A chymotrypsinogen B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17538]
EC 3.4.21.1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| staurosporine aglycone | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| ro 31-8220 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| indirubin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| indigo | Homo sapiens (human) | IC50 | 90.0000 | 1 | 1 |
| iodophthalein | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| razaxaban | Homo sapiens (human) | Ki | 5.4000 | 2 | 2 |
| bortezomib | Homo sapiens (human) | Ki | 0.3200 | 1 | 1 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| u 0126 | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| rottlerin | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| bms 740808 | Homo sapiens (human) | Ki | 2.8000 | 1 | 1 |
| dpc 423 | Homo sapiens (human) | Ki | 17.0000 | 1 | 1 |
This protein enables 1 target(s):
| Target | Category | Definition |
|---|---|---|
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| digestion | biological process | The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |