Page last updated: 2024-08-07 16:09:27
Neurotensin receptor type 1
A neurotensin receptor type 1 that is encoded in the genome of rat. [OMA:P20789, PRO:DNx]
Synonyms
NT-R-1;
NTR1;
High-affinity levocabastine-insensitive neurotensin receptor;
NTRH
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| sr 48692 | Rattus norvegicus (Norway rat) | IC50 | 0.0820 | 1 | 1 |
| sr 48692 | Rattus norvegicus (Norway rat) | Ki | 0.0026 | 1 | 1 |
| sr 142948 | Rattus norvegicus (Norway rat) | Ki | 0.0017 | 2 | 2 |
| neurotensin | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| neurotensin | Rattus norvegicus (Norway rat) | EC50 | 0.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| sr 48692 | Rattus norvegicus (Norway rat) | Ke | 0.0047 | 1 | 1 |
| sr 142948 | Rattus norvegicus (Norway rat) | Ke | 0.0015 | 1 | 1 |
| sr 48527 | Rattus norvegicus (Norway rat) | Ke | 0.0230 | 2 | 2 |
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.Journal of medicinal chemistry, , 09-12, Volume: 62, Issue:17, 2019
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.Bioorganic & medicinal chemistry, , Jul-15, Volume: 21, Issue:14, 2013
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 25, Issue:2, 2015
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 25, Issue:2, 2015
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014