hydralazine has been researched along with Necrosis in 33 studies
Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gestational hydralazine reduced renal global DNA methylation in offspring of obese mothers and attenuated maternal obesity-induced renal fibrosis." | 8.02 | Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet. ( Chen, H; Glastras, SJ; Hou, M; Larkin, BP; Nguyen, LT; Pollock, CA; Saad, S; Wang, R, 2021) |
| " Immune complex glomerulonephritis has been demonstrated in a few cases of SLE following procainamide or anticonvulsant therapy but has not been documented in association with hydralazine-induced SLE despite the recognition of this syndrome 30 years ago." | 7.67 | Immune complex glomerulonephritis in hydralazine-induced SLE. ( Harrington, JT; Levey, AS; Pinn, VW; Shapiro, KS, 1984) |
| " Hoarseness developed in a 60-year-old man that was secondary to ulcerated lesions, which involved the epiglottis and aryteno-epiglottic folds, with serologic evidence of SLE after he had been treated with hydralazine for six months." | 7.67 | Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus. ( Forouhar, FA; Weiser, GA; White, WB, 1984) |
| "A hepatitis with bridging necrosis following dihydralazine therapy has been diagnosed bioptically in 20 cases, preferably in women." | 7.66 | [Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases]. ( Roschlau, G, 1983) |
| "Gestational hydralazine reduced renal global DNA methylation in offspring of obese mothers and attenuated maternal obesity-induced renal fibrosis." | 4.02 | Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet. ( Chen, H; Glastras, SJ; Hou, M; Larkin, BP; Nguyen, LT; Pollock, CA; Saad, S; Wang, R, 2021) |
| "We investigated the role of angiotensin II and endothelin-1 using the angiotensin AT1 receptor antagonist losartan and the endothelin ETA receptor antagonist atrasentan, in malignant hypertension and renal failure and damage induced by nitric oxide (NO) synthase inhibition in Harlan Sprague-Dawley (SD) rats." | 3.75 | Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat. ( Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F, 2009) |
| " Immune complex glomerulonephritis has been demonstrated in a few cases of SLE following procainamide or anticonvulsant therapy but has not been documented in association with hydralazine-induced SLE despite the recognition of this syndrome 30 years ago." | 3.67 | Immune complex glomerulonephritis in hydralazine-induced SLE. ( Harrington, JT; Levey, AS; Pinn, VW; Shapiro, KS, 1984) |
| " Hoarseness developed in a 60-year-old man that was secondary to ulcerated lesions, which involved the epiglottis and aryteno-epiglottic folds, with serologic evidence of SLE after he had been treated with hydralazine for six months." | 3.67 | Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus. ( Forouhar, FA; Weiser, GA; White, WB, 1984) |
| "Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported." | 3.67 | [The so-called dihydralazine hepatitis. A contribution to the pathogenesis]. ( Jahn, G; Krombholz, B; Machnik, G; Reinhardt, M, 1985) |
| "A hepatitis with bridging necrosis following dihydralazine therapy has been diagnosed bioptically in 20 cases, preferably in women." | 3.66 | [Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases]. ( Roschlau, G, 1983) |
| "Three patients developed hepatic injury two months, ten months and two years, respectively, after hydralazine therapy for hypertension." | 3.66 | Hydralazine-induced hepatitis. ( Ichinoe, A; Itoh, S; Itoh, Y; Tsukada, Y, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (75.76) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Larkin, BP | 1 |
| Saad, S | 1 |
| Glastras, SJ | 1 |
| Nguyen, LT | 1 |
| Hou, M | 1 |
| Chen, H | 1 |
| Wang, R | 1 |
| Pollock, CA | 1 |
| Therrien, F | 1 |
| Lemieux, P | 1 |
| Bélanger, S | 1 |
| Agharazii, M | 1 |
| Lebel, M | 1 |
| Larivière, R | 1 |
| Mikaelian, I | 1 |
| Coluccio, D | 1 |
| Hirkaler, GM | 1 |
| Downing, JC | 1 |
| Rasmussen, E | 1 |
| Todd, J | 1 |
| Estis, J | 1 |
| Lu, QA | 1 |
| Nicklaus, R | 1 |
| MCQUIGGAN, MC | 1 |
| OLIVER, WJ | 1 |
| LITTLER, ER | 1 |
| CERNY, JC | 1 |
| Dikow, R | 1 |
| Kihm, LP | 1 |
| Zeier, M | 1 |
| Kapitza, J | 1 |
| Törnig, J | 1 |
| Amann, K | 1 |
| Tiefenbacher, C | 1 |
| Ritz, E | 1 |
| Shapiro, KS | 1 |
| Pinn, VW | 1 |
| Harrington, JT | 1 |
| Levey, AS | 1 |
| Drózdz, M | 1 |
| Piwowarczyk, B | 1 |
| Olczyk, K | 1 |
| Wieczorek, M | 1 |
| Wróblewska-Adamek, I | 1 |
| Weiser, GA | 1 |
| Forouhar, FA | 1 |
| White, WB | 1 |
| Jones, GR | 2 |
| Roschlau, G | 2 |
| Itoh, S | 2 |
| Ichinoe, A | 2 |
| Tsukada, Y | 2 |
| Itoh, Y | 1 |
| Balazs, T | 3 |
| Ferrans, VJ | 1 |
| El-Hage, A | 1 |
| Ehrreich, SJ | 1 |
| Johnson, GL | 1 |
| Herman, EH | 1 |
| Atkinson, JC | 1 |
| West, WL | 1 |
| Kendrey, G | 2 |
| László, B | 2 |
| Feld, LG | 1 |
| Van Liew, JB | 1 |
| Brentjens, JR | 1 |
| Boylan, JW | 1 |
| Baum, R | 1 |
| Merkel, R | 1 |
| Schwarz, M | 1 |
| Mölleken, K | 1 |
| Rüger, K | 1 |
| Yamaba, Y | 1 |
| Ikeda, K | 1 |
| Nara, Y | 1 |
| Tagami, M | 1 |
| Yamori, Y | 1 |
| Finseth, F | 1 |
| Adelberg, MG | 1 |
| Bartoli, E | 1 |
| Massarelli, G | 1 |
| Solinas, A | 1 |
| Faedda, R | 1 |
| Chiandussi, L | 1 |
| Zhang, C | 1 |
| Hsueh, W | 1 |
| Hanton, G | 1 |
| Longeart, L | 1 |
| Lodola, A | 1 |
| Baumgarten, R | 1 |
| Fengler, JD | 1 |
| Joseph, X | 1 |
| Hammond, TG | 1 |
| Mosesson, MW | 1 |
| Machnik, G | 2 |
| Bergert, A | 1 |
| Justus, J | 1 |
| Kunze, P | 1 |
| Müller, R | 1 |
| Reinhardt, M | 2 |
| Schulz, H | 1 |
| Stein, G | 1 |
| Thiele, R | 1 |
| Mesfin, GM | 1 |
| Shawaryn, GG | 1 |
| Higgins, MJ | 1 |
| Kunze, KD | 1 |
| Porst, H | 1 |
| Lohmann, J | 1 |
| Tschöpel, L | 1 |
| Krombholz, B | 1 |
| Jahn, G | 1 |
| Jasmin, G | 1 |
| Ho, EC | 1 |
| Moss, AJ | 1 |
| Payne, BJ | 1 |
33 other studies available for hydralazine and Necrosis
| Article | Year |
|---|---|
Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.
Topics: Albuminuria; Animals; Biomarkers; Body Weight; Collagen; Diet, High-Fat; DNA Methylation; Female; Fi | 2021 |
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasenta | 2009 |
Assessment of the toxicity of hydralazine in the rat using an ultrasensitive flow-based cardiac troponin I immunoassay.
Topics: Animals; Dose-Response Relationship, Drug; Heart; Hydralazine; Immunoassay; Male; Myocardium; Necros | 2009 |
HEMOLYTIC UREMIC SYNDROME.
Topics: Acute Kidney Injury; Anemia, Hemolytic; Child; Diagnosis; Dialysis; Diarrhea; Drug Therapy; Glomerul | 1965 |
Increased infarct size in uremic rats: reduced ischemia tolerance?
Topics: Animals; Body Weight; Coronary Vessels; Heart Ventricles; Hydralazine; Imidazoles; Ischemia; Male; M | 2004 |
Immune complex glomerulonephritis in hydralazine-induced SLE.
Topics: Aged; Arteritis; Female; Glomerulonephritis; Humans; Hydralazine; Immune Complex Diseases; Kidney Di | 1984 |
Leukocyte collagenolytic activity in normal and hydrazinophthalazine-treated rats during isoprenaline-induced cardiomyopathy.
Topics: Animals; Cardiomyopathies; Cathepsins; Collagen; Hydralazine; Isoproterenol; Leukocytes; Macrophages | 1983 |
Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus.
Topics: Epiglottis; Hoarseness; Humans; Hydralazine; Laryngeal Diseases; Lupus Erythematosus, Systemic; Male | 1984 |
Interference with energy production as a means of causing injury to a human pancreatic carcinoma.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism; | 1983 |
[Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases].
Topics: Adolescent; Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Huma | 1983 |
Hydralazine-induced hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Hypertension; Liver; Liver Cirr | 1981 |
Study of the mechanism of hydralazine-induced myocardial necrosis in the rat.
Topics: Animals; Calcium; Cardiomyopathies; Dihydrotachysterol; Heart Rate; Hydralazine; Male; Necrosis; Pro | 1981 |
[Morphologic observations in liver damage in patients taking Depressan (dihydralazinum sulfuricum)].
Topics: Antihypertensive Agents; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Dihydralazine; Huma | 1981 |
[Acute liver damage in patients treated with a depressant (dihydralazine sulfate)].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Humans; Hydralaz | 1981 |
Renal lesions and proteinuria in the spontaneously hypertensive rat made normotensive by treatment.
Topics: Age Factors; Animals; Arteriosclerosis; Blood Pressure; Chlorothiazide; Hydralazine; Hypertension; K | 1981 |
Disturbance to energy production in vivo caused by hormones and sympathomimetics in the S180 sarcoma, with consequent drug-induced necrosis [proceedings].
Topics: Animals; Endotoxins; Energy Metabolism; Epinephrine; Hormones; Hydralazine; Lypressin; Mice; Necrosi | 1980 |
[Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].
Topics: Adult; Ajmaline; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dihydral | 1980 |
Hydralazine-induced liver injury.
Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Hydralazine; Liver; Liver Function Tests; Male | 1980 |
Nitric oxide deficiency induces myocardial infarction in hypercholesterolaemic stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cerebrovascular Disorders; Coronary Vessels; Enzyme Inhibitors; Fibrosis; H | 1997 |
Prevention of skin flap necrosis by a course of treatment with vasodilator drugs.
Topics: Animals; Guanethidine; Hydralazine; Isoxsuprine; Necrosis; Phenoxybenzamine; Rats; Skin; Skin Transp | 1978 |
Acute hepatitis with bridging necrosis due to hydralazine intake. Report of a case.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Liver; Middle Ag | 1979 |
PAF-induced bowel necrosis. Effects of vasodilators.
Topics: Alprostadil; Animals; Hydralazine; Hypotension; Indazoles; Intestinal Diseases; Leukopenia; Male; Me | 1991 |
Cardiotoxicity of hydralazine and minoxidil in the rat. Influence of age.
Topics: Aging; Animals; Blood Pressure; Heart Diseases; Heart Rate; Hydralazine; Isoproterenol; Minoxidil; M | 1991 |
[Dihydralazine hepatitis. Morphologic and clinical criteria for diagnosis].
Topics: Acute Disease; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Different | 1990 |
Enhanced myocardial necrosis induced in rats by the combined administration of hydralazine and prenalterol.
Topics: Adrenergic beta-Antagonists; Animals; Cardiomyopathies; Drug Interactions; Hydralazine; Male; Myocar | 1986 |
Fatal small-bowel necrosis and pulmonary hypertension in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Humans; Hydralazine; Hypertension, Pulmonary; Hypotension; Infarction; I | 1989 |
[Drug-induced hepatitis after dihydralazine treatment with fatal consequences].
Topics: Aged; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Humans; Hydralazine; Liver; Mal | 1988 |
Cardiovascular alterations in dogs treated with hydralazine.
Topics: Animals; Blood Chemical Analysis; Body Weight; Dogs; Heart; Heart Rate; Hemorrhage; Hydralazine; Mal | 1987 |
[Liver lesions induced by dihydralazine and propranolol].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydralazine; Female; Humans; Hydralaz | 1985 |
[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Therapy, Combinatio | 1985 |
Factors influencing the production of cardiomyopathies by methoxamine and metaraminol.
Topics: Adrenalectomy; Adrenergic beta-Antagonists; Animals; Aortic Aneurysm; Blood Pressure; Diet; Edema; F | 1969 |
The syndrome of "mesenteric arteritis" following surgical repair of aortic coarctation. Report of nine cases and review of the literature.
Topics: Antihypertensive Agents; Aortic Coarctation; Arteritis; Child; Child, Preschool; Female; Humans; Hyd | 1972 |
Myocardial papillary muscle necrosis induced by hypotensive agents in dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carboxylic Acids; Dogs; Electrocardiography; Femal | 1971 |