Peptidyl-prolyl cis-trans isomerase A

A peptidyl-prolyl cis-trans isomerase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62937]

Synonyms

PPIase A;
EC 5.2.1.8;
Cyclophilin A;
Cyclosporin A-binding protein;
Rotamase A

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	7 (28.00)	29.6817
2010's	14 (56.00)	24.3611
2020's	2 (8.00)	2.80

Compounds (10)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2,4-pyridinedicarboxylic acid	Homo sapiens (human)	IC50	100.0000	1	1
daminozide	Homo sapiens (human)	IC50	2,200.0000	1	1
prolinal	Homo sapiens (human)	IC50	5,000.0000	1	1
oxalylglycine	Homo sapiens (human)	IC50	640.0000	1	1
cyclosporine	Homo sapiens (human)	IC50	0.0252	12	12
cyclosporine	Homo sapiens (human)	Ki	0.0645	8	8
(melle-4)cyclosporin	Homo sapiens (human)	Ki	0.0021	1	1
cyclosporin g	Homo sapiens (human)	IC50	0.2200	2	2
scy-635	Homo sapiens (human)	IC50	0.7792	2	2
scy-635	Homo sapiens (human)	Ki	0.0018	1	1
alisporivir	Homo sapiens (human)	Ki	0.0003	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cyclosporine	Homo sapiens (human)	Kd	0.6225	11	11
sanglifehrin a	Homo sapiens (human)	Kd	0.0033	1	1
(melle-4)cyclosporin	Homo sapiens (human)	Kd	0.0075	1	1
scy-635	Homo sapiens (human)	Kd	0.0032	1	1
alisporivir	Homo sapiens (human)	Kd	0.0066	2	2

Enables

This protein enables 8 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
peptidyl-prolyl cis-trans isomerase activity	molecular function	Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]
integrin binding	molecular function	Binding to an integrin. [GOC:ceb]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
cyclosporin A binding	molecular function	Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. [GOC:mb]
virion binding	molecular function	Binding to a virion, either by binding to components of the capsid or the viral envelope. [GOC:ai]
unfolded protein binding	molecular function	Binding to an unfolded protein. [GOC:ai]
heparan sulfate binding	molecular function	Binding to heparan sulfate. [GO_REF:0000067, GOC:TermGenie, PMID:8567685]

Located In

This protein is located in 11 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
focal adhesion	cellular component	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
vesicle	cellular component	Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]
secretory granule lumen	cellular component	The volume enclosed by the membrane of a secretory granule. [GOC:rph]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
ficolin-1-rich granule lumen	cellular component	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 28 target(s):

Target	Category	Definition
protein peptidyl-prolyl isomerization	biological process	The modification of a protein by cis-trans isomerization of a proline residue. [GOC:krc, PMID:16959570]
negative regulation of protein phosphorylation	biological process	Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
positive regulation of protein phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
protein folding	biological process	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb]
negative regulation of protein kinase activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. [GOC:go_curators]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
viral release from host cell	biological process	The dissemination of mature viral particles from a host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. [GOC:jl]
platelet activation	biological process	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [http://www.graylab.ac.uk/omd/]
neuron differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
neutrophil chemotaxis	biological process	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732]
leukocyte chemotaxis	biological process	The movement of a leukocyte in response to an external stimulus. [GOC:add, GOC:jl]
activation of protein kinase B activity	biological process	Any process that initiates the activity of the inactive enzyme protein kinase B. [GOC:pg]
negative regulation of stress-activated MAPK cascade	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. [GOC:mah]
lipid droplet organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]
cellular response to oxidative stress	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah]
positive regulation of protein dephosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. [GOC:bf]
endothelial cell activation	biological process	The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]
positive regulation of MAPK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
regulation of viral genome replication	biological process	Any process that modulates the frequency, rate or extent of viral genome replication. [GOC:ai]
positive regulation of viral genome replication	biological process	Any process that activates or increases the frequency, rate or extent of viral genome replication. [GOC:ai]
positive regulation of protein secretion	biological process	Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]
positive regulation of NF-kappaB transcription factor activity	biological process	Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
cell adhesion molecule production	biological process	The appearance of a cell adhesion molecule due to biosynthesis or secretion. [GOC:BHF, GOC:rl]
negative regulation of protein K48-linked ubiquitination	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. [GOC:BHF, GOC:rph, PMID:23460740]
platelet aggregation	biological process	The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk]
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]
negative regulation of viral life cycle	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle. [GO_REF:0000058, GOC:TermGenie, PMID:18005716]
regulation of apoptotic signaling pathway	biological process	Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis]