 assessed as reduction in bacterial growth incubated for 8 hrs by absorbance based assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery. |
| AID279182 | Antibacterial activity against Enterobacter cloacae S3 isolate by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID395161 | Antibacterial activity against Enterococcus faecium ATCC 10541 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID569349 | Antibacterial activity against Staphylococcus aureus OXFORD by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID522011 | Antimicrobial activity against Klebsiella pneumoniae isolate KpE expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID529618 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID542064 | Antibacterial activity against Klebsiella pneumoniae C expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID587996 | Bactericidal activity against 5 X 10'6 CFU/ml Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene at 2 ug/ml after 6 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID558533 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1698 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID96068 | Antibacterial activity against Klebsiella pneumoniae was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID562754 | Activity of Klebsiella pneumoniae AH24-270 CTX-M-71 beta-lactamase | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID424324 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID434292 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID285439 | Antimicrobial activity against Citrobacter gillenii CIP 106783 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID535357 | Antimicrobial activity against Streptococcus pyogenes clinical isolates by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1162171 | Antitubercular activity against XDR clinical isolates Mycobacterium tuberculosis H37Rv assessed as growth inhibition in presence of 2.5 mg/ml clavulanate | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | SAR analysis of new anti-TB drugs currently in pre-clinical and clinical development. |
| AID1161173 | Antimicrobial activity against Staphylococcus aureus isolate SWEETING after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID544436 | Antimicrobial activity against Escherichia coli CU164A harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID543274 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2b, pbp1a and murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID528613 | Antimicrobial activity against Escherichia coli J53 harboring blaKPC-2 and blaTEM-1 gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID546431 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID1781208 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth incubated for 18 hrs by CLSI protocol based method | 2021 | Journal of natural products, 08-27, Volume: 84, Issue:8 | The Total Chemical Synthesis and Biological Evaluation of the Cationic Antimicrobial Peptides, Laterocidine and Brevicidine. |
| AID285256 | Antimicrobial activity against Escherichia coli DH5-alpha CF1295 isolate expressing CMT and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID522049 | Antimicrobial activity against Klebsiella pneumoniae isolate KpE expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID519220 | Antibacterial activity against Streptococcus pneumoniae assessed as resistant isolates by microdilution method in presence of beta lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID87956 | Minimum inhibitory activity against clarithromycin- and metronidazole-resistant strain 16021 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID531663 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID562477 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 transconjugant expressing beta-lactamase KPC-2/TEM-1 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID1230229 | Antibacterial activity against Enterococcus hirae CIP 5855 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID530814 | Antibacterial activity against Klebsiella pneumoniae 11978 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID575088 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID511294 | Antibacterial activity against Pseudomonas aeruginosa NL68 expressing GES-13 beta lactamase in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID535704 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A S287N mutant protein by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID557473 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID279184 | Antibacterial activity against Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID522040 | Antimicrobial activity against Escherichia coli isolate J53 harboring p6A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID565660 | Antimicrobial activity against beta-lactamase negative ampicillin-resistant Haemophilus influenzae by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID372612 | Antibacterial activity against rifampin-resistant Escherichia coli C600 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID521352 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-612 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID557509 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID469307 | Antibacterial activity against Pseudomonas aeruginosa at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID557973 | Antimicrobial activity in Clostridium tertium by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID434285 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID557957 | Antimicrobial activity in Eggerthella lenta by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID373209 | Activity of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID470909 | Antibacterial activity against Escherichia coli at 100 ug after 24 to 48 hrs by diffusion agar technique | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives. |
| AID529612 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID575091 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID68581 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Enterococcus faecium(47) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID722028 | Antibacterial activity against Pasteurella ATCC 6529 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives. |
| AID564223 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid PH1 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID209933 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Streptococcus pyogenes(31) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID559921 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID351635 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID521471 | Antimicrobial activity against Escherichia coli S3 overexpressing penicillinase TEM-1 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID531487 | Antibacterial activity against Bacteroides fragilis isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID557518 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID555278 | Antibacterial activity against Enterococcus faecalis JH2-2 assessed as bacterial killing at 2 ug/ml by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID373057 | Antimicrobial activity against Bacillus clausii ATCC 21537 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID573751 | Antibacterial activity against Serratia marcescens isolate Sm220 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID558642 | Antimicrobial activity against Streptococcus pneumoniae 11 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID288967 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15 | Synthesis, antifungal and antimicrobial activity of alkylphospholipids. |
| AID546429 | Activity at Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID351220 | AUC (0 to 24 hrs) in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID557503 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID558584 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID402033 | Antimicrobial activity against Clarithromycin-resistant Helicobacter pylori TS281 after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID406621 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID476929 | Human intestinal absorption in po dosed human | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3 | Neural computational prediction of oral drug absorption based on CODES 2D descriptors. |
| AID562607 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID424319 | Antimicrobial activity against Dialister pneumosintes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID571934 | Antimicrobial activity against Escherichia coli MC4100 harboring promoter hybrid 1 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID558330 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P316 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID573575 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID544524 | Antimicrobial activity against Borrelia afzelii isolate G1039 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID495835 | Antimicrobial activity against Escherichia coli harbouring plasmidBK-CMV expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID285262 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-1 and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID372640 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-35 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID209069 | Antibacterial activity against Streptococcus faecalis NCTC 775 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID530813 | Antibacterial activity against Escherichia coli J53 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID1230225 | Antibacterial activity against Enterococcus faecium N823 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1507252 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID535713 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID534089 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID521993 | Antimicrobial activity against Klebsiella pneumoniae isolate KpB expressing OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID522000 | Antimicrobial activity against Escherichia coli isolate J53 harboring p4A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID520893 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant p6S3 expressing beta lactamase OXA-114a in presence of 4 ug/ml clavulanic acid by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID558594 | Antimicrobial activity against Streptococcus pneumoniae 6 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID43099 | The compound was tested against Bacteroides fragilis FP784 and its stability towards beta-lactamase relative to cephaloridine was evaluated | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID560128 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID87963 | Minimum inhibitory concentration against Helicobacter pylori under acidic conditions at pH 7.0 | 2001 | Journal of medicinal chemistry, Dec-06, Volume: 44, Issue:25 | 3-(Arylacetylamino)-N-methylbenzamides: a novel class of selective anti-Helicobacter pylori agents. |
| AID531480 | Antibacterial activity against Bacteroides spp. isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID87931 | Antibacterial activity against Helicobacter pylori HP020 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID40467 | Stability towards penicillinase was determined | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID520976 | Antibacterial activity against Pseudomonas aeruginosa KG2505 harboring pCOL plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID558588 | Antimicrobial activity against Streptococcus pneumoniae 19A by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID278310 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse lung at 15 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID278331 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-15986 infected Swiss mouse blood at 15 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID351651 | fAUC (0 to 24 hrs) in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID561100 | Antibacterial activity against Pasteurella multocida BB1034 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1001 bearing tetB gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID495820 | Antimicrobial activity against Klebsiella pneumoniae 6828 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID573790 | Antibacterial activity against Prevotella melaninogenica by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID467612 | Fraction unbound in human plasma | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID278571 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID557409 | Antimicrobial activity in Bacteroides fragilis by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1230216 | Antibacterial activity against Enterococcus faecalis CIP 104676 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1486244 | Antibacterial activity against Staphylococcus aureus isolate 13142 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID38346 | Antimicrobial activity was measured against B. fragilis; range is between (0.2-12.5). | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID691700 | Antibacterial activity against Staphylococcus aureus MTCC 96 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID1486243 | Antibacterial activity against methicillin-resistant Staphylococcus aureus NCTC 12493 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID562358 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID573732 | Antibacterial activity against Enterobacter cloacae isolate El1573 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID200526 | Tested for inhibition of visible growth of Salmonella schottmuelleri | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID558641 | Antimicrobial activity against Streptococcus pneumoniae 10 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID528600 | Antimicrobial activity against Escherichia coli TOP10 harboring blaKPC-2 and blaTEM-1 gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID522039 | Antimicrobial activity against Escherichia coli isolate J53 harboring p5A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID522041 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp7A expressing beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID548248 | Antibacterial activity against beta-lactamase SHV or TEM ESBL-producing Enterobacteriaceae by twofold dilution method in presence of beta-lactamase inhibitor clavulanate | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. |
| AID522038 | Antimicrobial activity against Escherichia coli isolate J53 harboring p4A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1533865 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1402 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID574053 | Antibacterial activity against beta-lactamase producing Finegoldia magna by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID573398 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID522061 | Antimicrobial activity against Citrobacter freundii isolate expressing beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID400385 | Antibacterial activity against Shigella boydii at 200 ug/100uL after 24 hrs by agar well diffusion method | 1998 | Journal of natural products, Feb, Volume: 61, Issue:2 | Antibacterial steroidal alkaloids from Sarcococca saligna. |
| AID373293 | Antibacterial activity against Streptococcus pyogenes at 30 ug after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID531427 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1347485 | Antibacterial activity against Klebsiella pneumoniae assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID27795 | AUC (area under curve) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice; Not checked | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID558633 | Antimicrobial activity against Streptococcus pneumoniae 2 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID544420 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID278275 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae P-15986 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID278301 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse lung at 7 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID608538 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID542062 | Antibacterial activity against Klebsiella pneumoniae D expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID278299 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse blood at 7 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID434478 | Antimicrobial activity against amoxicillin-intermediate resistant Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID534088 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID1819820 | Antibacterial activity against Pseudomonas aeruginosa SVB-B9 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID495805 | Antimicrobial activity against Klebsiella pneumoniae 6828 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID564545 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID351656 | Protein binding in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID543391 | Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as increase in mouse survival at 50 mg/kg, ip administered 36 hrs postinfection as single dose | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. |
| AID544527 | Antimicrobial activity against Borrelia garinii isolate G1 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID87926 | Antibacterial activity against Helicobacter pylori HP0019 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID531669 | Antibacterial activity against Streptococcus pneumoniae serotype 33 by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID678719 | Metabolic stability in human liver microsomes assessed as medium signal/noise ratio (S/N of 10 to 100) by measuring GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1246794 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID434460 | Unbound plasma clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID543822 | Antimicrobial activity against Borrelia spielmanii isolate PC-Eq17 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID544425 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID559918 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG4 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID567470 | Antimicrobial activity against gBLNAS Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID521324 | Antimicrobial activity against beta lactamase-nonproducing ampicillin-resistant Haemophilus influenzae MSC06647 isolate harboring Asn526Lys mutation in penicillin-binding protein 3 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes. |
| AID469304 | Ratio of compound to amoxicilline activity against Bacillus subtilis at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID326525 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis UCN41 challenged with ID90 bacterial size inoculum in Wistar rat assessed as infection at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID557969 | Antimicrobial activity in Clostridium sp. by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID549337 | Antimicrobial activity against Escherichia coli ATCC 25922 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID522028 | Antimicrobial activity against Escherichia coli isolate TOP10 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID536455 | Antimicrobial activity against Staphylococcus aureus at 100 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID393597 | Antimicrobial activity against Escherichia coli at 200 ug/mL after 24 hrs by disk diffusion method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID557949 | Antimicrobial activity in Propionibacterium acnes by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID535361 | Antimicrobial activity against Haemophilus influenzae clinical isolates by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1126562 | Antimicrobial activity against Bacillus subtilis MTCC 441 at 200 ug/ml after 24 hrs by cup plate method | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Synthesis and biological evaluation of N-dehydrodipeptidyl-N,N'-dicyclohexylurea analogs. |
| AID1546151 | Antifungal activity against Candida albicans assessed as zone of inhibition at 30 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID525041 | Antimicrobial activity against fluoroquinolone-resistant Escherichia coli NorE5 harboring GyrA S83L mutant, ParC S80R mutant, truncated SoxR and constitutively active SoxS by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. |
| AID574035 | Antibacterial activity against beta-lactamase producing Micromonas micros by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID575099 | Antimicrobial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID531438 | Antibacterial activity against Streptococcus pneumoniae serotype 19F assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID470906 | Antibacterial activity against Staphylococcus aureus at 100 ug after 24 to 48 hrs by diffusion agar technique | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives. |
| AID529464 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone A expressing beta-lactamase Oxa-48, TEM-1, SHV-12 and Oxa-9 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID285270 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM36 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID1546122 | Antifungal activity against Candida albicans assessed as zone of inhibition at 250 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID531678 | Antimicrobial activity against Acinetobacter baumannii TVICU53 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID520401 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID573745 | Antibacterial activity against Citrobacter amalonaticus isolate Ca1614 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID395160 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KS2007-6 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID606244 | Antibacterial activity against Staphylococcus aureus after 18 hrs by macro-dilution test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID520980 | Antibacterial activity against Klebsiella pneumoniae YC by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID573577 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID722034 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives. |
| AID549335 | Antimicrobial activity against Escherichia coli isolate Z1 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID87932 | Antibacterial activity against Helicobacter pylori HP021 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1445905 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA252 after 20 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms. |
| AID88103 | The compound was evaluated in vitro for the minimum inhibitory concentration against Helicobacter pylori (16021). | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID557271 | Antimicrobial activity against Streptococcus pneumoniae 2688 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID434279 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573741 | Antibacterial activity against Enterobacter cloacae isolate El3799 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID573569 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1294616 | Antibacterial activity against Klebsiella pneumoniae CIP 53153 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID521474 | Antimicrobial activity against Escherichia coli S6 expressing extended-spectrum beta-lactamase TEM-116 and SHV-12 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID534083 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID557961 | Antimicrobial activity in Clostridium perfringens by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID372613 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-158 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID558586 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID225343 | Total cytotoxic dose against Staphylococcus aureus after sc administration (1+5 hr post infection) to mouse | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18 | The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity. |
| AID521994 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBb containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID325157 | Antimicrobial activity against Haemophilus parasuis BB 1024 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID562364 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID424320 | Antimicrobial activity against Dialister micraerophilus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID528602 | Antimicrobial activity against blaKPC-2, blaKLUC-2 and blaTEM-1 producing Enterobacter cloacae 7506 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID326499 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis JH2-2 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID569357 | Antibacterial activity against Streptococcus pneumoniae 1629 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID543831 | Antimicrobial activity against Borrelia burgdorferi isolate LW2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID520969 | Antibacterial activity against Klebsiella pneumoniae GR by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID531617 | Antimicrobial activity against Escherichia coli JM109 harboring pSC1 plasmid expressing beta-lactamase SHV-56 by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID326518 | T>MIC in Enterococcus faecalis infected Wistar rat at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID434475 | Ratio of influx clearance to efflux clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID562753 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID1161162 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID67079 | Antibacterial activity was evaluated against Enterococcus faecalis (0115) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID535695 | Antimicrobial activity against Azide-resistant Escherichia coli J53 transconjugant harboring Escherichia coli DH5alpha-5825 qnrB2 gene by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID88246 | Minimum inhibitory activity against Helicobacter pylori FP1757 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID351643 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID326523 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis JH2-2 challenged with ID90 bacterial size inoculum in Wistar rat assessed as infection at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID524695 | Antibacterial activity against Moraxella catarrhalis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID558615 | Antimicrobial activity against Streptococcus pneumoniae isolate 2874 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID548247 | Antibacterial activity against beta-lactamase SHV or TEM ESBL-producing Enterobacteriaceae by twofold dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. |
| AID558585 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID562337 | Activity at Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID522046 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-2 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID531722 | Antibacterial activity against Bacteroides spp. assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1230205 | Antibacterial activity against Bacillus cereus CIP 6624 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID495839 | Ratio of Kcat to Km for Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID79589 | Minimum bactericidal concentration against Helicobacter pylori ATCC 43504 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 1. |
| AID560129 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by disk diffusion method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID549205 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by ELISA | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. |
| AID372620 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID1246797 | Antibacterial activity against Salmonella typhi after 5 days by microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID558602 | Antimicrobial activity against Streptococcus pneumoniae isolate 33 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID393600 | Antimicrobial activity against Salmonella Typhimurium after 24 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID573787 | Antibacterial activity against Prevotella buccae by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1577954 | Antimicrobial activity against Pseudomonas aeruginosa PA6 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID469306 | Ratio of compound to amoxicilline activity against Escherichia coli at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID528614 | Antimicrobial activity against Escherichia coli J53 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID1347487 | Antibacterial activity against Staphylococcus epidermidis assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID1445904 | Antibacterial activity against methicillin-resistant Staphylococcus aureus EMRSA-15 after 20 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms. |
| AID535680 | Antimicrobial activity against beta-lactamase negative Haemophilus influenzae expressing fst1 gene by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID557525 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID573758 | Antibacterial activity against Citrobacter koseri isolate Ck211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID542063 | Antibacterial activity against Klebsiella pneumoniae B expressing CTX-M group 1 beta-lactamase by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Nationwide survey of CTX-M-type extended-spectrum beta-lactamases among Klebsiella pneumoniae isolates in Slovenian hospitals. |
| AID560489 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-2 producing Escherichia coli MC4100 harboring plasmid AC-cmy2 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID520417 | Antimicrobial activity against quinolone-susceptible Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID1161158 | Antimicrobial activity against Streptococcus pneumoniae ERY2 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID558581 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID522019 | Antimicrobial activity against Enterobacter cloacae isolate 1 expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID535678 | Antimicrobial activity against beta-lactamase negative Haemophilus influenzae expressing fst1 gene assessed as resistant isolates by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID534082 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID544432 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID520981 | Antibacterial activity against Escherichia coli harboring pNYC plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID324360 | Antibacterial activity against Acinetobacter johnsonii 7037 expressing SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID521998 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp5A expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID542589 | Antimicrobial activity against plasmid encoded beta-lactamase OXA-58 deficient Acinetobacter radioresistens by CLSI method in presence of beta-lactamase inhibitor clavulanate | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. |
| AID573605 | Antibacterial activity against Fusobacterium necrophorum by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID543271 | Antimicrobial activity against Streptococcus pneumoniae 3191 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID278306 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse lung at 15 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID434466 | Unbound plasma clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573789 | Antibacterial activity against Prevotella intermedia by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID519205 | Antibacterial activity against Streptococcus pneumoniae by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID540957 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBCSK plasmid by agar dilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID1294617 | Antibacterial activity against Proteus vulgaris CIP 104989 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID531485 | Antibacterial activity against Bacteroides uniformis isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID529746 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate after 20 to 24 hrs by broth microdilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID595733 | Antimicrobial activity against Enterococcus faecalis after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID546428 | Activity at Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID351435 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1.5 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1533857 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3332 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID434461 | Unbound plasma clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 235 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID555291 | Antibacterial activity against atlA-deficient Enterococcus faecalis JH2-2 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID209781 | Tested for inhibition of visible growth of Streptococcus pyogenes | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID564524 | Antimicrobial activity against Acinetobacter baumannii KI by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID557396 | Antimicrobial activity against Helicobacter pylori ATCC 43504 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. |
| AID557488 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID558539 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P1826 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID40465 | Stability towards beta-lactamase was determined in Bacillus fragilis FP784 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID557519 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID520415 | Antimicrobial activity against macrolide-susceptible Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID529623 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae harboring fst1 mutant gene assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID543826 | Antimicrobial activity against Borrelia spielmanii isolate PMai after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID564539 | Antimicrobial activity against Acinetobacter baumannii AYE expressing VEB-1 gene by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID285266 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM151 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID561110 | Antibacterial activity against Pasteurella multocida BB1044 harboring plasmid pB1000 bearing blaROB-1 gene, plasmid 1006 bearing tetO gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID557524 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID543277 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID24421 | Partition coefficient (logD) | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID372615 | Activity of Escherichia coli DH5alpha beta-lactamase TEM-12 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID524258 | Activity at Escherichia coli beta-lactamase SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID278319 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 15 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID520973 | Antibacterial activity against Klebsiella pneumoniae KN2303 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID1449628 | Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 40, Issue:12 | Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. |
| AID206052 | In vitro Antibacterial activity of compound against Staphylococcus epidermidis | 2003 | Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4 | Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. |
| AID377030 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 after 24 hrs by disk diffusion assay | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. |
| AID434472 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID557469 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae 3009 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID558626 | Antimicrobial activity against Streptococcus pneumoniae isolate 3481 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID531430 | Antibacterial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID83648 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Haemophilus Influenzae(21) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID1577956 | Antimicrobial activity against Escherichia coli ATCC 25922 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID529647 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-15 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID573828 | Antibacterial activity against beta-lactamase producing Clostridium septicum by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID533206 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as susceptible isolates by PK/PD technique in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID573746 | Antibacterial activity against Citrobacter freundii isolate Cf1614 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID1161167 | Antimicrobial activity against Staphylococcus aureus isolate Ealing 32 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID574024 | Antibacterial activity against beta-lactamase producing Peptostreptococcus anaerobius by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID87937 | Antibacterial activity was evaluated against Helicobacter pylori (FP1757). | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID573962 | Antibacterial activity against Klebsiella oxytoca Ko238 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID558643 | Antimicrobial activity against Streptococcus pneumoniae 12 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID529751 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID558618 | Antimicrobial activity against Streptococcus pneumoniae isolate 3263 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID531666 | Antibacterial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID573611 | Antibacterial activity against Fusobacterium nucleatum assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID67908 | In vitro Antibacterial activity of compound against Enterococcus faecalis | 2003 | Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4 | Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. |
| AID535692 | Antimicrobial activity against beta-lactamase CTX-M-15-producing fluoroquinolone-resistant Escherichia coli FMV5825 expressing qnrB2 and aac(6')-Ib-cr and harboring gyrA Ser83Ile and Asp87Asn mutant gene and ParC Ser80Ile and Glu84Val mutant gene obtained | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID575945 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae by broth microdilution method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID495796 | Antimicrobial activity against Escherichia coli DH10B by Etest in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID434268 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera assessed as Vmax at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573760 | Antibacterial activity against Escherichia coli isolate Ec221 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID584835 | Antimicrobial activity against Aeromonas allosaccharophila AL-1 expressing beta-lactamase PER6 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID558635 | Antimicrobial activity against Streptococcus pneumoniae 4 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID531677 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid containing OXA-58-4 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID559824 | Antimicrobial activity against Escherichia coli J53 harboring pCHE-A plasmid expressing blaGES-5 gene by agar dilution in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID444055 | Fraction absorbed in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID495908 | Antimicrobial activity in Escherichia coli TOP10 harbouring recombinant plasmid VIM-1-N215K by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID544428 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID557417 | Antimicrobial activity in Bacteroides ovatus by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID684235 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate cpu3256 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID574011 | Antibacterial activity against beta-lactamase producing Clostridium perfringens assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID574054 | Antibacterial activity against beta-lactamase producing Finegoldia magna assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID544523 | Antimicrobial activity against Borrelia afzelii isolate G600 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1577945 | Antimicrobial activity against Pseudomonas aeruginosa under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID575075 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID530348 | Antimicrobial activity against azide-resistant Escherichia coli J53 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID207624 | Compound alone was evaluated for minimum inhibitory concentration against Staphylococcus aureus A9606 | 1985 | Journal of medicinal chemistry, Apr, Volume: 28, Issue:4 | Synthesis and beta-lactamase inhibitory properties of 2 beta-[(acyloxy)methyl]-2-methylpenam-3 alpha-carboxylic acid 1,1-dioxides. |
| AID518727 | Antimicrobial activity against Escherichia coli TOP10 by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID1774181 | Antibacterial activity against Staphylococcus aureus DSM11822 assessed as growth inhibition by measuring minimal concentration at OD600 by visual inspection with iron-limited media incubated for 24 hrs | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens. |
| AID278316 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 15 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID324359 | Antibacterial activity against Escherichia coli DH10B by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID208627 | In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Streptococcus pneumoniae (23) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID587990 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene at 2 ug/ml after 6 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID87958 | Minimum inhibitory activity against clarithromycin- and metronidazole-resistant strain 16043 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID573773 | Antibacterial activity against Fusobacterium mortiferum assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID285265 | Antimicrobial activity against Escherichia coli DH5-alpha isolate expressing pBK-CMV by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID560133 | Ratio of Kcat to Km for recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID681793 | TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, Amoxicillin: 2000 uM) in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 290, Issue:2 | The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. |
| AID544526 | Antimicrobial activity against Borrelia garinii isolate M2094 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID393594 | Antimicrobial activity against Staphylococcus aureus at 200 ug/mL after 24 hrs by disk diffusion method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID557453 | Antimicrobial activity in Prevotella intermedia by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID322321 | Antibacterial activity against Escherichia coli DH5 alpha-URA5776 isolates expressing CTX-M-14 enzyme by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID94045 | Tested for inhibition of visible growth of Klebsiella pneumoniae | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID1577951 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID573829 | Antibacterial activity against beta-lactamase producing Clostridium tertium by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID208758 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Streptococcus agalactiaeB(21) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID573734 | Antibacterial activity against Klebsiella pneumoniae isolate Kp7564 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1246782 | Antibacterial activity against Escherichia coli at 10 ug/disk after 24 hrs by agar plate disk diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID163217 | Antibacterial activity against Proteus vulgaris NCTC 4175 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID564530 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid with entire blaAmpC gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID557679 | Antimicrobial activity in Prevotella baroniae by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID520418 | Antimicrobial activity against quinolone-resistant Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID94067 | In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Klebsiella pneumoniae(20) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID1533872 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 774 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID522014 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBEL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID557508 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID572270 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 13709 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID434264 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as unbound Km at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID1545450 | Antibacterial activity against Klebsiella pneumoniae assessed as zone inhibition at 100 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID562752 | Antimicrobial activity against Escherichia coli DH5alpha harboring pBC-CTX-M-15 plasmid by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID522012 | Antimicrobial activity against Escherichia coli isolate J53 harboring pE containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID541016 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase PenB1 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID555279 | Antibacterial activity against atlA-deficient Enterococcus faecalis JH2-2 assessed as bacterial killing at 2 ug/ml by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID370915 | Antibacterial activity against Staphylococcus aureus after 18 hrs by macro dilution test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID1161187 | Antimicrobial activity against Staphylococcus aureus isolate 934334 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID179685 | In vitro gastric mucosa concentration administered perorally at 20 mg/kg was determined in rats at 1 hr | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID419822 | Antibacterial activity against Bacillus subtilis at 100 ug after 24 hrs by agar disc-diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles. |
| AID370914 | Antibacterial activity against Escherichia coli at 10 to 100 ug/mL after 18 hrs by halo zone test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID531486 | Antibacterial activity against Bacteroides thetaiotaomicron isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID558534 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P1699 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID374367 | Activity of Acinetobacter baumannii AC-54/97 metallo-beta-lactamase IMP-2 expressed in Escherichia coli DH5alpha | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID599613 | Antibacterial activity against Klebsiella pneumoniae isolate J/1/4 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID519006 | Antimicrobial activity against Escherichia coli HB101 harboring empty vector pBK-SK by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID608608 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID660261 | Ratio of MIC for wild type Escherichia coli JC7623 to MIC for acrAB-deficient Escherichia coli JZM120 | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID495632 | Antimicrobial activity against Pseudomonas luteola expressing blaLUT-2 to blaLUT-6 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID557493 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID562403 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID10412 | Recovery rate from urine and bile was determined after iv administration at 20 mg/kg in rats; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID1230206 | Antibacterial activity against Bacillus cereus N190 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID40337 | Compound was evaluated for antimicrobial activity against Bacteroides fragilis | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID1577955 | Antimicrobial activity against Pseudomonas aeruginosa PA6 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID495795 | Antimicrobial activity against Escherichia coli DH10B harbouring recombinant plasmid pSau1 expressing beta-lactamase BIC-1 from Pseudomonas fluorescens PF-1 by Etest in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID351645 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID546427 | Activity at Pseudomonas aeruginosa PDC-2 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID444054 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID565178 | Cytotoxicity against human CCD-32Sk cells after 48 hrs by MTT assay | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. |
| AID521472 | Antimicrobial activity against Escherichia coli S4 expressing inhibitor-resistant TEM-34 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID351440 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID529463 | Antimicrobial activity against Klebsiella pneumoniae isolate 21 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID678714 | Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID529615 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID1230248 | Antibacterial activity against Staphylococcus saprophyticus E260 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID285268 | Activity of Escherichia coli BL21(DE3) beta-lactamase TEM152 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID278304 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse blood at 15 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1525344 | Antibacterial activity against Pseudomonas aeruginosa KW799 after 20 hrs under iron-rich medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID434257 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID156434 | The compound was tested against Penicillinase (TEM) and its stability towards beta-lactamase relative to cephaloridine was evaluated | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID541010 | Antimicrobial activity against Burkholderia cenocepacia 212 expressing beta-lactamase PenB3 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID549206 | Antimicrobial activity against Enterococcus faecalis after 24 hrs by ELISA | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. |
| AID88247 | Minimum inhibitory activity against Helicobacter pylori FP1836 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID558628 | Antimicrobial activity against Streptococcus pneumoniae isolate 3681 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID495921 | Antimicrobial activity in Escherichia coli TOP10 harbouring recombinant plasmid VIM-1-N215K by Etest in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID530816 | Antibacterial activity against Escherichia coli J53 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID557449 | Antimicrobial activity in Prevotella denticola by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID519627 | Antimicrobial activity against Brachyspira pilosicoli 80.10 without producing beta-lactamase OXA-63 by disc diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID1533861 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2516 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID147159 | Compound was evaluated for antimicrobial activity against Neisseria meningitidis | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID543420 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID531599 | Antimicrobial activity against Klebsiella pneumoniae Kp2792 expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID574963 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID573553 | Antibacterial activity against Bacteroides fragilis assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID326265 | Antibacterial activity against Escherichia coli 3521r carrying pR352 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID434463 | Unbound plasma clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID558600 | Antimicrobial activity against Streptococcus pneumoniae 12 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID495631 | Antimicrobial activity against Pseudomonas luteola LAM expressing blaLUT-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID1533874 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2973 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID395163 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID197848 | MIC required to inhibit 90% of the growth of Staphylococcus aureus (n = 31) | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID402031 | Antimicrobial activity against Helicobacter pylori Sa-3 isolate after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID393598 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID558328 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P286 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID325161 | Antimicrobial activity against Haemophilus parasuis BB 1026 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID522052 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBEL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID558599 | Antimicrobial activity against Streptococcus pneumoniae 11 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID557445 | Antimicrobial activity in Prevotella melaninogenica by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID278337 | Effect on survival of Swiss mouse infected with penicillin-resistant Streptococcus pneumoniae P-12698 at 25 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1445901 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis NCTC 12201 after 20 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms. |
| AID1819809 | Cytotoxicity against NHDF cells assessed as reduction in cell viability measured after 24 hrs by MTT assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID326513 | Cmin in Enterococcus faecalis infected Wistar rat at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID278281 | Half life in leukopenic mouse with renal failure at 15 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID520416 | Antimicrobial activity against macrolide-resistant Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID564213 | Antimicrobial activity against Acinetobacter baumannii ATCC 135040 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID323659 | Antibacterial activity against Peptostreptococcus anaerobius | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Antimicrobial susceptibilities of Peptostreptococcus anaerobius and the newly described Peptostreptococcus stomatis isolated from various human sources. |
| AID515780 | Intrinsic solubility of the compound in water | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19 | QSAR-based solubility model for drug-like compounds. |
| AID543484 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1533853 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1344 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID424332 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID684242 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate cpu3569 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID520894 | Antibacterial activity against Escherichia coli TOP10 in presence of 4 ug/ml clavulanic acid by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID557723 | Antimicrobial activity in Fusobacterium varium by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID285442 | Activity of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID200259 | Minimum inhibitory activity against Staphylococcus aureus A20309 | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID520967 | Antibacterial activity against Escherichia coli harboring pNYC plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID569362 | Antibacterial activity against Streptococcus pyogenes 1308007P by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID264473 | Antibacterial activity against Staphylococcus epidermidis | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID573964 | Antibacterial activity against Serratia marcescens Sm265 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID562750 | Antimicrobial activity against Escherichia coli K-12 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID469295 | Antifungal activity against Syncephalastrum racemosum at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID557272 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae 3676 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID573603 | Antibacterial activity against Fusobacterium nucleatum by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID544576 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8130 expressing bla SHV-1 gene by microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID560120 | Antimicrobial activity against Acinetobacter baumannii by disk diffusion method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID542586 | Antimicrobial activity against Acinetobacter radioresistens 251-39C expressing beta-lactamase OXA-133 by CLSI method in presence of beta-lactamase inhibitor clavulanate | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. |
| AID558536 | Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P854 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID560488 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-30 producing Escherichia coli MC4100 harboring plasmid AC-cmy30 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID529651 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-2 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID434275 | Ratio of influx clearance to efflux clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID556015 | Antibacterial activity against Helicobacter pylori infected in human assessed as bacterial eradication rate at 20 mg, po BID for 7 days | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation. |
| AID481446 | Effective permeability across human jejunum | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID560493 | Antibacterial activity against 5 x 10'5 CFU/ml Escherichia coli MC4100 harboring plasmid ACYC184 by microdilution method in presence of 2 ug/ml clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID87952 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 80 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID519737 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID1438615 | Antibacterial activity against Enterococcus faecium isolate 015205731401 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID574010 | Antibacterial activity against beta-lactamase producing Clostridium tertium assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID606241 | Antibacterial activity against Streptococcus pyogenes measured at MIC after 18 hrs by halo zone test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID530602 | Antibacterial activity against Escherichia coli J53 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID434273 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as Vmax at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573566 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID495635 | Activity of Pseudomonas luteola LAM Beta-lactamase LUT-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID522001 | Antimicrobial activity against Escherichia coli isolate J53 harboring p5A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID568388 | Antimicrobial activity against Xanthomonas oryzae after 72 hrs by microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID557429 | Antimicrobial activity in Bacteroides uniformis by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID544522 | Antimicrobial activity against Borrelia afzelii isolate FEM1 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1916833 | Antibacterial activity against Bacillus subtilis NCIM 2079 assessed as reduction in bacterial growth incubated for 8 hrs by absorbance based assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery. |
| AID522024 | Antimicrobial activity against Escherichia coli isolate J53 harboring pCF containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID529456 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone A expressing beta-lactamase Oxa-48, TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID684234 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate cpu1098 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID1533849 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2490 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID373054 | Antimicrobial activity against Escherichia coli BL21(DE3) carrying pET9a expressing Bacillus clausii beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID524696 | Antibacterial activity against Haemophilus influenzae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A. |
| AID490324 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 at 25 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID544442 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID565672 | Antimicrobial activity against beta-lactamase positive (amoxicillin)clavulanate-resistant Haemophilus influenzae assessed as susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID351627 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1636440 | Drug activation in human Hep3B cells assessed as human CYP2D6-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. |
| AID1507273 | Antibacterial activity against Bifidobacterium infantis after 24 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID573950 | Antibacterial activity against Morganella morganii Mm38009 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID562814 | Antimicrobial activity against Escherichia coli J53 in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID87934 | Antibacterial activity was evaluated against Helicobacter pylori (13001). | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID469305 | Antibacterial activity against Escherichia coli at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID351624 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 3 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1230249 | Antibacterial activity against Staphylococcus sciuri N993 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID455986 | Permeability across human Caco-2 cells | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19 | Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. |
| AID490333 | Antimicrobial activity against Candida albicans ATCC 10231 after 48 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID322325 | Antibacterial activity against Escherichia coli DH5 alpha-URA5924 isolates expressing CTX-M-32 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID575074 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1438614 | Antibacterial activity against vancomycin A-resistant Enterococcus faecium isolate 0151850763 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID301029 | Antibacterial activity against Proteus vulgaris after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID393595 | Antimicrobial activity against Streptococcus pyogenes at 200 ug/mL after 24 hrs by disk diffusion method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID559819 | Antimicrobial activity against Escherichia coli J53 harboring pCHE-B plasmid expressing blaSHV-5 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID1634995 | Antimicrobial activity against Pseudomonas aeruginosa clinical isolates assessed as reduction in bacterial growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID573809 | Antibacterial activity against Prevotella intermedia assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID529645 | Antimicrobial activity against Pseudomonas aeruginosa 166301 expressing beta-lactamase VIM-16 obtained from urine of patient by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID481444 | Octanol-water partition coefficient, log P of the compound | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID373298 | Antibacterial activity against Salmonella Typhimurium after 18 hrs by microdilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID558610 | Antimicrobial activity against Streptococcus pneumoniae isolate 1424 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID531724 | Antibacterial activity against Bacteroides merdae assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID434255 | Influx clearance from plasma to middle ear fluid Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID207179 | Antibacterial activity against Staphylococcus aureus 209P JC was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1486237 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 9144 after 20 hrs by broth micro dilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID588219 | FDA HLAED, gamma-glutamyl transferase (GGT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID434470 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID541014 | Antimicrobial activity against Burkholderia cenocepacia 5007902 expressing beta-lactamase PenB4 in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID562737 | Antimicrobial activity against Escherichia coli K-12 transconjugant harboring blaCTX-M-71 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID541013 | Antimicrobial activity against Burkholderia cenocepacia 5007902 expressing beta-lactamase PenB4 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID469299 | Antifungal activity against Geotrichum candidum at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID1507257 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 to 48 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID528612 | Antimicrobial activity against blaKPC-2, blaKLUC-2 and blaTEM-1 producing Enterobacter cloacae 7506 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID1230250 | Antibacterial activity against Streptococcus agalactiae CIP 103227 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID434484 | Antimicrobial activity against amoxicillin-susceptible Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID521469 | Antimicrobial activity against Escherichia coli S1 expressing penicillinase TEM-1 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID521356 | Antimicrobial activity against Streptococcus pneumoniae isolate 2907 obtained from sinusitis of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID278569 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID582966 | Antimicrobial activity against beta-lactamase A-deficient Yersinia enterocolitica GY5717 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID573610 | Antibacterial activity against Fusobacterium varium assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID599622 | Antibacterial activity against Vibrio parahaemolyticus isolate 72016 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID573584 | Antibacterial activity against beta-lactamase producing Bacteroides caccae by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID599617 | Antibacterial activity against Bacillus subtilis UC564 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID557457 | Antimicrobial activity in Prevotella nigrescens by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID572271 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NB01021 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID40357 | Stability towards beta-lactamase was determined in Bacillus fragilis FP784 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID529621 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID541004 | Antimicrobial activity against Burkholderia cenocepacia 07-34 expressing beta-lactamase PenB1 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID50861 | Antimicrobial activity against Clostridium perfringens | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15 | Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles. |
| AID395162 | Antibacterial activity against Enterococcus faecalis ATCC 19433 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID557433 | Antimicrobial activity in Bacteroides stercoris by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID520890 | Antibacterial activity against Achromobacter xylosoxidans LOL in presence of 4 ug/ml clavulanic acid by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID434266 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as unbound Km at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID1294609 | Antibacterial activity against Escherichia coli ATCC 35218 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID495654 | Antimicrobial activity against Pseudomonas aeruginosa 531 expressing beta-lactamase BEL-2 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID518725 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase DIM-1 by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID1533873 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 200 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID519643 | Antimicrobial activity against Escherichia coli EPI300 transformant harboring pCC1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID1726845 | Cytotoxicity against human HaCaT cells after 24 hrs by MTT assay | 2021 | RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6 | Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity. |
| AID571938 | Antimicrobial activity against Escherichia coli MC4100 harboring promoter hybrid 1 and active promoter P2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID324729 | Antimicrobial activity against Fusobacterium nucleatum biofilms assessed as decrease in viable cell count at 2 uM after 30 mins | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria. |
| AID536463 | Antimicrobial activity against Staphylococcus aureus at 50 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID64066 | Minimum inhibitory activity against Escherichia coli A21223 | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID395157 | Antibacterial activity against Staphylococcus aureus Smith after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID278277 | Cmax in leukopenic mouse with renal failure at 15 mg/kg, sc after 0.5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID521354 | Antimicrobial activity against Streptococcus pneumoniae isolate 4134 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID557505 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID529614 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae assessed as resistant isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID681350 | TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells | 1997 | The American journal of physiology, 11, Volume: 273, Issue:5 | Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. |
| AID490331 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID544439 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID495917 | Antimicrobial activity in Klebsiella pneumoniae DIH-2 clinical isolate expressing beta-lactamase VIM-19 by Etest in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID522386 | Antimicrobial activity against Escherichia coli NI540 carrying cloned class C beta-lactamase TRU-1 gene | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID322323 | Antibacterial activity against Escherichia coli DH5 alpha-URA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID351641 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 2 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID558013 | Antimicrobial activity in Porphyromonas gingivalis by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID372607 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-158 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID205383 | Antibacterial activity was evaluated against Serratia marcescens (3013) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID278312 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse blood at 15 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID534086 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID558606 | Antimicrobial activity against Streptococcus pneumoniae isolate 1147 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573744 | Antibacterial activity against Klebsiella oxytoca isolate Ko1156 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID377033 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by disk diffusion assay | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. |
| AID495809 | Antimicrobial activity against Escherichia coli DH5alpha harbouring plasmid BK-VIM-19 expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID565684 | Antimicrobial activity against beta-lactamase-positive ampicillin-resistant Haemophilus influenzae harboring fst1 mutant gene by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID1634989 | Antimicrobial activity against Staphylococcus aureus 6271 assessed as reduction in bacterial growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID521991 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp11978 expressing beta-lactamase OXA-48, SHV-2a and TEM-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID543830 | Antimicrobial activity against Borrelia burgdorferi B31 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID434454 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID1634997 | Antifungal activity against Candida albicans assessed as reduction in fungal growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID540943 | Antimicrobial activity against Klebsiella pneumoniae HP205 expressing CMY-36 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID587989 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene at 2 ug/ml after 24 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID434289 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID1694326 | Bactericidal activity against Staphylococcus aureus MRSA-2 measured every 24 hrs for 5 days by serial dilution method | 2021 | Bioorganic & medicinal chemistry, 02-15, Volume: 32 | Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. |
| AID535668 | Antimicrobial activity against beta-lactamase positive, ampicillin-clavulanic acid resistant Haemophilus influenzae expressing fst1 mutant gene by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID87942 | Compound was evaluated for antimicrobial activity against Helicobacter pylori | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID278309 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse lung at 7 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID587995 | Bactericidal activity against 5 X 10'6 CFU/ml Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene at 2 ug/ml after 24 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID351648 | Cmax in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID567987 | Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID87807 | Antibacterial activity against Helicobacter pylori HP001 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID1294610 | Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID351222 | Half life in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID573946 | Antibacterial activity against Serratia marcescens Sm2723 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID543827 | Antimicrobial activity against Borrelia spielmanii A14S after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID678713 | Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID374363 | Activity of Aeromonas caviae A324R metallo-beta-lactamase IMP-19 expressed in Escherichia coli DH5alpha by computerized microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID24420 | Partition coefficient (logP) | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID434467 | Unbound plasma clearance in Chinchilla lanigera at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID341373 | Antibacterial activity against Staphylococcus aureus by manual microdilution technique | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Dexamethasone as adjuvant therapy to moxifloxacin attenuates valve destruction in experimental aortic valve endocarditis due to Staphylococcus aureus. |
| AID340729 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-14 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID1230232 | Antibacterial activity against Listeria monocytogenes N783 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID529458 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID69960 | Compound alone was evaluated for minimum inhibitory concentration against Escherichia coli A20107 | 1985 | Journal of medicinal chemistry, Apr, Volume: 28, Issue:4 | Synthesis and beta-lactamase inhibitory properties of 2 beta-[(acyloxy)methyl]-2-methylpenam-3 alpha-carboxylic acid 1,1-dioxides. |
| AID518519 | Antimicrobial activity against Capnocytophaga sputigena isolate NOR after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID434286 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID285264 | Antimicrobial activity against Escherichia coli DH5-alpha TC1179 isolate expressing TEM-1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID520419 | Antimicrobial activity against trimethoprim-sulfamethoxazole-susceptible Streptococcus pneumoniae by agar dilution method in presence of beta-lactam inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Antistreptococcal activity of AR-709 compared to that of other agents. |
| AID585206 | Antimicrobial activity against Escherichia coli DH5[alpha] in presence of clavulanic acid at compound/inhibitor ratio of 2:1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID114723 | Tested for the antimicrobial activity against Streptococcus pneumoniae (D137) in mice, subcutaneously | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID278329 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-15986 infected Swiss mouse lung at 15 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID372617 | Activity of Escherichia coli CF0042 beta-lactamase TEM-35 by microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID495793 | Antimicrobial activity against Escherichia coli DH10B by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID425867 | Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID522187 | Antimicrobial activity against Klebsiella pneumoniae isolate KpL expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573395 | Antibacterial activity against Bacteroides fragilis by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID522044 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-2 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1230220 | Antibacterial activity against Enterococcus faecium CIP 103014 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1577960 | Antimicrobial activity against Klebsiella pneumoniae ATCC 8303 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID469297 | Antifungal activity against Candida albicans at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID1533868 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1717 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID531675 | Antimicrobial activity against Escherichia coli DH5alpha by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID179686 | In vitro gastric mucosa concentration administered perorally at 20 mg/kg was determined in rats at 2 hr | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID1486246 | Antibacterial activity against Staphylococcus aureus NCTC 8325 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID208458 | Tested for inhibition of visible growth of Streptococcus pneumoniae | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID529611 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID557413 | Antimicrobial activity in Bacteroides thetaiotaomicron by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID559579 | Antimicrobial activity against Parachlamydia acanthamoebae infected in Acanthamoeba castellanii amoeba cells | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. |
| AID531679 | Antimicrobial activity against Acinetobacter baumannii Ab290 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID587997 | Bactericidal activity against 5 X 10'6 CFU/ml Enterococcus faecalis JH2-2 at 2 ug/ml after 24 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID1577952 | Antimicrobial activity against Pseudomonas aeruginosa PA4 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID557485 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1230238 | Antibacterial activity against Staphylococcus aureus CIP 53154 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID424329 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID1577944 | Antimicrobial activity against Pseudomonas aeruginosa under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID557953 | Antimicrobial activity in Actinomyces by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID24183 | Distribution coefficient in octanol/water at pH 5.5 | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID524251 | Antimicrobial activity against Escherichia coli INSRA4590 expressing SHV-84 in presence of 2 ug/ml clavulanic acid beta-lactamase inhibitor | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID544575 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 7668 expressing bla SHV-48 gene by microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID561102 | Antibacterial activity against Pasteurella multocida BB1036 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID531433 | Antibacterial activity against Streptococcus pneumoniae serotype 33 assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID521347 | Antimicrobial activity against Streptococcus pneumoniae isolate k-598 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID557516 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID87930 | Antibacterial activity against Helicobacter pylori HP008 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID373051 | Antimicrobial activity against Bacillus clausii ATCC 21537 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID420821 | Antibacterial activity against Staphylococcus aureus at 30 ug/disk after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID434482 | Cmax in Chinchilla lanigera at 15 mg/kg, iv followed by local dose of 13 to 235 ug/kg into intra-middle ear | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID543284 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, murM and Streptococcus pneumoniae 72521 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID351654 | Ratio of unbound to total drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1486240 | Antibacterial activity against Staphylococcus epidermidis ATCC 35984 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID560118 | Antibacterial activity against Escherichia coli TOP10 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID558324 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P835 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID567471 | Antimicrobial activity against gLow-BLNAR Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID544437 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID574959 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID372618 | Ratio of Kcat to Km for Escherichia coli CF0042 beta-lactamase TEM-35 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID533881 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID584840 | Antimicrobial activity against Aeromonas allosaccharophila AL-1 expressing beta-lactamase PER6 by agar dilution method in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID535345 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID278330 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-15986 infected Swiss mouse blood at 7 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID562362 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1486245 | Antibacterial activity against Staphylococcus aureus NCTC 6571 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID573752 | Antibacterial activity against Serratia marcescens isolate Sm201 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID541017 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase PenB1 in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID728909 | Antibacterial activity against levofloxacin-intermediate and levofloxacin-resistant Streptococcus pneumoniae after 18 hrs by microbroth dilution method | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5 | Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens. |
| AID559822 | Antimicrobial activity against Pseudomonas aeruginosa PU21 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID573806 | Antibacterial activity against Prevotella melaninogenica assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID561101 | Antibacterial activity against Pasteurella multocida BB1035 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID125251 | Antibacterial activity against Morganella morganii was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID529752 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by broth microdilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID377032 | Antimicrobial activity against Enterobacter cloacae ATCC 13047 after 24 hrs by disk diffusion assay | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID469311 | Antibacterial activity against Staphylococcus aureus after 24 to 48 hrs by serial dilution technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID569360 | Antibacterial activity against Escherichia coli by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID264472 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID278332 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-15986 infected Swiss mouse lung at 7 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID574961 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID43100 | The compound was tested against Bacteroides fragilis FP784 its stability towards beta-lactamase relative to cephaloridine was evaluated | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID557512 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID529748 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate after 20 to 24 hrs by broth microdilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID1573563 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2019 | Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2 | Thermodynamics of DNA Minor Groove Binders. |
| AID1161161 | Antimicrobial activity against Streptococcus pyogenes 1308007P after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID543828 | Antimicrobial activity against Borrelia spielmanii isolate TIsar2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1888846 | Antibacterial activity against Staphylococcus aureus 1199B measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID495823 | Antimicrobial activity against Providencia stuartii 6858 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID1438603 | Antibacterial activity against Listeria monocytogenes CIP 103575 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID340731 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase SHV-ES by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID718845 | Antibacterial activity against Bacillus subtilis after 18 hrs by macrodilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives. |
| AID1294612 | Antibacterial activity against Pseudomonas aeruginosa CIP 82118 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID572269 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 49951 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID434278 | Ratio of influx clearance to efflux clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 170 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID557502 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID549202 | Antimicrobial activity against Escherichia coli after 24 hrs by ELISA | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. |
| AID574014 | Antibacterial activity against beta-lactamase producing Clostridium tertium assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID558630 | Antimicrobial activity against Streptococcus pneumoniae isolate 4747 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID531482 | Antibacterial activity against Bacteroides distasonis isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID543279 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID573767 | Antibacterial activity against Klebsiella pneumoniae Kp1239 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID558632 | Antimicrobial activity against Streptococcus pneumoniae 1 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID574962 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID557521 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID569359 | Antibacterial activity against Streptococcus pneumoniae ERY2 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID557703 | Antimicrobial activity in Prevotella sp.by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID469302 | Ratio of compound to amoxicilline activity against Staphylococcus aureus at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID557480 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID395154 | Antibacterial activity against Staphylococcus aureus ATCC 6538P after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID684238 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis isolate cpu2089 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID557517 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID325446 | Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID533879 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID434251 | Maximum efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID373210 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID1230243 | Antibacterial activity against Staphylococcus epidermidis CIP 53124 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1161183 | Antimicrobial activity against Staphylococcus aureus isolate 68/8684 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1636357 | Drug activation in human Hep3B cells assessed as human CYP3A4-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. |
| AID520891 | Antibacterial activity against Achromobacter xylosoxidans DUC in presence of 4 ug/ml clavulanic acid by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID573772 | Antibacterial activity against Fusobacterium nucleatum assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID555290 | Antibacterial activity against Enterococcus faecalis JH2-2 by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID95730 | Antibacterial activity against Klebsiella aerogenes WRL CN 345 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID420828 | Antibacterial activity against Escherichia coli after 18 hrs by macro dilution test | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID325443 | Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID544440 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID400379 | Antibacterial activity against Klebsiella pneumoniae at 200 ug/100uL after 24 hrs by agar well diffusion method | 1998 | Journal of natural products, Feb, Volume: 61, Issue:2 | Antibacterial steroidal alkaloids from Sarcococca saligna. |
| AID1246781 | Antibacterial activity against Staphylococcus aureus at 10 ug/disk after 24 hrs by agar plate disk diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID303929 | Permeability across artificial membrane by PAMPA model | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability. |
| AID519894 | Antimicrobial activity against Escherichia coli Irk1224 harboring beta-lactamase CTX-M-3 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID560117 | Antibacterial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID588003 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 infected in rabbit assessed as bacterial load per gram of vegetation at 50 mg/kg, im administered three times a day starting 48 hrs post-infection measured after 24 hrs by time kill | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID569354 | Antibacterial activity against Haemophilus influenzae H128 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1238340 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by agar diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification. |
| AID573759 | Antibacterial activity against Enterobacter cloacae isolate El216 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1161188 | Antimicrobial activity against Staphylococcus aureus isolate 934335 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID519642 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID197879 | In vitro minimum inhibitory activity against Staphylococcus aureus Oxford strain | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID1812550 | In vivo antibacterial activity against Escherichia coli expressing TEM-1/CTX-M-15 infected in C3H/HeJ mouse assessed as log10 reduction in CFU in urine administration of compound:clavulanate 2:1 ratio at 10 to 300 mg/kg, sc every 12 hrs for 3 days startin | |||
| AID278856 | Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID288968 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs | 2007 | Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15 | Synthesis, antifungal and antimicrobial activity of alkylphospholipids. |
| AID564532 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid with entire blaAmpC gene with alanine residue deletion at 215 position by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID561103 | Antibacterial activity against Pasteurella multocida BB1037 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID495922 | Antimicrobial activity in Escherichia coli J53 transconjugate with Escherichia coli DIH-1 expressing natural plasmid containing beta-lactamase VIM-19 in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID1161163 | Antimicrobial activity against Staphylococcus aureus isolate A53 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID64379 | In vitro minimum inhibitory activity against Enterococcus faecalis 1 strain | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID278302 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse lung at 15 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1577958 | Antimicrobial activity against Klebsiella pneumoniae ATCC 8303 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID558595 | Antimicrobial activity against Streptococcus pneumoniae 7 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID569355 | Antibacterial activity against AcrA deficient Haemophilus influenzae H128 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID678716 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID548240 | Antibacterial activity against beta-lactamase CTX-M ESBL-producing Enterobacteriaceae assessed as percent susceptible isolates by twofold dilution method in presence of beta-lactamase inhibitor clavulanate | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. |
| AID530815 | Antibacterial activity against human urinary Klebsiella pneumoniae UCL-1 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID351439 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID522057 | Antimicrobial activity against Enterobacter cloacae isolate 1 expressing beta-lactamase OXA-48 and SHV-5 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID434462 | Unbound plasma clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 170 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573757 | Antibacterial activity against Serratia marcescens isolate Sm211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID351436 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 2 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID587993 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 at 2 ug/ml after 3 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID114715 | Tested for the antimicrobial activity against Staphylococcus aureus (M240) in mice, perorally | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID1577957 | Antimicrobial activity against Escherichia coli ATCC 25922 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID606240 | Antibacterial activity against Staphylococcus aureus measured at MIC after 18 hrs by halo zone test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID400384 | Antibacterial activity against Salmonella typhi at 200 ug/100uL after 24 hrs by agar well diffusion method | 1998 | Journal of natural products, Feb, Volume: 61, Issue:2 | Antibacterial steroidal alkaloids from Sarcococca saligna. |
| AID544427 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID351620 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID543423 | Antimicrobial activity against Escherichia coli XL-1 Blue transconjugant harboring beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID373050 | Antimicrobial activity against Bacillus clausii NR expressing beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID588002 | Antibacterial activity against Enterococcus faecalis JH2-2 by CLSI method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID571932 | Antimicrobial activity against Escherichia coli MC4100 harboring a weak promoter in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID325153 | Antimicrobial activity against Haemophilus parasuis BB 1020 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID68585 | In vitro minimum inhibitory concentration against Enterococcus faecium | 2003 | Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4 | Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. |
| AID1230221 | Antibacterial activity against Enterococcus faecium CIP 107387 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID531725 | Antibacterial activity against Bacteroides stercoris assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID573731 | Antibacterial activity against Citrobacter amalonaticus isolate Ca3927 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID424331 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID434297 | Influx clearance from plasma to middle ear fluid Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 235 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID87806 | Antibacterial activity against Helicobacter pylori ATCC 43504 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID520889 | Antibacterial activity against Achromobacter xylosoxidans MER in presence of 4 ug/ml clavulanic acid by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID562479 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID529459 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase Oxa-48 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID1662855 | Bactericidal activity against clinical isolate amoxicillin and ciprofloxacin resistance Staphylococcus aureus | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action. |
| AID29845 | Estimation of fraction absorbed (Fa) in the human intestine using biosensor technology. | 2000 | Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11 | SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans. |
| AID558334 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1093 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID490315 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 278533 at 25 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID340727 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-2 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID543270 | Antimicrobial activity against Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID573768 | Antibacterial activity against Klebsiella pneumoniae Kp2730 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 and dfrA12-orfF-aadA2 arrays by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID200260 | Minimum inhibitory activity against Staphylococcus aureus A9606 | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID495633 | Antimicrobial activity against Escherichia coli DH10B transfected with pBK-L3 expressing blaLUT-1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID524250 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-84 in presence of 2 ug/ml clavulanic acid beta-lactamase inhibitor | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID722033 | Antibacterial activity against Escherichia coli ATCC 8739 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives. |
| AID322322 | Antibacterial activity against Escherichia coli INSRA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID522035 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp4A expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1161177 | Antimicrobial activity against Staphylococcus aureus isolate NEQAS 4026 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID560490 | Antibacterial activity against 5 x 10'5 CFU/ml Escherichia coli MC4100 harboring plasmid ACYC184 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID1916450 | Induction of drug resistance in Escherichia coli ATCC 25922 assessed as fold change in MIC incubated for 15 days | |||
| AID533864 | Antibacterial activity against toxin-positive Clostridium difficile clinical isolate by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile. |
| AID469294 | Ratio of compound to grisofulvin activity against Aspergillus fumigatus at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID565664 | Antimicrobial activity against beta-lactamase negative ampicillin-resistant Haemophilus influenzae assessed as susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID434295 | Influx clearance from plasma to middle ear fluid Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID434474 | Ratio of influx clearance to efflux clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID373295 | Antibacterial activity against Escherichia coli at 30 ug after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID478872 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after overnight incubation by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9 | Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams. |
| AID340733 | Antimicrobial activity against Chryseobacterium indologenes NF16 isolate assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID574960 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID434293 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID278279 | Cmax in human at 1 g, po after 0.5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID599614 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID521682 | Antimicrobial activity against Escherichia coli S3 overexpressing penicillinase TEM-1 in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID559827 | Antimicrobial activity against Pseudomonas aeruginosa PU21 harboring pCHE-A plasmid expressing blaGES-5 gene by agar dilution in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID1413531 | Toxicity in Escherichia coli after 18 to 24 hrs by two-fold serial dilution method | 2018 | MedChemComm, Aug-01, Volume: 9, Issue:8 | Design, synthesis, and biological evaluation of |
| AID27797 | Maximum plasma concentration (Cmax) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice; Not checked | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID544421 | Antimicrobial activity against Escherichia coli CU164A expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID681114 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1 | Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID540948 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c2 plasmid expressing cephalosporinase CMY-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID531720 | Antibacterial activity against Bacteroides distasonis assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1413532 | Toxicity in Enterococcus faecalis after 18 to 24 hrs by two-fold serial dilution method | 2018 | MedChemComm, Aug-01, Volume: 9, Issue:8 | Design, synthesis, and biological evaluation of |
| AID1507255 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 to 48 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID406622 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7 | Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID543278 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and Streptococcus pneumoniae 72521 pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID519640 | Antimicrobial activity against Escherichia coli AB14156 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID529626 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae harboring fst1 mutant gene assessed as resistant isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID522047 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBIC expressing beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID532220 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus isolate 5 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID325150 | Antimicrobial activity against Haemophilus parasuis ATCC 19417 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID543404 | Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as reduction in bacterial count in spleen at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 6 hr | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID558639 | Antimicrobial activity against Streptococcus pneumoniae 8 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID575095 | Antimicrobial activity against Streptococcus pneumoniae serotype 22F assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID562741 | Antimicrobial activity against Escherichia coli DH5[alpha] by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID502776 | Antibacterial activity against Helicobacter pylori ATCC 700392 at 0.05 ug/ml by disk agar diffusion method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID582965 | Antimicrobial activity against Yersinia enterocolitica Biovar 1B 8081 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID535341 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID569351 | Antibacterial activity against Enterococcus faecalis by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID325152 | Antimicrobial activity against Haemophilus parasuis BB 1019 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID564537 | Antimicrobial activity against Acinetobacter baumannii KI by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID522034 | Antimicrobial activity against Escherichia coli isolate J53 harboring p3A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573956 | Antibacterial activity against Klebsiella oxytoca Ko0426 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID525546 | Antimicrobial activity against Haemophilus influenzae Rd KW20 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID370918 | Antibacterial activity against Escherichia coli after 18 hrs by macro dilution test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID530349 | Antimicrobial activity against Escherichia coli TOP10 harboring pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID573587 | Antibacterial activity against beta-lactamase producing Bacteroides caccae assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID637612 | Antibacterial activity against coagulase-positive Staphylococcus aureus at 30 ug/ml after 24 hrs by agar well diffusion method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID434267 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as unbound Km at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID540950 | Antimicrobial activity against Salmonella enterica serotype Newport AM17274 expressing CMY-31 cephalosporinase by agar dilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID529753 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID560491 | Antibacterial activity against 5 x 10'5 CFU/ml CMY-30 producing Escherichia coli MC4100 harboring plasmid AC-cmy30 by microdilution method in presence of 2 ug/ml clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase. |
| AID1819807 | Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID530819 | Antibacterial activity against Escherichia coli J53 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID1230217 | Antibacterial activity against Enterococcus faecalis N491 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID518724 | Antimicrobial activity against Escherichia coli TOP10 harboring beta-lactamase DIM-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID530605 | Antibacterial activity against Escherichia coli J53 by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID557475 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1202201 | Antibacterial activity against Bacillus subtilis ATCC 6051 after 24 hrs by two-fold broth microdilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Novel imidazo[2,1-b]-1,3,4-thiadiazoles as promising antifungal agents against clinical isolate of Cryptococcus neoformans. |
| AID522065 | Antimicrobial activity against Escherichia coli isolate J53 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID556020 | Antibacterial activity against Helicobacter pylori infected in human assessed as bacterial eradication rate at 1 g, po BID for 10 days by 13C-urea breath test | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation. |
| AID555672 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring recombinant plasmid carrying CTX-M-53 gene by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID522059 | Antimicrobial activity against Enterobacter cloacae isolate 2 expressing beta-lactamase OXA-48 and SHV-5 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1774180 | Antibacterial activity against Escherichia coli BW25113 assessed as growth inhibition by measuring minimal concentration at OD600 by visual inspection with iron-limited media incubated for 24 hrs | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens. |
| AID606247 | Antibacterial activity against Escherichia coli after 18 hrs by macro-dilution test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID420823 | Antibacterial activity against Salmonella Typhimurium at 30 ug/disk after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID1210069 | Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID544532 | Antimicrobial activity against Borrelia clinical isolate after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID351196 | Volume of distribution in neonates | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks. |
| AID1230244 | Antibacterial activity against Staphylococcus haemolyticus CIP 8156 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1438613 | Antibacterial activity against Enterococcus faecium CIP 103510 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID558319 | Antibacterial activity against Campylobacter coli by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID529624 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID573827 | Antibacterial activity against beta-lactamase producing Clostridium paraputrificum by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID495636 | Ratio of kcat/Km for Pseudomonas luteola LAM Beta-lactamase LUT-1 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID1533875 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 85 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID225342 | Total cytotoxic dose against Staphylococcus aureus after po administration (1+5 hr post infection) to mouse | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18 | The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity. |
| AID326267 | Antibacterial activity against Escherichia coli DH5-alpha carrying pSCO1 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID1546118 | Antimicrobial activity against Staphylococcus aureus assessed as zone of inhibition at 250 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID1162170 | Antitubercular activity against Mycobacterium tuberculosis infected in mouse J774A.1 assessed as reduction in bacterial count | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | SAR analysis of new anti-TB drugs currently in pre-clinical and clinical development. |
| AID529461 | Antimicrobial activity against Escherichia coli J53 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID301021 | Antibacterial activity against Staphylococcus aureus 209p after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID544528 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID478870 | Antibacterial activity against Streptococcus pneumoniae ATCC 6305 after overnight incubation by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9 | Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams. |
| AID529743 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID519744 | Antibacterial activity against Klebsiella pneumoniae INSRA1229 harboring SHV-72 Ile8Phe, Ala146Val, and Lys234Arg mutations by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID1726825 | Antibacterial activity against Pseudomonas aeruginosa MTCC 2488 incubated for 14 to 16 hrs by micro broth dilution method | 2021 | RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6 | Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity. |
| AID557522 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID444056 | Fraction escaping gut-wall elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID373296 | Antibacterial activity against Staphylococcus aureus after 18 hrs by microdilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID87967 | Minimum inhibitory concentration required to inhibit macroscopic colonial growth of Helicobacter pylori; ranges from (0.00625-0.1) | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues. |
| AID722029 | Antibacterial activity against Salmonella ATCC 14028 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives. |
| AID1230233 | Antibacterial activity against Listeria monocytogenes N836 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1246783 | Antibacterial activity against Proteus vulgaris at 10 ug/disk after 24 hrs by agar plate disk diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID520978 | Antibacterial activity against Escherichia coli harboring pCOL plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID1546150 | Antimicrobial activity against Staphylococcus aureus assessed as zone of inhibition at 30 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID529653 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID520985 | Antibacterial activity against Klebsiella pneumoniae 633 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID573951 | Antibacterial activity against Klebsiella pneumoniae Kp38045 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID351221 | Half life of free unbound fraction in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID522002 | Antimicrobial activity against Escherichia coli isolate J53 harboring p6A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID543281 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID434274 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as Vmax at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID373055 | Antimicrobial activity against Escherichia coli BL21(DE3) by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID87928 | Antibacterial activity against Helicobacter pylori HP004 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID548236 | Antibacterial activity against beta-lactamase CTX-M ESBL-producing Enterobacteriaceae by twofold dilution method in presence of beta-lactamase inhibitor clavulanate | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. |
| AID495802 | Antimicrobial activity against Escherichia coli 138 expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID535493 | Antimicrobial activity against beta-lactamase positive, ampicillin-clavulanic acid resistant Haemophilus influenzae expressing fst1 mutant gene assessed as resistant isolates by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID114716 | Tested for the antimicrobial activity against Staphylococcus aureus (M240) in mice, subcutaneously | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID519645 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2320 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID549330 | Antimicrobial activity against Escherichia coli isolate 16 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID373294 | Antibacterial activity against Salmonella Typhimurium at 30 ug after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID519628 | Antimicrobial activity against beta-lactamase OXA-63 producing Brachyspira pilosicoli isolate BM4442 isolated from feces of patient with diarrhea by disc diffusion method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID558583 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID420826 | Antibacterial activity against Streptococcus pyogenes after 18 hrs by macro dilution test | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID68023 | Antibacterial activity against Enterobacter cloacae NCTC 10005 strain | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID502520 | Inhibition of Helicobacter pylori invasion into human AGS cells at 2.5 uM after 6 hrs | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID522042 | Antimicrobial activity against Escherichia coli isolate J53 harboring p7A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID531603 | Antimicrobial activity against Escherichia coli JM109 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID351630 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID541019 | Antimicrobial activity against Escherichia coli TOP10 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID434272 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as Vmax at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID522384 | Antimicrobial activity against Aeromonas enteropelogenes ATCC 49803 producing endogenous class C beta-lactamase TRU-1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID544426 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase L1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1202200 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by two-fold broth microdilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Novel imidazo[2,1-b]-1,3,4-thiadiazoles as promising antifungal agents against clinical isolate of Cryptococcus neoformans. |
| AID87803 | Antibacterial activity against Helicobacter pylori strain. | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | Structure-activity relationship of 2-[[(2-pyridyl)methyl]thio]-1H- benzimidazoles as anti Helicobacter pylori agents in vitro and evaluation of their in vivo efficacy. |
| AID519218 | Antibacterial activity against Streptococcus pneumoniae by microdilution method in presence of beta lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID278568 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci. |
| AID521684 | Antimicrobial activity against Escherichia coli S2 expressing penicillinase TEM-1 in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID564222 | Antimicrobial activity against Escherichia coli TOP10 harboring plasmid PH1 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID522025 | Antimicrobial activity against Escherichia coli isolate A expressing beta-lactamase OXA-48 and TEM-150 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID285260 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-28 and ESBL by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID1916086 | Bactericidal activity against Escherichia coli ATCC 25922 assessed as log reduction in viable bacteria at 8 times MIC measured after 2 hrs by time-killing assay | |||
| AID560126 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG3 gene by disk diffusion method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID521348 | Antimicrobial activity against Streptococcus pneumoniae isolate 187 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID544433 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID557507 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID573765 | Antibacterial activity against Acinetobacter baumannii isolate AbN450 harboring blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID278290 | T>MIC in leukopenic mouse with renal failure at 25 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID531481 | Antibacterial activity against Bacteroides ovatus isolate by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID558318 | Antibacterial activity against Campylobacter jejuni by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID495838 | Hydrolytic activity of Escherichia coli BL21 DE3 beta-lactamase VIM-19 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID351626 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID557747 | Antimicrobial activity in Anaerococcus prevotii by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID529625 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae harboring fst1 mutant gene assessed as susceptible isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID535060 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID326501 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis 309 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID511297 | Antibacterial activity against Escherichia coli DH5alpha in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID395155 | Antibacterial activity against Staphylococcus aureus ATCC 10537 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID1533855 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3589 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID264474 | Antibacterial activity against Haemophilus influenzae | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID50730 | Antimicrobial activity against Clostridium difficile | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15 | Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles. |
| AID518522 | Antimicrobial activity against Capnocytophaga sputigena CIP 104301T after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID573807 | Antibacterial activity against Prevotella buccae assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1161174 | Antimicrobial activity against Staphylococcus aureus isolate CL 1033 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID530554 | Antimicrobial activity against Escherichia coli BicA expressing blaTEM-1, blaCTX-M-15 and qepA2 gene by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID372616 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-12 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID1161185 | Antimicrobial activity against Staphylococcus aureus isolate 929035 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID494626 | Antibacterial activity against beta-lactamase deficient Staphylococcus aureus COL | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams. |
| AID678715 | Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID495911 | Antimicrobial activity in Escherichia coli J53 strain | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID528603 | Antimicrobial activity against Escherichia coli J53 harboring blaKPC-2 and blaTEM-1 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID574958 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1546149 | Antimicrobial activity against Escherichia coli assessed as zone of inhibition at 30 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID495829 | Antimicrobial activity against Escherichia coli DH5alpha 2878 transformant expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID520880 | Antibacterial activity against Achromobacter xylosoxidans TB1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID310256 | Antimicrobial activity against Bacillus subtilis ATCC 6633 | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives. |
| AID525040 | Antimicrobial activity against fluoroquinolone-susceptible Escherichia coli PS5 harboring GyrA S83L mutant gene by Etest | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG. |
| AID531440 | Antibacterial activity against Streptococcus pneumoniae serotype 23A assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID535711 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 S287N mutant protein by agar dilution method in presence of 2 mg/liter clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID573763 | Antibacterial activity against Serratia marcescens isolate Sm265 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID557491 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID285440 | Antimicrobial activity against Escherichia coli DH10B expressing GIL1 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID562338 | Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menten equation | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID555677 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring phagemid pBK-CMV by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID559920 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID1246785 | Antibacterial activity against Salmonella typhi at 10 ug/disk after 24 hrs by agar plate disk diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID541857 | Antimicrobial activity against Escherichia coli ATCC 29522 carrying Edwardsiella ictaluri pM07-1 by microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. |
| AID1694327 | Bactericidal activity against Staphylococcus aureus 209P measured every 24 hrs for 5 days by serial dilution method | 2021 | Bioorganic & medicinal chemistry, 02-15, Volume: 32 | Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. |
| AID531439 | Antibacterial activity against Streptococcus pneumoniae serotype 35B assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID543415 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 transconjugant by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID1230242 | Antibacterial activity against Staphylococcus aureus CRBIP 2121 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID278334 | Effect on survival of Swiss mouse infected with penicillin-resistant Streptococcus pneumoniae P-52181 at 15 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID573726 | Antibacterial activity against Klebsiella pneumoniae isolate Kp1239 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID529745 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae harboring fst1 mutant gene assessed as resistant isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID372641 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-1 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID393601 | Antimicrobial activity against Escherichia coli after 24 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID562771 | Antimicrobial activity against Escherichia coli DH10B transformant harboring blaTEM-168 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID351631 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1.5 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1533867 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2728 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID264468 | Antibacterial activity against Streptococcus pyogenes | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID1726826 | Antibacterial activity against methicillin resistant Staphylococcus aureus incubated for 14 to 16 hrs by micro broth dilution method | 2021 | RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6 | Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity. |
| AID494624 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams. |
| AID533875 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID599621 | Antibacterial activity against Salmonella typhi DIRW | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID495814 | Antimicrobial activity against Escherichia coli 2603 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID535672 | Antimicrobial activity against beta-lactamase negative, ampicillin-resistant Haemophilus influenzae expressing fst1 mutant gene by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID1546121 | Antimicrobial activity against Pseudomonas aeruginosa assessed as zone of inhibition at 250 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID549331 | Antimicrobial activity against Escherichia coli isolate 32 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID87809 | Antibacterial activity against Helicobacter pylori HP0017 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID518726 | Antimicrobial activity against Escherichia coli TOP10 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID377031 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by disk diffusion assay | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. |
| AID557270 | Antimicrobial activity against Streptococcus pneumoniae 1564 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID557490 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID559923 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-V49 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID564526 | Antimicrobial activity against Acinetobacter baumannii AYE expressing VEB-1 gene by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID394492 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID434281 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID58628 | Non-toxic dose in dogs after 4 weeks of oral administration; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID573750 | Antibacterial activity against Klebsiella pneumoniae isolate Kp149 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID573947 | Antibacterial activity against Klebsiella pneumoniae Kp7564 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1781207 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 18 hrs by CLSI protocol based method | 2021 | Journal of natural products, 08-27, Volume: 84, Issue:8 | The Total Chemical Synthesis and Biological Evaluation of the Cationic Antimicrobial Peptides, Laterocidine and Brevicidine. |
| AID278861 | Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID519203 | Antibacterial activity against Streptococcus pneumoniae assessed as susceptible isolates by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID540955 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c36 plasmid expressing cephalosporinase CMY-36 by agar dilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID1577948 | Antimicrobial activity against Pseudomonas aeruginosa 61 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID434453 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID557472 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID351619 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 10 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID434477 | Antimicrobial activity against Streptococcus pneumoniae WT3 infected in bolus iv dosed Chinchilla lanigera assessed as log reduction in bacterial count within 10 hrs of additional local drug administration into intra-middle ear | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID558598 | Antimicrobial activity against Streptococcus pneumoniae 10 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID584836 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER6 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID522060 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc2 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573568 | Antibacterial activity against beta-lactamase producing Bacteroides vulgatus assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID520977 | Antibacterial activity against Escherichia coli DH10B expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID394494 | Antimicrobial activity against Escherichia coli MC4100 harboring pACYC184 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID495832 | Antimicrobial activity against Escherichia coli DH5alpha harbouring plasmid BK-VIM-19 expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID531680 | Antimicrobial activity against Acinetobacter baumannii Ab290 harboring TVICU53 plasmid by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID125506 | The ratio of the number of Mongolian gerbils in which Helicobacter pylori was not detected to that of Mongolian gerbils tested (percent) was represented as clearance rate | 1998 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 8, Issue:16 | Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents. |
| AID544443 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID557425 | Antimicrobial activity in Bacteroides distasonis by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID351622 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1.5 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID558627 | Antimicrobial activity against Streptococcus pneumoniae isolate 3587 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID575097 | Antimicrobial activity against Streptococcus pneumoniae serotype 23B assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID42873 | Antimicrobial activity was measured against Campylobacter jejuni organism; range is between ( 0.39-6.25). | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID571937 | Antimicrobial activity against Escherichia coli MC4100 harboring strong promoter and active promoter P2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID546432 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-3 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID558589 | Antimicrobial activity against Streptococcus pneumoniae 1 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID369641 | Antibacterial activity against Acinetobacter baumannii B clone by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID587992 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 at 2 ug/ml after 6 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID558614 | Antimicrobial activity against Streptococcus pneumoniae isolate 2688 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID587987 | Antibacterial activity against Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene assessed as induction of membrane permeabilization at 2 ug/ml after 3 hrs by propidium iodide and Syto9 staining based confocal microscopic analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID585203 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-5 E104, S170 mutant in presence of clavulanic acid at compound/inhibitor ratio of 2:1 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID571935 | Antimicrobial activity against Escherichia coli MC4100 harboring promoter hybrid 2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID522058 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID535710 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 S287N mutant protein by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID565688 | Antimicrobial activity against beta-lactamase-positive ampicillin-resistant Haemophilus influenzae harboring fst1 mutant gene assessed as susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID567472 | Antimicrobial activity against gBLNAR Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID276338 | Antimicrobial activity against Helicobacter pylori DSMZ 4867 | 2006 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 16, Issue:21 | In vitro inhibitory activity of boropinic acid against Helicobacter pylori. |
| AID595731 | Antimicrobial activity against Enterobacter aerogenes after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID599620 | Antibacterial activity against Shigella flexneri DN13 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID478874 | Antibacterial activity against Haemophilus influenzae ATCC 49247 after overnight incubation by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9 | Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams. |
| AID301023 | Antibacterial activity against Klebsiella pneumoniae after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID520966 | Antibacterial activity against Klebsiella pneumoniae YC by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID1634991 | Antimicrobial activity against Staphylococcus aureus clinical isolates from Liberec regional hospital assessed as reduction in bacterial growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID533878 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID1209456 | Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 40, Issue:1 | In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. |
| AID637611 | Antibacterial activity against Klebsiella pneumoniae at 30 ug/ml after 24 hrs by agar well diffusion method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID43097 | The compound was tested against Bacteroides fragilis FP784 and its stability towards beta-lactamase was evaluated | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID588209 | Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset | 2010 | Chemical research in toxicology, Jul-19, Volume: 23, Issue:7 | Developing structure-activity relationships for the prediction of hepatotoxicity. |
| AID1819812 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis RBWH1 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID283320 | Antimicrobial activity against Klebsiella pneumoniae KPN15-NL | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID522007 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-1 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID521473 | Antimicrobial activity against Escherichia coli S5 expressing extended-spectrum beta-lactamase TEM-116 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID278860 | Antiproliferative effect against HeLa cells after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID495808 | Antimicrobial activity against Escherichia coli DH5alpha 2878 transformant expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID372626 | Ratio of Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-12 to Kcat/Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID519743 | Antibacterial activity against Klebsiella pneumoniae INSRA1229 harboring SHV-72 Ile8Phe, Ala146Val, and Lys234Arg mutations by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID561106 | Antibacterial activity against Pasteurella multocida BB1040 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID422493 | Antimicrobial activity against Carnobacterium divergens BM4490 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID522023 | Antimicrobial activity against Citrobacter freundii isolate expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573810 | Antibacterial activity against Prevotella melaninogenica assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID530354 | Antimicrobial activity against Escherichia coli TOP10 harboring pQep plasmid carrying qepA2 gene by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID530600 | Antibacterial activity against Aeromonas sp. isolate A72 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID556014 | Antibacterial activity against Helicobacter pylori infected in human assessed as bacterial eradication rate at 1 g, po BID for 7 days | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation. |
| AID521475 | Antimicrobial activity against Escherichia coli S7 expressing extended-spectrum beta-lactamase SHV-12 and penicillinase TEM-1 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID564527 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID495905 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID520984 | Antibacterial activity against Escherichia coli harboring pNGR plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID574012 | Antibacterial activity against beta-lactamase producing Clostridium paraputrificum assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID569353 | Antibacterial activity against Haemophilus influenzae Q1 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID585205 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-13 K104, N170 mutant in presence of clavulanic acid at compound/inhibitor ratio of 2:1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID69810 | Tested for inhibition of visible growth of Escherichia coli | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID1634992 | Antimicrobial activity against Staphylococcus aureus clinical isolates from university hospital in Motol assessed as reduction in bacterial growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID138318 | The compound was evaluated in vivo for the therapeutic efficacy at 1.0 mg/kg in mouse infection model; 3/8 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID351633 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 3 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID560119 | Antimicrobial activity against Acinetobacter baumannii by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID540953 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pH205 plasmid expressing cephalosporinase CMY-36 by agar dilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID555286 | Antibacterial activity against Enterococcus faecalis JH2-2 infected in New Zealand White rabbit assessed as bacterial count per gram vegetation at 50 mg/kg, im TID for 3 days administered 48 hrs post bacterial challenge (Rvb = 9.40+/-0.62 log10 CFU/g) | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID1525348 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 20 hrs under iron-rich medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID21713 | Solubility at a pH of 4.0; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID434269 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera assessed as Vmax at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID502782 | Inhibition of Helicobacter pylori-induced inflammation in human AGS cells assessed as reduction of IL-8 production at 10 uM by ELISA | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID535676 | Antimicrobial activity against beta-lactamase positive Haemophilus influenzae expressing fst1 gene by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID557945 | Antimicrobial activity in Bifidobacterium by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID574008 | Antibacterial activity against beta-lactamase producing Clostridium paraputrificum assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID558592 | Antimicrobial activity against Streptococcus pneumoniae 4 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID373292 | Antibacterial activity against Staphylococcus aureus at 30 ug after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID584842 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER1 by agar dilution method in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID495826 | Antimicrobial activity against Escherichia coli C600 2878 transconjugate expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID684231 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate cpu1344 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID520968 | Antibacterial activity against Escherichia coli harboring pRYC plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID278276 | Cmax in leukopenic mouse with renal failure at 7 mg/kg, sc after 0.5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID564220 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID556340 | Activity of Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID599619 | Antibacterial activity against Streptococcus faecalis isolate 29212 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID40355 | Relative stability towards penicillinase was determined | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID557497 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID574009 | Antibacterial activity against beta-lactamase producing Clostridium septicum assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID562739 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBC-CTX-M-71 plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID557465 | Antimicrobial activity in Prevotella disiens by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID557715 | Antimicrobial activity in Fusobacterium necrophorum by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID531667 | Antibacterial activity against Streptococcus pneumoniae serotype 23A by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID522005 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-1 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID530350 | Antimicrobial activity against Escherichia coli TOP10 by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID429077 | Antibacterial activity against Escherichia coli J53 by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID46743 | Antimicrobial activity against Campylobacter jejuni | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15 | Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles. |
| AID531681 | Antimicrobial activity against Acinetobacter baumannii Ab290 containing plasmid harboring OXA-58-3 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID64378 | MIC required to inhibit 90% of the growth of Enterococcus faecalis (n = 10) | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID573957 | Antibacterial activity against Klebsiella oxytoca Ko1156 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID521323 | Antimicrobial activity against rifampin-resistant Haemophilus influenzae Rd clone by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes. |
| AID400382 | Antibacterial activity against Staphylococcus aureus at 200 ug/100uL after 24 hrs by agar well diffusion method | 1998 | Journal of natural products, Feb, Volume: 61, Issue:2 | Antibacterial steroidal alkaloids from Sarcococca saligna. |
| AID278284 | AUC in leukopenic mouse with renal failure at 7 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID310254 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives. |
| AID557461 | Antimicrobial activity in Prevotella corporis by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID573805 | Antibacterial activity against Prevotella intermedia assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID557731 | Antimicrobial activity in Micromonas micros by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID373211 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID522055 | Antimicrobial activity against Providencia rettgeri isolate expressing beta-lactamase OXA-48 and TEM-101 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID372603 | Antibacterial activity against Escherichia coli BER1 producing beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID495658 | Antimicrobial activity against Escherichia coli TOP10 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID574037 | Antibacterial activity against beta-lactamase producing Micromonas micros assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID424330 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID558619 | Antimicrobial activity against Streptococcus pneumoniae isolate 3275 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1546120 | Antimicrobial activity against Escherichia coli assessed as zone of inhibition at 250 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID207623 | Compound alone was evaluated for minimum inhibitory concentration against Staphylococcus aureus A15033 | 1985 | Journal of medicinal chemistry, Apr, Volume: 28, Issue:4 | Synthesis and beta-lactamase inhibitory properties of 2 beta-[(acyloxy)methyl]-2-methylpenam-3 alpha-carboxylic acid 1,1-dioxides. |
| AID549333 | Antimicrobial activity against Escherichia coli isolate 36 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID520979 | Antibacterial activity against Pseudomonas aeruginosa KG2505 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID341108 | Antibacterial activity against Escherichia coli 26R793 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID1577961 | Antimicrobial activity against Klebsiella pneumoniae X68 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID114725 | Tested for the antimicrobial activity against Streptococcus pneumoniae (D815) in mice, subcutaneously | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID521680 | Antimicrobial activity against Escherichia coli S6 expressing extended-spectrum beta-lactamase TEM-116 and SHV-12 in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID162890 | Tested for inhibition of visible growth of Proteus mirabilis | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID1545448 | Antibacterial activity against Bacillus subtilis assessed as zone inhibition at 100 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID285257 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha CL1295 isolate expressing pBK-TEM-151 and CMT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID1161159 | Antimicrobial activity against Escherichia coli isolate 3 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID495910 | Antimicrobial activity in Escherichia coli TOP10 strain | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID564536 | Antimicrobial activity against Escherichia coli TOP10 harboring pTOPO plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID144010 | Antibacterial activity against Mycobacterium fortuitum NCTC 10394 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID518521 | Antimicrobial activity against Capnocytophaga sputigena CRBIP 17.39 after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID324358 | Antibacterial activity against Escherichia coli DH10B expressing SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. |
| AID519067 | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 assessed as resistant strains by CLSI microdilution susceptibility testing method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Activity of the Diaminopyrimidine AR-709 against recently collected multidrug-resistant isolates of invasive Streptococcus pneumoniae from North America. |
| AID1230211 | Antibacterial activity against Enterococcus avium CIP 104053 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID470908 | Antibacterial activity against Bacillus subtilis at 100 ug after 24 to 48 hrs by diffusion agar technique | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives. |
| AID599615 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID325447 | Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID573612 | Antibacterial activity against Fusobacterium mortiferum assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID278292 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse blood at 15 mg/kg, sc after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID278274 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae P-12698 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID519740 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-72 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID372608 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-12 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID434261 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera assessed as unbound Km at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID543402 | Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as mouse survival at 50 mg/kg, ip administered 36 hrs postinfection every 12 hrs for 5 days measured after 2 months | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. |
| AID535714 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method in presence of 2 mg/liter clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID1294613 | Antibacterial activity against Staphylococcus aureus ATCC 6583 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID535703 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A by agar dilution method in presence of 2 mg/liter clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID564219 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID562476 | Antimicrobial activity against Klebsiella pneumoniae isolate 2641/08 obtained from urine of patient with ischemic cardiomyopathy and several comorbidities by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID584843 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER2 by agar dilution method in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID1161156 | Antimicrobial activity against Streptococcus pneumoniae 1629 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID572273 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID557477 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID529470 | Antimicrobial activity against Klebsiella pneumoniae isolate 11 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-1 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID544430 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID574055 | Antibacterial activity against beta-lactamase producing Finegoldia magna assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID351219 | fAUC (0 to 24 hrs) in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID522056 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pPR containing beta-lactamase and TEM-101 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID543823 | Antimicrobial activity against Borrelia spielmanii isolate PHap after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID557470 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae 1076 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID351434 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID206785 | In vitro minimum inhibitory concentration against Staphylococcus aureus | 2003 | Bioorganic & medicinal chemistry letters, Feb-24, Volume: 13, Issue:4 | Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. |
| AID1916812 | Antibacterial activity against Bacillus subtilis NCIM 2079 assessed as bacterial growth inhibition incubated for 8 hrs by absorbance based assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery. |
| AID373299 | Antibacterial activity against Escherichia coli after 18 hrs by microdilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID522027 | Antimicrobial activity against Escherichia coli isolate J53 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1533854 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2901 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID531665 | Antibacterial activity against Streptococcus pneumoniae serotype 19F by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1230247 | Antibacterial activity against Staphylococcus saprophyticus CIP 76125 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID434247 | Maximum efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID522020 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1916813 | Antibacterial activity against Escherichia coli NCIM 2688 assessed as bacterial growth inhibition incubated for 8 hrs by absorbance based assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Recent contribution of medicinally active 2-aminothiophenes: A privileged scaffold for drug discovery. |
| AID1636356 | Drug activation in human Hep3B cells assessed as human CYP2C9-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 300 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NA | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. |
| AID425866 | Antimicrobial activity against Carnobacterium divergens BM4489 expressing beta-lactamase CAD1 at 3 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID573586 | Antibacterial activity against beta-lactamase producing Bacteroides caccae assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID522004 | Antimicrobial activity against Escherichia coli isolate J53 harboring p7A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID326528 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis UCN41 challenged with 10 times ID90 bacterial size inoculum in Wistar rat assessed as infection at single administration of 600 mg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID478875 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after overnight incubation by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9 | Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams. |
| AID395159 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID1533859 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1136 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID370912 | Antibacterial activity against Streptococcus pyogenes at 10 to 100 ug/mL after 18 hrs by halo zone test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID522030 | Antimicrobial activity against Escherichia coli isolate J53 harboring pA-1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID521351 | Antimicrobial activity against Streptococcus pneumoniae isolate k-585 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID1774182 | Antibacterial activity against Acinetobacter baumannii DSM30007 assessed as growth inhibition by measuring minimal concentration at OD600 by visual inspection with iron-limited media incubated for 24 hrs | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens. |
| AID1202203 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by two-fold broth microdilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Novel imidazo[2,1-b]-1,3,4-thiadiazoles as promising antifungal agents against clinical isolate of Cryptococcus neoformans. |
| AID278320 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 25 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID522026 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEcA containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID207184 | Antibacterial activity against Staphylococcus aureus NCTC 6571 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID1819814 | Antibacterial activity against macrolide- and tetracycline-resistant Streptococcus pyogenes HKU16 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID522033 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp3A expressing beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID420827 | Antibacterial activity against Salmonella Typhimurium after 18 hrs by macro dilution test | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID127511 | Antibacterial activity was evaluated against M.(B).catarrhalis (6014) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID326503 | Cmax in Enterococcus faecalis infected Wistar rat at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID680866 | TP_TRANSPORTER: inhibition of Cefadroxil uptake (apical pH 6.5, Cefadroxil: 1000 uM, Amoxicillin: 10000 uM) in Caco-2 cells | 1996 | The Journal of pharmacology and experimental therapeutics, May, Volume: 277, Issue:2 | Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. |
| AID595730 | Antimicrobial activity against Pseudomonas aeruginosa after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID522021 | Antimicrobial activity against Enterobacter cloacae isolate 2 expressing beta-lactamase OXA-48 and SHV-5 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID87954 | Minimum inhibitory activity against clarithromycin- and metronidazole-resistant strain 15069 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID1230227 | Antibacterial activity against Enterococcus gallinarum N489 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID520878 | Antibacterial activity against Achromobacter xylosoxidans LOL by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID1230228 | Antibacterial activity against Enterococcus gallinarum N492 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID522032 | Antimicrobial activity against Escherichia coli isolate J53 harboring pBb containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID573733 | Antibacterial activity against Serratia marcescens isolate Sm2723 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID573755 | Antibacterial activity against Escherichia coli isolate Ec211 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID574013 | Antibacterial activity against beta-lactamase producing Clostridium septicum assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID684233 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate cpu0887 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID341107 | Antibacterial activity against Escherichia coli transconjugant carrying pEC28 isolate eby Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12. |
| AID310257 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives. |
| AID587998 | Bactericidal activity against 5 X 10'6 CFU/ml Enterococcus faecalis JH2-2 at 2 ug/ml after 6 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID520975 | Antibacterial activity against Pseudomonas aeruginosa 2404 plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID543412 | Antimicrobial activity against Shigella sonnei UIH-1 expressing beta-lactamase CTX-M-64 by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID536466 | Antimicrobial activity against Salmonella typhi at 50 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID1161170 | Antimicrobial activity against Staphylococcus aureus isolate RN4220 pmz1 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID531668 | Antibacterial activity against Streptococcus pneumoniae serotype 15A by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID531683 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151T by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID429078 | Antibacterial activity against Escherichia coli J53 expressing Klebsiella pneumoniae Greece blaKPC-2 gene by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID206391 | Compound was tested for photoinhibition of Staphylococcus aureus(CIP 53156); No data | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. |
| AID325156 | Antimicrobial activity against Haemophilus parasuis BB 1023 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID1161160 | Antimicrobial activity against Streptococcus pyogenes 1307006P after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID495803 | Antimicrobial activity against Escherichia coli 2603 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID691702 | Antibacterial activity against Pseudomonas aeruginosa MTCC 2642 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID1755787 | Antimicrobial activity against Helicobacter pylori ATCC 43504 incubated for 3 days by agar dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID179684 | In vitro gastric mucosa concentration administered perorally at 20 mg/kg was determined in rats at 0.5 hr | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID558596 | Antimicrobial activity against Streptococcus pneumoniae 8 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID521996 | Antimicrobial activity against Escherichia coli isolate J53 harboring p3A containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID519663 | Antimicrobial activity against Escherichia coli Irk1224 harboring beta-lactamase CTX-M-3 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID555667 | Antimicrobial activity against Escherichia coli DH10B harboring natural plasmid pWES-1 carrying CTX-M-53 gene by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID521350 | Antimicrobial activity against Streptococcus pneumoniae isolate 40 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID373059 | Antimicrobial activity against Escherichia coli DH10B by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID1238016 | Antibacterial activity against Helicobacter pylori ATCC 43504 after 24 hrs by microdilution broth method | 2015 | Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15 | Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agent. |
| AID557511 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID88104 | The compound was evaluated in vitro for the minimum inhibitory concentration against Helicobacter pylori (9005). | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID574045 | Antibacterial activity against beta-lactamase producing Peptoniphilus asaccharolyticus assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID684236 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis isolate cpu0315 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID369642 | Antibacterial activity against Acinetobacter baumannii C clone by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID698056 | Antimicrobial activity against Helicobacter pylori 26695 ATCC 700392 at 50 ug/ml by disk agar diffusion method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. |
| AID1230208 | Antibacterial activity against Bacillus cereus N349 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID351652 | Ratio of unbound to total drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID87935 | Antibacterial activity was evaluated against Helicobacter pylori (8007). | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID573735 | Antibacterial activity against Citrobacter amalonaticus isolate Ca38009 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID326530 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis 309 challenged with ID90 bacterial size inoculum in Wistar rat assessed as infection at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID567323 | Antimicrobial activity against Escherichia coli TUM4670 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID1161165 | Antimicrobial activity against Staphylococcus aureus isolate CL 939 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID637615 | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID1246798 | Antibacterial activity against Salmonella paratyphi after 24 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID1533864 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1749 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID558634 | Antimicrobial activity against Streptococcus pneumoniae 3 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1507254 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID1161176 | Antimicrobial activity against Staphylococcus aureus isolate MN 1255 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID573739 | Antibacterial activity against Escherichia coli isolate Ec9381 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID781326 | pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/047145026X | 2014 | Pharmaceutical research, Apr, Volume: 31, Issue:4 | Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. |
| AID1209457 | Unbound Cmax in human plasma | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 40, Issue:1 | In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID278315 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 7 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID424328 | Antimicrobial activity against Dialister invisus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID520971 | Antibacterial activity against Klebsiella pneumoniae 633 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID1238342 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification. |
| AID531723 | Antibacterial activity against Bacteroides eggerthii assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID519647 | Antimicrobial activity against Escherichia coli AB14156 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID540954 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c31 plasmid expressing cephalosporinase CMY-31 by agar dilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID525549 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1052 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID608609 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 278533 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID544429 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1321386 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2016 | Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19 | The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases. |
| AID528601 | Antimicrobial activity against Escherichia coli TOP10 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID87808 | Antibacterial activity against Helicobacter pylori HP0016 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID373297 | Antibacterial activity against Streptococcus pyogenes after 18 hrs by microdilution method | 2009 | European journal of medicinal chemistry, May, Volume: 44, Issue:5 | Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes. |
| AID522016 | Antimicrobial activity against Escherichia coli isolate J53 harboring pL containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID283322 | Antimicrobial activity against Escherichia coli XL10/pSHV-31 | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID560116 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG3 gene by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID534087 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11 | In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID544441 | Antimicrobial activity against mreB-deficient Escherichia coli YLS-3 harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID67907 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Enterococcus faecalis(47) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID1202202 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by two-fold broth microdilution method | 2015 | European journal of medicinal chemistry, May-05, Volume: 95 | Novel imidazo[2,1-b]-1,3,4-thiadiazoles as promising antifungal agents against clinical isolate of Cryptococcus neoformans. |
| AID637613 | Antibacterial activity against Escherichia coli after 24 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID278317 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 25 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID540945 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pH205 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID522053 | Antimicrobial activity against Klebsiella pneumoniae isolate KpL expressing beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID420825 | Antibacterial activity against Staphylococcus aureus after 18 hrs by macro dilution test | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID562748 | Antimicrobial activity against Klebsiella pneumoniae AH24-270 expressing blaCTX-M-71 gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID434250 | Maximum efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID279183 | Antibacterial activity against Escherichia coli DH10B expressing recombinant beta lactamase LAP1 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID325444 | Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID521325 | Antimicrobial activity against beta lactamase-nonproducing ampicillin-resistant Haemophilus influenzae MSC06663 isolate harboring Met377Ile, Ser385Thr and Asn526Lys mutations in penicillin-binding protein 3 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes. |
| AID532219 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus isolate 4 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID555682 | Antimicrobial activity against Escherichia coli DH10B by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID395153 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID575090 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID562816 | Antimicrobial activity against Escherichia coli J53 harboring pEK204 plasmid encoding CTX-M extended-spectrum beta-lactamases in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID1545449 | Antibacterial activity against Staphylococcus aureus assessed as zone inhibition at 100 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID573766 | Antibacterial activity against Citrobacter youngae isolate CyB38 harboring blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID558005 | Antimicrobial activity in Clostridium hastiforme by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID557496 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID519641 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-3 gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID1230215 | Antibacterial activity against Enterococcus faecalis CIP 103214 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID434485 | Antimicrobial activity against Streptococcus pneumoniae WT3 infected in bolus iv dosed Chinchilla lanigera assessed as log reduction in bacterial count within 5 hrs of additional local drug administration into intra-middle ear | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID524244 | Antimicrobial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID544438 | Antimicrobial activity against Escherichia coli MC4100A expressing beta-lactamase TEM-1 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1577946 | Antimicrobial activity against Pseudomonas aeruginosa KW799 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID1161148 | Antimicrobial activity against Staphylococcus aureus OXFORD after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID138312 | The compound was evaluated in vivo for the therapeutic efficacy at 0.1 mg/kg in mouse infection model; 0/8 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID722030 | Antibacterial activity against Proteus vulgaris ATCC 35659 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives. |
| AID1662857 | Bactericidal activity against clinical isolate amoxicillin resistance Staphylococcus aureus | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action. |
| AID541005 | Antimicrobial activity against Burkholderia cenocepacia 07-34 expressing beta-lactamase PenB1 in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID557474 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID564216 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 harboring plasmid PH98 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID117524 | Beta-lactamase inhibitory activity against Staphylococcus aureus A9606 using oral mouse protection test in mice | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID366945 | Antibacterial activity against Helicobacter pylori clinical isolates at 1 ug/disk after 3 to 5 days by filter paper disk diffusion method | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8 | Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds. |
| AID588210 | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | 2010 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12 | A predictive ligand-based Bayesian model for human drug-induced liver injury. |
| AID531616 | Antimicrobial activity against Escherichia coli JM109 harboring pE1 plasmid expressing beta-lactamase SHV-11 by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID278297 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse lung at 7 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID522003 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp7A expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID562740 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBC-CTX-M-15 plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID490318 | Antimicrobial activity against Mycobacterium phlei ATCC 10142 at 25 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID340730 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase TEM-ES by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID87953 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 81 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID557481 | Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1634994 | Antimicrobial activity against Pseudomonas aeruginosa 5482 assessed as reduction in bacterial growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID549207 | Antimicrobial activity against Bacillus megaterium after 24 hrs by ELISA | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. |
| AID567321 | Antimicrobial activity against Escherichia coli ML4901 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID434479 | Terminal half life in Chinchilla lanigera at 40 mg/kg, iv | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573959 | Antibacterial activity against Klebsiella pneumoniae Kp149 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID558601 | Antimicrobial activity against Streptococcus pneumoniae isolate 24 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID138315 | The compound was evaluated in vivo for the therapeutic efficacy at 0.32 mg/kg in mouse infection model; 1/8 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID1162169 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition in presence of 2.5 mg/ml clavulanate | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | SAR analysis of new anti-TB drugs currently in pre-clinical and clinical development. |
| AID278278 | Cmax in leukopenic mouse with renal failure at 25 mg/kg, sc after 0.5 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID422494 | Antimicrobial activity against Escherichia coli BL21 (DE3) by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID495840 | Hydrolytic activity of beta-lactamase VIM-1 in Escherichia coli DH5alpha expressing pBCLL/39H by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID1278840 | Antimycobacterial activity against Mycobacterium marinum ATCC BAA-535 infected in Zebra fish model assessed as reduction in bacterial load at 10 mg/kg, po administered for 7 days measured after 14 days by MPN assay | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors. |
| AID434249 | Maximum efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID234044 | Therapeutic efficacy at an oral dose of 2 mg/kg in guinea pig; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID278305 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse lung at 7 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID557683 | Antimicrobial activity in Prevotella oralis group by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID571933 | Antimicrobial activity against Escherichia coli MC4100 harboring strong promoter in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID522066 | Antimicrobial activity against Escherichia coli isolate TOP10 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID138320 | The compound was evaluated in vivo for the therapeutic efficacy at 3.2 mg/kg in mouse infection model; 7/8 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID1533876 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 1449 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID511295 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-13 plasmid in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID1533866 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2919 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID519629 | Antimicrobial activity against Escherichia coli JM83 without producing beta-lactamase OXA-63 after 3 days by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID1533871 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3580 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID573953 | Antibacterial activity against Morganella morganii Mm1229 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID573955 | Antibacterial activity against Klebsiella pneumoniae Kp3799 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID402027 | Antimicrobial activity against Helicobacter pylori ATCC 43504 after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID402030 | Antimicrobial activity against Helicobacter pylori Sa-2 isolate after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID132927 | Antibacterial activity against Helicobacter felis strain in mouse. | 1998 | Journal of medicinal chemistry, May-21, Volume: 41, Issue:11 | Structure-activity relationship of 2-[[(2-pyridyl)methyl]thio]-1H- benzimidazoles as anti Helicobacter pylori agents in vitro and evaluation of their in vivo efficacy. |
| AID568387 | Antimicrobial activity against Escherichia coli after 72 hrs by microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID564535 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue insertion at 215 position and R210P substitution by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID546433 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-5 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID606246 | Antibacterial activity against Salmonella Typhimurium after 18 hrs by macro-dilution test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID564214 | Antimicrobial activity against Acinetobacter baumannii ATCC 135040 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID419823 | Antibacterial activity against Escherichia coli at 100 ug after 24 hrs by agar disc-diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles. |
| AID558637 | Antimicrobial activity against Streptococcus pneumoniae 6 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1161178 | Antimicrobial activity against Staphylococcus aureus isolate OGA833 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID117521 | Beta-lactamase inhibitory activity against Staphylococcus aureus A15091 using oral mouse protection test in mice | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID372604 | Antibacterial activity against Escherichia coli BER1 producing TEM-158 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID522064 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEcA containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID691701 | Antibacterial activity against Escherichia coli MTCC 82 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID558336 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1618 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID560115 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG3 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID567475 | Antimicrobial activity against gBLPACR-2 Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID87951 | Minimum inhibitory concentration against Helicobacter pylori (Helicobacter pylori) ARHp strain 206 | 2002 | Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19 | Novel structures derived from 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, Part 2. |
| AID557397 | Antimicrobial activity against Helicobacter pylori clinical isolate by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. |
| AID228170 | Inhibition of histamine-stimulated gastric acid secretion in lumen-perfused stomach of anesthetized rats after 1 mg/kg iv administration; ND is No Data. | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues. |
| AID43007 | Antimicrobial activity was measured against Clostridium perfringens organism; range is between (0.025-0.05) | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID536454 | Antimicrobial activity against Escherichia coli at 50 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID66922 | Antibacterial activity against Enterococcus faecalis was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID394495 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID531441 | Antibacterial activity against Streptococcus pneumoniae serotype 15A assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID378076 | Antimicrobial activity against Helicobacter pylori ATCC 43504 at 0.25 ug/disk after 4 days by disk diffusion method | 2006 | Journal of natural products, Aug, Volume: 69, Issue:8 | Chemical constituents from the peels of Citrus sudachi. |
| AID567318 | Antimicrobial activity against Escherichia coli TUM4670 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID264469 | Antibacterial activity against Streptococcus pneumoniae | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9 | Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID1662854 | Antibacterial activity against clinical isolate amoxicillin and ciprofloxacin resistance Staphylococcus aureus | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action. |
| AID434277 | Ratio of influx clearance to efflux clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 235 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID519648 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-3 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID351647 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID351649 | fCmax in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID43448 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Branhamella catarrhalis(27) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID495638 | Antimicrobial activity against Pseudomonas luteola expressing blaLUT-2 to blaLUT-6 at 2:1 ratio of compound to clavulanic acid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID200258 | Minimum inhibitory activity against Staphylococcus aureus A15091 | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID40359 | Stability towards beta-lactamase was determined in penicillinase | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID519630 | Antimicrobial activity against Escherichia coli JM83 harboring beta-lactamase OXA-63 after 3 days by Etest | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. |
| AID573749 | Antibacterial activity against Escherichia coli isolate Ec158 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1659471 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as induction of changes in mass spectral profile of bacteria by measuring decrease in peak at m/z 6320 and increase in peak at m/z 6405 at 1/16 to 1 times MIC uM by MALDI-TOF MS analysis | 2020 | Journal of medicinal chemistry, 08-27, Volume: 63, Issue:16 | Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening. |
| AID540956 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c2 plasmid expressing cephalosporinase CMY-2 by agar dilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID567326 | Antimicrobial activity against Escherichia coli ML4901 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID558322 | Antibacterial activity against bla gene-positive and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni NCTC 11168 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID558597 | Antimicrobial activity against Streptococcus pneumoniae 9 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID544572 | Antimicrobial activity against Escherichia coli ATCC 25922 by microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID557695 | Antimicrobial activity in Prevotella salivae by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID583652 | Antibacterial activity against Escherichia coli TOP10 expressing metallo-beta-lactamase NDM-1 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID568390 | Antimicrobial activity against coagulase positive Staphylococcus after 72 hrs by microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID574029 | Antibacterial activity against beta-lactamase producing Peptostreptococcus anaerobius assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID560134 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 assessed as Ratio of Kcat to Km by nitrocefin hydrolysis assay relative to benzylpenicillin | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID557498 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID573728 | Antibacterial activity against Klebsiella pneumoniae isolate Kp2730 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 and dfrA12-orfF-aadA2 arrays by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID88253 | In vitro antibacterial activity against Helicobacter pylori (CPY 2052) | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10 | A highly stereoselective synthesis of plaunotol and its thiourea derivatives as potent antibacterial agents against Helicobacter pylori. |
| AID544423 | Antimicrobial activity against Escherichia coli MC4100A harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID722032 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives. |
| AID467613 | Volume of distribution at steady state in human | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID205565 | Antibacterial activity against Staphylococcus epidermidis was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID531721 | Antibacterial activity against Bacteroides ovatus assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID1230209 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID559919 | Antibacterial activity against Escherichia coli TOP10 harboring beta-lactamase RTG4 gene by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID555287 | Antibacterial activity against atlA-deficient Enterococcus faecalis JH2-2 infected in New Zealand White rabbit assessed as bacterial count per gram vegetation at 50 mg/kg, im TID for 3 days administered 48 hrs post bacterial challenge (Rvb = 8.34+/-1.66 l | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID559922 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-V49 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID565179 | Antimicrobial activity against Staphylococcus aureus 8235 by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. |
| AID325159 | Antimicrobial activity against Escherichia coli | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID531432 | Antibacterial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID543393 | Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as log reduction in bacterial CFU per ml of blood at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured withi | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. |
| AID340728 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-9 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID147020 | Antimicrobial activity against Neisseria gonorrhoeae | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15 | Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles. |
| AID557476 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID572485 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NB01021 infected in po dosed BALB/c mouse administered 0, 4, 23 hrs post infection | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID434283 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID597167 | Antimicrobial activity against Escherichia coli after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID558624 | Antimicrobial activity against Streptococcus pneumoniae isolate 3455 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1142218 | Antimicrobial activity against Helicobacter pylori isolated from gastrointestinal disease patient after 72 hrs by Etest method | 2014 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11 | Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori. |
| AID294966 | Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 after 24 hrs by serial dilution method | 2007 | European journal of medicinal chemistry, Oct, Volume: 42, Issue:10 | Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. |
| AID326532 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis 1209 challenged with 10 times ID90 bacterial size inoculum in Wistar rat assessed as infection at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID424323 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID543482 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 murM, pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID544434 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase AmpC by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID1819813 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID573736 | Antibacterial activity against Klebsiella pneumoniae isolate Kp38009 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID434258 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID311534 | Antibacterial activity against Helicobacter pylori ATCC 43504 by agar dilution method | 2007 | Journal of natural products, Oct, Volume: 70, Issue:10 | Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. |
| AID559825 | Antimicrobial activity against Escherichia coli J53 harboring pCHE-B plasmid expressing blaSHV-5 gene by agar dilution in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID351642 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 3 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID521685 | Antimicrobial activity against Escherichia coli S1 expressing penicillinase TEM-1 in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID562405 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID557707 | Antimicrobial activity in Porphyromonas asaccharolytica by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID444053 | Renal clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID478871 | Antibacterial activity against Moraxella catarrhalis ATCC 23246 after overnight incubation by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9 | Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams. |
| AID393596 | Antimicrobial activity against Salmonella Typhimurium at 200 ug/mL after 24 hrs by disk diffusion method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID530821 | Antibacterial activity against Klebsiella pneumoniae 11978 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID557468 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae 3665 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID572274 | Antimicrobial activity against multiple drug-resistant Streptococcus pneumoniae ATCC 700677 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID573771 | Antibacterial activity against Fusobacterium varium assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID522051 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBEL expressing beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID531472 | Antibacterial activity against Bacteroides caccae assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID278307 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse blood at 7 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID434458 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 233 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID372614 | Ratio of Kcat to Km for Escherichia coli DH5alpha beta-lactamase TEM-158 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID521491 | Antibacterial activity against Pseudomonas aeruginosa KG2505 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID88255 | In vitro antibacterial activity against Helicobacter pylori (No. 7) | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10 | A highly stereoselective synthesis of plaunotol and its thiourea derivatives as potent antibacterial agents against Helicobacter pylori. |
| AID1774183 | Antibacterial activity against Enterococcus faecium DSM20477 assessed as growth inhibition by measuring minimal concentration at OD600 by visual inspection with iron-limited media incubated for 24 hrs | 2021 | Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20 | Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens. |
| AID564540 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1662856 | Antibacterial activity against clinical isolate amoxicillin resistance Staphylococcus aureus | 2020 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13 | Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action. |
| AID278328 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-15986 infected Swiss mouse lung at 7 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID571939 | Antimicrobial activity against Escherichia coli MC4100 expressing promoterless beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID660265 | Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID530347 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M carrying blaCTX-M-15 and pQep plasmid carrying qepA2 gene by disk diffusion method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID582968 | Antimicrobial activity against beta-lactamase A and B-deficient Yersinia enterocolitica GY5718 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID395158 | Antibacterial activity against Staphylococcus aureus SP-N2 after 16 hrs at 36 degC by microdilution method | 2009 | European journal of medicinal chemistry, Jan, Volume: 44, Issue:1 | 2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
| AID419821 | Antibacterial activity against Staphylococcus aureus at 100 ug after 24 hrs by agar disc-diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles. |
| AID588077 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene infected in rabbit assessed as bacterial load per gram of vegetation at 50 mg/kg, im administered three times a day starting 48 hrs po | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID1161186 | Antimicrobial activity against Staphylococcus aureus isolate 934324 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID556341 | Ratio of Kcat/Km for Salmonella enterica serotype Westhampton beta-lactamase CTX-M-53 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID279186 | Activity of Enterobacter cloacae S3 isolate beta lactamase LAP1 expressed in Escherichia coli DH10B | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1. |
| AID1577950 | Antimicrobial activity against Pseudomonas aeruginosa PAO1 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID558617 | Antimicrobial activity against Streptococcus pneumoniae isolate 3260 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID519650 | Antimicrobial activity against Escherichia coli EPI300 harboring plasmid pCC1 by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID558537 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter coli isolate P321 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID573965 | Antibacterial activity against Citrobacter youngae CyB38 transconjugant harboring blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID564217 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 harboring plasmid PH98 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID573578 | Antibacterial activity against beta-lactamase producing Bacteroides uniformis assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID585204 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-6 K104, S170 mutant in presence of clavulanic acid at compound/inhibitor ratio of 2:1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID544525 | Antimicrobial activity against Borrelia garinii isolate PSth after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID559818 | Antimicrobial activity against Escherichia coli J53 harboring pCHE-A plasmid expressing blaGES-5 gene by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID1246792 | Antibacterial activity against Proteus vulgaris after 24 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID544431 | Antimicrobial activity against translocase tatC-deficient Escherichia coli B1LK0A harboring beta-lactamase L2 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID114732 | Tested for the antimicrobial activity against Streptococcus pyogenes (ST139) in mice, subcutaneously | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID531670 | Antibacterial activity against Streptococcus pneumoniae serotype 22 by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID564550 | Antimicrobial activity against Escherichia coli TOP10 harboring pTOPO plasmid by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID522387 | Antimicrobial activity against Escherichia coli TOP10 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID531435 | Antibacterial activity against Streptococcus pneumoniae serotype 19A assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID573742 | Antibacterial activity against Klebsiella pneumoniae isolate Kp3799 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID684243 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate cpu2736 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID528599 | Antimicrobial activity against blaKPC-2 and blaTEM-1 producing Escherichia coli 2138 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID340735 | Antimicrobial activity against Escherichia coli HB101 harboring pBC-IND-5 plasmid containing metallo-beta-lactamase IND5 assessed as drug level at which microbial resistance was observed by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. |
| AID557520 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID573963 | Antibacterial activity against Klebsiella pneumoniae Kp204 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID179688 | In vitro gastric mucosa concentration administered perorally at 20 mg/kg was determined in rats at 4 hr; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID531429 | Antibacterial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID573945 | Antibacterial activity against Enterobacter cloacae El1573 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID520972 | Antibacterial activity against Escherichia coli harboring pBC633 plasmid expressing blaKPC gene by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID374362 | Ratio of Kcat to Km of Aeromonas caviae A324R metallo-beta-lactamase IMP-19 expressed in Escherichia coli DH5alpha by computerized microacidimetric method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. |
| AID1486238 | Antibacterial activity against methicillin-resistant Staphylococcus aureus EMRSA-15 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID283321 | Antimicrobial activity against Escherichia coli XL10/vector | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | Detection of a new SHV-type extended-spectrum beta-lactamase, SHV-31, in a Klebsiella pneumoniae strain causing a large nosocomial outbreak in The Netherlands. |
| AID1230245 | Antibacterial activity against Staphylococcus intermedius N987 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID88254 | In vitro antibacterial activity against Helicobacter pylori (NCTC 11637) | 1999 | Bioorganic & medicinal chemistry letters, May-17, Volume: 9, Issue:10 | A highly stereoselective synthesis of plaunotol and its thiourea derivatives as potent antibacterial agents against Helicobacter pylori. |
| AID1161157 | Antimicrobial activity against Streptococcus pneumoniae N1387 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID555282 | Antibacterial activity against Enterococcus faecalis JH2-2 assessed as decrease in decrease in bacterial count at 2 ug/ml after 24 hrs by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID278321 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse blood at 7 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID434252 | Maximum efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID522013 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBEL expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID549336 | Antimicrobial activity against Escherichia coli isolate 49 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID560132 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay relative to benzylpenicillin | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID1577953 | Antimicrobial activity against Pseudomonas aeruginosa PA4 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID522017 | Antimicrobial activity against Providencia rettgeri isolate expressing beta-lactamase OXA-48 and TEM-101 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID529750 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate harboring fst1 mutant gene after 20 to 24 hrs by broth microdilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID521992 | Antimicrobial activity against Escherichia coli isolate J53 harboring pA-1 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID528609 | Antimicrobial activity against blaKPC-2 and blaTEM-1 Escherichia coli 2138 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID557494 | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1888847 | Antibacterial activity against Staphylococcus aureus 1199 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID1230239 | Antibacterial activity against Staphylococcus aureus CIP 53156 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID322324 | Antibacterial activity against Escherichia coli INSRA5924 isolates expressing CTX-M-32 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID495906 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-4 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID444052 | Hepatic clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID535702 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID625277 | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of less concern for DILI | 2011 | Drug discovery today, Aug, Volume: 16, Issue:15-16 | FDA-approved drug labeling for the study of drug-induced liver injury. |
| AID220254 | In Vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Yersinia species(20) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID467611 | Dissociation constant, pKa of the compound | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11 | Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID1634993 | Antimicrobial activity against Escherichia coli assessed as reduction in bacterial growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID278322 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse blood at 15 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID558001 | Antimicrobial activity in Clostridium clostridioforme by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID495794 | Antimicrobial activity against Pseudomonas fluorescens isolate PF-1 expressing beta-lactamase BIC-1 by Etest in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID540944 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pA172 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID114731 | Tested for the antimicrobial activity against Streptococcus pyogenes (ST139) in mice, perorally | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID234039 | Therapeutic efficacy at an oral dose of 0.1 mg/kg in mouse | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID285263 | Antimicrobial activity against Escherichia coli DH5-alpha TC1295 isolate expressing TEM-1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID1294611 | Antibacterial activity against Enterococcus faecalis ATCC 25912 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID495920 | Antimicrobial activity in Escherichia coli TOP10 strain harbouring recombinant plasmid VIM-1 by Etest in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID573960 | Antibacterial activity against Citrobacter koseri Ck211 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID567325 | Antimicrobial activity against Escherichia coli ML4909 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID529747 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae isolate after 20 to 24 hrs by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID561104 | Antibacterial activity against Pasteurella multocida BB1038 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB1005 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID681347 | TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells | 1997 | The American journal of physiology, 11, Volume: 273, Issue:5 | Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. |
| AID326500 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis UCN41 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID567473 | Antimicrobial activity against gBLPAR-TEM1 Haemophilus influenzae by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | In vitro activity of tebipenem, a new oral carbapenem antibiotic, against beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. |
| AID1533862 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3267 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID402035 | Antimicrobial activity against Helicobacter pylori ATCC 43504 at 250 ng/disk after 4 days by disk diffusion method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID531615 | Antimicrobial activity against Klebsiella pneumoniae Kp2792 expressing beta-lactamase SHV-56 by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID558623 | Antimicrobial activity against Streptococcus pneumoniae isolate 3412 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID310253 | Antimicrobial activity against Staphylococcus aureus ATCC 6538p | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives. |
| AID51015 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Clostridium perfringens(27) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID573808 | Antibacterial activity against Prevotella bivia assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID370911 | Antibacterial activity against Staphylococcus aureus at 10 to 100 ug/mL after 18 hrs by halo zone test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID599623 | Antibacterial activity against Micrococcus luteus AGD1 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID1161181 | Antimicrobial activity against Staphylococcus aureus isolate RN1030 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID557506 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID498872 | Antimicrobial activity against Acinetobacter baumannii B9 containing carbapenemase blaOXA-23 gene assessed as growth inhibition by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate. |
| AID531475 | Antibacterial activity against Bacteroides thetaiotaomicron assessed as percent resistant isolates by agar dilution me in presence of clavulanate thod | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID530603 | Antibacterial activity against Aeromonas sp. isolate A72 by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID521349 | Antimicrobial activity against Streptococcus pneumoniae isolate 909 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID587991 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 at 2 ug/ml after 24 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID278289 | T>MIC in leukopenic mouse with renal failure at 15 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID278326 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 25 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID278324 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 7 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID562780 | Antimicrobial activity against Escherichia coli DH10B by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID1246788 | Antibacterial activity against Staphylococcus aureus after 24 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID1438609 | Antibacterial activity against Listeria monocytogenes isolate 015189074801 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID434276 | Ratio of influx clearance to efflux clearance in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID532020 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus isolate 3 | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID1706286 | Protein binding in plasma (unknown origin) | 2020 | European journal of medicinal chemistry, Dec-15, Volume: 208 | β-lactam antibiotics: An overview from a medicinal chemistry perspective. |
| AID1546123 | Antifungal activity against Aspergillus niger assessed as zone of inhibition at 250 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID543419 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID1633937 | Antimicrobial activity against Streptococcus pneumoniae Ery-2 in presence of clavulanic acid | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections. |
| AID573803 | Antibacterial activity against Prevotella buccae assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID562329 | Antimicrobial activity against Chryseobacterium indologenes 597 expressing metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID285255 | Antimicrobial activity against Escherichia coli DH5-alpha CF1179 isolate expressing CMT and TEM1 by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID558329 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P305 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID434468 | Unbound plasma clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 233 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID535670 | Antimicrobial activity against beta-lactamase negative, ampicillin-resistant Haemophilus influenzae expressing fst1 mutant gene assessed as resistant isolates by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID561109 | Antibacterial activity against Pasteurella multocida BB1043 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID573764 | Antibacterial activity against Acinetobacter isolate A74510 harboring blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID555284 | Antibacterial activity against atlA-deficient Enterococcus faecalis JH2-2 assessed as decrease in decrease in bacterial count at 2 ug/ml after 6 hrs by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID522031 | Antimicrobial activity against Klebsiella pneumoniae isolate KpB expressing OXA-48 and CTX-M-15 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID568383 | Antimicrobial activity against coagulase positive Staphylococcus after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID156204 | Binding to POPC/GMI liposomes using biosensor system | 2000 | Journal of medicinal chemistry, Jun-01, Volume: 43, Issue:11 | SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans. |
| AID207487 | Antibacterial activity was evaluated against Staphylococcus aureus (209P JC-1) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID543483 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a and Streptococcus pneumoniae 72521 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1230240 | Antibacterial activity against Staphylococcus aureus CIP 5710 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID569352 | Antibacterial activity against Enterococcus faecium X7501 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID1755790 | Antimicrobial activity against Helicobacter pylori clinical isolate3 for 3 days by agar dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID549204 | Antimicrobial activity against Enterobacter aerogenes after 24 hrs by ELISA | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12 | Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. |
| AID522008 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-2 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID555281 | Antibacterial activity against Enterococcus faecalis JH2-2 assessed as decrease in decrease in bacterial count at 2 ug/ml after 6 hrs by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID434254 | Influx clearance from plasma to middle ear fluid Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID393599 | Antimicrobial activity against Streptococcus pyogenes after 24 hrs by broth microdilution method | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis, characterization and in vitro antibacterial activity of new steroidal 5-en-3-oxazolo and thiazoloquinoxaline. |
| AID521151 | Antibacterial activity against intracellular Listeria monocytogenes EGDe infected in bone marrow-derived BALB/c mouse macrophage assessed as reduction in bacterial count at four-eitght times of MIC after 3 hrs | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. |
| AID521344 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-343 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID294963 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by serial dilution method | 2007 | European journal of medicinal chemistry, Oct, Volume: 42, Issue:10 | Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. |
| AID584838 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID595732 | Antimicrobial activity against Staphylococcus aureus after 24 hrs by broth microdilution method | 2011 | European journal of medicinal chemistry, May, Volume: 46, Issue:5 | Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. |
| AID519646 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2322 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID521485 | Antibacterial activity against Klebsiella pneumoniae KN2303 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID326508 | Tmax in Enterococcus faecalis infected Wistar rat at single administration of 2 to 3 g, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID71055 | Compound was tested for photoinhibition of Escherichia coli (CIP 548T); Sensitive | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 | Nitroglycosylated meso-arylporphyrins as photoinhibitors of gram positive bacteria. |
| AID536468 | Antimicrobial activity against Escherichia coli at 100 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID543269 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1755789 | Antimicrobial activity against Helicobacter pylori SS1 clinical isolate2 for 3 days by agar dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID24185 | Distribution coefficient in octanol/water at pH 7.4 | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID544574 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8128 expressing bla SHV-105 gene by microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID469296 | Ratio of compound to grisofulvin activity against Syncephalastrum racemosum at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID434265 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as unbound Km at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID541855 | Antimicrobial activity against Escherichia coli ATCC 29522 by microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. |
| AID564546 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid carrying entire blaAmpC gene with alanine residue deletion at 215 position by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID564529 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID562407 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID562815 | Antimicrobial activity against Escherichia coli J53 harboring pEK499 plasmid encoding CTX-M extended-spectrum beta-lactamases in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID543282 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b genes and Streptococcus pneumoniae 3191 genomic DNA by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID206180 | Tested for inhibition of visible growth of Staphylococcus aureus, benzyl-penicillin sensitive | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID278287 | AUC in human at 1 g, po | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1694322 | Antibacterial activity against Staphylococcus aureus MRSA-2 assessed as bacterial growth inhibition in Mueller-Hinton broth 2 measured every 24 hrs for 5 days by serial dilution method | 2021 | Bioorganic & medicinal chemistry, 02-15, Volume: 32 | Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. |
| AID285258 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha CL1179 isolate expressing pBK-TEM-152 and CMT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID1486241 | Antibacterial activity against Staphylococcus aureus A1988 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID529617 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID535708 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 by agar dilution method in presence of 2 mg/liter clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID156428 | The compound was tested against Penicillinase (TEM) and its stability towards beta-lactamase was evaluated | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID1161169 | Antimicrobial activity against Staphylococcus aureus isolate MILES HALL after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID558605 | Antimicrobial activity against Streptococcus pneumoniae isolate 1146 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID351636 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID558611 | Antimicrobial activity against Streptococcus pneumoniae isolate 1564 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID351632 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 2 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1713539 | Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA substrate | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22 | ArgTX-636, a polyamine isolated from spider venom: A novel class of melanogenesis inhibitors. |
| AID1546153 | Antimicrobial activity against Bacillus subtilis assessed as zone of inhibition at 30 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID540951 | Antimicrobial activity against Klebsiella pneumoniae HP205 expressing CMY-36 cephalosporinase by agar dilution method in presence of clavulanic acid in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID373214 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 to ratio of Kcat/Km for Bacillus anthracis beta-lactamase Bla1 | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID495916 | Antimicrobial activity in Escherichia coli DIH-1 expressing beta-lactamase VIM-19 by Etest in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID372606 | Antibacterial activity against rifampin-resistant Escherichia coli C600 transconjugant producing beta-lactamase of pI 5.2 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID608607 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID1246789 | Antibacterial activity against Staphylococcus aureus after 5 days by microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID278286 | AUC in leukopenic mouse with renal failure at 25 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID522043 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-1 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1577949 | Antimicrobial activity against Pseudomonas aeruginosa 61 under iron-deficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID434481 | Cmax in Chinchilla lanigera at 40 mg/kg, iv followed by local dose of 13 to 235 ug/kg into intra-middle ear | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID1230222 | Antibacterial activity against Enterococcus faecium N490 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID434296 | Influx clearance from plasma to middle ear fluid Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID569358 | Antibacterial activity against Streptococcus pneumoniae N1387 by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID562332 | Antimicrobial activity against Escherichia coli DH5alpha harboring metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID565182 | Bacteriostatic activity against Staphylococcus aureus isolate 8235 assessed as log reduction in bacterial count at 32 times MIC after 24 hrs by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. |
| AID1347489 | Antibacterial activity against Serratia marcescens assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID87927 | Antibacterial activity against Helicobacter pylori HP003 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID562335 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid pBC-SK after 18 hrs by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID1755788 | Antimicrobial activity against Helicobacter pylori SS1 incubated for 3 days by agar dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID519639 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2322 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID434473 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID469308 | Ratio of compound to amoxicilline activity against Pseudomonas aeruginosa at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID373053 | Antimicrobial activity against Escherichia coli DH10B by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID557997 | Antimicrobial activity in Clostridium butyricum by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID535705 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-A S287N mutant protein by agar dilution method in presence of 2 mg/liter clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID326266 | Antibacterial activity against Escherichia coli K12 carrying pR3521 encoding SCO1 by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID322319 | Antibacterial activity against Escherichia coli DH5 alpha isolates by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID207253 | Minimal inhibitory concentration against Staphylococcus aureus Smith | 1996 | Journal of medicinal chemistry, Aug-30, Volume: 39, Issue:18 | The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity. |
| AID278300 | Bacterial clearance in Streptococcus pneumoniae P-52181 infected Swiss mouse blood at 15 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID495903 | Antimicrobial activity in Escherichia coli DIH-1 expressing beta-lactamase VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID562818 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pEK516 plasmid encoding CTX-M extended-spectrum beta-lactamases in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. |
| AID278291 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse blood at 7 mg/kg, sc after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID543416 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 transconjugant by broth microdilution method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID1533860 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2895 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID521142 | Antibacterial activity against extracellular Listeria monocytogenes EGDe at MIC by time-kill study | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. |
| AID522063 | Antimicrobial activity against Escherichia coli isolate A expressing beta-lactamase OXA-48 and TEM-150 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID434248 | Maximum efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID558640 | Antimicrobial activity against Streptococcus pneumoniae 9 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID684229 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate cpu0587 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID434294 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 233 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID69916 | Antibacterial activity against Escherichia coli K-12 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID531436 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID372610 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-1 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID540949 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBCSK plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID402028 | Antimicrobial activity against Helicobacter pylori SS1 after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID1347488 | Antibacterial activity against Staphylococcus aureus assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID278273 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae P-54988 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID557482 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID434291 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID567320 | Antimicrobial activity against Escherichia coli ML4909 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID42863 | Antimicrobial activity was measured against Clostridium difficile organism; range is between (0.1-0.78) | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID530820 | Antibacterial activity against Escherichia coli J53 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID227700 | Anticonvulsant activity | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. |
| AID88105 | The compound was evaluated in vitro for the minimum inhibitory concentration against Helicobacter pylori (FP1757). | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID529620 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae assessed as resistant isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID370916 | Antibacterial activity against Streptococcus pyogenes after 18 hrs by macro dilution test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID1726842 | Synergistic antibacterial activity against Staphylococcus aureus assessed as amoxicillin MIC encapsulated by compound | 2021 | RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6 | Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity. |
| AID583653 | Antibacterial activity against Escherichia coli TOP10 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID438298 | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID557985 | Antimicrobial activity in Clostridium bifermentans by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1546119 | Antimicrobial activity against Bacillus cereus assessed as zone of inhibition at 250 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID520983 | Antibacterial activity against Klebsiella pneumoniae GR by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID544573 | Antimicrobial activity against Escherichia coli DH5[alpha] isolate GC 8133 expressing bla TEM-55 gene by microdilution method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155 |
| AID519980 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-55 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID518523 | Antimicrobial activity against Escherichia coli TOP10 after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID1230213 | Antibacterial activity against Enterococcus casseliflavus CIP 103018 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID278859 | Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID543394 | Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as log reduction in bacterial CFU in brain at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 1 hr | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. |
| AID559828 | Antimicrobial activity against Pseudomonas aeruginosa PU21 by agar dilution in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID377035 | Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 after 24 hrs by disk diffusion assay | 2005 | Journal of natural products, Jan, Volume: 68, Issue:1 | Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity. |
| AID1230236 | Antibacterial activity against Staphylococcus aureus ATCC 9144 oxford after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1525346 | Antibacterial activity against Pseudomonas aeruginosa KW799/61 after 20 hrs under iron-rich medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID557269 | Antimicrobial activity against Streptococcus pneumoniae 1394 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID522022 | Antimicrobial activity against Escherichia coli isolate J53 harboring pEnc2 containing beta-lactamase OXA-48 located within transposon Tn1999 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID147155 | Compound was evaluated for antimicrobial activity against Neisseria gonorrhoeae | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID1161151 | Antimicrobial activity against Enterococcus faecium X7501 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID525545 | Antimicrobial activity against Haemophilus influenzae Rd KW20 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID429079 | Antibacterial activity against Klebsiella pneumoniae Greece producing KPC-2 beta-lactamase by E test method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. |
| AID26400 | pKa value of the compound. (extrapolated value) | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID557467 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae 3243 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID722031 | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Synthesis and evaluation of antibacterial activity of 7-alkyloxy-4,5-dihydro-imidazo[1,2-a]quinoline derivatives. |
| AID198016 | MIC required to inhibit 90% of the growth of Staphylococcus epidermidis (n = 10) | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID544424 | Antimicrobial activity against Escherichia coli CU164A harboring beta-lactamase CTX-M-14 by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID530351 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M plasmid carrying blaCTX-M-15 gene by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID434270 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as Vmax at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID558629 | Antimicrobial activity against Streptococcus pneumoniae isolate 3791 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID535061 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pYMAb3 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID524245 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID209260 | Tested for inhibition of visible growth of Streptococcus faecalis | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID1294618 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID278280 | Half life in leukopenic mouse with renal failure at 7 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID519649 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID278325 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 15 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID521487 | Antibacterial activity against Pseudomonas aeruginosa 2404 plasmid by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID68542 | Tested for inhibition of visible growth of Enterobacter cloacae | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID394496 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID434280 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID585202 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-2 E104, N170 mutant in presence of clavulanic acid at compound/inhibitor ratio of 2:1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1533869 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 2224 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID637610 | Antibacterial activity against Xanthomonas oryzae at 30 ug/ml after 24 hrs by agar well diffusion method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID372609 | Antibacterial activity against Escherichia coli DH5alpha producing beta-lactamase TEM-35 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID522385 | Antimicrobial activity against Aeromonas enteropelogenes M1 hyperproducing beta-lactamase AmpC | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID301022 | Antibacterial activity against Escherichia coli ESS 2231 after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID573949 | Antibacterial activity against Klebsiella pneumoniae Kp38009 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID223214 | Inhibition of histamine-stimulated chronotropic response in isolated guinea pig right atrium at 1*10e-6 g/mL; ND is No Data. | 2002 | Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1 | Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues. |
| AID557489 | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID575086 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID684228 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate cpu0211 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID531442 | Antibacterial activity against Streptococcus pneumoniae serotype 33 assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID588220 | Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset | 2008 | Toxicology mechanisms and methods, , Volume: 18, Issue:2-3 | Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. |
| AID555289 | Ratio of MBC to MIC in atlA-deficient Enterococcus faecalis JH2-2 | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID434455 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID573804 | Antibacterial activity against Prevotella bivia assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID543262 | Antimicrobial activity against Streptococcus pneumoniae R6 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID575096 | Antimicrobial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID278294 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse lung at 15 mg/kg, sc after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID278314 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse lung at 15 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID529749 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae isolate after 20 to 24 hrs by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID21252 | Partition coefficient by HPLC as an index of polarity; Not tested | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID1755797 | Antimicrobial activity against Helicobacter pylori clinical isolate1 for 3 days by agar dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID524246 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID558593 | Antimicrobial activity against Streptococcus pneumoniae 5 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID495639 | Antimicrobial activity against Escherichia coli DH10B transfected with pBK-L3 expressing blaLUT-1 at 2:1 ratio of compound to clavulanic acid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID531619 | Antimicrobial activity against Escherichia coli JM109 by agar dilution method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID560131 | Activity of recombinant beta-lactamase RTG4 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID1577959 | Antimicrobial activity against Klebsiella pneumoniae X68 under iron-sufficient condition by CLSI protocol based broth microdilution method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | An overview of recent progress in siderophore-antibiotic conjugates. |
| AID106700 | Antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) PHLS M1 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID469298 | Ratio of compound to grisofulvin activity against Candida albicans at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID584841 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER6 by agar dilution method in presence of 4 ug/ml of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID301024 | Antifungal activity against Aspergillus fumigatus after 48 hrs by agar well diffusion technique | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Synthesis and antimicrobial evaluation of new chalcones containing piperazine or 2,5-dichlorothiophene moiety. |
| AID558621 | Antimicrobial activity against Streptococcus pneumoniae isolate 3346 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID582967 | Antimicrobial activity against beta-lactamase B-deficient Yersinia enterocolitica GY5542 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID529643 | Antimicrobial activity against Pseudomonas aeruginosa 9551 expressing beta-lactamase VIM-15 obtained from urine of patient by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID351653 | Ratio of unbound to total drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID495804 | Antimicrobial activity against Klebsiella pneumoniae 2878 strain expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID495656 | Antimicrobial activity against Escherichia coli TOP10 expressing recombinant beta-lactamase BEL-2 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID522036 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp5A expressing beta-lactamase OXA-48 and SHV-5 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID561112 | Antibacterial activity against Pasteurella multocida BB1046 harboring plasmid pB1003 bearing blaROB-1 gene and plasmid pB1002 bearing strA, sul2 genes by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID573753 | Antibacterial activity against Serratia marcescens isolate Sm203 harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID571936 | Antimicrobial activity against Escherichia coli MC4100 harboring weak promoter and active promoter P2 in beta-lactamase GES-1 by Etest | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. |
| AID303797 | Permeability across artificial membrane by PAMPA | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24 | Multiple N-methylation by a designed approach enhances receptor selectivity. |
| AID599624 | Antibacterial activity against Salmonella Typhimurium isolate 11 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID438297 | Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X preincubated for 1 hr before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19 | Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID1246791 | Antibacterial activity against Escherichia coli after 5 days by microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID369643 | Antibacterial activity against Acinetobacter haemolyticus expressing carbapenemase-encoding blaOXA-40 gene by Etest method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital. |
| AID557492 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID575085 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID470907 | Antibacterial activity against Pseudomonas aeruginosa at 100 ug after 24 to 48 hrs by diffusion agar technique | 2009 | European journal of medicinal chemistry, Sep, Volume: 44, Issue:9 | Convenient synthesis and antimicrobial evaluation of some novel 2-substituted-3-methylbenzofuran derivatives. |
| AID481440 | Dissociation constant, pKa of the compound | 2010 | Journal of medicinal chemistry, May-13, Volume: 53, Issue:9 | How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? |
| AID540942 | Antimicrobial activity against Salmonella enterica serotype Newport AM17274 expressing CMY-31 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID531602 | Antimicrobial activity against Escherichia coli JM109 harboring pE1MD plasmid expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID530601 | Antibacterial activity against Escherichia coli J53 harboring plasmid pAM carrying beta-lactamase PER-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID718846 | Antibacterial activity against Staphylococcus aureus after 18 hrs by macrodilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives. |
| AID532242 | Antibacterial activity against macrolide-lincosamide-streptogramin B-negative, beta-lactamase-positive, methicillin-susceptible Staphylococcus aureus ATCC 29213 in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. |
| AID351637 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 10 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID606243 | Antibacterial activity against Escherichia coli measured at MIC after 18 hrs by halo zone test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID564543 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid carrying entire blaAmpC gene by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID409954 | Inhibition of mouse brain MAOA | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21 | Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID531684 | Antimicrobial activity against Acinetobacter baumannii ATCC 15151T containing plasmid harboring OXA-58-3 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID543273 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID400383 | Antibacterial activity against Streptococcus pyogenes at 200 ug/100uL after 24 hrs by agar well diffusion method | 1998 | Journal of natural products, Feb, Volume: 61, Issue:2 | Antibacterial steroidal alkaloids from Sarcococca saligna. |
| AID351625 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID567322 | Antimicrobial activity against Proteus mirabilis TUM4660 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID718844 | Antibacterial activity against Pseudomonas aeruginosa after 18 hrs by macrodilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives. |
| AID557687 | Antimicrobial activity in Prevotella veroralis by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID144207 | Antimicrobial activity was measured against Neisseria gonorrhoeae organism; range is between (0.39-100). | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID684239 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis isolate cpu1561 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID562478 | Antimicrobial activity against rifampicin-resistant Escherichia coli A15 transconjugant expressing beta-lactamase SHV-12 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. |
| AID529460 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, SHV-12 and Oxa-9 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID420824 | Antibacterial activity against Escherichia coli at 30 ug/disk after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID521997 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp4A expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID529466 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase TEM-1, CTX-M-15 and Oxa-1 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID691698 | Antibacterial activity against Bacillus subtilis MTCC 2451 after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID206363 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of S. epidermidis(13) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID310255 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolate | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives. |
| AID494629 | Antibacterial activity against Escherichia coli UB1005 | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams. |
| AID520892 | Antibacterial activity against Achromobacter xylosoxidans TB1 in presence of 4 ug/ml clavulanic acid by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID495907 | Antimicrobial activity in Escherichia coli TOP10 strain harbouring recombinant plasmid VIM-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID556013 | Antibacterial activity against Helicobacter pylori infected in human assessed as bacterial eradication rate at 400 mg, po QD for 7 days | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Sitafloxacin and garenoxacin may overcome the antibiotic resistance of Helicobacter pylori with gyrA mutation. |
| AID1230207 | Antibacterial activity against Bacillus cereus N258 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID531426 | Antibacterial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1161164 | Antimicrobial activity against Staphylococcus aureus isolate CARTER 37 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID533204 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as resistant isolates by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID278336 | Effect on survival of Swiss mouse infected with penicillin-resistant Streptococcus pneumoniae P-12698 at 15 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID543392 | Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as increase in mouse survival at 50 mg/kg, ip administered 36 hrs postinfection every 12 hrs for 5 days | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. |
| AID402036 | Antimicrobial activity against Helicobacter pylori SS1 at 250 ng/disk after 4 days by disk diffusion method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID587999 | Bactericidal activity against 5 X 10'6 CFU/ml Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene at 2 ug/ml after 3 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID564533 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue insertion at 215 position by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1726820 | Antibacterial activity against Staphylococcus aureus MTCC 96 incubated for 14 to 16 hrs by micro broth dilution method | 2021 | RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6 | Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity. |
| AID278272 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae P-52181 | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID544977 | Antimicrobial activity against Klebsiella pneumoniae 52OmpA2Com | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. |
| AID520974 | Antibacterial activity against Escherichia coli harboring pBC2303 expressing blaKPC gene plasmid by Etest method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID490332 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 278533 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID541011 | Antimicrobial activity against Burkholderia cenocepacia 212 expressing beta-lactamase PenB3 in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID558631 | Antimicrobial activity against Streptococcus pneumoniae isolate 4755 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID502781 | Antibacterial activity against multidrug-resistant Helicobacter pylori v1354 | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID1726821 | Antibacterial activity against Escherichia coli MTCC 1687 incubated for 14 to 16 hrs by micro broth dilution method | 2021 | RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6 | Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity. |
| AID558609 | Antimicrobial activity against Streptococcus pneumoniae isolate 1397 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID549334 | Antimicrobial activity against Escherichia coli isolate 100 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID1230230 | Antibacterial activity against Listeria innocua E044 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID521345 | Antimicrobial activity against Streptococcus pneumoniae isolate k-637 obtained from CSF of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID529613 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae assessed as susceptible isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID46744 | Compound was evaluated for antimicrobial activity against Campylobacter jejuni | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID511290 | Antibacterial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID495792 | Antimicrobial activity against Escherichia coli DH10B harbouring recombinant plasmid pSau1 expressing beta-lactamase BIC-1 from Pseudomonas fluorescens PF-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID680869 | TP_TRANSPORTER: inhibition of Cefadroxil uptake (apical pH 5.5, Cefadroxil: 1000 uM, Amoxicillin: 10000 uM) in Caco-2 cells | 1996 | The Journal of pharmacology and experimental therapeutics, May, Volume: 277, Issue:2 | Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. |
| AID535059 | Antimicrobial activity against Acinetobacter genomic species 13TU by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID522029 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp11978 expressing beta-lactamase OXA-48, SHV-2a and TEM-1 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID528610 | Antimicrobial activity against Escherichia coli TOP10 harboring blaKPC-2 and blaTEM-1 gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. |
| AID234041 | Therapeutic efficacy at an oral dose of 0.32 mg/kg in mouse | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879. |
| AID502780 | Antibacterial activity against multidrug-resistant Helicobacter pylori v1254 | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID1533856 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 256 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID524249 | Antimicrobial activity against Escherichia coli DH5alpha expressing SHV-1 in presence of 2 ug/ml clavulanic acid beta-lactamase inhibitor | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID117520 | Beta-lactamase inhibitory activity against Escherichia coli A21223 using oral mouse protection test in mice | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID206772 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Staphylococcus aureus MS (6) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID495634 | Antimicrobial activity against Escherichia coli DH10B by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID569361 | Antibacterial activity against Streptococcus pyogenes 1307006P by broth micro dilution technique | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors. |
| AID521683 | Antimicrobial activity against Escherichia coli S4 expressing inhibitor-resistant TEM-34 in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID114733 | Tested for the antimicrobial activity against Streptococcus pyogenes (St141) in mice, perorally | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID434256 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID520882 | Antibacterial activity against Escherichia coli TOP10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID557478 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1445906 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 9144 after 20 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms. |
| AID558538 | Antibacterial activity against bla-positive and beta-lactamase-weakly positive Campylobacter coli isolate P1627 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID444057 | Fraction escaping hepatic elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID524247 | Antimicrobial activity against Escherichia coli INSRA4590 expressing SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID1525345 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 20 hrs under iron-deficient medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID400381 | Antibacterial activity against Pseudomonas aeruginosa at 200 ug/100uL after 24 hrs by agar well diffusion method | 1998 | Journal of natural products, Feb, Volume: 61, Issue:2 | Antibacterial steroidal alkaloids from Sarcococca saligna. |
| AID521153 | Antibacterial activity against intracellular Listeria monocytogenes EGDe infected in bone marrow-derived BALB/c mouse macrophage assessed as reduction in the number of infected macrophages after 3 hrs | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. |
| AID1294614 | Antibacterial activity against Enterobacter cloacae CIP 103475 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID558625 | Antimicrobial activity against Streptococcus pneumoniae isolate 3458 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID519014 | Antimicrobial activity against Enterobacter aerogenes isolate SS-13 by broth macrodilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. |
| AID434471 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 66 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID543654 | Elimination rate constant in extracorporeal membrane oxygenation-treated human neonatal plasma at 25 mg/kg QID by UPLC-MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. |
| AID564226 | Antimicrobial activity against Escherichia coli TOP10 by Etest method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID88102 | The compound was evaluated in vitro for the minimum inhibitory concentration against Helicobacter pylori (13001). | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative. |
| AID278293 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse lung at 7 mg/kg, sc after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID278313 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse lung at 7 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID575092 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID434452 | Influx clearance from plasma to middle ear fluid Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 170 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID15711 | Calculated partition coefficient (clogP) | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID573769 | Antibacterial activity against Enterobacter cloacae El3518 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID87938 | Antimicrobial activity against Helicobacter pylori | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15 | Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles. |
| AID684241 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate cpu3889 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID573948 | Antibacterial activity against Citrobacter amalonaticus Ca38009 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID529467 | Antimicrobial activity against Escherichia coli J53 harboring beta-lactamase Oxa-48 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID567894 | Antimicrobial activity against Escherichia coli after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID567091 | Drug absorption in human assessed as human intestinal absorption rate | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Prediction of drug intestinal absorption by new linear and non-linear QSPR. |
| AID684230 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus isolate cpu1044 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID50732 | Compound was evaluated for antimicrobial activity against Clostridium difficile | 1998 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 8, Issue:11 | Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles. |
| AID114713 | Tested for the antimicrobial activity against Staphylococcus aureus (M202) in mice, perorally | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID521486 | Antibacterial activity against Escherichia coli harboring pBC2303 expressing blaKPC gene plasmid by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID536465 | Antimicrobial activity against Bacillus subtilis at 50 ug/mL after 24 hrs by well plate method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11 | Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. |
| AID117523 | Beta-lactamase inhibitory activity against Staphylococcus aureus A20649 using oral mouse protection test in mice | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID1507250 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 to 48 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID531682 | Antimicrobial activity against Acinetobacter baumannii Ab290 containing plasmid harboring OXA-58-4 by broth dilution test | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii. |
| AID522050 | Antimicrobial activity against Escherichia coli isolate J53 harboring pE containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID519749 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-72 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID522006 | Antimicrobial activity against Klebsiella pneumoniae isolate KpI-2 expressing beta-lactamase OXA-48 and CTX-M-15 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID495842 | Hydrolytic activity of Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID495904 | Antimicrobial activity in Klebsiella pneumoniae DIH-2 clinical isolate expressing beta-lactamase VIM-19 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID1525349 | Antibacterial activity against Pseudomonas aeruginosa KW799 after 20 hrs under iron-deficient medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID525547 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1050 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID1246799 | Antibacterial activity against Salmonella paratyphi after 5 days by microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID684240 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis isolate cpu2623 after 18 to 20 hrs by agar dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Novel pleuromutilin derivatives as antibacterial agents: synthesis, biological evaluation and molecular docking studies. |
| AID1161180 | Antimicrobial activity against Staphylococcus aureus isolate RN1024 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID558535 | Antibacterial activity against bla gene-negative and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P843 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1428627 | Antimycobacterial activity against Mycobacterium smegmatis MC2 155 after 3 days by broth macrodilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. |
| AID546430 | Ratio of Kcat to Km for Pseudomonas aeruginosa PDC-1 by spectrophotometer | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Extended-spectrum cephalosporinases in Pseudomonas aeruginosa. |
| AID519738 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-1 by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID522048 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pBIC containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1755798 | Antimicrobial activity against Helicobacter pylori clinical isolate4 for 3 days by agar dilution method | 2021 | European journal of medicinal chemistry, Jan-15, Volume: 210 | Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective. |
| AID114722 | Tested for the antimicrobial activity against Streptococcus pneumoniae (D137) in mice, perorally | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID529622 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae harboring fst1 mutant gene assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID434253 | Maximum efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID718843 | Antibacterial activity against Staphylococcus aureus | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal thiosemicarbazone derivatives. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID519747 | Activity of Klebsiella pneumoniae Beta-Lactamase SHV-72 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID557500 | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID533211 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by PK/PD technique in presence of 125 mg/kg beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID543405 | Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as reduction in bacterial count in liver at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 6 hr | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis. |
| AID18861 | GOF value represents multisets of log P data | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID564525 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID519981 | Ratio of Kcat to Km for Klebsiella pneumoniae Beta-Lactamase SHV-1 | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. |
| AID1230210 | Antibacterial activity against Corynebacterium striatum N840 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID351438 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 4 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID562738 | Antimicrobial activity against Escherichia coli K-12 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID530355 | Antimicrobial activity against Escherichia coli TOP10 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID1438612 | Antibacterial activity against Enterococcus faecalis isolate 015206179901 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID565177 | Antimicrobial activity against Staphylococcus aureus 8235 selected after 4 times MIC pre-incubated for 1 hr by microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. |
| AID351209 | fTmax in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID1230246 | Antibacterial activity against Staphylococcus lugdunensis ATCC 43809 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID584837 | Antimicrobial activity against Escherichia coli DH10B harboring recombinant Aeromonas allosaccharophila AL-1 beta-lactamase PER1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID340726 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-15 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID278311 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse blood at 7 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID420822 | Antibacterial activity against Streptococcus pyogenes at 30 ug/disk after 18 hrs by disk diffusion method | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6 | Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents. |
| AID1161155 | Antimicrobial activity against Moraxella catarrhalis 1502 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID520879 | Antibacterial activity against Achromobacter xylosoxidans DUC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID637616 | Antibacterial activity against coagulase-positive Staphylococcus aureus after 24 hrs by microdilution method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID557510 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID531474 | Antibacterial activity against Bacteroides uniformis assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID278318 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse lung at 7 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1438611 | Antibacterial activity against Listeria monocytogenes isolate 015181840701 after 18 hrs by broth microdilution assay | 2017 | European journal of medicinal chemistry, Mar-10, Volume: 128 | Synthesis, surfactant properties and antimicrobial activities of methyl glycopyranoside ethers. |
| AID529619 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae assessed as susceptible isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID1161172 | Antimicrobial activity against Staphylococcus aureus isolate Smith ATCC 13709 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID530352 | Antimicrobial activity against azide-resistant Escherichia coli J53 harboring pCTX-M carrying blaCTX-M-15 and pQep plasmid carrying qepA2 gene by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID434260 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID562749 | Antimicrobial activity against Escherichia coli K-12 transconjugant harboring blaCTX-M-71 gene by agar dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10 | New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. |
| AID69935 | Antibacterial activity was evaluated against Escherichia coli (NIHJ JC-2) | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14 | Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity. |
| AID1141072 | Cytotoxicity against HEK293 cells after 72 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11 | Cell permeable vanX inhibitors as vancomycin re-sensitizing agents. |
| AID1546152 | Antimicrobial activity against Pseudomonas aeruginosa assessed as zone of inhibition at 30 ug/ml | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID511296 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-1in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID558620 | Antimicrobial activity against Streptococcus pneumoniae isolate 3282 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1347491 | Antibacterial activity against Escherichia coli assessed as zone of inhibition after 24 to 48 hrs by well diffusion method | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations. |
| AID1161168 | Antimicrobial activity against Staphylococcus aureus isolate F89 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID557993 | Antimicrobial activity in Clostridium sordellii by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID587988 | Antibacterial activity against Enterococcus faecalis JH2-2 assessed as induction of membrane permeabilization at 2 ug/ml after 3 hrs by propidium iodide and Syto9 staining based confocal microscopic analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID585200 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-1 E104, G170 mutant in presence of clavulanic acid at compound/inhibitor ratio of 2:1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID1161175 | Antimicrobial activity against Staphylococcus aureus isolate CL 938 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID521995 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp3A expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID520881 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant p6S3 expressing beta lactamase OXA-114a by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID530822 | Antibacterial activity against Escherichia coli J53 harboring plasmid pA-1carrying beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID557501 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID370917 | Antibacterial activity against Salmonella Typhimurium after 18 hrs by macro dilution test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID529471 | Antimicrobial activity against Klebsiella pneumoniae isolate 21 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-9 by Etest in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID558325 | Antibacterial activity against bla gene-negative and nitrocefin reaction-negative beta-lactamase harboring Campylobacter jejuni isolate P850 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID1694325 | Bactericidal activity against Staphylococcus aureus MRSA-1 measured every 24 hrs for 5 days by serial dilution method | 2021 | Bioorganic & medicinal chemistry, 02-15, Volume: 32 | Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. |
| AID495640 | Antimicrobial activity against Escherichia coli DH10B at 2:1 ratio of compound to clavulanic acid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. |
| AID543427 | Antimicrobial activity against Escherichia coli XL-1 Blue harboring plasmid CL1920 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID522010 | Antimicrobial activity against Escherichia coli isolate TOP10 harboring pBIC containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID575089 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID326272 | Activity of Escherichia coli K12 beta-lactamase TEM1 relative to penicillin G | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID1209455 | Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 40, Issue:1 | In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. |
| AID549332 | Antimicrobial activity against Escherichia coli isolate 86 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID530823 | Antibacterial activity against human urinary Klebsiella pneumoniae UCL-1 harboring plasmid-encoded beta-lactamase OXA-48 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID541007 | Antimicrobial activity against Burkholderia cenocepacia 09-54 expressing beta-lactamase PenB2 | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID1633938 | Antimicrobial activity against Streptococcus pneumoniae Ery-2 infected in respiratory tract infection rat model assessed as log reduction in bacterial CFU at 350 mg/kg, po BID dosed 1 hr post infection and measured for 96 hrs in presence of 50 mg/kg clavu | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16 | Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections. |
| AID434262 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera assessed as unbound Km at 40000 ug/kg, iv followed by local dose of 96 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID557514 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1230212 | Antibacterial activity against Enterococcus casseliflavus N487 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID543651 | Clearance in human neonates undergoing extracorporeal membrane oxygenation treatment at 50 mg/kg BID by UPLC-MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. |
| AID588001 | Antibacterial activity against Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene by CLSI method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID558338 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P1730 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID543275 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID326268 | Antibacterial activity against Escherichia coli DH5-alpha by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. |
| AID285441 | Antimicrobial activity against Escherichia coli DH10B after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID524256 | Activity at Escherichia coli beta-lactamase SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID561111 | Antibacterial activity against Pasteurella multocida BB1045 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID588000 | Bactericidal activity against 5 X 10'6 CFU/ml Enterococcus faecalis JH2-2 at 2 ug/ml after 3 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID351650 | AUC (0 to 24 hrs) in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID530353 | Antimicrobial activity against azide-resistant Escherichia coli J53 by disk diffusion method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France. |
| AID541008 | Antimicrobial activity against Burkholderia cenocepacia 09-54 expressing beta-lactamase PenB2 in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID557989 | Antimicrobial activity in Clostridium innocuum by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID1161179 | Antimicrobial activity against Staphylococcus aureus isolate PAV 5 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1486239 | Antibacterial activity against methicillin-resistant Staphylococcus aureus EMRSA-16 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID575094 | Antimicrobial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID575947 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae assessed as susceptible isolates by broth microdilution method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates. |
| AID531601 | Antimicrobial activity against Escherichia coli JM109 harboring pSC1 plasmid expressing beta-lactamase SHV-56 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID351646 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 10 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID584839 | Antimicrobial activity against Escherichia coli DH10B by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila. |
| AID535707 | Antibacterial activity against Escherichia coli TOP10 expressing AmpC-B2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Role of the Ser-287-Asn replacement in the hydrolysis spectrum extension of AmpC beta-lactamases in Escherichia coli. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID555687 | Antimicrobial activity against Escherichia coli ATCC 25922 by disk diffusion method in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID1161149 | Antimicrobial activity against Staphylococcus aureus WCUH29 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID88233 | The lowest drug concentration that inhibited macroscopic colonial growth against Helicobacter pylori; value range is between 0.0063-0.1 | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. |
| AID373060 | Antimicrobial activity against Escherichia coli BL21(DE3) carrying pET9a expressing Bacillus clausii beta-lactamase BCL1 by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID278295 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse blood at 7 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID531431 | Antibacterial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1634990 | Antimicrobial activity against Staphylococcus epidermidis assessed as reduction in bacterial growth after 20 hrs by drop diffusion test | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. |
| AID87810 | Antibacterial activity against Helicobacter pylori HP0018 was determined | 2003 | Bioorganic & medicinal chemistry letters, Aug-18, Volume: 13, Issue:16 | A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori. |
| AID529628 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae harboring fst1 mutant gene assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID564541 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-50 plasmid by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1161189 | Antimicrobial activity against Staphylococcus aureus isolate 934387 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID531443 | Antibacterial activity against Streptococcus pneumoniae serotype 22 assessed as percent resistant isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID319579 | Antibacterial activity against Helicobacter pylori isolate assessed as inhibition zone diameter at 1 ug/disk after 3-5 days by paper disk diffusion assay | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11 | Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain. |
| AID278338 | Effect on survival of Swiss mouse infected with penicillin-resistant Streptococcus pneumoniae P-15986 at 15 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID573737 | Antibacterial activity against Morganella morganii isolate Mm38009 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID434263 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera assessed as unbound Km at 40000 ug/kg, iv followed by local dose of 19 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID564534 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid carrying entire blaAmpC gene with alanine residue deletion at 215 position and R210P substitution by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID294964 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by serial dilution method | 2007 | European journal of medicinal chemistry, Oct, Volume: 42, Issue:10 | Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. |
| AID529744 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae harboring fst1 mutant gene assessed as susceptible isolates after 20 to 24 hrs by Etest method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID531664 | Antibacterial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID147158 | Antimicrobial activity against Neisseria meningitidis | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15 | Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles. |
| AID285443 | Ratio of kcat to Km of Citrobacter gillenii CIP 106783 Beta-lactamase GIL1 expressed in Escherichia coli DH10B relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID575093 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B assessed as percent susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID117522 | Beta-lactamase inhibitory activity against Staphylococcus aureus A20379 using oral mouse protection test in mice | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID543653 | Volume of distribution in extracorporeal membrane oxygenation-treated human neonatal plasma at 25 mg/kg SID by UPLC-MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. |
| AID557691 | Antimicrobial activity in Prevotella bergensis by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID573958 | Antibacterial activity against Escherichia coli Ec158 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID535698 | Antimicrobial activity against Azide-resistant Escherichia coli J53 by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog. |
| AID434259 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 215 ug/kg into intra-middle ear by compartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID637609 | Antibacterial activity against Escherichia coli at 30 ug/ml after 24 hrs by agar well diffusion method | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Synthesis of uriedo and thiouriedo derivatives of peptide conjugated heterocycles - A new class of promising antimicrobials. |
| AID351638 | Unbound drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 12 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID564548 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-33 plasmid carrying entire blaAmpC gene with alanine residue deletion at 215 position and R210P substitution by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID606245 | Antibacterial activity against Streptococcus pyogenes after 18 hrs by macro-dilution test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID511287 | Antibacterial activity against Pseudomonas aeruginosa NL68 expressing GES-13 beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID572272 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6301 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID531662 | Antibacterial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID278303 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse blood at 7 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID573747 | Antibacterial activity against Morganella morganii isolate Mm1614 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID163287 | Tested for inhibition of visible growth of Pseudomonas aeruginosa | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID562609 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1238341 | Antibacterial activity against Bacillus subtilis NCTC 2116 after 18 hrs by agar diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 | Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification. |
| AID424327 | Antimicrobial activity against Dialister propionicifaciens by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID557513 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1246790 | Antibacterial activity against Escherichia coli after 24 hrs by agar dilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID490330 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID278327 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-15986 infected Swiss mouse blood at 15 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1161152 | Antimicrobial activity against Haemophilus influenzae Q1 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID530604 | Antibacterial activity against Escherichia coli J53 harboring plasmid pAM carrying beta-lactamase PER-1 by Etest in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Expanded-spectrum beta-lactamase PER-1 in an environmental Aeromonas media isolate from Switzerland. |
| AID325155 | Antimicrobial activity against Haemophilus parasuis BB 1022 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID469293 | Antifungal activity against Aspergillus fumigatus at 5 mg/ml after 24 to 48 hrs by agar diffusion technique | 2009 | European journal of medicinal chemistry, Dec, Volume: 44, Issue:12 | Stereoselective synthesis and antimicrobial activity of benzofuran-based (1E)-1-(piperidin-1-yl)-N2-arylamidrazones. |
| AID502523 | Inhibition of Helicobacter pylori-induced inflammation in human AGS cells assessed as reduction of NF-kappaB activity at 2.5 uM after 6 hrs by luciferase reporter gene assay relative to control | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID555283 | Antibacterial activity against atlA-deficient Enterococcus faecalis JH2-2 assessed as decrease in decrease in bacterial count at 2 ug/ml after 3 hrs by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID1819815 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID540947 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c36 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID521355 | Antimicrobial activity against Streptococcus pneumoniae isolate 657 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID564549 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue deletion at 215 position and R210P substitution by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID561108 | Antibacterial activity against Pasteurella multocida BB1042 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID278308 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-54988 infected Swiss mouse blood at 15 mg/kg/8 hrs, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID535363 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as susceptible isolates by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1246793 | Antibacterial activity against Proteus vulgaris after 5 days by microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID494628 | Antibacterial activity against Streptococcus pneumoniae R6 | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15 | Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams. |
| AID1161153 | Antimicrobial activity against Haemophilus influenzae H128 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID1812548 | In vivo antibacterial activity against Escherichia coli expressing TEM-1/CTX-M-15 infected in C3H/HeJ mouse assessed as log10 reduction in CFU in kidney administration of compound:clavulanate 2:1 ratio at 10 to 300 mg/kg, sc every 12 hrs for 3 days starti | |||
| AID529462 | Antimicrobial activity against Klebsiella pneumoniae isolate 11 expressing beta-lactamase Oxa-48, TEM-1 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID691703 | Antibacterial activity against Salmonella typhi after 24 hrs by serial dilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 22, Issue:20 | Synthesis of β-ionone derived chalcones as potent antimicrobial agents. |
| AID326502 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis 1209 after 24 hrs by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Single-dose oral amoxicillin or linezolid for prophylaxis of experimental endocarditis due to vancomycin-susceptible and vancomycin-resistant Enterococcus faecalis. |
| AID533212 | Antimicrobial activity against Haemophilus influenzae clinical isolates assessed as susceptible isolates by PK/PD technique in presence 125 mg/kg of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID1413530 | Toxicity in Staphylococcus aureus after 18 to 24 hrs by two-fold serial dilution method | 2018 | MedChemComm, Aug-01, Volume: 9, Issue:8 | Design, synthesis, and biological evaluation of |
| AID535062 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pOXA-58-5 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID599616 | Antibacterial activity against Vibrio cholerae isolate 7201 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID1230235 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID372605 | Antibacterial activity against Escherichia coli BER1 producing beta-lactamase pI 5.2 and pI 5.4 by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID1507253 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID1230214 | Antibacterial activity against Enterococcus durans CIP 104999 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1161171 | Antimicrobial activity against Staphylococcus aureus isolate RUSSELL after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID495843 | Ratio of Kcat to Km for Escherichia coli DH10B beta-lactamase VIM-2 by microacidimetric method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID573952 | Antibacterial activity against Escherichia coli Ec9381 transconjugant harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID495807 | Antimicrobial activity against Escherichia coli C600 2878 transconjugate expressing beta-lactamase VIM-19 by microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID278858 | Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. |
| AID495657 | Antimicrobial activity against Escherichia coli TOP10 expressing recombinant beta-lactamase BEL-1 by solid agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. |
| AID557523 | Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP3 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID583651 | Antibacterial activity against Escherichia coli isolate 271 | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia. |
| AID351437 | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 3 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID559823 | Antimicrobial activity against Enterobacter cloacae CHE-2 harboring blaGES-5 and blaSHV-5 gene by agar dilution in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID567324 | Antimicrobial activity against Escherichia coli TUM4672 by broth dilution method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID599612 | Antibacterial activity against Escherichia coli ATCC 25938 | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6 | Amberlite-IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: antibacterial and antifungal evaluation of the products. |
| AID351639 | Unbound drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 1 hr | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID567319 | Antimicrobial activity against Escherichia coli TUM4672 by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate. |
| AID535347 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as susceptible isolates by PK/PD technique in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7 | Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007). |
| AID560113 | Antibacterial activity against Escherichia coli TOP10 harboring recombinant plasmid RTG4-S69-V49 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID564528 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-50 plasmid by Etest method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID530817 | Antibacterial activity against Escherichia coli J53 by Etest method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Plasmid-encoded carbapenem-hydrolyzing beta-lactamase OXA-48 in an imipenem-susceptible Klebsiella pneumoniae strain from Belgium. |
| AID558608 | Antimicrobial activity against Streptococcus pneumoniae isolate 1394 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID285261 | Antimicrobial activity against recombinant Escherichia coli DH5-alpha isolate expressing pBK-TEM-36 and IRT by disk diffusion assay | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. |
| AID525550 | Antimicrobial activity against ampicillin resistant serotype-e Haemophilus influenzae isolate BB1053 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID573961 | Antibacterial activity against Escherichia coli Ec221 transconjugant harboring IncA/C plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID564538 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID444058 | Volume of distribution at steady state in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3 | Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID558622 | Antimicrobial activity against Streptococcus pneumoniae isolate 3374 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1230226 | Antibacterial activity against Enterococcus gallinarum CIP 105985 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID114714 | Tested for the antimicrobial activity against Staphylococcus aureus (M202) in mice, subcutaneously | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID278283 | Half life in human at 1 g, po | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID568389 | Antimicrobial activity against Klebsiella pneumoniae after 72 hrs by microdilution method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID557479 | Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP1A | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID557981 | Antimicrobial activity in Clostridium cadaveris by CLSI agar dilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Antianaerobic activity of sulopenem compared to six other agents. |
| AID114734 | Tested for the antimicrobial activity against Streptococcus pyogenes (St141) in mice, subcutaneously | 1980 | Journal of medicinal chemistry, Apr, Volume: 23, Issue:4 | Orally active cephalosporins and penicillins. |
| AID351216 | Tmax in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 48 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID529610 | Antibacterial activity against Beta-lactamase negative Haemophilus influenzae assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID424321 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID558638 | Antimicrobial activity against Streptococcus pneumoniae 7 by time-kill analysis in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1246786 | Antibacterial activity against Salmonella paratyphi at 10 ug/disk after 24 hrs by agar plate disk diffusion method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID1694321 | Antibacterial activity against Staphylococcus aureus MRSA-1 assessed as bacterial growth inhibition in Mueller-Hinton broth 2 measured every 24 hrs for 5 days by serial dilution method | 2021 | Bioorganic & medicinal chemistry, 02-15, Volume: 32 | Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. |
| AID555277 | Antibacterial activity against atlA-deficient Enterococcus faecalis JH2-2 assessed as decrease in bacterial count at 2 ug/ml by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID1533852 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 417 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID490327 | Antimicrobial activity against Bacillus subtilis ATCC 6633 at 25 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID574036 | Antibacterial activity against beta-lactamase producing Micromonas micros assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID573743 | Antibacterial activity against Klebsiella oxytoca isolate Ko0426 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID325151 | Antimicrobial activity against Haemophilus parasuis BB 1018 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID531600 | Antimicrobial activity against Escherichia coli JM109 harboring pE1 plasmid expressing beta-lactamase SHV-11 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10 | Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID518730 | Antimicrobial activity against Pseudomonas stutzeri clinical isolate expressing beta-lactamase DIM-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6 | Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands. |
| AID394493 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID434476 | Antimicrobial activity against amoxicillin-resistant Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID518520 | Antimicrobial activity against Escherichia coli TOP10(pNOR-1) expressing CSP-1 gene after 2 days by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena. |
| AID522009 | Antimicrobial activity against Klebsiella pneumoniae isolate KpBIC expressing beta-lactamase OXA-48 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1533850 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 254 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID573740 | Antibacterial activity against Morganella morganii isolate Mm1229 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID434284 | Ratio of influx clearance to efflux clearance in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 233 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID529649 | Antimicrobial activity against Escherichia coli DH5alpha harboring beta-lactamase VIM-16 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany. |
| AID564225 | Antimicrobial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12 | OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii. |
| AID325449 | Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Polyamine effects on antibiotic susceptibility in bacteria. |
| AID558331 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P338 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID495817 | Antimicrobial activity against Klebsiella pneumoniae 2878 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 2 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. |
| AID278323 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-12698 infected Swiss mouse blood at 25 mg/kg/8 hrs, sc after 84 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID402034 | Antimicrobial activity against Clarithromycin-resistant Helicobacter pylori TS648 after 4 days by twofold plate dilution method | 2005 | Journal of natural products, Jun, Volume: 68, Issue:6 | Anti-Helicobacter pylori compounds from Santalum album. |
| AID529457 | Antimicrobial activity against Klebsiella pneumoniae containing PFGE clone B expressing beta-lactamase Oxa-48, TEM-1, CTX-M-15 and Oxa-1 by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. |
| AID540946 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c31 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID1445902 | Antibacterial activity against vancomycin-resistant Enterococcus faecium NCTC 12204 after 20 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms. |
| AID531473 | Antibacterial activity against Bacteroides vulgatus assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID561107 | Antibacterial activity against Pasteurella multocida BB1041 harboring plasmid pB1000 bearing blaROB-1 gene and plasmid pB9956 bearing tetH gene by CLSI M31-A3 broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. |
| AID521679 | Antimicrobial activity against Escherichia coli S7 expressing extended-spectrum beta-lactamase SHV-12 and penicillinase TEM-1 in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of ce |
| AID521346 | Antimicrobial activity against Streptococcus pneumoniae isolate 2904 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID64380 | In vitro minimum inhibitory activity against Enterococcus faecalis 7 strain | 2002 | Journal of medicinal chemistry, May-09, Volume: 45, Issue:10 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
| AID1230241 | Antibacterial activity against Staphylococcus aureus CIP 7625 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID560123 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG4 gene by disk diffusion method in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID69961 | Compound alone was evaluated for minimum inhibitory concentration against Escherichia coli A20111 | 1985 | Journal of medicinal chemistry, Apr, Volume: 28, Issue:4 | Synthesis and beta-lactamase inhibitory properties of 2 beta-[(acyloxy)methyl]-2-methylpenam-3 alpha-carboxylic acid 1,1-dioxides. |
| AID541020 | Antimicrobial activity against Escherichia coli TOP10 in presence of 4 ug/ml beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3 | Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex. |
| AID573820 | Antibacterial activity against Veillonella parvula by by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID1545451 | Antibacterial activity against Escherichia coli assessed as zone inhibition at 100 ug/ml | 2019 | Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7 | Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances. |
| AID490321 | Antimicrobial activity against Escherichia coli ATCC 25922 at 25 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID573559 | Antibacterial activity against beta-lactamase producing Bacteroides thetaiotaomicron assessed as susceptible isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID562611 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method in presence of clavulanate | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID434290 | Efflux clearance from middle ear fluid to plasma in Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 13 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID535674 | Antimicrobial activity against beta-lactamase positive Haemophilus influenzae expressing fst1 gene assessed as resistant isolates by microdilution method in presence of beta-lactamase inhibitor clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers. |
| AID1726843 | Synergistic antibacterial activity against Escherichia coli assessed as amoxicillin MIC encapsulated by compound | 2021 | RSC medicinal chemistry, Jun-23, Volume: 12, Issue:6 | Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity. |
| AID567895 | Antimicrobial activity against Xanthomonas oryzae after 24 hrs by agar well diffusion method | 2011 | European journal of medicinal chemistry, Feb, Volume: 46, Issue:2 | Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials--A novel approach to enhance biocompatibility. |
| AID543652 | Volume of distribution in extracorporeal membrane oxygenation-treated human neonatal plasma at 20 mg/kg, po by UPLC-MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. |
| AID557484 | Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1916103 | Induction of drug resistance in Escherichia coli ATCC 25922 assessed as fold change in MIC measured after 19 passages by CLSI based broth dilution method | |||
| AID543280 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2 | In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID1270910 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method | 2015 | Journal of natural products, Nov-25, Volume: 78, Issue:11 | Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp. |
| AID1230234 | Antibacterial activity against Listeria monocytogenes N851 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID1819810 | Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay | 2022 | ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4 | Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines. |
| AID608610 | Antimicrobial activity against Candida albicans ATCC 10231 after 24 hrs by microdilution technique | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID1230219 | Antibacterial activity against Enterococcus faecalis N520 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID351623 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 2 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID370913 | Antibacterial activity against Salmonella Typhimurium at 10 to 100 ug/mL after 18 hrs by halo zone test | 2008 | European journal of medicinal chemistry, Sep, Volume: 43, Issue:9 | Synthesis and in vitro antibacterial activity of new steroidal thiosemicarbazone derivatives. |
| AID524257 | Ratio of Kcat to Km in Escherichia coli beta-lactamase SHV-1 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID409956 | Inhibition of mouse brain MAOB | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21 | Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID1294615 | Antibacterial activity against Citrobacter freundii CIP 5732 after 16 to 20 hrs by broth microdilution method | 2016 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 26, Issue:10 | Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines. |
| AID559820 | Antimicrobial activity against Escherichia coli J53 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Integron mobilization unit as a source of mobility of antibiotic resistance genes. |
| AID1533851 | Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 231 by broth microdilution assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor. |
| AID1276594 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 hrs by two-fold microdillution method | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Naphtho[1',2':4,5]imidazo[1,2-a]pyridine-5,6-diones: Synthesis, enzymatic reduction and cytotoxic activity. |
| AID520888 | Antibacterial activity against Achromobacter xylosoxidans CIP69598 in presence of 4 ug/ml clavulanic acid by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. |
| AID555288 | Ratio of MBC to MIC in Enterococcus faecalis JH2-2 | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID434457 | Influx clearance from plasma to middle ear fluid in Chinchilla lanigera at 15000 ug/kg, iv followed by local dose of 164 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID558333 | Antibacterial activity against bla gene-positive and nitrocefin reaction-positive beta-lactamase harboring Campylobacter jejuni isolate P790 by NCCLS agar doubling dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. |
| AID544435 | Antimicrobial activity against Escherichia coli MC4100A harboring empty plasmid by liquid microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. |
| AID64067 | Minimum inhibitory activity against Escherichia coli A9675 | 1981 | Journal of medicinal chemistry, Dec, Volume: 24, Issue:12 | Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. |
| AID519219 | Antibacterial activity against Streptococcus pneumoniae assessed as susceptible isolates by microdilution method in presence of beta lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID101665 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Listeria monocytogenes (20) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID573730 | Antibacterial activity against Enterobacter cloacae isolate El3518 harboring IncL/M plasmid and blaIMP-4-qacG2-aacA4-catB3 array by Etest method in presence of clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8 | bla(IMP-4) in different genetic contexts in Enterobacteriaceae isolates from Australia. |
| AID1507251 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID558613 | Antimicrobial activity against Streptococcus pneumoniae isolate 2686 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID585201 | Antimicrobial activity against Escherichia coli DH5[alpha] transformed with pAC-ges1 plasmid encoding Beta-lactamase GES-7 K104, G170 mutant in presence of clavulanic acid at compound/inhibitor ratio of 2:1 by Etest method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11 | Comparative biochemical and computational study of the role of naturally occurring mutations at Ambler positions 104 and 170 in GES β-lactamases. |
| AID322320 | Antibacterial activity against Escherichia coli INSRA5776 isolates expressing CTX-M-14 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID678722 | Covalent binding affinity to human liver microsomes assessed per mg of protein at 10 uM after 60 mins presence of NADPH | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10 | Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID87961 | Minimum inhibitory concentration against Helicobacter pylori under acidic conditions at pH 5.0 | 2001 | Journal of medicinal chemistry, Dec-06, Volume: 44, Issue:25 | 3-(Arylacetylamino)-N-methylbenzamides: a novel class of selective anti-Helicobacter pylori agents. |
| AID1812549 | In vivo antibacterial activity against Escherichia coli expressing TEM-1/CTX-M-15 infected in C3H/HeJ mouse assessed as log10 reduction in CFU in bladder administration of compound:clavulanate 2:1 ratio at 10 to 300 mg/kg, sc every 12 hrs for 3 days start | |||
| AID535064 | Antimicrobial activity against Acinetobacter genomic species 13TU ATCC 17903 harboring pOXA-58-7 plasmid by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU. |
| AID41403 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Bacteroides fragilis(15) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID490312 | Antimicrobial activity against Candida albicans ATCC 10231 at 25 ug/disk by disk diffusion method | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID557483 | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP1B | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID502779 | Antibacterial activity against Helicobacter pylori Hp 26695 | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells. |
| AID558590 | Antimicrobial activity against Streptococcus pneumoniae 2 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID278285 | AUC in leukopenic mouse with renal failure at 15 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID40336 | Antimicrobial activity against Bacteroides fragilis | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15 | Anti-Helicobacter pylori agents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles. |
| AID495791 | Antimicrobial activity against Pseudomonas fluorescens isolate PF-1 expressing beta-lactamase BIC-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. |
| AID522045 | Antimicrobial activity against Escherichia coli isolate J53 harboring pI-1 containing beta-lactamase OXA-48 located within transposon Tn1999.2 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID1230237 | Antibacterial activity against Staphylococcus aureus CIP 483 after 18 hrs by agar dilution method | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 | Antibacterial Labdane Diterpenoids from Vitex vestita. |
| AID521149 | Antibacterial activity against intracellular Listeria monocytogenes EGDe infected in bone marrow-derived BALB/c mouse macrophage assessed as reduction in the formation of filopodium-like projections at >= MIC after 48 hrs by microscopy | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | Comparison of the in vitro efficacies of moxifloxacin and amoxicillin against Listeria monocytogenes. |
| AID521488 | Antibacterial activity against Pseudomonas aeruginosa KG2505 harboring pCOL plasmid by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID557268 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae 3413 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID606242 | Antibacterial activity against Salmonella Typhimurium measured at MIC after 18 hrs by halo zone test | 2011 | European journal of medicinal chemistry, Jul, Volume: 46, Issue:7 | 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity. |
| AID519741 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-72 by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID278282 | Half life in leukopenic mouse with renal failure at 25 mg/kg, sc | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID372611 | Antibacterial activity against Escherichia coli DH5alpha by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. |
| AID544976 | Antimicrobial activity against Klebsiella pneumoniae 52145 | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1 | Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides. |
| AID1246795 | Antibacterial activity against Pseudomonas aeruginosa after 5 days by microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19 | Re-engineering nalidixic acid's chemical scaffold: A step towards the development of novel anti-tubercular and anti-bacterial leads for resistant pathogens. |
| AID524259 | Ratio of Kcat to Km in Escherichia coli beta-lactamase SHV-84 | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID520982 | Antibacterial activity against Escherichia coli harboring pRYC plasmid expressing blaKPC gene by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4 | Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. |
| AID573774 | Antibacterial activity against Fusobacterium necrophorum assessed as resistant isolates by CLSI agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9 | Increasing trends in antimicrobial resistance among clinically important anaerobes and Bacteroides fragilis isolates causing nosocomial infections: emerging resistance to carbapenems. |
| AID587994 | Bactericidal activity against 5 X 10'8 CFU/ml Enterococcus faecalis JH2-2 harboring deletion at AltA, AltB and AltC gene at 2 ug/ml after 3 hrs by time kill analysis | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2 | The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis. |
| AID557267 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae 24 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID560125 | Antimicrobial activity against Acinetobacter baumannii CIP70.10 harboring beta-lactamase RTG3 gene by disk diffusion method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7 | Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii. |
| AID558612 | Antimicrobial activity against Streptococcus pneumoniae isolate 2617 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1525347 | Antibacterial activity against Pseudomonas aeruginosa KW799/61 after 20 hrs under iron-deficient medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID490329 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by microdilution assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. |
| AID373061 | Antimicrobial activity against Escherichia coli BL21(DE3) by agar-dilution technique in presence of beta-lactamase inhibitor clavulanic acid | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID564547 | Antimicrobial activity against Escherichia coli TOP10 harboring pADC-11 plasmid carrying entire blaAmpC gene with alanine residue insertion at 215 position by Etest method in presence of clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | Extended-spectrum cephalosporinase in Acinetobacter baumannii. |
| AID529742 | Antibacterial activity against Beta-lactamase positive Haemophilus influenzae harboring fst1 mutant gene assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method. |
| AID425863 | Antimicrobial activity against Carnobacterium divergens CIP101029 at 0.5 McFarland inoculum size by E-test | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens. |
| AID33219 | In vitro 90% of tested clinical Isolates of Aeromonas species(21) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID351628 | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 10 hrs | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 | influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhi |
| AID434288 | Efflux clearance from middle ear fluid to plasma in Streptococcus pneumoniae WT3-infected Chinchilla lanigera at 40000 ug/kg, iv followed by local dose of 170 ug/kg into intra-middle ear by noncompartmental microdialysis | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect. |
| AID1445903 | Antibacterial activity against vancomycin-sensitive Enterococcus faecalis NCTC 775 after 20 hrs by broth microdilution method | 2017 | Journal of medicinal chemistry, 07-27, Volume: 60, Issue:14 | Triaryl Benzimidazoles as a New Class of Antibacterial Agents against Resistant Pathogenic Microorganisms. |
| AID24184 | Distribution coefficient in octanol/water at pH 6.5 | 1998 | Journal of medicinal chemistry, Dec-03, Volume: 41, Issue:25 | Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. |
| AID557495 | Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2X | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID555280 | Antibacterial activity against Enterococcus faecalis JH2-2 assessed as decrease in decrease in bacterial count at 2 ug/ml after 3 hrs by macrodilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2. |
| AID1507256 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 to 48 hrs by agar well diffusion method | 2017 | European journal of medicinal chemistry, Aug-18, Volume: 136 | Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. |
| AID278296 | Bacterial clearance in penicillin-resistant Streptococcus pneumoniae P-52181 infected Swiss mouse blood at 15 mg/kg, sc after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1 | Amoxicillin is effective against penicillin-resistant Streptococcus pneumoniae strains in a mouse pneumonia model simulating human pharmacokinetics. |
| AID1161154 | Antimicrobial activity against AcrA-deficient Haemophilus influenzae H128 after 24 hrs by broth microdilution method | 2014 | European journal of medicinal chemistry, Oct-30, Volume: 86 | Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. |
| AID1525350 | Antibacterial activity against Pseudomonas aeruginosa PA4 after 20 hrs under iron-rich medium by broth microdilution method | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17 | Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance. |
| AID525548 | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1051 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4 | Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination. |
| AID340725 | Antimicrobial activity against Enterobacter isolates producing extended-spectrum beta-lactamase CTX-M-1 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland. |
| AID495919 | Antimicrobial activity in Escherichia coli TOP10 hourbouring recombinant plasmid VIM-4 by Etest in presence of 4 ug/ml clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID325158 | Antimicrobial activity against Haemophilus parasuis BB 1025 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Beta-lactam resistance in Haemophilus parasuis Is mediated by plasmid pB1000 bearing blaROB-1. |
| AID531434 | Antibacterial activity against Streptococcus pneumoniae serotype 22 assessed as percent susceptible isolates by broth microdilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID400380 | Antibacterial activity against Proteus mirabilis after at 200 ug/100uL 24 hrs by agar well diffusion method | 1998 | Journal of natural products, Feb, Volume: 61, Issue:2 | Antibacterial steroidal alkaloids from Sarcococca saligna. |
| AID562762 | Antimicrobial activity against Escherichia coli NO8-1503 harboring blaTEM-168 gene by Etest in presence of clavulanic acid | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | TEM-168, a heretofore laboratory-derived TEM beta-lactamase variant found in an Escherichia coli clinical isolate. |
| AID1888848 | Antibacterial activity against Staphylococcus aureus K1758 measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID495909 | Antimicrobial activity in Escherichia coli J53 transconjugate with Escherichia coli DIH-1 expressing natural plasmid containing beta-lactamase VIM-19 | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. |
| AID522037 | Antimicrobial activity against Klebsiella pneumoniae isolate Kp6A expressing beta-lactamase OXA-48 and TEM-150 by Etest method in presence of beta-lactamase inhibitor clavulanic acid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Spread of OXA-48-encoding plasmid in Turkey and beyond. |
| AID531476 | Antibacterial activity against Bacteroides fragilis assessed as percent resistant isolates by agar dilution method in presence of clavulanate | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Resistance trends of the Bacteroides fragilis group over a 10-year period, 1997 to 2006, in Madrid, Spain. |
| AID206773 | In vitro Anti Bacterial Activity (MIC90) against 90% of tested clinical Isolates of Staphylococcus aureus MV (20) | 1995 | Journal of medicinal chemistry, Oct-13, Volume: 38, Issue:21 | 2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics. |
| AID1486242 | Antibacterial activity against Staphylococcus aureus BGW541 after 20 hrs by broth microdilution method | 2017 | Bioorganic & medicinal chemistry, 08-01, Volume: 25, Issue:15 | Novel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1586 (15.58) | 18.7374 |
| 1990's | 2299 (22.59) | 18.2507 |
| 2000's | 2560 (25.15) | 29.6817 |
| 2010's | 2521 (24.77) | 24.3611 |
| 2020's | 1213 (11.92) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (136.88) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,661 (24.38%) | 5.53% |
| Reviews | 869 (7.96%) | 6.00% |
| Case Studies | 1,432 (13.12%) | 4.05% |
| Observational | 50 (0.46%) | 0.25% |
| Other | 5,903 (54.08%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anti-Helicobacter Pylori Therapy With Dexlansoprazole MR-Based Concomitant Quadruple Therapy- A Prospective Randomized Trial [NCT03829150] | 202 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial to Study the Efficacy and Safety of Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium in the Treatment of Diabetic Foot Infections in Chinese Adults [NCT01370616] | Phase 3 | 565 participants (Actual) | Interventional | 2011-09-02 | Completed | ||
| Effect of Antibiotic Prophylaxis in Dental Implant Surgery - a Multicenter Placebo-controlled Double-blinded Randomized Clinical Trial [NCT03412305] | Phase 4 | 474 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Antibiotic Prophylaxis Prior to the Insertion of Orthodontic Mini-screw Implants: a Randomized Controlled Trial [NCT03582605] | Early Phase 1 | 31 participants (Actual) | Interventional | 2018-08-07 | Completed | ||
| Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers [NCT00066066] | Phase 2 | 146 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| A Monocentric, Open-label, Efficacy and Safety Evaluation Study of the Triple Therapy of 500 mg Levofloxacin, 1000 mg Amoxicillin and 30 mg Lansoprazole on Helicobacter Pylori Eradication in 60 Patients Infected With H. Pylori [NCT01131026] | Phase 3 | 60 participants (Anticipated) | Interventional | 2010-06-30 | Completed | ||
| Helicobacter Pylori Eradication According to Sequencing-based 23S Ribosomal RNA Point Mutation Associated With Clarithromycin Resistance [NCT03884348] | 431 participants (Actual) | Observational | 2017-01-01 | Completed | |||
| A Randomized, Double-Blind, Placebo Controlled, Phase 2 Study to Assess Treatment of Gardnerella Vaginalis Vaginal Colonization With Amoxicillin [NCT03211156] | Phase 2 | 97 participants (Actual) | Interventional | 2017-09-11 | Completed | ||
| Clinical, Microbiological and Quality of Life Outcomes Following Use of Systemic and Local Antimicrobials in the Management of Odontogenic Infections in Paediatric Patients [NCT03761264] | Phase 2 | 55 participants (Actual) | Interventional | 2018-09-18 | Completed | ||
| Safety, Validity and Efficiency of a Direct Graded Oral Challenge With Amoxicillin for the Evaluation of Penicillin Allergy in Adults [NCT03757052] | 1,000 participants (Anticipated) | Interventional | 2018-11-20 | Recruiting | |||
| 14-day PCAB-based and Reverse Hybrid Therapy Fro Helicobacter Pylori [NCT05191888] | Phase 4 | 906 participants (Anticipated) | Interventional | 2021-08-06 | Recruiting | ||
| A Randomized Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection [NCT01219764] | Phase 4 | 200 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| A Multi-centre, Non-inferiority, Randomized, Double-blind, Phase IV Study Comparing Pristinamycin (2g x 2 Per Day for 2 Days Then 1g x 3 Per Day for 5 to 7 Days) to Amoxicillin (1g x 3 Per Day) for 7 to 9 Days in Adults With Acute Community Acquired Pneum [NCT02332577] | Phase 4 | 161 participants (Actual) | Interventional | 2015-04-30 | Terminated(stopped due to The sponsor stopped the study due to low recruitment with no safety concerns) | ||
| Comparison of Standard Versus Double Dose of Amoxicillin in the Treatment of Non-Severe Pneumonia in Children Aged 2-59 Months: A Multi-centre Randomized Double Blind Controlled Trial in Pakistan [NCT01375426] | Phase 1/Phase 2 | 900 participants | Interventional | 2003-09-30 | Completed | ||
| Treatment of Pharyngitis Study (TOPS): A Randomized Equivalence Trial of Intramuscular Penicillin G vs. Oral Amoxicillin Antibiotics for the Treatment of Streptococcal Pharyngitis in Children in Developing Countries [NCT01156740] | 558 participants (Actual) | Interventional | 2001-08-31 | Completed | |||
| Oral Antibiotics to Prevent Infection and Wound Dehiscence After Obstetric Perineal Tear - a Double-blinded Placebo Controlled Randomized Trail [NCT05830162] | Phase 4 | 442 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| A Comparison of Single Preoperative Dose of Co-amoxiclav Versus Postoperative Full Course of Amoxicillin/ Co-amoxiclav in Prevention of Postoperative Complications in Dentoalveolar Surgery: a Randomized Controlled Trial [NCT03844776] | 135 participants (Anticipated) | Interventional | 2019-10-02 | Recruiting | |||
| Rescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of High-dose Esomeprazole and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy [NCT04678492] | Phase 4 | 658 participants (Actual) | Interventional | 2020-12-20 | Completed | ||
| THE EFFECT OF HELICOBACTER PYLORI ERADICATION THERAPY TO GASTRIC WALL THICKNESS BEFORE THE LAPAROSCOPIC SLEEVE GASTRECTOMY [NCT03757650] | Phase 4 | 3 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
| Analysis of the Impact of Helicobacter Pylori Infection and Eradication on Salivary Microbiome in Adults by 16S Pyrosequencing [NCT03730766] | Phase 4 | 60 participants (Anticipated) | Interventional | 2018-08-01 | Recruiting | ||
| A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Trial of the Efficacy and Safety of Treating Acute Tonsillitis With Reyanning Mixture Alone/in Combination With Antibiotics. [NCT03704506] | Phase 4 | 144 participants (Anticipated) | Interventional | 2018-10-22 | Not yet recruiting | ||
| Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study [NCT03727620] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| A Randomized, Double-blind, Multicenter Trial to Evaluate the Safety and Efficacy of Sequential (Intravenous, Oral) Moxifloxacin Versus Comparator in Pediatric Subjects With Complicated Intra-abdominal Infection [NCT01069900] | Phase 3 | 458 participants (Actual) | Interventional | 2010-07-21 | Completed | ||
| Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics [NCT03755765] | Early Phase 1 | 66 participants (Actual) | Interventional | 2019-07-23 | Completed | ||
| Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. [NCT01211223] | Phase 4 | 42 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| The Use of Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment [NCT03933501] | Phase 4 | 48 participants (Actual) | Interventional | 2006-01-01 | Completed | ||
| Prospective Randomized Clinical Trial Comparing Efficacy Surgical Versus Medical Treatment of Osteomyelitis in Diabetic Foot Ulcers [NCT01137903] | 88 participants (Anticipated) | Interventional | 2010-04-30 | Recruiting | |||
| Rescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy [NCT03609892] | Phase 4 | 658 participants (Actual) | Interventional | 2018-08-01 | Completed | ||
| Comparison of the Efficacy of 14-day Sequential Therapy and 10-day Bismuth Quadruple Therapy in the Second Line Therapy for Helicobacter Pylori Infection: A Multi-center Randomized Trial [NCT03208426] | Phase 4 | 240 participants (Anticipated) | Interventional | 2017-10-01 | Recruiting | ||
| Clinical, Microbiological and Immunological Evaluation of the Effects of Systemic Probiotics in the Periodontal Treatment [NCT03733379] | Phase 3 | 176 participants (Anticipated) | Interventional | 2018-11-05 | Recruiting | ||
| Trial of Faropenem and Cefadroxil (in Combination With Amoxicillin/Clavulanic Acid and Standard TB Drugs) in Patients With Pulmonary Tuberculosis: Measurement of Early Bactericidal Activity and Effects on Novel Biomarkers [NCT02381470] | Phase 2 | 58 participants (Actual) | Interventional | 2019-02-11 | Completed | ||
| Population Pharmacokinetics of Anti-infective Drugs in Children in Anti-infectious Therapies [NCT03113344] | 800 participants (Anticipated) | Observational [Patient Registry] | 2017-06-21 | Recruiting | |||
| A Prospective, Single-center, Open-label, Clinical Trial to Compare the 10-day Sequential Therapy and 7-day Culture Based Tailored Therapy for the Eradication of Helicobacter Pylori [NCT02373280] | 600 participants (Anticipated) | Interventional | 2014-08-31 | Recruiting | |||
| A Phase 2 Trial to Evaluate the Early Bactericidal Activity and Safety of Meropenem With Amoxicillin/Clavulanate Plus Either Pyrazinamde or Bedaquiline in Adults With Newly Diagnosed Rifampicin-susceptible Pulmonary Tuberculosis [NCT04629378] | Phase 2 | 22 participants (Actual) | Interventional | 2020-08-17 | Completed | ||
| Treatment of High-Risk Moderate Acute Malnutrition Using Expanded Admission Criteria (Hi-MAM Study): A Cluster-randomized Controlled Trial Protocol [NCT03647150] | 1,322 participants (Actual) | Interventional | 2018-11-13 | Completed | |||
| A Phase IV Double-Blind, Placebo-Controlled, Randomized Trial to Evaluate Short Course vs.Standard Course Outpatient Therapy of Community Acquired Pneumonia in Children (SCOUT-CAP) [NCT02891915] | Phase 4 | 385 participants (Actual) | Interventional | 2016-12-02 | Completed | ||
| Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori Infection-A Randomized Clinical Trial [NCT03658746] | Phase 4 | 420 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| Manipulating the Microbiome in IBD by Antibiotics and Fecal Microbiota Transplantation (FMT): a Randomized Controlled Trial [NCT02033408] | 28 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Bismuth-containing Quadruple Therapy for Helicobacter Pylori First-line Treatment: A Multicenter Randomized Clinical Trial of Different Tetracycline Doses and Frequencies. [NCT05431075] | Phase 4 | 407 participants (Anticipated) | Interventional | 2022-07-31 | Not yet recruiting | ||
| Visiting Staff, Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan [NCT04853875] | Phase 4 | 104 participants (Actual) | Interventional | 2021-04-19 | Completed | ||
| Comparison of Genotypic Resistance Guided Versus Susceptibility Testing Guided Therapy for the Third-line Eradication of H. Pylori- a Multicenter Randomized Trial [NCT03555526] | Phase 4 | 320 participants (Anticipated) | Interventional | 2017-12-15 | Recruiting | ||
| [NCT02090738] | Phase 2 | 0 participants (Actual) | Interventional | 2014-03-31 | Withdrawn | ||
| Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics [NCT02099240] | Early Phase 1 | 11 participants (Actual) | Interventional | 2014-03-06 | Terminated(stopped due to Not enough patient enrollment and lack of staffing) | ||
| Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Therapy: A Multicenter Randomized Non-Inferiority Trial of Different Tetracycline Doses and Frequencies. [NCT05432115] | Phase 4 | 407 participants (Anticipated) | Interventional | 2022-06-25 | Recruiting | ||
| A New Antibiotic Prophylaxis Regimen to Prevent Bacteremia Following Dental Procedures [NCT02115776] | 266 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Penicillin Allergy De-Labelling in Elective Surgical Patients - A Study to Determine the Safety, Efficacy and Feasibility of Abbreviated Allergy Testing [NCT03607734] | 150 participants (Actual) | Interventional | 2017-04-24 | Completed | |||
| Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients [NCT04408508] | 50 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | |||
| A Prospective, Single-center, Randomized, Open-label, Parallel Design Clinical Trial to Compare the 14-day Bismuth Quadruple Therapy and 7-day Culture Based Tailored Therapy for the Eradication of Helicobacter as a Rescue 2nd Therapy. [NCT02359331] | 370 participants (Actual) | Interventional | 2014-08-31 | Terminated | |||
| 10-Day Antimicrobial Susceptibility Testing Guided Triple Therapy Versus 14-Day Empirical Tailored Therapy for the First-line Treatment of Helicobacter Pylori Infection-A Randomized Controlled Trail [NCT03571230] | Phase 4 | 400 participants (Anticipated) | Interventional | 2018-07-01 | Not yet recruiting | ||
| Tick Borne Diseases in Norwegian General Practice. A Randomized, Controlled Trial for Treatment of Erythema Migrans in Norwegian General Practice. A Comparison of Phenoxymethylpenicillin, Amoxicillin and Doxycycline. [NCT01368341] | Phase 4 | 225 participants (Anticipated) | Interventional | 2011-06-30 | Completed | ||
| COMPARISON OF CLINICAL EFFICACY OF COMBINATION Amoxycillin Plus Clavulanic Acid and Oxacillin Plus Ceftriaxone for HOSPITAL TREATMENT OF COMMUNITY Acquired PNEUMONIA IN CHILDREN : A Randomized Clinical Study [NCT01166932] | Phase 4 | 104 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| Clinical Efficacy of Amoxicillin Given Twice or Three Times a Day Among Children With Non-severe Community-acquired Pneumonia [NCT01200706] | Phase 4 | 820 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| A Phase 3 Randomized Multicenter Study to Evaluate the Efficacy and Safety of Open-Label Dual Therapy With Oral Vonoprazan 20 mg or Double-Blind Triple Therapy With Oral Vonoprazan 20 mg Compared to Double-Blind Triple Therapy With Oral Lansoprazole 30 mg [NCT04167670] | Phase 3 | 1,046 participants (Actual) | Interventional | 2019-12-10 | Completed | ||
| Effects of Periodontal Therapy on Markers of Systemic Inflammation in Subjects at Cardiovascular Disease Risk [NCT01046435] | 186 participants (Actual) | Interventional | 2007-03-31 | Completed | |||
| The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines [NCT01089218] | Phase 4 | 241 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| A Phase 3, Randomized, Double-blind, Active-controlled, Multicenter Study to Evaluate the Efficacy and Safety of a Triple Therapy With Tegoprazan, Amoxicillin, and Clarithromycin in H. Pylori Positive Patients [NCT03498456] | Phase 3 | 284 participants (Actual) | Interventional | 2018-06-28 | Completed | ||
| Prospective, Randomized Controlled Trial Comparing High Dose Amoxicillin Versus Tetracycline Based Quadruple Therapy as Second-line Treatment for Resistant Helicobacter Pylori Infection [NCT02175927] | Phase 4 | 312 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections [NCT04350502] | 11 participants (Actual) | Interventional | 2020-04-04 | Completed | |||
| Prospective Randomized Clinical Study: Role of Platelet Rich Fibrin (PRF) in the Tooth Extraction Site in the Prevention of Jaw Osteonecrosis on Patients Under Bisphosphonates Therapy [NCT02198001] | 100 participants (Anticipated) | Interventional | 2014-01-31 | Recruiting | |||
| Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life [NCT02258763] | Phase 4 | 19 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| A Phase Ⅰb/Ⅱa, Single-center, Randomized, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Helicobacter Pylori Eradication Efficacy in Asymptomatic Subjects With Helicobacter Pylori Infection After Multiple Doses of [NCT06076681] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2021-09-27 | Completed | ||
| [NCT04082598] | Phase 4 | 165 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| An Open-Label, Single-Dose, Two-Way Crossover Bioequivalence Study of Two Oral Suspension Formulations of Amoxicillin/Clavulanate Potassium, 600/42.9 mg/5 mL in Healthy Subjects Under Fasting Conditions [NCT00840099] | Phase 1 | 48 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| Randomized, 2-Way Crossover, Bioequivalence Study of Amoxicillin-Clavulanic Acid 400 mg-57 mg Chewable Tablets and AUGMENTIN® 400 mg-57 mg Chewable Tablets Administered as 1 x 400 mg-57 mg Chewable Tablet in Healthy Subjects Under Fed Conditions [NCT00836901] | Phase 1 | 52 participants (Actual) | Interventional | 2003-09-30 | Completed | ||
| Helicobacter Pylori Eradication Rates of Concomitant Therapy and Tailored Therapy Based on 23S Ribosomal RNA Point Mutations Associated With Clarithromycin Resistance: A Multicenter Prospective Randomized Study [NCT03130452] | Phase 4 | 280 participants (Anticipated) | Interventional | 2017-02-01 | Active, not recruiting | ||
| Evaluation of the Efficacy of an Antibiotic Combined With Standard Treatment in Severe Alcoholic Hepatitis [NCT02281929] | Phase 3 | 297 participants (Actual) | Interventional | 2015-06-13 | Completed | ||
| Helicobacter Pylori Eradication and Motor Fluctuations in Parkinson's Disease [NCT00664209] | Phase 3 | 64 participants (Actual) | Interventional | 2008-01-31 | Terminated(stopped due to Prevalence of H Pylori in the study population was much lower than anticipated) | ||
| Supportive Treatment and Antibiotics for Mild Pediatric Pneumonia [NCT05726253] | Phase 4 | 10 participants (Anticipated) | Interventional | 2023-01-09 | Recruiting | ||
| Effects of Helicobacter Pylori Eradication Therapy in Children With Chronic Immune Thrombocytopenic Purpura [NCT03172676] | Phase 4 | 75 participants (Anticipated) | Interventional | 2020-01-01 | Recruiting | ||
| Visiting Staff, Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan [NCT03516669] | Phase 4 | 20 participants (Actual) | Interventional | 2018-05-07 | Completed | ||
| Population Pharmacokinetics of Anti-tuberculosis Drugs in Children With Tuberculosis [NCT03625739] | 800 participants (Anticipated) | Observational [Patient Registry] | 2018-07-01 | Recruiting | |||
| Study Of The Antibiotic Role In Post Tonsillectomy Complications [NCT03491085] | Phase 1/Phase 2 | 200 participants (Anticipated) | Interventional | 2018-05-15 | Not yet recruiting | ||
| Effect of Antibiotic and Probiotic Therapies in the Adjuvant Treatment of Chronic Periodontitis: Randomized Controlled Clinical Trial. [NCT03692819] | 45 participants (Actual) | Interventional | 2018-05-02 | Completed | |||
| Short-course Antimicrobial Therapy for Paediatric Respiratory Infections [NCT02380352] | Phase 4 | 281 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Efficacy and Safety of a 14-day Modified Sequential Therapy for Refractory Helicobacter Pylori Infection: an Open Randomized Pilot Study [NCT03658733] | Phase 4 | 120 participants (Anticipated) | Interventional | 2018-12-15 | Not yet recruiting | ||
| Effect of the CYP2C19 Polymorphism in Helicobacter Pylori Eradication [NCT03650543] | Phase 4 | 133 participants (Actual) | Interventional | 2012-09-10 | Completed | ||
| Use of a Novel Diet (UC DIET) Targeting the Microbiota for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis: An Open Label Pilot Study [NCT02345733] | Phase 4 | 20 participants (Anticipated) | Interventional | 2015-09-01 | Completed | ||
| Efficacy and Safety of a 14-day Modified Sequential Therapy for Refractory Helicobacter Pylori Infection: a Pilot Study [NCT03616405] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-04-01 | Not yet recruiting | ||
| Efficacy of Two Doses of Parenteral Amoxicillin Plus Single Dose Gentamicin Compared to Four Doses of Parenteral Ampicillin Plus Single Dose Gentamicin in Managing Children Hospitalized With WHO Classified Severe Pneumonia: a RCT [NCT03369093] | 308 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| Efficacies of Tetracycline-levofloxacin Quadruple Therapy, Standard Bismuth Quadruple Therapy and Amoxicillin-levofloxacin Quadruple Therapy in the Second-line Treatment of H Pylori Infection [NCT05850117] | 240 participants (Anticipated) | Interventional | 2020-02-10 | Recruiting | |||
| Phase 4 Study Into the Effect of Minocycline and Amoxicillin Administration of the Prevalence of Antibiotic Resistant Bacteria and on the Indigenous Oral, Faecal, Cutaneous and Nasal Microbiotas [NCT02030912] | Phase 4 | 42 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Azithromycin With or Without Amoxicillin to Prevent Peripartum Infection and Sepsis in Laboring High-risk Women: 3-Arm RCT [NCT03248297] | Phase 4 | 756 participants (Actual) | Interventional | 2018-01-12 | Completed | ||
| Oral Versus Intravenous Antibiotics for the Management of the Osteomyelitis of the Jaws: An Open-Label Non-Inferiority Single-Arm Clinical Trial [NCT05867654] | 100 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| The Evaluation of Saccharomyces Boulardii Sachets Combined With Standard Quadruple Therapy for Eradication of Helicobacter Pylori: a Prospective, Multi-Center Trial [NCT03688828] | 360 participants (Actual) | Interventional | 2018-11-11 | Completed | |||
| An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following [NCT02783404] | Phase 4 | 40 participants (Actual) | Interventional | 2017-02-27 | Terminated(stopped due to Significant results (no control neither amoxicillin new arms needed)) | ||
| A Randomized Controlled Trial of Triple Therapy Versus Sequential Therapy Versus Concomitant Therapy as First Line Treatment for Helicobacter Pylori Infection [NCT02092506] | Phase 4 | 462 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Efficacy of Clarithromycin and Flouroquinolones Based Regimens in H.Pylori Eradication in Covid-19 Era: a Randomized Controlled Trial [NCT05035186] | 233 participants (Actual) | Interventional | 2021-03-21 | Completed | |||
| High-Dose Dual Therapy vs Standard Triple Therapy for Treatment-Naïve H. Pylori: A Prospective Randomized Control Trial in a Diverse Urban New York City Population [NCT05342532] | Phase 4 | 112 participants (Actual) | Interventional | 2019-06-12 | Completed | ||
| Necessity of Antibiotics for Prevention of Delivery-associated Infections After Spontaneous Vaginal Delivery at Term [NCT02131818] | Phase 4 | 5 participants (Actual) | Interventional | 2014-05-31 | Terminated(stopped due to The enrollment process is too difficult to complete) | ||
| Visiting Staff, Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan [NCT03521726] | Phase 4 | 20 participants (Actual) | Interventional | 2018-05-11 | Completed | ||
| Comparison of Triple Therapy Regimens Effectiveness Over 10 Days and 14 Days in Eradication of Helicobacter Pylori Infection: Double Blind Randomized Clinical Trial [NCT03134378] | Phase 4 | 73 participants (Anticipated) | Interventional | 2016-10-03 | Recruiting | ||
| Effect of Probiotic Along With Scaling and Root Planing in the Treatment of Chronic Periodontitis [NCT03499184] | 60 participants (Actual) | Interventional | 2017-11-01 | Completed | |||
| Antibiotic Treatment in Patients With Chronic Low Back Pain and Modic Changes: a Randomized Double-blind Placebo Controlled Trial [NCT02323412] | Phase 3 | 180 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Helicobacter Pylori Resistance. A Study of Morbidity, Immunological and Clinical Phenotypes [NCT05019586] | 185 participants (Actual) | Observational | 2010-04-15 | Completed | |||
| Efficacy and Safety of 14-day Concomitant Therapy for Helicobacter Pylori: A Pilot Study [NCT04991584] | 60 participants (Anticipated) | Interventional | 2021-08-04 | Not yet recruiting | |||
| A Randomized, Open-label, Multiple Dose, Two-part Phase I Clinical Trial to Compare the Pharmacokinetics, Pharmacodynamics and Safety/Tolerability of DWP14012 After Administrations of DWP14012 Alone and Combinations of DWP14012, Clarithromycin and Amoxici [NCT03487562] | Phase 1 | 48 participants (Actual) | Interventional | 2018-04-08 | Completed | ||
| Study on the Effect of Fucoidan Combined With the Eradication Program Containing Vonoprazan on H.Pylori Eradication Rate and Gastrointestinal Flora. [NCT05461508] | Phase 1/Phase 2 | 60 participants (Anticipated) | Interventional | 2022-10-01 | Recruiting | ||
| Penicillin De-labeling in the Pediatric Primary Care Setting [NCT05010304] | Phase 4 | 23 participants (Actual) | Interventional | 2021-12-09 | Completed | ||
| Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response [NCT02197260] | Phase 4 | 80 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Antibiotic PRophylAxis Based on infeCTIve Risk in Cardiac Implantable Electronic Device - PRACTICE Study [NCT04736979] | 1,044 participants (Actual) | Observational | 2017-01-01 | Completed | |||
| A Randomized, Double-blind Pilot Study of Polyunsaturated Fatty Acid-optimized Ready-to-use Therapeutic Food, Compared to Standard RUTF, in the Therapy of Severe Acute Malnutrition [NCT02053857] | 141 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy Due to Acute Cholecystitis. Is it Necessary? [NCT02057679] | Phase 4 | 200 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Impact of Non-surgical Periodontal Therapy With or Without Antibiotics on Oral and Gut Microbiome in Patients With Stage III/IV and Grade C Periodontitis [NCT04580355] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-07-31 | Recruiting | ||
| Different Duration and Dosing of Amoxicillin in Patients With Erythema Migrans. A Randomized Clinical Trial. [NCT03966014] | 510 participants (Anticipated) | Interventional | 2019-06-01 | Recruiting | |||
| Рrospective Multicenter Randomized 3 Phase Study Evaluating the Role of Prolonged Antibiotic Prophylaxis as a Measure to Reduce the Incidence of Postoperative Complications After Radical Cystectomy With ERAS Protocol [NCT05392634] | Phase 3 | 98 participants (Anticipated) | Interventional | 2022-02-02 | Recruiting | ||
| An Open-Label, Single-Dose, Two-Way Crossover Bioequivalence Study of Two Oral Suspension Formulations of Amoxicillin/Clavulanate Potassium, 600/42.9 mg/5 mL in Healthy Subjects, Under Fed Conditions [NCT00840840] | Phase 1 | 48 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| The Norwegian Antibiotics for Pneumonia in Children Study [NCT03446534] | Phase 4 | 884 participants (Anticipated) | Interventional | 2018-03-07 | Recruiting | ||
| Antimicrobial Therapy for Ulcerative Colitis : Evaluation of Two Antibiotic Combinations for Refractory Ulcerative Colitis [NCT03986996] | Phase 2 | 20 participants (Actual) | Interventional | 2019-07-25 | Terminated(stopped due to There is no feasibility to conduct the study) | ||
| Oral Penicillin Challenge in the Pediatric Emergency Department [NCT03404804] | Phase 4 | 300 participants (Anticipated) | Interventional | 2017-12-04 | Active, not recruiting | ||
| Study the Efficacy of Lactoferrin in Helicobacter Pylori Eradication Either With Standard Triple Therapy or Sequential Therapy in Egyptian Patients [NCT04445948] | Phase 4 | 400 participants (Actual) | Interventional | 2019-11-30 | Completed | ||
| Local Effect of Periodontal Debridement Associated With Different Systemic Antibiotic Protocols and Single or Repeated Application of Photodynamic Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial [NCT03132714] | Phase 2/Phase 3 | 46 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Randomised Controlled Clinical Trial Investigating Benefits of Using Response to Broad Spectrum Antibiotics as an Exclusion Diagnostic for Tuberculosis (TB) in Primary Care Adult Patients Versus Risk of Antimicrobial Resistance (AMR) [NCT03545373] | Phase 3 | 1,583 participants (Actual) | Interventional | 2019-02-25 | Completed | ||
| Helicobacter Pylori and Chronic Dyspepsia in Eastern Uganda [NCT04525664] | Early Phase 1 | 376 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
| Efficacy of Intensive Periodontal Therapy and Premedication With Oral Amoxicilline on Inflammatory Markers and Bacteremia in Patients With Chronic Periodontitis. A Randomized Controlled Trial. [NCT03354338] | Phase 2 | 90 participants (Anticipated) | Interventional | 2017-09-21 | Active, not recruiting | ||
| Evaluation of a on Community-Based Management of Neonatal Sepsis [NCT01333982] | 20,000 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Rifabutin-containing Triple Therapy for Helicobacter Pylori Rescue Treatment: a Randomized Controlled Trial [NCT05874544] | Phase 4 | 357 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | ||
| Shortened Antibiotic Therapy for Febrile Urinary Tract Infection (UTI) in Childhood: a Multicenter Randomized Controlled Trial [NCT04400110] | Phase 4 | 154 participants (Actual) | Interventional | 2020-06-08 | Completed | ||
| A Randomized, Open-label, Multiple-dose, 3-way Crossover Phase 1 Clinical Trial to Evaluate Drug-drug Interactions and Safety Among JP-1366, Amoxicillin, and Clarithromycin in Healthy Volunteers [NCT05194046] | Phase 1 | 29 participants (Actual) | Interventional | 2020-11-18 | Completed | ||
| A Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Sanfetrinem Cilexetil Administered Orally to Adults With Newly Diagnosed, Smear-Positive, Rifampicin-Susceptible Pulmonary Tuberculosis [NCT05388448] | Phase 2 | 105 participants (Anticipated) | Interventional | 2022-04-21 | Recruiting | ||
| Medico-economic Evaluation of a Therapeutic Strategy Based on Molecular Detection of Antibiotic Resistance in the Management of H Pylori Infection [NCT01168063] | 1,386 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate: A Confirmation Study [NCT03431337] | Phase 4 | 157 participants (Actual) | Interventional | 2018-02-26 | Terminated(stopped due to Futility found by interim analysis) | ||
| Cluster Randomized Trial of Community Case Management of the Severe Pneumonia With Oral Amoxicillin in Children 2-59 Months of Age in Hala and Matiari District, Pakistan [NCT01192789] | 4,070 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| DIABOLO Trial: A Multicenter Randomized Clinical Trial Investigating the Cost-effectiveness of Treatment Strategies With or Without Antibiotics for Uncomplicated Acute Diverticulitis. [NCT01111253] | Phase 4 | 533 participants (Anticipated) | Interventional | 2010-05-31 | Active, not recruiting | ||
| Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) [NCT05156437] | Phase 4 | 20 participants (Anticipated) | Interventional | 2022-03-16 | Enrolling by invitation | ||
| Antibiotic-associated Gastrointestinal Side Effects and the Role of the Gut Microbiome [NCT04156555] | Phase 4 | 30 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| Comparative Efficacy of Single-dose Doxycycline Versus Standard 5- Day Amoxicillin Treatment for Patients With Non-malarial Fever: a Randomized Non-inferiority Trial in Senegal [NCT03765931] | Phase 4 | 274 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Efficacy of Tailored for Helicobacter Pylori Rescue Treatment Based on Antimicrobial-susceptibility Testing [NCT03413020] | Phase 4 | 200 participants (Actual) | Interventional | 2018-01-03 | Completed | ||
| "Drug Use Surveillance of Takecab Tablets Supplement to Helicobacter Pylori Eradication" [NCT03219723] | 560 participants (Actual) | Observational | 2015-09-01 | Completed | |||
| Intraluminal Therapy for Helicobacter Pylori Infection [NCT03124420] | Phase 4 | 100 participants (Actual) | Interventional | 2017-04-28 | Completed | ||
| A Randomized Double Blind Active Comparator Controlled Phase III Study to Assess the Safety and Efficacy of RHB-105 in the Treatment of Confirmed Helicobacter Pylori (H. Pylori) Infection [NCT03198507] | Phase 3 | 455 participants (Actual) | Interventional | 2017-06-18 | Completed | ||
| A Phase 1, Double-Blind, Parallel Group Study to Evaluate the Safety and Pharmacokinetics of Quadruple Therapy (Bismuth, Clarithromycin, and Amoxicillin) With TAK-438 Versus Quadruple Therapy With Lansoprazole [NCT02892409] | Phase 1 | 30 participants (Actual) | Interventional | 2016-09-05 | Completed | ||
| Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and Quality of Life After Surgical Extraction of Impacted Mandibular Third Molars [NCT05681312] | Phase 3 | 55 participants (Anticipated) | Interventional | 2023-10-01 | Recruiting | ||
| High Eradication Rate of Helicobacter Pylori Infection With Moxifloxacin-Based Triple Therapy in Comparison With Levofloxacin-Based Sequential Therapy: Randomized Controlled Trials [NCT05863858] | Phase 3 | 162 participants (Actual) | Interventional | 2020-06-01 | Completed | ||
| Study on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line Eradication [NCT05014334] | Phase 4 | 300 participants (Actual) | Interventional | 2021-12-01 | Completed | ||
| Efficacy and Safety of Berberine Hydrochloride, Amoxicillin and Rabeprazole Triple Therapy in the First Eradication of Helicobacter Pylori [NCT04697186] | Phase 4 | 524 participants (Actual) | Interventional | 2021-01-07 | Completed | ||
| The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial) [NCT03783845] | Phase 4 | 44 participants (Actual) | Interventional | 2015-06-01 | Completed | ||
| Efficacy of Two-week Therapy With Levofloxacin-based Concomitant Regimen Versus Levofloxacin-based Sequential Regimen for Helicobacter Pylori Infection in Syrian Population: a Prospective Single-center Randomized Controlled Trial [NCT06065267] | Phase 4 | 150 participants (Anticipated) | Interventional | 2024-01-02 | Not yet recruiting | ||
| Efficacy of Vonoprazan-containing Triple Therapy Versus Empiric Bismuth Quadruple Therapy for First-line Helicobacter Pylori Treatment: a Randomized Clinical Trial [NCT05726734] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-02-06 | Not yet recruiting | ||
| [NCT02873065] | Phase 4 | 0 participants | Interventional | 2014-09-30 | Completed | ||
| TREAT: Treatment of ppROM With Erythromycin vs. Azithromycin Trial [NCT03060473] | Phase 3 | 324 participants (Anticipated) | Interventional | 2017-02-23 | Recruiting | ||
| Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice [NCT01273441] | Phase 4 | 338 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Susceptibility-Guided Sequential Therapy Versus Empirical Therapy for Helicobacter Pylori Infection: a Randomised Controlled Trial [NCT05549115] | 500 participants (Anticipated) | Interventional | 2022-09-20 | Recruiting | |||
| Comparative Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control on the Gastric Lesions Induced by the Aspirin With the Low Dose Among Patients Treated With the Long Course [NCT00713947] | Phase 4 | 0 participants (Actual) | Interventional | 2008-04-30 | Withdrawn(stopped due to no inclusion) | ||
| Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs [NCT00720811] | 6,456 participants (Actual) | Interventional | 2009-10-31 | Completed | |||
| Multicenter, Open, Randomized Comparative Trial To Compare Bacteriological And Clinical Efficacy Of Azithromycin Versus Amoxicillin In Children With Streptococcus Tonsillitis [NCT00643539] | Phase 4 | 360 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| Oral Amoxicillin Challenge in the Primary Care Setting [NCT05165212] | Phase 4 | 0 participants (Actual) | Interventional | 2024-12-31 | Withdrawn(stopped due to Unable to host study at clinic site.) | ||
| Efficacy and Safety of Quadruple Therapy by Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Given X 10 Days With Omeprazole in Eradication of Helicobacter Pylori: A Comparison to Omeprazole, Amoxicillin and Clarithromycin Given X 7 Days [NCT00669955] | Phase 3 | 440 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Effect of Eradication of Helicobacter Pylori on the Dyspeptic Symptoms. [NCT00772837] | 370 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| Tailored Therapy Versus Standard Triple Therapy for Helicobacter Pylori Eradication in Children: A Randomized Trial [NCT02635191] | Phase 4 | 200 participants (Anticipated) | Interventional | 2014-03-31 | Recruiting | ||
| Effects of Phenoximethylpenicillin, Amoxicillin and Amoxicillin-clavulanic Acid on the Gut Microbiota of Healthy Volunteers: a Randomized Clinical Trail [NCT04084106] | Phase 4 | 104 participants (Actual) | Interventional | 2019-09-10 | Completed | ||
| Comparing Oral Versus Parenteral Antimicrobial Therapy (COPAT) Trial [NCT05977868] | Phase 4 | 135 participants (Anticipated) | Interventional | 2023-08-04 | Enrolling by invitation | ||
| Single-center, Randomized, Open-label Phase Ic/IIb Clinical Study to Evaluate the Efficacy and Safety of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules Combined With Multiple Doses of Rabeprazole Sodium Enteric-coate [NCT06076694] | Phase 2 | 80 participants (Actual) | Interventional | 2022-06-26 | Completed | ||
| Oral Penicillin Challenge and Allergy De-labeling in the Phoenix Children's Hospital Emergency Department [NCT05563610] | Phase 4 | 300 participants (Anticipated) | Interventional | 2022-09-26 | Recruiting | ||
| Comparing the Efficacy and Impact on Gastrointestinal Microbiome of Reverse Hybrid Therapy and Bismuth Quadruple Therapy in Helicobacter Pylori Eradication [NCT02547038] | 352 participants (Actual) | Interventional | 2015-02-28 | Completed | |||
| Randomized, 2-Way Crossover, Bioequivalence Study of Amoxicillin-Clavulanic Acid 400 mg-57 mg Chewable Tablets and AUGMENTIN® 400 mg-57 mg Chewable Tablets Administered as 1 x 400 mg-57 mg Chewable Tablet in Healthy Subjects Under Fasting Conditions [NCT00835705] | Phase 1 | 52 participants (Actual) | Interventional | 2003-09-30 | Completed | ||
| Prevention of Early Ventilator-associated Pneumonia With Antibiotic Therapy in Patients Treated With Mild Therapeutic Hypothermia After Cardiac Arrest. [NCT02186951] | Phase 3 | 197 participants (Actual) | Interventional | 2014-08-18 | Completed | ||
| A Single-center, Randomized, Open-label, Crossover Study to Evaluate the Pharmacokinetic Drug-drug Interaction of the Quadruple Therapy With Anaprazole/Amoxicilin/Clarithromycin/Bismuth in Healthy Chinese Male Subjects [NCT04444011] | Phase 1 | 32 participants (Anticipated) | Interventional | 2020-07-01 | Not yet recruiting | ||
| An Open Label, Single Arm Study, to Evaluate the Pharmacokinetics of LP-001 Oral Suspension in Children With a Bacterial Infection [NCT05584683] | Phase 1 | 24 participants (Anticipated) | Interventional | 2022-12-12 | Not yet recruiting | ||
| Prospective Randomized Trial: Comparison Between High-dose Amoxicillin Dual Therapy and Pylera Quadruple Therapy in the Treatment of Helicobacter Pylori Infection [NCT05100446] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | ||
| Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients [NCT03120663] | 120 participants (Anticipated) | Observational | 2016-11-30 | Recruiting | |||
| Efficacy of High-dose Dual Therapy Versus Bismuth-containing Quadruple Therapy for First-line Treatment of Helicobacter Pylori Infection - A Prospective, Randomized, Comparative Study [NCT02483715] | Phase 4 | 589 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Home Intravenous Versus Oral Antibiotics Following Appendectomy for Perforated Appendicitis in Children, a Randomized Controlled Trial [NCT02724410] | 82 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| A Multicenter Randomized Controlled Open-label Trial of Conservative Management Versus Minimally Invasive Treatment With Leukocyte- and Platelet-rich Fibrin Versus Primary Surgery in Patients With Newly Diagnosed Osteonecrosis of the Jaw [NCT04512638] | Phase 4 | 125 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | ||
| Comparing the Efficacy and Impact on Gastrointestinal Microbiota of Reverse Hybrid Therapy and Concomitant Therapy in Helicobacter Pylori Eradication [NCT02646332] | 248 participants (Actual) | Interventional | 2015-12-31 | Completed | |||
| Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice: A PBRN Clinical Trial [NCT06131021] | Phase 3 | 544 participants (Anticipated) | Interventional | 2024-04-30 | Not yet recruiting | ||
| PROMIZE: A Phase I/II Trial to Assess the Safety, Tolerability and Preliminary Anti-tumour Activity of Oral Combination Antibiotic Therapy to Modulate the Microbiome in Combination With Enzalutamide With Metastatic Castration Resistant Prostate Cancer (mC [NCT06126731] | Phase 1/Phase 2 | 39 participants (Anticipated) | Interventional | 2023-11-02 | Recruiting | ||
| Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: a Feasibility Randomized Controlled Trial of Short-course Antibiotic Therapy [NCT06125340] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | ||
| Efficacy of 7-day Versus 14-day Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori : A Multicenter Randomized Non-Inferiority Trial [NCT05997433] | 254 participants (Anticipated) | Interventional | 2023-09-02 | Recruiting | |||
| Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology [NCT05742568] | Phase 4 | 120 participants (Anticipated) | Interventional | 2022-12-01 | Recruiting | ||
| Efficacy of High Dose of Amoxicillin And Metronidazole Plus Bismuth For Helicobacter Pylori Treatment In Naive Patients : A Randomized Clinical Trial [NCT03557437] | Phase 4 | 216 participants (Actual) | Interventional | 2018-05-25 | Completed | ||
| ONE WEEK VS. TWO WEEKS VONOPRAZAN CONTAINING TRIPLE REGIMEN FOR ERADICATION OF HELICOBACTER PYLORI: [NCT05728424] | Phase 3 | 246 participants (Anticipated) | Interventional | 2022-09-20 | Recruiting | ||
| Clindamycin Versus Amoxicillin With Clavulanic Acid in Prevention of Early Dental Implants Failure [NCT04980170] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2021-11-01 | Not yet recruiting | ||
| Geisinger Antibiotic Allergy Pilot Program: Assess and Address (GAAP) Penicillin Allergy De-labeling in Inpatient Setting by Performing Direct Oral Amoxicillin Challenge in Low-risk Patients [NCT05464615] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2024-01-15 | Not yet recruiting | ||
| Antibiotic Dosing in Pediatric Intensive Care [NCT02456974] | 640 participants (Anticipated) | Observational [Patient Registry] | 2012-05-31 | Recruiting | |||
| Optimization of Vonoprazan--amoxicillin Dual Therapy for Eradicating Helicobacter pyloriinfection-a Multicenter, Prospective, Randomized, Parallel-controlled Study [NCT05719831] | Phase 3 | 516 participants (Actual) | Interventional | 2023-02-01 | Completed | ||
| Prospective, Randomized Controlled Trial Comparing Amoxicillin and Metronidazole Based Bismuth-containing Quadruple Therapy With Amoxicillin and Clarithromycin Based Quadruple Therapy for First-line Helicobacter Pylori Eradication [NCT02175901] | Phase 4 | 215 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Efficacy of Amoxicillin-Esomeprazole High Dose Dual Therapy Compared to Levofloxacin Containing Triple Therapy for the Eradication of Helicobacter Pylori in a Tertiary Care Hospital: A Single-blind Randomized Controlled Trial [NCT06088316] | Phase 4 | 70 participants (Anticipated) | Interventional | 2023-02-10 | Recruiting | ||
| A Randomized Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Bismuth-Containing Quadruple Therapy With Oral TAK-438 20 mg Compared to Esomeprazole 20 mg Twice Daily in Subjects With Helicobacter Pylori Infection [NCT04198363] | Phase 3 | 510 participants (Actual) | Interventional | 2020-04-30 | Completed | ||
| Phase 2/3 Evaluation of Three Lactobacilli Strains Isolated From Human Milk for the Treatment of Infectious Mastitis During the Lactation Period [NCT00716183] | Phase 2/Phase 3 | 300 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Pharmacokinetic Study of the Amoxicillin / Clavulanic Acid Association to Optimize Dosage Among Obese Adults (PHACO) [NCT02571959] | Phase 1/Phase 2 | 36 participants (Actual) | Interventional | 2015-07-24 | Completed | ||
| Prospective Study of the Effects of Helicobacter Pylori Eradication on Renal Functions and Proteinuria in Patients With Membranous Nephropathy [NCT00983034] | 70 participants (Actual) | Interventional | 2006-03-31 | Completed | |||
| Early Bactericidal Activity of Cephalexin and Amoxicillin-clavulanate for Susceptible Tuberculosis - BLAST 1 Trial [NCT05664568] | Phase 2 | 30 participants (Anticipated) | Interventional | 2023-03-15 | Recruiting | ||
| Comparative, Randomized, Single-Dose, 2-Way Crossover Bioavailability Study of Ranbaxy and GlaxoSmithKline (Augmentin®) 400 mg Amoxicillin (as the Trihydrate)/57 mg Clavulanic Acid (as the Potassium Salt) Chewable Tablets in Healthy Adult Volunteers Follo [NCT00778661] | 40 participants (Actual) | Interventional | 2002-10-31 | Completed | |||
| Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain [NCT01096927] | Phase 4 | 160 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection [NCT02553083] | Phase 4 | 300 participants (Anticipated) | Interventional | 2015-10-22 | Recruiting | ||
| Efficacy of Antimicrobials in Young Children With Acute Otitis Media (AOM) [NCT00377260] | Phase 4 | 291 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia [NCT02735707] | Phase 3 | 10,000 participants (Anticipated) | Interventional | 2016-04-11 | Recruiting | ||
| Control of Periodontal Infections [NCT01098448] | Phase 3 | 187 participants (Actual) | Interventional | 1999-09-30 | Completed | ||
| Visiting Staff, Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan [NCT03524833] | Phase 4 | 20 participants (Actual) | Interventional | 2018-05-07 | Completed | ||
| Benefit of a Single Preoperative Dose of Antibiotics in a Sub-Saharan District Hospital: Minimal Input, Massive Impact [NCT00801099] | 276 participants (Actual) | Interventional | 2004-12-31 | Completed | |||
| Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery [NCT02764710] | Phase 3 | 250 participants (Anticipated) | Interventional | 2016-05-31 | Not yet recruiting | ||
| Double-blind Randomized Controlled Clinical Trial of 3 Days of Amoxicillin Disperable Tablet (DT) Versus Placebo for Fast Breathing Childhood Pneumonia Among Children 2-59 Months of Age Presenting to Kamuzu Central Hospital in Lilongwe, Malawi [NCT02760420] | Phase 4 | 1,126 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Pharmacodynamic Drug Interaction Between Warfarin and Amoxicillin-clavulanic Acid [NCT00603317] | Phase 4 | 13 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| Clinical Efficacy of Cotrimoxazole Versus Amoxicillin in the Treatment of Community Acquired Pneumonia in Children Aged 2-59 Months Attending Mulago Hospital: A Randomized Clinical Trial. [NCT00933049] | Phase 3 | 505 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| Helicobacter Pylori Eradication Therapy on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection of Gastric Neoplastic Lesions: a Multicenter, Randomized, Double Blind, and Placebo Controlled Trial [NCT00926809] | Phase 4 | 232 participants (Anticipated) | Interventional | 2008-09-30 | Recruiting | ||
| The Observation on the Efficacy of Dual Therapy Based on Vonoprazan in Eradicating Helicobacter Pylori [NCT06004401] | 400 participants (Anticipated) | Interventional | 2023-08-20 | Not yet recruiting | |||
| Comparison Efficacy of 14-day Triple Therapy Between Clarithromycin and Levofloxacin on the Eradication of Helicobacter Pylori in Syrian Population [NCT02693574] | Phase 4 | 74 participants (Actual) | Interventional | 2015-12-01 | Active, not recruiting | ||
| A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial Of Azithromycin SR Versus Amoxicillin For The Treatment Of Group A Β-Hemolytic Streptococcal Pharyngitis/Tonsillitis In Children [NCT00643149] | Phase 3 | 693 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
| A Phase IIIB/IV Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets vs. Amoxicillin-Clavulanate for the Treatment of Subjects With Acute Bacterial Sinusitis [NCT00644553] | Phase 3 | 437 participants (Actual) | Interventional | 2003-05-31 | Completed | ||
| A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media [NCT00644943] | Phase 4 | 425 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers: A Randomized, Parallel-controlled Multi-center Study [NCT03342456] | Phase 4 | 184 participants (Actual) | Interventional | 2017-12-13 | Completed | ||
| Construction and Application of the Treatment of Refractory Helicobacter Pylori Infection Based on the High-throughput Sequencing Technologies [NCT02741414] | 4,428 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | |||
| A RCT of the Efficacy of Vonoprazan 20mg QD Combined With Amoxicillin 750mg QID in the Treatment of Helicobacter Pylori Infection [NCT05590286] | Phase 4 | 100 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Aged 7-17 Years Old - Antibiotics Versus Primary Appendectomy in Children With Simple Appendicitis: APAC Study [NCT02848820] | Phase 4 | 302 participants (Actual) | Interventional | 2016-12-31 | Active, not recruiting | ||
| A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin SR Versus Amoxicillin/Clavulanate Potassium (Augmentin ES-600 Trademark) for the Treatment of Acute Otitis Media in Children Undergoing Diagnostic Tympanocentesis [NCT00643292] | Phase 3 | 902 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Sequential Helicobacter Pylori Eradication Therapy in Myanmar; a Randomized Clinical Trial of Efficacy and Tolerability [NCT04132479] | Phase 4 | 313 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| A Prospective, Randomized, Open Label, Active Comparator, Multicenter, National Trial to Compare the Efficacy and Safety of Sequential IV/PO Moxifloxacin 400 mg Once Daily Versus IV Amoxicillin/Clavulanate 2,0/0,2 g Every 8 Hours Followed by Oral Amoxicil [NCT00828971] | Phase 3 | 16 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Safety and Efficacy of Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh [NCT00844337] | 2,490 participants (Actual) | Interventional | 2009-03-31 | Completed | |||
| Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Oral Antibiotics in the Community-based Treatment of Severe Acute Malnutrition in Malawian Children [NCT01000298] | 2,700 participants (Anticipated) | Interventional | 2009-12-31 | Completed | |||
| Prophylaxis of Surgical Wound Infection in Incisional Hernia Repair With Topical Antibiotics (PROTOP-PAR) [NCT05508152] | Phase 3 | 260 participants (Actual) | Interventional | 2021-02-01 | Completed | ||
| Study of Patient's Outcomes After a Negative Reintroduction Test for Amoxicillin [NCT04922034] | 190 participants (Actual) | Observational | 2022-01-13 | Completed | |||
| Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis [NCT06076304] | Phase 4 | 144 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media [NCT02567825] | 250 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| Zambia Integrated Management of Malaria and Pneumonia Study [NCT00513500] | 3,125 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| Prospective, Multicenter, Randomized, Double Blind, Parallel Arm Study to Evaluate the Efficacy and Safety of Moxifloxacin 400 mg OD for 7 Days Versus a Standard Antibiotic Therapy for 10 Days in the Treatment of Acute Bacterial Rhino Sinusitis [NCT00493038] | Phase 4 | 293 participants (Actual) | Interventional | 2006-02-28 | Terminated(stopped due to The study was prematurely terminated due to slow enrollment beyond the planned study timelines.) | ||
| Randomized Clinical Trial to Evaluate Guidelines for Acute Rhinosinusitis (Phase IV Study) [NCT00377403] | Phase 4 | 172 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| Randomized Non Inferiority Study Comparing Short Course of Oral Amoxicillin to One of the Usual Treatments of Lower Leg Erysipelas [NCT01059123] | Phase 4 | 10 participants (Actual) | Interventional | 2010-09-30 | Terminated(stopped due to Insufficient number of inclusion) | ||
| Once-daily Therapy for Streptococcal Pharyngitis [NCT01310361] | Phase 1 | 0 participants | Interventional | 2004-01-31 | Completed | ||
| Efficacy and Safety of 14-day Concomitant Therapy for Helicobacter Pylori: A Pilot Study [NCT03726099] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-03-15 | Recruiting | ||
| Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study) [NCT02707042] | Phase 1 | 210 participants (Anticipated) | Interventional | 2017-03-22 | Recruiting | ||
| A Comparison of High-dose Dual Therapy and Half-dose Clarithromycin-containing Bismuth Quadruple Therapy for H.P Eradication in Elderly Patients [NCT04101708] | Phase 4 | 100 participants (Anticipated) | Interventional | 2019-09-20 | Not yet recruiting | ||
| Double-blind Randomized Controlled Clinical Trial of 3 Days Versus 5 Days Amoxicillin Dispersible Tablets for Chest-indrawing Childhood Pneumonia Among Children 2-59 Months of Age Presenting to Kamuzu Central Hospital in Lilongwe, Malawi [NCT02678195] | Phase 4 | 3,000 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| A Comparative, Multi-Center, Pediatric Taste Test Study of Cefdinir (Omnicef) Versus Amoxicillin Antibiotic Suspension Medications [NCT00644891] | Phase 4 | 158 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| A Comparative, Single-Center, Pediatric Taste Test Study of Omnicef Versus Amoxicillin Antibiotic Suspension Medications [NCT00645125] | Phase 4 | 154 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization [NCT00707369] | Phase 4 | 540 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| Comparative Recurrence Rate Investigation of Esomeprazole Versus Lansoprazole in Triple-Combination Therapy to Eradicate Helicobacter Pylori Infection Among Pediatrics: Multicentre, Randomized, and Controlled Trials [NCT05861687] | Phase 2/Phase 3 | 51 participants (Actual) | Interventional | 2021-08-01 | Completed | ||
| Antibiotic Therapy is Not Necessary to Implant Totally Implantable Venous Access Devices: Randomized Prospective Study [NCT00665873] | Phase 4 | 100 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| Effect of Duration of Antibiotic Therapy on Recovery Following Tonsillectomy [NCT00662987] | 50 participants (Actual) | Interventional | 2005-09-30 | Completed | |||
| MAESTRAL - A Prospective, Multinational, Multicenter, Randomized, Double Blind, Double Dummy, Controlled Study Comparing the Efficacy and Safety of Moxifloxacin to That of Amoxicillin Clavulanic Acid for the Treatment of Subjects With Acute Exacerbations [NCT00656747] | Phase 4 | 1,372 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| A Phase 2 Randomized, Double-blind, Double-dummy Efficacy, Safety And Tolerability Study Of Iv Sulopenem With Switch To Oral Pf-03709270 Compared To Ceftriaxone With Step Down To Amoxicillin/Clavulanate Potassium (Augmentin) In Subjects With Community Acq [NCT00797108] | Phase 2 | 35 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Efficacy and Safety of Black Seed Oil With Vonoprazan Based Triple Therapy in Treatment of Helicobacter Pylori [NCT05957432] | Phase 2 | 90 participants (Anticipated) | Interventional | 2023-07-15 | Not yet recruiting | ||
| Simplified Antibiotic Regimens for the Management of Sepsis in Young Infants in First-level Facilities: Randomized Controlled Trial [NCT01027429] | Phase 3 | 2,543 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Randomized Controlled Trial Short Antibiotic Therapy (3-Day) Versus Long Antibiotic Therapy (7-Day) in Odontology-Stomatology: Impact on the Resistance of Oral Streptococci [NCT00764062] | Phase 4 | 81 participants (Actual) | Interventional | 2005-09-30 | Terminated(stopped due to The trial was stopped earlier than planned because of the slow accrual rate.) | ||
| Supportive Care and Antibiotics for Severe Pneumonia Among Hospitalized Children [NCT04041791] | Phase 3 | 4,392 participants (Anticipated) | Interventional | 2019-08-19 | Recruiting | ||
| Comparison Between Tailored Therapy Guided by a Non-invasive Antibiotic Susceptibility Test and Empiric Treatment for First-line Helicobacter Pylori Eradication in Patients With Dyspepsia: a Randomized Controlled Trial. [NCT04107194] | Phase 3 | 362 participants (Anticipated) | Interventional | 2020-01-14 | Recruiting | ||
| Randomized, Open - Label, 2 - Way Crossover, Bioequivalence Study of Amoxicillin-Clavulanic Acid 600mg - 42.9 mg/ 5 mL Oral Suspension and Augmentin ES - 600 (Reference) Following a 600 mg - 42.9 mg Dose in Healthy Subjects Under Fasting Conditions [NCT00778414] | 48 participants (Actual) | Interventional | 2006-06-30 | Completed | |||
| A National, Prospective, Randomized, Open Label Study to Assess the Efficacy and Safety of IV/PO Moxifloxacin vs IV Ceftriaxone + IV Azithromycin Followed by PO Amoxicilline/Clavulanate and PO Clarithromycin in Subjects With Community-acquired Pneumonia [NCT00717561] | Phase 3 | 60 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Plasma Concentrations of Amoxicillin Administered in High-doses During the First Week of Treatment : Intra- and Inter-individual Variability, Factors Associated With Overdose and Adverse Events [NCT04070469] | Phase 4 | 100 participants (Anticipated) | Interventional | 2019-12-04 | Recruiting | ||
| Pivmecillinam With Amoxicillin/Clavulanic Acid for Step Down Oral Therapy in Febrile UTIs Caused by ESBL-producing Enterobacterales (PACUTI) [NCT05224401] | Phase 3 | 330 participants (Anticipated) | Interventional | 2023-05-29 | Recruiting | ||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial [NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age [NCT04047849] | Phase 4 | 34 participants (Anticipated) | Interventional | 2019-08-28 | Recruiting | ||
| Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection - A Prospective Randomized, Comparative Study [NCT05332444] | Phase 4 | 450 participants (Anticipated) | Interventional | 2022-04-11 | Recruiting | ||
| Azithromycin (Zithromax®) 5 Days Versus Amoxicillin-Clavulanic Acid (Augmentin®): Multicentre, Randomised, Open-Label Study To Compare The Clinical Efficacy And Safety Of Azithromycin With Those Of Amoxicillin-Clavulanic Acid In Patients Presenting With A [NCT00649831] | Phase 3 | 250 participants (Anticipated) | Interventional | 2002-10-31 | Completed | ||
| The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in Helicobacter Pylori Patients [NCT02648659] | Phase 4 | 50 participants (Actual) | Interventional | 2016-03-02 | Completed | ||
| Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children [NCT01166945] | 98 participants (Actual) | Interventional | 2010-11-30 | Completed | |||
| A Randomized Clinical Trial to Examine the Efficacy of a Clarithromycin-, Amoxicillin-, and Metronidazole-Based Regimen to Eradicate Helicobacter Pylori Infections in Pasto, Colombia [NCT00719420] | Phase 3 | 151 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| EFFICACY OF ORAL AROEIRA (Schinus Terebinthifolius Raddi), AMOXYCILLIN AND CLARITROMYCIN COMPARED WITH CONVENTIONAL TRIPLE THERAPY FOR Helicobacter Pylori ERADICATION IN GASTRITE AND SYMPTOM PATIENTS: A RANDOMIZED AND DOUBLE-BLIND STUDY [NCT04069286] | Phase 2/Phase 3 | 200 participants (Anticipated) | Interventional | 2021-08-31 | Not yet recruiting | ||
| A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Cefepime in Hospitalized Children With Complicated Urinary Tract Infections [NCT01110408] | Phase 3 | 41 participants (Actual) | Interventional | 2010-12-31 | Terminated(stopped due to Trial terminated early per business decision) | ||
| Treatment of Non-severe Community Acquired Pneumonia With Twice Daily Compared to Thrice Daily Regimen- A Non-inferiority Pragmatic Randomized-controlled Trial. [NCT03031210] | Phase 2/Phase 3 | 1,370 participants (Anticipated) | Interventional | 2017-06-11 | Recruiting | ||
| Comparison of Dual Amoxicillin/Vonoprazan Therapy and Triple Vonoprazan/Amoxicillin/Clarithromycin or Metronidazole Therapy for H. Pylori Eradication [NCT02827942] | Phase 3 | 112 participants (Actual) | Interventional | 2016-07-01 | Completed | ||
| A Prospective, Randomized, Double Dummy, Double Blind, Multinational, Multicenter Trial Comparing the Safety and Efficacy of Sequential (Intravenous/Oral) Moxifloxacin 400 mg OD to Intravenous Piperacillin/Tazobactam 4.0/0.5 g Every 8 Hours Followed by Or [NCT00402727] | Phase 3 | 813 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| Effect of Helicobacter Pylori Treatment on Remission of Idiopathic Central Serous Chorioretinopathy (ICSCR) [NCT00817245] | Phase 1/Phase 2 | 50 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| A Phase III, Open, Randomised, Multicentre Study Comparing the Efficacy and Safety of Pristinamycin, at Dosages of 50 mg/kg/d in 2 Doses for Children, and 1g Twice Daily in Adults for 4 Days Versus Amoxicillin at a Dosage of 50 mg/kg/d in 2 Doses in Child [NCT00393744] | Phase 3 | 395 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| Comparison of Daily Single Dose Triple and Conventional Triple Therapies for Helicobacter Pylori Infection [NCT02711176] | Phase 4 | 212 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Comparison of Standard Versus Double Dose of Amoxicillin in the Treatment of Non-Severe Pneumonia in Children Aged 2-59 Months: A Multi-Centre Randomized Double Blind Controlled Trial in Pakistan [NCT00130013] | Phase 1/Phase 2 | 900 participants | Interventional | 2003-09-30 | Completed | ||
| A Randomized Multicentre Double Blind Trial of Amoxicillin Compared With Placebo for Treatment of WHO Defined Non-Severe Pneumonia in Children Aged 2-59 Months: NARIMA Study Group [NCT00851487] | 900 participants (Actual) | Interventional | 2006-01-31 | Completed | |||
| Community Case Management of Chest Indrawing Pneumonia With Oral Amoxicillin in Children Aged 2-59 Months Old by Community Oriented Resources Persons (CORPs) in Niger State, Nigeria [NCT02878031] | Phase 4 | 191 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| A Prospective Study of Immediate Versus Delayed Treatment of Odontogenic Infections [NCT04057014] | Phase 4 | 0 participants (Actual) | Interventional | 2020-10-31 | Withdrawn(stopped due to No funding available for the activity) | ||
| Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection - A Combination of Clinical and Pharmacogenetic Study [NCT00854451] | Phase 4 | 128 participants (Actual) | Interventional | 1996-08-31 | Completed | ||
| Pharmacokinetic Considerations and Dosing Strategies of Amoxicillin and Metronidazole or Azithromycin as Adjunct to Non-surgical Periodontal Therapy. A Randomized,6-month, Parallel-group, Clinical Trial. [NCT04669717] | Phase 4 | 45 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | ||
| Comparison of Three Antibiotic Protocols in Prevention of Infection in Dental Implant Surgery [NCT04620018] | 450 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| A Prospective, Phase 3, Randomized, Multi-center, Double-blind Study of the Efficacy, Tolerability, and Safety of Oral Sulopenem Etzadroxil/Probenecid Versus Oral Amoxicillin/Clavulanate for Treatment of Uncomplicated Urinary Tract Infections (uUTI) in Ad [NCT05584657] | Phase 3 | 2,229 participants (Actual) | Interventional | 2022-10-18 | Active, not recruiting | ||
| Inpatient Penicillin Allergy Delabeling Pilot Project at University Hospitals-Rainbow Babies and Children's Hospital in Cleveland, Ohio [NCT05020327] | Phase 4 | 40 participants (Actual) | Interventional | 2021-09-22 | Completed | ||
| Situations That do Not Require Antibiotics for Acute Exacerbations of Mild-to-moderate Chronic Obstructive Pulmonary Disease [NCT00495586] | Phase 4 | 318 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Prospective, Doubleblind, Randomized Multicenter Study to Proof the Clinical and Bacteriological Non-inferiority of Ampicillin/Amoxicillin Versus Moxifloxacin in Hospitalized Patients With Non-severe Community-acquired Pneumonia [NCT00887276] | Phase 4 | 290 participants (Actual) | Interventional | 2008-11-30 | Terminated | ||
| Azithromycin for Severe Acute Malnutrition in CMAM, Nigeria [NCT05473234] | Phase 3 | 600 participants (Anticipated) | Interventional | 2022-10-06 | Recruiting | ||
| A Relative Bioavailability Study of 600 mg Amoxicillin Dispersible Tablets vs 400 mg/ 5 mL Amoxil ® for Oral Suspension Under Fasting Conditions. [NCT00778050] | 26 participants (Actual) | Interventional | 2002-10-31 | Completed | |||
| Comparative, Randomized, Single-Dose, 2-Way Crossover Bioavailability Study of Ranbaxy and GlaxoSmithKline (Augmentin®) 400 mg Amoxicillin (as the Trihydrate)/57 mg Clavulanic Acid (as the Potassium Salt) Chewable Tablets in Healthy Adult Volunteers Follo [NCT00778284] | 40 participants (Actual) | Interventional | 2002-10-31 | Completed | |||
| Evaluation of the Changes in Oral and Gut Bacterial Resistance Caused by Short Term Antibiotic Treatment Following a Surgical Dental Procedure - A Prospective Clinical Study. [NCT02830347] | 16 participants (Anticipated) | Observational | 2015-06-30 | Active, not recruiting | |||
| Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy: A Multicenter Randomized Non-Inferiority Trial of Different Tetracycline Doses and Frequencies. [NCT05802888] | Phase 4 | 260 participants (Anticipated) | Interventional | 2023-03-12 | Recruiting | ||
| Optimization of Vonoprazan-based Dual Therapy for Helicobacter Pylori:a Prospective, Multicenter, Open Label, Randomized Controlled Study: [NCT05649540] | Phase 4 | 900 participants (Anticipated) | Interventional | 2023-01-20 | Recruiting | ||
| Randomized, Multicenter, Phase III, Controlled Clinical Trial, to Demonstrate the no Inferiority of Reduced Antibiotic Treatment vs a Broad Spectrum Betalactam Antipseudomonal Treatment in Patients With Bacteremia by Enterobacteriaceae [NCT02795949] | Phase 3 | 344 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children: Prospective, Multi-center, Randomize, Parallel Group Placebo Controlled Clinical Trial [NCT02765217] | Phase 4 | 1,325 participants (Actual) | Interventional | 2017-06-01 | Completed | ||
| Randomized, Open-Label, 2 - Way Crossover, Bioequivalence Study of Amoxicillin-Clavulanic Acid 600 mg- 42.9 mg/ 5 mL Oral Suspension and Augmentin ES-600 (Reference) Following a 600 mg- 42.9 mg Dose in Healthy Subjects Under Fed Conditions. [NCT00778544] | 48 participants (Actual) | Interventional | 2006-06-30 | Completed | |||
| Beta-lactam Monotherapy Versus Beta-lactam - Macrolide Association as Empiric Antibiotherapy Strategies in Non-severe Hospitalized Community-acquired Pneumonia: a Randomized, Non-inferiority, Open Trial. [NCT00818610] | Phase 4 | 601 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Bioequivalence Study of Two Commercial Amoxicillin Suspension Formulations in Healthy Human Volunteers [NCT01933698] | Phase 4 | 25 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Multiple-dose Pharmacokinetics of Ampicillin / Sulbactam and Amoxicillin / Clavulanic Acid During Haemodialysis in Longterm Haemodialysis Patients [NCT02007603] | Phase 3 | 16 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| The Effect of Systemic Antibiotics on Post-surgical Complications and Patient-centered Outcomes in Patients Undergoing Implant Surgery With Guided Bone Regeneration and Simultaneous Sinus Floor Elevation [NCT04552080] | Phase 4 | 30 participants (Anticipated) | Interventional | 2022-12-29 | Recruiting | ||
| Efficacies of High-dose Dual Therapy With or Without Bismuth Versus Amoxicillin-metronidazole Bismuth Quadruple Therapy for First-line Helicobacter Pylori Eradication - A Prospective, Randomized, Comparative Study [NCT03897244] | Phase 4 | 702 participants (Anticipated) | Interventional | 2019-05-30 | Recruiting | ||
| Pharmacogenomics-Based Tailor-Made Strategy for Eradication of Helicobacter Pylori [NCT00149084] | Phase 3 | 296 participants | Interventional | 2003-04-30 | Recruiting | ||
| Local, Phase IV, Multicenter, Double-blind, Randomized, Parallel, With Two Treatment Arms, Placebo-controlled Study to Evaluate the Reduction of Inflammatory Symptoms in the Treatment of Bacterial Pharyngitis With Ketoprofen and Amoxicillin in Pediatric P [NCT00799838] | Phase 4 | 106 participants (Actual) | Interventional | 2008-11-30 | Terminated(stopped due to Recruitment challenges despite several attenpts to increase enrollment) | ||
| Adjunctive Therapy of Andrographolid Sulfonatein Community Acquired Pneumonia: A Multicenter Randomized Controlled Clinical Trial [NCT02913118] | Phase 4 | 462 participants (Anticipated) | Interventional | 2016-07-31 | Recruiting | ||
| Amoxycillin Versus Placebo for Resolution of Otitis Media With Effusion and Prevention of Acute Otitis Media With Perforation in Aboriginal Infants: a Randomised Controlled Trial. [NCT00539149] | Phase 4 | 126 participants (Actual) | Interventional | 1996-04-30 | Completed | ||
| ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD [NCT00190437] | Phase 4 | 520 participants (Actual) | Interventional | 2003-08-31 | Completed | ||
| [NCT01566266] | 77 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| The Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure [NCT05173493] | 670 participants (Actual) | Observational | 2021-12-30 | Completed | |||
| "Prevention of Dry Socket by Means of Single Preoperative Oral Dose of Metronidazole and Amoxicillin Compared to Conventional Therapy" [NCT03992144] | Phase 2 | 225 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
| Rescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy [NCT06168084] | Phase 4 | 688 participants (Anticipated) | Interventional | 2023-06-06 | Recruiting | ||
| The Effect of Helicobacter Pylori Eradication on Liver Fat Content in Subjects With Non-alcoholic Fatty Liver Disease [NCT01876108] | Phase 2 | 100 participants (Anticipated) | Interventional | 2012-07-31 | Completed | ||
| Perianal Abscess Recurrence and Fistula Formation: Antibiotics Following Incision and Drainage Trial - (PARFAIT) A Vanguard Randomized Controlled Trial [NCT04549311] | Phase 3 | 15 participants (Actual) | Interventional | 2021-11-18 | Active, not recruiting | ||
| A Randomized Multicentre Equivalency Study Of Oral Amoxicillin Versus Injectable Penicillin In Children Aged 3 To 59 Months With Severe Pneumonia [NCT00227331] | 0 participants | Interventional | 1998-01-31 | Completed | |||
| A Phase 2a Study of the Early Bactericidal Activity of Rifampin (RIF) in Combination With Meropenem Plus Amoxicillin/Clavulanate Among Adults With Rifampin-resistant or Rifampin-susceptible Pulmonary Tuberculosis [NCT03174184] | Phase 2 | 112 participants (Actual) | Interventional | 2017-08-23 | Completed | ||
| Erythromycin Versus Amoxicillin for Treatment of Antenatal Chlamydia Trachomatis Infection: A Randomized Controlled Trial [NCT01946256] | Phase 2 | 220 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| Bismuth-Metronidazole Triple Versus Quadruple Therapy for Helicobacter Pylori First-line Treatment: A Randomized Controlled Trial [NCT04667299] | Phase 4 | 270 participants (Anticipated) | Interventional | 2020-12-20 | Recruiting | ||
| Bioequivalence Study of an Amoxicillin-Clavulanic Acid Suspension Preparation. Cross-over, Randomized, Single Dose, Two Treatments, Two Periods and Two Sequences Trial in Fasting Conditions [NCT01772238] | Phase 1 | 35 participants (Actual) | Interventional | 2011-03-22 | Completed | ||
| Comparing Different Regimens for Eradication of Helicobacter Pylori in Kuwait [NCT04617613] | Phase 4 | 603 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Timing of Administration of Systemic Antibiotics Associated With Scaling and Root Planing in the Treatment of Periodontitis: Clinical and Microbiological Evaluation [NCT06177119] | 72 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | |||
| Choline to Improve Malnutrition and Enhance Cognition [NCT06154174] | 1,500 participants (Anticipated) | Interventional | 2023-12-05 | Recruiting | |||
| Phase I Study of Safety and Immunogenicity of ADU-623, a Live-attenuated Listeria Monocytogenes Strain (ΔactA/ΔinlB) Expressing the EGFRvIII-NY-ESO-1 Vaccine, in Patients With Treated and Recurrent WHO Grade III/IV Astrocytomas [NCT01967758] | Phase 1 | 11 participants (Actual) | Interventional | 2014-01-08 | Completed | ||
| Dyspeptic Symptoms Evolution After Eradication of Helicobacter Pylori in Patients With Different Endoscopic Findings: a Randomized Double-blind Placebo-controlled Clinical Trial With 12 Months of Follow-up [NCT00404534] | Phase 3 | 407 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| Phytomedicine-based and Quadruple Therapies in Helicobacter Pylori Infection. A Comparative Randomized Trial [NCT02004197] | Phase 2/Phase 3 | 176 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| "A Screen and Treat Helicobacter Pylori Eradication Trial in 14-18 Years Old Adolescents Residing in Three Regions of Chile: Effectiveness and Microbiological-host Implications" [NCT05926804] | 500 participants (Anticipated) | Interventional | 2022-08-02 | Recruiting | |||
| Comparison of the Efficacy of Tegoprazan-containing Versus Esomeprazole-containing Dual Therapy for Helicobacter Pylori Eradication: a Prospective, Multicenter, Randomized Controlled Study （SHARE2301） [NCT05870683] | 368 participants (Anticipated) | Interventional | 2023-05-24 | Recruiting | |||
| Vonoprazan-based Triple Therapy vs. Standard Triple Therapy for Helicobacter Pylori Eradication in Adolescents: A Randomized, Double-blinded Controlled Trial [NCT06162949] | Phase 3 | 240 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| A Randomized Controlled Trial: Quadruple vs Tailored Therapy in the Treatment of Helicobacter Pylori Infection [NCT04621487] | 80 participants (Actual) | Interventional | 2019-01-15 | Completed | |||
| An Open Label Non Randomized Pilot Study: Use of the Ulcerative Colitis Diet for Induction of Remission. [NCT02217722] | 9 participants (Actual) | Interventional | 2014-10-31 | Terminated(stopped due to We have submitted a multi center study, with the same nutritional therapy) | |||
| Efficacy and Safety of 14-day Concomitant Therapy for Difficult-to-Treat Helicobacter Pylori: A Pilot Study [NCT05126121] | 60 participants (Anticipated) | Interventional | 2021-11-20 | Not yet recruiting | |||
| Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy: Comparison of 8 Weeks Standard Therapy (Rifampicin Plus Clarithromycin) vs. 4 Weeks Standard Plus Amoxicillin/Clavulanate Therapy [RC8 vs. RCA4] [NCT05169554] | Phase 2 | 140 participants (Anticipated) | Interventional | 2021-12-01 | Recruiting | ||
| CAT BITE Antibiotic Prophylaxis and Durations for the Hand/Forearm (CATBITE): A Prospective, Randomized, Placebo-controlled, Double-blinded, Clinical Trial [NCT05846399] | Phase 4 | 72 participants (Anticipated) | Interventional | 2023-09-07 | Recruiting | ||
| Comparison of the Efficacy of Clarithromycin-based Triple Therapy for 14 Days Versus Sequential Therapy for 10 Days in the First Line Therapy for Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial [NCT01607918] | Phase 4 | 1,300 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | ||
| A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Meropenem in Hospitalized Children With Complicated Intra-Abdominal Infections [NCT01110382] | Phase 3 | 41 participants (Actual) | Interventional | 2010-12-31 | Terminated(stopped due to Trial terminated early per business decision) | ||
| Phase 4 Study of Helicobacter Pylori Eradication Therapy [NCT00990405] | Phase 4 | 400 participants (Anticipated) | Interventional | 2009-10-31 | Active, not recruiting | ||
| An Open-Label, Randomized, Multicenter, Two-Arms Efficacy and Safety Study of 14 Days Treatment With Finafloxacin 400 mg b.i.d. Plus Amoxicillin 1000 mg b.i.d.Versus Finafloxacin 400 mg b.i.d. Plus Esomeprazole 40 mg b.i.d. in Patients With Helicobacter P [NCT00723502] | Phase 2 | 30 participants (Anticipated) | Interventional | 2008-09-30 | Completed | ||
| Helicobacter Pylori Eradication With Berberine Hydrochloride, Lansoprazole, Amoxicillin and Bismuth Versus Clarithromycin Bismuth, Lansoprazole and Amoxicillin: A Randomized, Open-label, Non-inferiority, Phase Ⅳ Trial [NCT02633930] | Phase 4 | 566 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) [NCT02701595] | Phase 3 | 324 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | ||
| Does Adjuvant Antibiotic Treatment After Drainage of Anorectal Abscess Prevent the Development of Anal Fistulae? A Prospective Randomized, Placebo Controlled, Double Blind, Multi-Center Clinical Study [NCT01012843] | 151 participants (Actual) | Interventional | 2005-09-30 | Completed | |||
| Antibiotic Treatment Versus no Antibiotics in the Postoperative Acute Cholecystitis Low and Moderately Severe [NCT01015417] | Phase 3 | 414 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| Double-blind, Placebo-controlled, Randomized Study for Assesment of the Efficiency and Safety Quadruple Therapy for Helicobacter Pylori Infection With or Without the Addition of Saccharomyces Boulardi Probiotic [NCT03997279] | Phase 4 | 200 participants (Anticipated) | Interventional | 2019-06-30 | Not yet recruiting | ||
| Fourteen-Day Vonoprazan-Based Dual Therapy With Amoxicillin as First-Line Helicobacter Pylori Treatment in Comparison With Extended Sequential Therapy: A Randomized Controlled Trial in Taiwan [NCT06156085] | Phase 4 | 318 participants (Anticipated) | Interventional | 2023-11-14 | Recruiting | ||
| Bacteremia From Dental Extractions vs. Oral Hygiene [NCT00454285] | Phase 2 | 290 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| A Study on the Efficacy and Safety of Egg Yolk Antibody in Adjuvant Treatment of Helicobacter Pylori Infection [NCT05410223] | 100 participants (Anticipated) | Interventional | 2021-04-06 | Recruiting | |||
| [NCT02837614] | Early Phase 1 | 60 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Traditional Chinese Medicine Combined With Standard Triple Region for Eradication of Helicobacter Pylori: a Prospective, Double-blinded, Randomized Trial [NCT02803216] | Phase 1/Phase 2 | 576 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis): A Comparison Between Photodynamic Therapy and Antibiotic Therapy as an Adjunct to Non-Surgical Periodontal Treatment [NCT05655338] | 20 participants (Actual) | Interventional | 2015-01-10 | Completed | |||
| Open-label Comparative Safety and Efficacy Study of Levofloxacin and Amoxicillin Clavulanic Acid in Patients With Acute ,Bacterial Rhinosinusitis [NCT02712502] | 100 participants (Actual) | Observational | 2014-09-30 | Completed | |||
| The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair [NCT02688634] | 0 participants (Actual) | Observational | 2016-04-30 | Withdrawn | |||
| Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics [NCT02785549] | Phase 4 | 480 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| Clinical Trial to Define the Effect of Perioperative H. Pylori Eradication With Antibiotic Treatment on Long Term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin Undergoing Cytoreductive Surgery/Hyperthermic Intraperitoneal Chemothe [NCT02387203] | Phase 2 | 80 participants (Anticipated) | Interventional | 2015-01-31 | Active, not recruiting | ||
| Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) [NCT01406275] | 363 participants (Actual) | Observational | 2008-01-31 | Completed | |||
| A Multicenter Randomized Controlled Trial of Antibiotic Treatment in Children With Urinary Tract Infections: Oral Amoxicillin/Clavulanic Acid vs Initial iv Ceftriaxone. [NCT00161330] | Phase 3 | 440 participants | Interventional | 2000-06-30 | Terminated | ||
| Risk of Acute Liver Injury in Users of Antimicrobials in the HealthCore Integrated Research Database Population [NCT01434173] | 1,299,056 participants (Actual) | Observational | 2001-07-31 | Completed | |||
| Fast-track Absolute Neutrophil Count in Suspected Neutropenic Fever (The FRANCiS-NF Trial): A Single-centre, Pragmatic, Open-label, Randomised, Controlled Trial [NCT05393505] | Phase 4 | 344 participants (Anticipated) | Interventional | 2022-10-24 | Recruiting | ||
| Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics [NCT04414722] | Early Phase 1 | 138 participants (Actual) | Interventional | 2021-01-01 | Completed | ||
| Prophylactic Versus Clinically-driven Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest [NCT02899507] | Phase 4 | 60 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| A Phase III, Randomized, Double-Blind, Double-Dummy Multicenter Study to Evaluate the Efficacy and Safety of 775 mg APC-111 MP Tablet QD for 7 Days vs Penicillin VK 250 mg QID for 10 Days in Patients With Streptococcus Pyogenes [NCT00095368] | Phase 3 | 500 participants | Interventional | 2004-10-31 | Completed | ||
| Antibiotics Versus Therapeutic Ultrasound for Treatment of Sinusitis: a Randomized Clinical Trial [NCT00934830] | Phase 3 | 48 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Genotypic Resistance-guided Triple Therapy Versus Empirical Concomitant Therapy for First-line H. Pylori Eradication. [NCT04090021] | Phase 4 | 304 participants (Anticipated) | Interventional | 2019-09-01 | Recruiting | ||
| The Efficiency of Postoperative Antibiotics in Orthognathic Surgery: A Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial [NCT02740647] | 25 participants (Anticipated) | Interventional | 2016-04-30 | Not yet recruiting | |||
| Randomized and Controlled Clinical Study of High-dose Dual Therapy With Different Administration Frequencies in the Treatment of Helicobacter Pylori [NCT05901051] | Phase 4 | 327 participants (Actual) | Interventional | 2021-03-30 | Completed | ||
| Effectiveness of Rifabutin Triple Therapy for First-line and Rescue Treatment of Helicobacter Pylori Infection [NCT04652284] | Phase 3 | 300 participants (Anticipated) | Interventional | 2021-05-01 | Not yet recruiting | ||
| Comparison Between Two Different Antibiotic Regimens for the Placement of Dental Implants: a Randomized Clinical Trial [NCT01851681] | Phase 1 | 42 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Surgical Treatment of Peri-implantitis With and Without Adjunctive Use of Antibiotics : a Controlled and Randomized Clinical Study [NCT01857804] | Phase 4 | 100 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Multicentre, Randomised, Double-blinded, Placebo-controlled Trial of Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus [NCT01860300] | 46 participants (Anticipated) | Interventional | 2013-03-31 | Recruiting | |||
| Director of Research Division [NCT01863823] | Phase 1/Phase 2 | 350 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Helicobacter Pylori Eradication Clostridium Butyricum Capsule and Bacillus Coagulans Tablets With Hydrochloride,Esomeprazole,Amoxicillin and Bismuth-containing Quadruple Therapy: a Randomized,Single-center，Open-label,Phase Ⅳ Trail [NCT05237115] | Phase 4 | 600 participants (Actual) | Interventional | 2020-05-05 | Completed | ||
| Penicillin Allergy in Shfayim Clinic [NCT03499457] | 100 participants (Anticipated) | Interventional | 2018-06-30 | Not yet recruiting | |||
| [NCT01481844] | Phase 3 | 101 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| A Prospective Randomised Phase III Trial of Early Hospital Discharge Versus Standard Inpatient Management of Cancer Patients With Low-Risk Febrile Neutropenia Receiving Oral Antibiotics. Oral Antibiotics for Neutropenic Sepsis Giving Early Hospital Discha [NCT00445497] | Phase 3 | 400 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| The Effect of a Combination of Systemic Steroids and Antibiotics on Obstructive Sleep Apnea Syndrome in Children [NCT00456339] | Phase 4 | 4 participants (Actual) | Interventional | 2006-07-31 | Terminated(stopped due to Problems recruiting; patient relapse following treatment) | ||
| Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura [NCT00467571] | Phase 4 | 26 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [NCT00475527] | Phase 4 | 0 participants (Actual) | Interventional | Withdrawn(stopped due to problem of accrual) | |||
| Influence of Moment of Systemic Metronidazole and Amoxicillin Administration in the Treatment of Chronic Periodontitis: a Randomized Clinical Trial. [NCT02954393] | 180 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Quadruple Therapy Using Esomeprazole, Colloidal Bismuth Subcitrate, Amoxicillin-Clavulanate, and Furazolidone in Patients Who Failed to Eradicate H. Pylori With Triple Therapy [NCT00520949] | 176 participants (Actual) | Interventional | 2006-10-31 | Completed | |||
| Soft and Hard Tissue Stability After Immediate Tooth Replacement With Implant in Fresh Sockets Grafted With Different Soft Tissue Grafts [NCT02922075] | Phase 4 | 24 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Efficacy of Antibiotic Susceptibility-based Tailored Versus Empiric Therapy for Helicobacter Pylori First-line Treatment：a Randomized Clinical Trial [NCT02935010] | Phase 4 | 382 participants (Actual) | Interventional | 2017-02-05 | Completed | ||
| Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication [NCT02934152] | Phase 4 | 400 participants (Anticipated) | Interventional | 2016-10-31 | Not yet recruiting | ||
| Efficacies of Hybrid and High-dose Dual Therapies for the First-line Anti-H Pylori Treatment - a Randomized Trial [NCT05152004] | 240 participants (Actual) | Interventional | 2018-09-01 | Completed | |||
| Clinical Relevance of Middle Meatal Bacteriology During Acute Respiratory Infection in Children - Randomised, Double-Blinded Clinical Study [NCT00545961] | Phase 4 | 120 participants (Anticipated) | Interventional | 2007-11-30 | Not yet recruiting | ||
| A Phase 4 Double Blinded Study With Two Different Interventions, Each With Two Arms, to Evaluate the Clinical Efficacy of Antibiotics and the Role of Microbiology, Immunology and Genetics in Children Aged 9-36 Months With Chronic Wet Cough. [NCT06020716] | Phase 4 | 350 participants (Anticipated) | Interventional | 2023-08-16 | Recruiting | ||
| Efficacy and Safety of Vonoprazan- Amoxicillin Dual Therapy for Helicobacter Pylori Eradication : a Prospective, Multicenter, Randomized Controlled Trial [NCT05469685] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | ||
| Ten-day Amoxicillin-containing Dual Therapy as First-line Helicobacter Pylori Treatment in Elderly Patients: a Randomized Trial [NCT05419674] | Phase 4 | 393 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | ||
| Efficacy and Safety of 200 mcg QD or 200 mcg BID Mometasone Furoate Nasal Spray (MFNS) vs Amoxicillin vs Placebo as Primary Treatment of Subjects With Acute Rhinosinusitis [NCT00750750] | Phase 2 | 981 participants (Actual) | Interventional | 2003-01-01 | Completed | ||
| Conventional Therapy vs Sequential Therapy for the Treatment of Helicobacter Pylori Infection [NCT01723059] | 184 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | |||
| Helicobacter Pylori Eradication and Follow-up in Zhongshan Hospital [NCT05061732] | Phase 4 | 4,447 participants (Anticipated) | Interventional | 2021-09-30 | Recruiting | ||
| A Phase 2/3, Randomized, Open-Label, Multi-center Study to Determine the Safety and Efficacy of Solithromycin in Adolescents and Children With Suspected or Confirmed Community-Acquired Bacterial Pneumonia [NCT02605122] | Phase 2/Phase 3 | 97 participants (Actual) | Interventional | 2016-04-30 | Terminated(stopped due to Development not proceeding) | ||
| Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial. [NCT03033147] | 72 participants (Actual) | Interventional | 2019-10-18 | Completed | |||
| Rifabutin-containing Triple Therapy for Rescue Treatment of Helicobacter Pylori: A Randomized Clinical Trial [NCT04879992] | 413 participants (Actual) | Interventional | 2021-05-07 | Completed | |||
| Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients [NCT00002052] | 0 participants | Interventional | Completed | ||||
| CURRENT PRACTICE STUDY OF ANTIBIOTIC TREATMENT OF GASTRIC MALT LYMPHOMA [NCT00002682] | Phase 2 | 5 participants (Actual) | Interventional | 1995-08-10 | Completed | ||
| Azithromycin With Amoxicillin/Clavulanate Versus Amoxicillin/Clavulanate Alone in COVID-19 Patients With Pneumonia and Hospitalized in a Non-intensive Care Unit Ward (AziA): a Superiority Open-label Randomized Controlled Trial [NCT04363060] | Phase 3 | 104 participants (Anticipated) | Interventional | 2020-04-30 | Not yet recruiting | ||
| Usefulness of Antimicrobial Susceptibility in the Eradication of Helicobacter Pylori [NCT01486082] | 1 participants (Anticipated) | Observational | 2011-02-28 | Recruiting | |||
| Comparison of Efficacy and Safety of Triple Regimen Based on Clarithromycin VS Metronidazole in Pediatric Population in Pakistan [NCT04721704] | 36 participants (Anticipated) | Interventional | 2020-09-14 | Recruiting | |||
| The Effect of Vonoprazan-based Dual Eradication Therapy vs PPI Treatment on Gastrointestinal Bleeding in ACS Patients With Hp Infection and Coronary Stents: an Open-label, Randomized, Controlled Trial [NCT04728516] | Phase 4 | 2,600 participants (Anticipated) | Interventional | 2021-08-10 | Not yet recruiting | ||
| Phase 4 Efficacy Study of Antimicrobials in the Treatment of Acute Otitis Media in Young Children [NCT00299455] | Phase 4 | 320 participants (Anticipated) | Interventional | 2006-03-31 | Active, not recruiting | ||
| [NCT01667575] | Phase 4 | 180 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Efficacy of Amoxicillin for Treatment of Enteral Nutrition Intolerance in Pediatric Intensive Care Unit [NCT05828758] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2023-04-24 | Recruiting | ||
| Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication: A Multicenter Randomized Clinical Trial of 10 and 14 Days [NCT05049902] | Phase 4 | 1,300 participants (Actual) | Interventional | 2021-09-21 | Completed | ||
| An Open, Non-comparative Study to Evaluate the Efficacy and Safety of AUGMENTIN 1gm (875mg Amoxicillin/125mg Clavulanic Acid) po q 12 Hours in the Treatment of Uncomplicated Skin and Soft Tissue Infections in Pakistan [NCT00343135] | Phase 4 | 195 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| A Prospective Randomized Multicentric Trial Comparing Amoxicillin/Clavulanate Potassium Therapy to Appendectomy for Acute Non Complicated Appendicitis [NCT00135603] | 243 participants (Actual) | Interventional | 2004-02-29 | Completed | |||
| A Prospective Multi-Center Study on Pediatric Patients With Fever in Severe Chemotherapy Induced Neutropenia, Including a Randomized Comparison of Outpatient Management and Oral Antimicrobial Therapy Versus Inpatient Management and Intravenous Antimicrobi [NCT00107081] | Phase 3 | 70 participants (Actual) | Interventional | 2004-01-31 | Terminated(stopped due to Accrual goal for interventional part not achievable) | ||
| Randomized, Controlled, Multicenter Phase III Study for the Efficacy and Tolerability of Triple Therapy With Esomeprazole, Moxifloxacin and Amoxicillin for Rescue Therapy of Helicobacter Pylori Infection [NCT00455806] | Phase 3 | 132 participants | Interventional | 2007-01-31 | Recruiting | ||
| Oral Amoxicillin-clavulanate in Treating Acute Otitis Media in Children: Randomized Double-blind Placebo-controlled Study Including Daily Monitoring With Tympanometry [NCT01244581] | Phase 3 | 84 participants (Actual) | Interventional | 1999-09-30 | Completed | ||
| Sequential Therapy Versus Triple Therapy for Helicobacter Pylori Eradication: a Placebo-controlled Trial [NCT00403364] | Phase 2/Phase 3 | 300 participants | Interventional | 2003-07-31 | Completed | ||
| Evaluation of National Guidelines for Acute Sinusitis [NCT00132275] | 240 participants (Anticipated) | Interventional | 2003-11-30 | Completed | |||
| Treatment of Low-Grade Gastric Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Type Stages IE & II1E (HELYX-Study) [NCT00154440] | Phase 3 | 200 participants | Interventional | 2001-11-30 | Recruiting | ||
| Efficacy of Helicobacter Pylori Eradication on Symptoms of Functional Dyspepsia - A Randomised Controlled Trial [NCT04697641] | 202 participants (Actual) | Interventional | 2017-09-01 | Completed | |||
| Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition: the AMOUR Trial [NCT06010719] | Phase 4 | 7,000 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce Clinically Relevant PostOperative Pancreatic Fistula: A Phase 2 Randomized Control Trial (X-POPF) [NCT05753735] | Phase 2 | 96 participants (Anticipated) | Interventional | 2023-12-20 | Recruiting | ||
| Comparison of Vonoprazan Fumarate-based Triple Therapy Versus Proton Pump Inhibitor and Bismuth Based Quadruple Therapy in the Eradication of Helicobacter Pylori: a Single-center Prospective Open-label Controlled Study [NCT05097846] | 100 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | |||
| Prospective Randomised Trial of First and Second Line Treatments of Helicobacter Pylori Infection in Slovenia [NCT04359966] | 560 participants (Anticipated) | Interventional | 2020-05-10 | Not yet recruiting | |||
| Bioavailability of Amoxicillin Dissolved in Human Milk: An Adult Volunteer Study as a First Step Towards Defining Drug Doses for Infants [NCT01435824] | Phase 2 | 16 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Randomized Double Blind Placebo Controlled Trial of Amoxycillin in the Treatment of Non-Severe Pneumonia With Wheeze in Children Aged 2- 59 Months of Age: A Multi-Centric Study [NCT00407394] | Phase 3 | 2,000 participants | Interventional | 2004-04-30 | Completed | ||
| A Comparison Study Between Cefdinir and Amoxicilline/Clavulanate in Patients With Acute Sinusitis and Assessment of Quality of Life (QOL) [NCT00147914] | Phase 4 | 100 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Dual Therapy With High-Dose of Rabeprazole and Amoxicilline Versus Triple Therapy With Rabeprazole, Amoxicilline and Metronidazole as the Second Line Therapy for the Cure of H. Pylori Infection [NCT00197418] | Phase 2/Phase 3 | 0 participants | Interventional | 2003-08-31 | Recruiting | ||
| Comparing the Efficacy of Two Weeks Therapy of Doxycycline,Levofloxacin,Tinidazole Versus Levofloxacin With Tinidazole on Rate of Eradication of Helicobacter Pylori Infected Patients on Syrian Population [NCT04626193] | Phase 4 | 80 participants (Anticipated) | Interventional | 2020-10-31 | Recruiting | ||
| Bacteriological Study of Acute Follicular Tonsillitis in Patients Attending the ENT Outpatient Clinic of Assiut University Hospital [NCT04321733] | 66 participants (Anticipated) | Observational | 2020-04-30 | Not yet recruiting | |||
| Effectiveness of Maxillary Sinus Saline Irrigation in Conjunction With Systemic Antibiotic Therapy Versus Systemic Antibiotic Therapy Alone in the Management of Chronic Rhinosinusitis, a Prospective Randomized Controlled Trial [NCT00335309] | 50 participants (Actual) | Interventional | 2005-10-31 | Completed | |||
| Effect of Antibiotics on Gut Microbiome and Plasma Metabolome [NCT03273296] | Phase 4 | 39 participants (Actual) | Interventional | 2017-10-15 | Completed | ||
| New Dual Therapy for Primary Treatment of Helicobacter Pylori Infection：a Pilot Study [NCT01513785] | Phase 2 | 40 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Phase 3 Study of Antibiotic Prophylaxis Use Prior Emergent Surgery, Because of Acute Appendicitis [NCT01524081] | Phase 3 | 187 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| The Usefulness of Melatonin Supplementation in Postmenopausal Women With Helicobacter Pylori-associated Dyspepsia [NCT04352062] | 152 participants (Actual) | Interventional | 2011-01-09 | Completed | |||
| A Multicenter, Randomized, Observer-Blinded, Active-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Ceftaroline Versus Ceftriaxone in Pediatric Subjects With Community-acquired Bacterial Pneumonia Requiring Hospital [NCT01530763] | Phase 2/Phase 3 | 161 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| Community Based Management of Fast Breathing in Infants Aged < 60 Days: A Double-Blind, Randomized Placebo-Controlled Trial in Low-income Settlements of Karachi [NCT01533818] | Phase 4 | 963 participants (Actual) | Interventional | 2012-05-31 | Terminated(stopped due to The study was stopped by DSMB based on high treatment failure rate in placebo compared to active drug.) | ||
| Comparison of the Efficacy of Levofloxacin-based Sequential Therapy and Triple Therapy as Second Line Therapy for Refractory Helicobacter Pylori Infection- A Multi-center Randomized Trial [NCT01537055] | Phase 4 | 600 participants (Anticipated) | Interventional | 2012-02-29 | Recruiting | ||
| Five-day Concomitant Versus 10-day Sequential Therapy for Eradication of Helicobacter Pylori Infection: a Randomized Trial of Levofloxacin-based Regimens [NCT01544517] | Phase 3 | 180 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| A Phase III, Investigator Blind, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of APC-231 Sprinkle QD for 7 Days vs Penicillin VK 10 mg/kg QID for 10 Days in Pediatric Patients With Streptococcus Pyogenes [NCT00100126] | Phase 3 | 500 participants | Interventional | 2004-12-31 | Completed | ||
| Evaluation of the Efficacy of Concomitant Therapy for Eradication of Helicobacter Pylori [NCT01922765] | Phase 4 | 540 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | ||
| Effectiveness of 3 Day Amoxycillin Versus 5 Day co-Trimoxazole in the Treatment of Non-Severe Pneumonia in Children Aged 2- 59 Months of Age: - A Multi-Centric Open Labeled Trial [NCT00396526] | Phase 3 | 2,000 participants | Interventional | 2004-04-30 | Completed | ||
| [NCT00042718] | Phase 3 | 659 participants (Actual) | Interventional | 2001-11-30 | Completed | ||
| Food Effect on the Eradication Rate of H. Pylori With Triple Therapy With Esomeprazole [NCT02552641] | Phase 4 | 0 participants (Actual) | Interventional | 2015-09-30 | Withdrawn | ||
| A Multicenter, Randomized, Comparative Study to Evaluate the Efficacy and Safety of Levofloxacin in the Treatment of Children Who Have Recurrent and/or Persistent Acute Otitis Media [NCT00051753] | Phase 3 | 1,643 participants (Actual) | Interventional | 2002-11-30 | Completed | ||
| A Phase 2b, Multicenter, Randomized, Double Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy of Short-Course Antimicrobial Therapy for Young Children With Acute Otitis Media (AOM) and Impact on Antimicrobial Resistance [NCT01511107] | Phase 2 | 520 participants (Actual) | Interventional | 2012-01-31 | Terminated(stopped due to The primary objective of the study was met.) | ||
| Cranberry: Interactions With Anti-Infectious Agents [NCT00084201] | 18 participants | Interventional | 2006-07-31 | Completed | |||
| Oral Empirical Therapy of Fever in Low-Risk Neutropenic Cancer Patients: A Prospective, Double-Blind, Randomized, Multicenter Trial Comparing Monotherapy (Single Daily Dose Moxifloxacin) With Combination Therapy (Ciprofloxacin Plus Amoxicillin/Clavulanic [NCT00062231] | 351 participants (Actual) | Interventional | 2002-04-30 | Terminated(stopped due to low accrual) | |||
| Comparison Efficacy of 14-day Concomitant Therapy:Clarithromycin vs.Levofloxacin in Eradication of H.Pylori [NCT03021590] | Phase 4 | 0 participants (Actual) | Interventional | 2017-06-01 | Withdrawn(stopped due to No Participants Enrolled) | ||
| Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis [NCT05398679] | Phase 4 | 360 participants (Anticipated) | Interventional | 2022-06-01 | Not yet recruiting | ||
| Improved Polyunsaturated Ready-to-use Therapeutic Food for Improved Neurocognitive Outcomes in Severe Acute Malnutrition [NCT03094247] | 2,897 participants (Actual) | Interventional | 2017-10-02 | Completed | |||
| Efficacy of Quadruple Therapy Based on Fecal Molecular Antimicrobial Susceptibility Tests as First-line Treatment for Helicobacter Pylori Infection [NCT05718609] | Phase 4 | 855 participants (Anticipated) | Interventional | 2023-03-01 | Recruiting | ||
| Comparison of Different Helicobacter Pylori Detection Methods in Patients With Chronic Atrophic Gastritis [NCT04923113] | 281 participants (Actual) | Interventional | 2021-06-28 | Completed | |||
| Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media [NCT02630992] | Phase 3 | 112 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Clinical and Microbiological Effects of Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis: 1-year Randomized Double-blinded Controlled Clinical Trial [NCT05444218] | 94 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Higher Versus Standard Dose of Amoxicillin-clavulanate in Pediatric Protracted Bacterial Bronchitis: a Randomized Controlled Study. [NCT04378231] | 100 participants (Anticipated) | Interventional | 2020-05-31 | Not yet recruiting | |||
| A Prospective Randomized Trial of Levofloxacin-amoxicillin Triple Therapy vs. Levofloxacin-tetracycline Quadruple Therapy in Second-line Helicobacter Pylori Treatment [NCT02978157] | 102 participants (Actual) | Interventional | 2015-02-28 | Completed | |||
| Long-term Effects of Sub Gingival Debridement Associated With Antibiotics in Individual Undergoing Maintenance Periodontal Therapy [NCT05934227] | 50 participants (Anticipated) | Interventional | 2023-07-01 | Enrolling by invitation | |||
| A Phase 1, Double-Blind, Parallel Group Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Quadruple Therapy (Bismuth, Clarithromycin, and Amoxicillin) With Vonoprazan Versus Quadruple Therapy With Esomeprazole [NCT04753437] | Phase 1 | 44 participants (Actual) | Interventional | 2021-04-06 | Completed | ||
| Clinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine Culture [NCT05206500] | Phase 4 | 100 participants (Anticipated) | Interventional | 2022-05-17 | Recruiting | ||
| A Prospective, Multi-center, Randomized, Open-label, Parallel Design Clinical Trial to Compare 10-day Sequential Therapy and 14-day Modified Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea [NCT02159976] | 390 participants (Actual) | Interventional | 2014-07-31 | Completed | |||
| Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial [NCT02223702] | Phase 4 | 39 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Comparison of Hybrid and Bismuth Containing Quadruple Therapies for Helicobacter Pylori Eradication: a Randomized Controlled Trial [NCT02541864] | 330 participants (Actual) | Interventional | 2013-07-31 | Completed | |||
| Comparison of Two Rescue Therapies for Helicobacter Pylori Infection - A Multicenter Randomized Controlled Trial [NCT02547012] | 51 participants (Actual) | Interventional | 2013-11-30 | Completed | |||
| Eradication of Helicobacter Pylori in the Management of Stage IE & IIE-1 Primary Low-grade B Cell Lymphoma of Mucosa-associated Lymphoid Tissue Type of The Stomach [NCT00201422] | 70 participants (Actual) | Interventional | 1996-06-30 | Completed | |||
| Comparing 10-day Reverse Hybrid Therapy and 10-day Triple Therapy Plus Bismuth Therapy on Helicobacter Pylori Eradication [NCT04566211] | 440 participants (Anticipated) | Interventional | 2020-01-01 | Recruiting | |||
| Phase 2 Trial to Evaluate the Early EBA, Safety and Tolerability of Amoxicillin/Clavulanate With or Without Meropenem, Ertapenem or Rifampicin in Adults With Newly Diagnosed, Smear-Positive Rifampicin-Susceptible Pulmonary Tuberculosis [NCT05896930] | Phase 2 | 134 participants (Actual) | Interventional | 2017-11-09 | Completed | ||
| Prospective, Observational Study of Clinical Outcomes Among Children 2 to 59 Months of Age With Childhood Pneumonia and Other Co-morbidities in Lilongwe, Malawi Who Have Been Excluded From Pneumonia Clinical Trials [NCT02960919] | 1,001 participants (Actual) | Observational | 2016-10-19 | Completed | |||
| Effect of Antibiotics on Submucosal Enteric Neurons and Glia in the Lower Gastrointestinal [NCT05834036] | Phase 4 | 9 participants (Actual) | Interventional | 2023-06-23 | Completed | ||
| Multicentre,Prospective Study of First-line Antibiotic Therapy for Early-stage Low-grade and High-grade Gastric Mucosa-associated Lymphoid Tissue-type Lymphoma and Potential Predicting Factor for Treatment Outcome [NCT00327132] | 47 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| Randomized Multi-Intervention Trial to Inhibit Precancerous Gastric Lesions in Lingu, Shandong Province, China [NCT00339768] | Phase 3 | 3,411 participants (Actual) | Interventional | 1995-07-01 | Completed | ||
| Oral Amoxicillin and Cephalexin Pharmacokinetics/Pharmacodynamics (PK/PD) in the Neonatal Intensive Care Unit [NCT04916951] | Phase 1 | 60 participants (Anticipated) | Interventional | 2021-07-14 | Enrolling by invitation | ||
| Safety Efficacy, and Cost-effectiveness of Modified Doses of Ready-to-use Therapeutic and Supplementary Foods for the Treatment of Moderate Acute Malnutrition Among Children 6-59 Months of Age in Ethiopia [NCT06056089] | 2,400 participants (Anticipated) | Interventional | 2023-09-25 | Not yet recruiting | |||
| A Phase 3, Randomized, Double-Blind, Double Dummy, Multicenter, Parallel Group Comparison Study to Evaluate Efficacy and Safety of a Triple Therapy With TAK-438, Amoxicillin and Clarithromycin by Comparison With a Triple Therapy With AG-1749 (Lansoprazole [NCT01505127] | Phase 3 | 650 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| The Efficacy of Preventive Antibiotic Treatment During the Puerperium Among Pregnant Women With Recurrent Urinary Tract Infections [NCT01507974] | 220 participants (Actual) | Interventional | 2012-01-16 | Completed | |||
| The Exploration for Pharmacodynamics and Pharmacokinetic Interaction Between YH4808, Amoxicillin and Clarithromycin in Healthy Subjects [NCT01921647] | Phase 1 | 95 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water [NCT01635608] | Phase 1 | 12 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Comparison of Ofloxacin and Metronidazole/Amoxicillin on the Treatment of Periodontitis. [NCT04353362] | Phase 4 | 74 participants (Actual) | Interventional | 2017-04-01 | Completed | ||
| Efficacy of Potassium Competitive Acid Blockers (P-CABs) Versus Proton Pump Inhibitors (PPIs) in the First and the Second Lines Eradication Regimens for H. Pylori in Egyptian Patients [NCT06101420] | Phase 3 | 232 participants (Actual) | Interventional | 2022-01-01 | Completed | ||
| Clinical Efficacy and Health Economic Evaluation of Susceptibility-Guided Therapy for Helicobacter Pylori Infection Treatment：Multicenter Randomized Controlled Study [NCT05250050] | Phase 4 | 388 participants (Anticipated) | Interventional | 2022-03-25 | Recruiting | ||
| Levofloxacin-containing Therapy for Helicobacter Pylori Treatment [NCT01667718] | Phase 4 | 161 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Helicobacter Pylori Treatment [NCT01668927] | Phase 4 | 424 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
| The Study on the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure [NCT04810793] | 820 participants (Actual) | Observational [Patient Registry] | 2020-07-01 | Completed | |||
| Non-antibiotic Prescribing for Acute Upper Respiratory Tract Infection：a Randomized-control Trial [NCT01930955] | 0 participants (Actual) | Interventional | 2011-08-01 | Withdrawn(stopped due to no patients were included) | |||
| The Evaluation of Triple Therapy With Vonoprazan, Amoxicillin and Bismuth for Eradication of Helicobacter Pylori: a Prospective, Multi-Center, Randomized Controlled Trial [NCT05189444] | 672 participants (Anticipated) | Interventional | 2022-03-25 | Not yet recruiting | |||
| Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis [NCT01697059] | 73 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| A Third Phase, Multicentre, Randomized as a Double Blind Study, Triple Placebo, Comparative of the Efficacy and Safety of an Association Secnidazol-Ciprofloxacin Compared With Amoxicillin-Clavulanic Acid for the Treatment of Uncomplicated Episode of Diver [NCT01733966] | Phase 3 | 100 participants (Actual) | Interventional | 2010-05-31 | Terminated(stopped due to difficulties to recruit patients who suffer from this pathology) | ||
| [NCT01742429] | Phase 4 | 200 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| Study on Treatment of Recurrent Urinary Tract Infection by Traditional Chinese Medicine [NCT01745328] | 150 participants (Anticipated) | Interventional | 2009-01-31 | Recruiting | |||
| Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication: A Single-center, Randomised, Controlled Trial. [NCT06168214] | Phase 4 | 1,404 participants (Anticipated) | Interventional | 2023-09-04 | Recruiting | ||
| Ten Days Quadruple Versus Sequential Therapy as Empirical First and Second Line Treatment for Helicobacter Pylori Eradication: a Randomized Crossover Trial [NCT01760824] | 391 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| Bacteriology and Sputum and Systemic Inflammation in Steady-state, Acute Exacerbation and Recovery of Bronchiectasis [NCT01761214] | 80 participants (Anticipated) | Interventional | 2012-09-30 | Recruiting | |||
| The Effect of Propolis and Nutritional Education in Patients With H. Pylori on Gastrointestinal Symptoms [NCT05259007] | Phase 4 | 96 participants (Anticipated) | Interventional | 2022-02-22 | Not yet recruiting | ||
| Does a Single Dose of Systemic Antibiotics Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial [NCT03130933] | Phase 1/Phase 2 | 400 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Bacterial Infections Associated With Healthcare (Healthcare-Associated) in Hospitalized Cirrhotic Patients: Randomized Study of Use of Traditional Empirical Antibiotic Therapy and Second-line Targeted at Multi-resistant Bacteria [NCT01820026] | Phase 4 | 96 participants (Anticipated) | Interventional | 2012-12-31 | Recruiting | ||
| Susceptibility Changes Among Oral Microorganisms Following Single Dose Antibiotic Prophylaxis [NCT01829529] | Phase 3 | 29 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Comparison of a Serum Procalcitonin (PRO-CT) Guided Treatment Plan With the Standard Guideline Recommended Antibiotic Treatment Plan for Patients Hospitalized With a Diagnosis of Exacerbation of COPD [NCT01125098] | 183 participants (Actual) | Observational | 2006-10-31 | Completed | |||
| An Open-label, Randomized Study to Evaluate Pharmacokinetic Interaction, Pharmacodynamics and Safety After Multiple Oral Dosing of CJ-12420 and Amoxicillin/Clarithromycin in Healthy Subjects [NCT03011996] | Phase 1 | 60 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis: A Cluster Randomized Cluster Crossover Non-Inferiority Study. [NCT04803422] | 2,631 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Open Label, Randomized Pilot Study to Examine The Effects of the Probiotic Saccharomyces Boulardii, the Antibiotic Amoxicillin/Clavulanate and the Combination on the Gut Microbiota of Healthy Volunteers [NCT01473368] | 53 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Effects of Mushroom Extract, S Boulardii and Amoxicillin on the Human Microbiome [NCT01414010] | 32 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Efficacy of Two Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment [NCT02988089] | Phase 4 | 480 participants (Anticipated) | Interventional | 2017-04-20 | Recruiting | ||
| A Multicenter, Open-Label Study To Assess The Efficacy And Safety Of Potassium Clavulanate/Amoxicillin (CVA/AMPC 1:14 Combination) In The Treatment Of Children With Acute Bacterial Rhinosinusitis [NCT01934231] | Phase 3 | 27 participants (Actual) | Interventional | 2013-08-30 | Completed | ||
| Comparison of the Efficacy of Triple Therapy With or Without Acetylcysteine in the First Line of Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial [NCT02249546] | Phase 4 | 654 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | ||
| Confirmatory Study to Examine Negative Predictive Value (NPV) and Safety of Skin Testing With PRE-PEN, a Minor Determinant MIxture (MDM) of Penicillin Antigens, and Amoxicillin Reagent Against an Oral Challenge With Amoxicillin [NCT01818336] | Phase 3 | 481 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| A Study to Determine PK Profiles of AUGMENTIN XR in Adolescents Weight at Least 40 kg Receiving Augmentin XR BID for 10 Days [NCT00354965] | Phase 1 | 52 participants (Actual) | Interventional | 2006-01-19 | Completed | ||
| Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate [NCT02340000] | Phase 4 | 315 participants (Actual) | Interventional | 2014-11-18 | Completed | ||
| Efficacy of High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori Rescue Treatment: A Randomized Clinical Trial [NCT04024527] | Phase 4 | 306 participants (Actual) | Interventional | 2019-07-25 | Completed | ||
| A Phase 1, Randomized, Open-label, Crossover, Drug Interaction Study Evaluating the Pharmacokinetic Profiles of Amoxicillin Administered Alone and in Combination With MMX® Mesalazine/Mesalamine in Healthy Adult Subjects [NCT01442688] | Phase 1 | 62 participants (Actual) | Interventional | 2011-10-07 | Completed | ||
| "Phase 4, Prospective, Randomized Study Comparing 14-day Non-bismuth Quadruple Hybrid and Concomitant Therapies for Helicobacter Pylori Eradication in Settings With High Clarithromycin Resistance" [NCT01464060] | Phase 4 | 400 participants (Anticipated) | Interventional | 2011-09-30 | Recruiting | ||
| Prospective, Phase 3, Randomized, Multi-center, Double-blind Study of Efiicacy, Tolerability & Safety of Sulopenem & Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro-metronidazole for Treatment of cIAI in Adults [NCT03358576] | Phase 3 | 674 participants (Actual) | Interventional | 2018-09-18 | Completed | ||
| Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in the Treatment of Periodontitis in Patients With Diabetes [NCT03374176] | Phase 3 | 42 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia [NCT01110421] | Phase 3 | 7 participants (Actual) | Interventional | 2010-12-31 | Terminated(stopped due to Trial terminated early per business decision) | ||
| The Effect of Different Time Intervals on Rescue Treatment of Helicobacter Pylori Infection: a Prospective, Multicenter Observational Study [NCT05620589] | 626 participants (Anticipated) | Observational | 2022-11-11 | Not yet recruiting | |||
| Effectiveness of Minocycline-Containing Bismuth Quadruple Therapy as First-Line Regimen for Helicobacter Pylori Eradication [NCT04558502] | Phase 4 | 339 participants (Anticipated) | Interventional | 2022-01-05 | Not yet recruiting | ||
| A Phase 3, Randomized, Double-blind, Active-controlled, Multicenter Study to Evaluate the Efficacy and Safety of a Triple Therapy With CJ-12420, Amoxicillin and Clarithromycin in H. Pylori Positive Patients [NCT03317223] | Phase 3 | 350 participants (Actual) | Interventional | 2017-10-17 | Completed | ||
| Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso [NCT03187834] | Phase 4 | 252 participants (Actual) | Interventional | 2017-07-04 | Completed | ||
| Azithromycin as Adjunctive Therapy for Uncomplicated Severe Acute Malnutrition: [NCT03568643] | Phase 3 | 301 participants (Actual) | Interventional | 2020-06-03 | Completed | ||
| Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics [NCT05761080] | Phase 4 | 158 participants (Anticipated) | Interventional | 2021-04-22 | Recruiting | ||
| Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Rifasutenizol (TNP 2198) in Combination With Rabeprazole and Amoxicillin in the Primary Treatment of Participants With H. Pylori Infection [NCT05857163] | Phase 3 | 700 participants (Anticipated) | Interventional | 2023-05-18 | Recruiting | ||
| Systemic Antibiotic Therapy (Amoxicillin Plus Metronidazole) as an Adjunct to Initial Non-surgical Treatment of Peri-implantitis; a Single Blind Randomized Controlled Study [NCT04149327] | Phase 4 | 62 participants (Actual) | Interventional | 2012-08-01 | Completed | ||
| The Efficacy of 10-day Metronidazole and Levofloxacin Containing Sequential Therapy and 10-day Levofloxacin-containing Triple Therapy In Second Line Helicobacter Pylori Eradication Therapies [NCT02596620] | 164 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: a Randomized Controlled Study -DALFEN Study [NCT03003273] | Phase 3 | 142 participants (Anticipated) | Interventional | 2017-01-31 | Terminated(stopped due to poor accrual) | ||
| Prophylactic Antibiotic Treatment in End Stage Kidney Disease and Central Venous Catheter as Hemodialysis Vascular Access [NCT05248620] | 800 participants (Anticipated) | Interventional | 2022-02-14 | Recruiting | |||
| A Multi-centre Double-blind Randomised Controlled Trial to Determine if a Longer Duration of Amoxicillin-clavulanic Acid (Compared to Shorter Duration) Improves Clinical Outcomes of Children Hospitalised With Community-acquired Pneumonia [NCT02783859] | Phase 4 | 314 participants (Anticipated) | Interventional | 2016-06-30 | Active, not recruiting | ||
| A Multicenter, Randomized, Open Label Comparative Study Of Azithromycin Extended Release (ZMAX) Versus Amoxicillin/Clavulanate Potassium In Subjects With Acute Bacterial Sinusitis (ABS) In A Physician Practice Environment [NCT00367120] | Phase 4 | 762 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| A Randomised Controlled Trial of Continuing Immunoglobulin Therapy, or Stopping With or Without Prophylactic Antibiotics, on Infection Rate in Patients With Acquired Hypogammaglobulinemia Secondary to Haematological Malignancies. [NCT05678621] | Phase 2/Phase 3 | 300 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | ||
| The Effect of the Knock Down of Gut Microbiota by Antibiotics on Parameters of Body Weight Control and Insulin Sensitivity [NCT02241421] | 57 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Clinical and Microbiological Effects of Adjunctive Metronidazole Plus Amoxicillin in the Treatment of Generalized Chronic Periodontitis: Smokers Versus Non-Smokers. [NCT01837199] | Phase 4 | 64 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Evaluation of Pharmaceutical Bioequivalence of Amoxicillin Trihydrate - Clamoxyl 500mg/5mL (Glaxo Wellcome Production.) in the Form Powder for Oral Suspension Versus Amoxil ® 500mg/5mL (GlaxoSmithKline Mexico SA) in the Form of Powder for Oral Suspension [NCT01431989] | Phase 1 | 28 participants (Actual) | Interventional | 2011-05-27 | Completed | ||
| Comparison of Two Lengths of Treatment in Early-onset Ventilated Associated Pneumonia [NCT01559753] | Phase 4 | 225 participants (Actual) | Interventional | 1998-01-31 | Completed | ||
| Duration of Postoperative Antibiotic Prophylaxis in Facial Fractures (Mandibular Fractures, Zygomaticoorbital Fractures, Isolated Orbital Blow-out Fractures and LeFort I/II/III Fractures): 1 Day vs. 5 Days: a Prospective, Randomized, Double Blind and Plac [NCT01583062] | Phase 4 | 217 participants (Actual) | Interventional | 2006-01-31 | Terminated(stopped due to Limited number of patients) | ||
| Efficacy and Cost Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Locally Advanced Head and Neck Cancer to Prevent Aspiration Pneumonia. A Randomized Phase II-III Study [NCT01598402] | Phase 2/Phase 3 | 106 participants (Anticipated) | Interventional | 2011-12-31 | Recruiting | ||
| The Effect of Routine Antibiotic Use in the Outpatient Treatment of Severely Malnourished Children Without Complications: Maradi, Niger [NCT01613547] | 2,412 participants (Anticipated) | Interventional | 2012-10-31 | Completed | |||
| Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children: A Randomized Controlled Trial [NCT02935374] | Phase 4 | 73 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| The Efficacy of Prophylactic Antibiotics in the Management of Pneumonitis Following Paraffin (Kerosene) Ingestion in Children [NCT01253980] | 74 participants (Actual) | Interventional | 2010-07-31 | Completed | |||
| Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial [NCT01919411] | Phase 4 | 134 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months [NCT03818815] | Phase 2 | 103 participants (Actual) | Interventional | 2019-02-21 | Completed | ||
| Efficacy, Safety and Tolerability of Amoxicillin + Clavulanic Acid (875mg/125mg) Two Times a Day Compared to Clindamycin (150mg) Four Times a Day for 5-7 Days in Treatment of Acute Odontogenic Infection With or Without Abscess [NCT02141217] | Phase 4 | 472 participants (Actual) | Interventional | 2013-03-21 | Completed | ||
| Acupuncture and Herbal Treatment of Chronic HIV Sinusitis [NCT00002149] | 40 participants | Interventional | Completed | ||||
| A Phase II Clinical Trial of Anti-Helicobacter Pylori Treatment in Endoscopically Diagnosed Low-Grade Localized Gastric Lymphoma [NCT00003151] | Phase 2 | 96 participants (Anticipated) | Interventional | 1997-09-30 | Completed | ||
| Antibiotic Prophylaxis in Critically Ill Patients After Suspected Aspiration [NCT05079620] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-11-30 | Recruiting | ||
| Comparison of 7-day Triple, 10-day Sequential, and 7-day Concomitant Therapies for Helicobacter Pylori Infection in Taiwan [NCT01769365] | Phase 4 | 307 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| A Controlled Human Pneumococcal Infection Model (PIM) Study [NCT05361499] | 20 participants (Actual) | Interventional | 2022-05-31 | Completed | |||
| 14-day High-dose Tegoprazan Double Therapy Versus Bismuth Quadruple Therapy in First-line Treatment of Helicobacter Pylori Infection: a Prospective, Randomized, Controlled Study [NCT05438550] | Phase 4 | 258 participants (Anticipated) | Interventional | 2023-02-14 | Not yet recruiting | ||
| The Effect of Probiotics With Vonoprazan-amoxicillin Dual Therapy on Gut Microbiotain After Helicobacter Pylori Eradication: A Randomized Controlled Trial [NCT05658055] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit? [NCT02554383] | Phase 3 | 515 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Efficacy and Safety of Helicobacter Pylori Eradication Dual or Triple Regimes Using Vonoprazan as the Antacid [NCT05345210] | Phase 4 | 500 participants (Anticipated) | Interventional | 2022-04-25 | Recruiting | ||
| Prospective, Phase 3, Randomized, Multi-center, Double-blind, Double-dummy Study of Efficacy, Tolerability & Safety of Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Treatment of cUTI in Adults [NCT03357614] | Phase 3 | 1,395 participants (Actual) | Interventional | 2018-09-18 | Completed | ||
| Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection - a Multi-center Randomized Controlled Trial [NCT03779087] | 112 participants (Actual) | Interventional | 2018-07-11 | Completed | |||
| Efficacies of Hybrid, High-dose Dual and Bismuth Quadruple Therapies for the First-line Anti-H Pylori Treatment and Tetracycline-levofloxacin Quadruple Therapy for the Second-line Anti-H Pylori Treatment - a Multicentre Randomized Trial [NCT03779074] | Phase 3 | 918 participants (Actual) | Interventional | 2018-09-03 | Completed | ||
| Personalized Treatment for Refractory H Pylori Infection [NCT02547025] | 126 participants (Actual) | Interventional | 2012-08-01 | Completed | |||
| Delineation of Therapeutic Potential and the Causal Relationship Between Vitamin D and Helicobacter Pylori (HP) Infection and Gastritis [NCT03142620] | Phase 3 | 96 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| Compare 14-day Reverse Hybrid Therapy and 14-day Triple Therapy Plus Bismuth on Helicobacter Pylori Eradication [NCT03321773] | 440 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | |||
| Efficacy of High-dose Dual Therapy Versus Bismuth-containing Quadruple Therapy for Rescue Treatment of Helicobacter Pylori Infection - A Prospective, Randomized, Comparative Study [NCT02490839] | Phase 4 | 450 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age [NCT05345457] | Phase 4 | 88 participants (Anticipated) | Interventional | 2023-01-13 | Recruiting | ||
| Adding Bismuth to Rabeprazole-based First-line Triple Therapy Does Not Improve the Eradication of Helicobacter Pylori [NCT03108287] | Phase 4 | 162 participants (Actual) | Interventional | 2013-04-01 | Completed | ||
| Comparing Efficacy of Postoperative Antibiotic Use in Transoral Thyroidectomy: a Prospective Randomized Controlled Trial Study [NCT03295955] | 50 participants (Anticipated) | Interventional | 2017-09-04 | Recruiting | |||
| Group A Streptococcal Pharyngitis: Six Days Amoxicillin, oR Six Days Placebo in Children Between 3 and 15 Years Old:a Randomized, Double Blinded, Multicentred, Non-inferiority Trial [NCT03264911] | Phase 4 | 360 participants (Anticipated) | Interventional | 2017-01-27 | Recruiting | ||
| A Placebo Controlled Trial of Amoxicillin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections [NCT00001658] | Phase 4 | 30 participants | Interventional | 1997-07-31 | Completed | ||
| Efficacy of High Doses of Oral Penicillin V Versus High Doses of Oral Amoxicillin in the Treatment of Non-severe Community-acquired Pneumonia in Adults [NCT03208361] | Phase 3 | 43 participants (Actual) | Interventional | 2013-11-05 | Terminated(stopped due to Lack of financial support to continue with the study recruitment. Independent study financially supported by a national grant with a 4.5 years duration.) | ||
| 2-day Prophylactic Antibiotic is Effective in Transoral Endoscopic Thyroidectomy [NCT04268407] | 60 participants (Actual) | Interventional | 2020-02-26 | Completed | |||
| Multicentre, Prospective Study of First-line Antibiotic Therapy for Early-stage H. Pylori-Positive Gastric Pure (de Novo) Diffuse Large B-cell Lymphoma and Potential Predicting Factor for Treatment Outcome [NCT02388581] | Phase 2 | 30 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | ||
| Efficacy and Safety of Basic Triple Therapy Including Ilaprazole, Levofloxacin on the First Line Eradication Treatment of H.Pylori [NCT02352701] | 320 participants (Actual) | Observational | 2012-12-31 | Completed | |||
| Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment [NCT03139253] | Phase 4 | 120 participants (Anticipated) | Interventional | 2017-05-30 | Not yet recruiting | ||
| Dual Therapy With High Doses of Ilaprazole and Amoxicillin for Helicobacter Pylori Infection; Studies From Korea [NCT02401477] | Phase 4 | 90 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Antibiotic Profile of Pathogenic Bacteria Isolated From Postsurgical Site Infections in Public Hospitals in Northern Jordan [NCT05106803] | 24 participants (Actual) | Observational | 2019-08-01 | Completed | |||
| "The Effects of the Synbiotic Bifidobacterium Lactis B94 Plus Inulin Addition on Standard Triple Therapy of Helicobacter Pylori Eradication in Children" [NCT03165253] | 69 participants (Actual) | Interventional | 2011-06-30 | Completed | |||
| A Double Blind Community-based Randomized Trial of Amoxicillin Versus Placebo for Fast Breathing Pneumonia in Children Aged 2-59 Months in Karachi, Pakistan [NCT02372461] | 4,000 participants (Actual) | Interventional | 2014-11-09 | Completed | |||
| A Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem, Administered Intravenously, Plus Amoxycillin/CA and Faropenem, Administered Orally, Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed, Smear-positi [NCT02349841] | Phase 2 | 46 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Functionalization of a Volume-stable Collagen Matrix (VCMX) Using Injectable Platelet Rich Fibrin (i-PRF) for the Treatment of Single Gingival Recession [NCT05916742] | 75 participants (Anticipated) | Interventional | 2022-04-15 | Recruiting | |||
| Use of a Novel Volume-stable Collagen Matrix (VCMX) in the Treatment of Single Gingival Recession Associated With Non-carious Cervical Lesion Partially Restored. A Randomized Clinical Trial [NCT05916716] | 50 participants (Anticipated) | Interventional | 2022-08-01 | Recruiting | |||
| Proton Pump Inhibitor and Amoxicillin Combined Bismuth or Metronidazole for Helicobacter Pylori First-line Treatment: A Randomized Controlled Trial [NCT05014685] | Phase 4 | 732 participants (Anticipated) | Interventional | 2021-08-20 | Recruiting | ||
| Efficacy of Seven-day Combined Rabeprazole Plus Levofloxacin Plus Augmentin for Eradication of Helicobacter Pylori. [NCT01575899] | Phase 4 | 208 participants (Actual) | Interventional | 2007-12-31 | Terminated(stopped due to Early termination due to efficacy) | ||
| A Randomized, Open-label, Parallel-design Study to Evaluate Pharmacokinetic Drug Interactions and Safety After Coadministration of Clarithromycin, Amoxicillin and Ilaprazole [NCT02998437] | Phase 1 | 28 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| Amoxicillin Versus Benzyl Penicillin for Severe Childhood Pneumonia Amongst Inpatients: An Open Label Randomised Controlled Non-inferiority Trial [NCT01399723] | Phase 3 | 561 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp: A Randomized, Double-blind Clinical Trial [NCT03809312] | Phase 4 | 134 participants (Anticipated) | Interventional | 2019-08-14 | Recruiting | ||
| [NCT01792700] | Phase 4 | 648 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Postoperative Healthcare Utilization in Adenotonsillectomy Patients With Postoperative Antibiotic Administration Compared to Patients Without Antibiotic Administration [NCT01561703] | 58 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Procalcitonin to Reduce Antibiotic Use in Pediatric Pneumonia [NCT04963764] | Phase 4 | 5 participants (Actual) | Interventional | 2021-10-18 | Completed | ||
| Efficacy of High Dose of Dual Therapy Plus Bismuth for Helicobacter Pylori Treatment：a Randomized Clinical Trial [NCT03405584] | Phase 4 | 160 participants (Actual) | Interventional | 2018-01-03 | Completed | ||
| Comparison of 14-day Sequential and Hybrid Therapies for H Pylori Infection [NCT01085786] | Phase 4 | 240 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| Clinical and Microbiological Effects of Local and Systemic Antimicrobials as an Adjunctive Therapy in Periodontitis Stages 2 and 3 [NCT05608564] | 40 participants (Actual) | Interventional | 2022-01-17 | Active, not recruiting | |||
| Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection - a Randomized Controlled Trial (REHYTRI Study) [NCT02359435] | 440 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Safety Efficacy, and Cost-effectiveness of Modified Doses of Ready-to-use Therapeutic Food for the Treatment of Severe Acute Malnutrition Among Children 6-59 Months of Age in Ethiopia [NCT06061484] | 2,400 participants (Anticipated) | Interventional | 2023-09-25 | Not yet recruiting | |||
| A Rational Approach to the Identification of New Treatment Options to Prevent Congenital Syphilis: Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy [NCT05309928] | Phase 1 | 20 participants (Anticipated) | Interventional | 2023-08-29 | Recruiting | ||
| Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract [NCT02021006] | Phase 3 | 292 participants (Actual) | Interventional | 2013-12-31 | Active, not recruiting | ||
| Prospective Randomized Clinical Trial Assessing the Efficacy of a Short Course of Intravenous Amoxicillin Plus Clavulanic Acid Followed by Oral Antibiotic in Patients With Uncomplicated Acute Diverticulitis [NCT00917592] | Phase 4 | 50 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| Impact of Bariatric Surgery on the Pharmacokinetics Parameters of Amoxicillin [NCT03588273] | 8 participants (Actual) | Interventional | 2016-06-24 | Completed | |||
| A Comparison Study of Helicobacter Pylori Eradication Rates Between Daily Four Times and Daily Two Times Usage of Proton Pump Inhibitor and Amoxicillin for the First Line and the Second Line Eradication Therapy [NCT03802318] | 530 participants (Anticipated) | Interventional | 2019-01-02 | Enrolling by invitation | |||
| Phase 1 Study to Evaluate the Effect of Oral Administration of Tebipenem Pivoxil Hydrobromide on Normal Human Intestinal Microbiota in Healthy Volunteers [NCT04376554] | Phase 1 | 30 participants (Actual) | Interventional | 2020-02-10 | Completed | ||
| Effect of Helicobacter Pylori Eradication on Glandular Atrophy and Metachronous Cancer in Patients Undergoing Endoscopic Mucosal Resection for Gastric Cancer [NCT02407119] | Phase 3 | 470 participants (Actual) | Interventional | 2003-06-30 | Active, not recruiting | ||
| Surgical Treatment of Peri-implantitis With and Without Systemically Adjunctive Antibiotics A Prospective, Double Blind, Randomized, Three Armed, Parallel, Placebo Controlled Clinical Trial [NCT02185209] | Phase 4 | 77 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Efficacy and Safety of Furazolidone-based Quadruple Therapy With Vonoprazan as First-line Treatment for Helicobacter Pylori Eradication: A Prospective Randomized Trial [NCT04907747] | Phase 4 | 234 participants (Anticipated) | Interventional | 2021-05-18 | Recruiting | ||
| Comparison of Vonoprazan and Amoxicillin Dual Therapy With Standard Triple Therapy With Proton Pump Inhibitor for Helicobacter Pylori Eradication; a Randomized Control Trial [NCT04901663] | Phase 4 | 179 participants (Actual) | Interventional | 2021-06-21 | Completed | ||
| Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication: A Multicenter Randomized Clinical Trial of 10 and 14 Days [NCT04901117] | Phase 4 | 1,300 participants (Anticipated) | Interventional | 2021-06-30 | Not yet recruiting | ||
| Efficacy and Safety of 200 mcg QD or 200 mcg BID Mometasone Furoate Nasal Spray (MFNS) vs Amoxicillin vs Placebo as Primary Treatment of Subjects With Acute Rhinosinusitis [NCT00751075] | Phase 3 | 981 participants (Actual) | Interventional | 2003-12-01 | Completed | ||
| Eradication Efficacy and Safety of High-dose Dual Therapy Compared With Furazolidone-based Quadruple Therapy as a Rescue Treatment for Helicobacter Pylori Infection: a Randomized Controlled Trial [NCT05176821] | 186 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | |||
| Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint Infections [NCT05902221] | Phase 3 | 235 participants (Anticipated) | Interventional | 2023-07-01 | Not yet recruiting | ||
| PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery [NCT03574090] | Phase 4 | 268 participants (Actual) | Interventional | 2020-10-20 | Completed | ||
| Full-mouth Periodontal Debridement Associated With Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial [NCT02969928] | Phase 2/Phase 3 | 46 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial [NCT03007342] | 78 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | |||
| Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients: a Double Blind Placebo Controlled Randomized Clinical Trial [NCT01593592] | 70 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| The Effect of Amoxicillin Versus Placebo on Gastrointestinal Motility in Children [NCT01530009] | 33 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection. [NCT03583476] | 1,821 participants (Anticipated) | Observational | 2018-04-01 | Recruiting | |||
| Helicobacter Pylori Eradication With Berberine Hydrochloride,Esomeprazole,Amoxicillin and Clarithromycin Versus Bismuth,Esomeprazole,Amoxicillin,and Clarithromycin: a Randomized,Open-label, Non-inferiority, Phase Ⅳ Trail [NCT02296021] | Phase 4 | 612 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Change of Gut Microbiome and Symptom After H.Pylori Eradication Therapy in Patients With Functional Dyspepsia [NCT04449185] | Phase 4 | 60 participants (Anticipated) | Interventional | 2020-06-30 | Not yet recruiting | ||
| Comparison of Two Novel First-line Anti-Helicobacter Pylori Therapy: A Prospective Randomized Trial [NCT03383003] | 240 participants (Actual) | Interventional | 2016-03-01 | Completed | |||
| Efficacy and Safety of Intravenous IIaprazole for Peptic Ulcer Bleeding: A Randomized, Double-Blind, Omeprazole-Controlled, Multicenter, and Phase 3 Trail in China [NCT03362281] | Phase 3 | 540 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| Amoxicillin-clavulanate Alone or in Combination With Ciprofloxacin in Low-Risk Febrile Neutropenic Adult Patients: A Prospective, Double-blind, Randomized, Non-Inferiority Multicenter, Phase III Clinical Trial. [NCT04698057] | Phase 3 | 0 participants (Actual) | Interventional | 2022-03-01 | Withdrawn(stopped due to No enrolment due to Covid-19) | ||
| 10 Day Concomitant Versus 14 Day Hybrid Regimen as First Line H. Pylori Eradication Treatment in a High Clarithromycin Resistance Area. A Multicenter Randomized Equivalence Trial [NCT03592069] | Phase 4 | 345 participants (Actual) | Interventional | 2018-02-21 | Completed | ||
| The Evaluation of Postoperative Antibiotics in Non-Infected Mandible Fractures [NCT04198129] | Phase 1 | 174 participants (Anticipated) | Interventional | 2020-10-01 | Recruiting | ||
| Efficacy on Helicobacter Pylori Eradication With Sequential Antibiotic Compared to Triple Therapy for 14 Days [NCT02395458] | Phase 4 | 142 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| Evaluating Pharmacokinetics and Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Single Doses of Faropenem Plus Amoxicillin/Clavulanic Acid in Healthy Volunteers [NCT02393586] | Phase 1 | 43 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Vonoprazan Fumarate in Combination With Amoxicillin for the First-line Eradication - a Multicenter, Randomized, Parallel Controlled Study [NCT05196945] | Phase 4 | 316 participants (Anticipated) | Interventional | 2022-03-31 | Not yet recruiting | ||
| Strategy on the Increment of H. Pylori Eradication Rate and Investigating the Gastric Pathology and Antimicrobial Resistance in Diabetic Patients [NCT02466919] | Phase 4 | 114 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome : a Monocentric Pilot Study [NCT05302531] | Phase 1 | 10 participants (Anticipated) | Interventional | 2022-12-09 | Recruiting | ||
| Bioavailability of Paracetamol, Amoxicillin and Talinolol and Expression of Intestinal Drug Metabolizing Enzymes and Transport Proteins Before, Immediately and One Year After Proximal Roux-en-Y Gastric Bypass Operation in Patients With Morbid Adipositas [NCT02514941] | Phase 1 | 12 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Intravenous to Oral Antibiotic Switch Therapy for Probable Neonatal Bacterial Infections: Clinical Efficacy, Safety and Cost-effectiveness [NCT03247920] | Phase 4 | 510 participants (Actual) | Interventional | 2017-11-04 | Completed | ||
| The Effect of Rectal Swab Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy on Infectious Complications and Cost of Care: A Randomized Controlled Trial in the Netherlands. [NCT03228108] | Phase 4 | 1,538 participants (Actual) | Interventional | 2018-04-03 | Completed | ||
| Comparing the Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinidazole on Rate of Eradication of Helicobacter Pylori Infected Patients on Syrian Population [NCT04348786] | Phase 4 | 78 participants (Actual) | Interventional | 2019-02-01 | Completed | ||
| The Effect of Broccoli Sprout Extract and Probiotics on Proton Pump Inhibitor-based Triple Therapy for Eradication of Helicobacter Pylori: a Prospective Randomized Trial [NCT03220542] | Phase 4 | 360 participants (Anticipated) | Interventional | 2016-01-31 | Active, not recruiting | ||
| Assessment of Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa [NCT02974348] | Phase 3 | 300 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||