fluoxetine

Description

Fluoxetine, also known as Prozac, is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It was first synthesized by Eli Lilly and Company in 1974 and approved by the Food and Drug Administration (FDA) in 1987. Fluoxetine works by increasing the levels of serotonin in the brain, a neurotransmitter that plays a role in mood, sleep, appetite, and other functions. It is commonly prescribed for the treatment of major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Fluoxetine is also used off-label for other conditions, such as anxiety, social phobia, and post-traumatic stress disorder. Fluoxetine is generally well-tolerated, but common side effects include nausea, headache, drowsiness, and sexual dysfunction. More serious side effects, such as serotonin syndrome and suicidal thoughts, are possible but rare. Fluoxetine is a highly effective treatment for depression and other mental health conditions. It is widely studied to understand its mechanisms of action, therapeutic effects, and potential for new applications. Research on fluoxetine continues to contribute to the understanding of brain function and the development of new treatments for mental illness.'

(S)-fluoxetine : An N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine that has S configuration. [The antidepressant drug fluoxetine is a racemate comprising equimolar amounts of (R)- and (S)-fluoxetine]. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]