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Histone deacetylase 1
A histone deacetylase 1 that is encoded in the genome of mouse. [OMA:O09106, PRO:DNx]
Synonyms
HD1;
EC 3.5.1.98
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| vorinostat | Mus musculus (house mouse) | IC50 | 0.1120 | 5 | 5 |
| vorinostat | Mus musculus (house mouse) | Ki | 0.0676 | 1 | 1 |
| trapoxin a | Mus musculus (house mouse) | IC50 | 0.1000 | 1 | 1 |
| trichostatin a | Mus musculus (house mouse) | IC50 | 0.0043 | 7 | 7 |
| trichostatin a | Mus musculus (house mouse) | Ki | 0.0011 | 1 | 1 |
| tubastatin a | Mus musculus (house mouse) | IC50 | 8.1000 | 1 | 1 |
Histone deacetylase inhibitors: from bench to clinic.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002
Histone deacetylase inhibitors: from bench to clinic.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.Journal of medicinal chemistry, , Oct-05, Volume: 49, Issue:20, 2006
Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.Bioorganic & medicinal chemistry letters, , May-17, Volume: 14, Issue:10, 2004
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004
Histone deacetylase inhibitors.Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.Journal of medicinal chemistry, , Apr-25, Volume: 45, Issue:9, 2002