Page last updated: 2024-08-08 00:14:30
Poly [ADP-ribose] polymerase tankyrase-2
A poly [ADP-ribose] polymerase tankyrase-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H2K2]
Synonyms
EC 2.4.2.30;
ADP-ribosyltransferase diphtheria toxin-like 6;
ARTD6;
Poly [ADP-ribose] polymerase 5B;
Protein poly-ADP-ribosyltransferase tankyrase-2;
2.4.2.-;
TNKS-2;
TRF1-interacting ankyrin-related ADP-ribose polymerase 2;
Research
Bioassay Publications (33)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 27 (81.82) | 24.3611 |
| 2020's | 5 (15.15) | 2.80 |
Compounds (29)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| phenanthridone | Homo sapiens (human) | IC50 | 0.0139 | 1 | 2 |
| pj-34 | Homo sapiens (human) | IC50 | 1.2683 | 3 | 5 |
| carbostyril | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| flavone | Homo sapiens (human) | IC50 | 0.1440 | 1 | 2 |
| 4-methylquinolin-2(1H)-one | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| 4-Methoxybenzamide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 3',4'-dihydroxyflavone | Homo sapiens (human) | IC50 | 0.1739 | 1 | 2 |
| e-z cinnamic acid | Homo sapiens (human) | IC50 | 0.6850 | 1 | 1 |
| iwr-1 exo | Homo sapiens (human) | IC50 | 0.0292 | 1 | 1 |
| N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamide | Homo sapiens (human) | IC50 | 1.7838 | 3 | 4 |
| apigenin | Homo sapiens (human) | IC50 | 2.9256 | 1 | 2 |
| luteolin | Homo sapiens (human) | IC50 | 1.0858 | 1 | 2 |
| 3',4',7-trihydroxyflavone | Homo sapiens (human) | IC50 | 0.8705 | 1 | 2 |
| rucaparib | Homo sapiens (human) | IC50 | 0.4523 | 2 | 4 |
| veliparib | Homo sapiens (human) | IC50 | 23.9941 | 1 | 2 |
| olaparib | Homo sapiens (human) | IC50 | 2.4458 | 5 | 6 |
| niraparib | Homo sapiens (human) | IC50 | 5.1293 | 1 | 2 |
| iwr-1 endo | Homo sapiens (human) | IC50 | 17.0886 | 7 | 8 |
| g007-lk | Homo sapiens (human) | IC50 | 0.0386 | 8 | 8 |
| CCT251545 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| xav939 | Homo sapiens (human) | IC50 | 11.3832 | 23 | 24 |
| 2-(4-methoxyphenyl)-1H-quinazolin-4-one | Homo sapiens (human) | IC50 | 0.2383 | 3 | 3 |
| nvp-tnks656 | Homo sapiens (human) | IC50 | 0.0060 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| lestaurtinib | Homo sapiens (human) | Kd | 0.0066 | 1 | 1 |
| sorafenib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| iwr-1 exo | Homo sapiens (human) | EC50 | 5.0000 | 1 | 1 |
| tandutinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| su 11248 | Homo sapiens (human) | Kd | 8.9000 | 1 | 1 |
| midostaurin | Homo sapiens (human) | Kd | 0.1200 | 1 | 1 |
| veliparib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| quizartinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| niraparib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| iwr-1 endo | Homo sapiens (human) | EC50 | 1.3500 | 2 | 2 |
| xav939 | Homo sapiens (human) | Kd | 0.0094 | 3 | 3 |
| 2-(4-methoxyphenyl)-1H-quinazolin-4-one | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| NAD+ ADP-ribosyltransferase activity | molecular function | Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| nucleotidyltransferase activity | molecular function | Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732] |
| enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| NAD+-protein ADP-ribosyltransferase activity | molecular function | Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243] |
Located In
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| pericentriolar material | cellular component | A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. [GOC:clt, ISBN:0815316194] |
| chromosome, telomeric region | cellular component | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nuclear envelope | cellular component | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Involved In
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| protein polyubiquitination | biological process | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. [ISBN:0815316194] |
| Wnt signaling pathway | biological process | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397] |
| positive regulation of telomere maintenance via telomerase | biological process | Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah] |
| protein localization to chromosome, telomeric region | biological process | Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. [GOC:BHF, GOC:mah] |
| protein poly-ADP-ribosylation | biological process | The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379] |
| protein auto-ADP-ribosylation | biological process | The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl] |
| positive regulation of canonical Wnt signaling pathway | biological process | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb] |
| positive regulation of telomere capping | biological process | Any process that activates or increases the frequency, rate or extent of telomere capping. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] |
| negative regulation of telomere maintenance via telomere lengthening | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] |