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hydralazine and Necrosis

hydralazine has been researched along with Necrosis in 33 studies

Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.
hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Gestational hydralazine reduced renal global DNA methylation in offspring of obese mothers and attenuated maternal obesity-induced renal fibrosis."8.02Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet. ( Chen, H; Glastras, SJ; Hou, M; Larkin, BP; Nguyen, LT; Pollock, CA; Saad, S; Wang, R, 2021)
" Immune complex glomerulonephritis has been demonstrated in a few cases of SLE following procainamide or anticonvulsant therapy but has not been documented in association with hydralazine-induced SLE despite the recognition of this syndrome 30 years ago."7.67Immune complex glomerulonephritis in hydralazine-induced SLE. ( Harrington, JT; Levey, AS; Pinn, VW; Shapiro, KS, 1984)
" Hoarseness developed in a 60-year-old man that was secondary to ulcerated lesions, which involved the epiglottis and aryteno-epiglottic folds, with serologic evidence of SLE after he had been treated with hydralazine for six months."7.67Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus. ( Forouhar, FA; Weiser, GA; White, WB, 1984)
"A hepatitis with bridging necrosis following dihydralazine therapy has been diagnosed bioptically in 20 cases, preferably in women."7.66[Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases]. ( Roschlau, G, 1983)
"Gestational hydralazine reduced renal global DNA methylation in offspring of obese mothers and attenuated maternal obesity-induced renal fibrosis."4.02Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet. ( Chen, H; Glastras, SJ; Hou, M; Larkin, BP; Nguyen, LT; Pollock, CA; Saad, S; Wang, R, 2021)
"We investigated the role of angiotensin II and endothelin-1 using the angiotensin AT1 receptor antagonist losartan and the endothelin ETA receptor antagonist atrasentan, in malignant hypertension and renal failure and damage induced by nitric oxide (NO) synthase inhibition in Harlan Sprague-Dawley (SD) rats."3.75Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat. ( Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F, 2009)
" Immune complex glomerulonephritis has been demonstrated in a few cases of SLE following procainamide or anticonvulsant therapy but has not been documented in association with hydralazine-induced SLE despite the recognition of this syndrome 30 years ago."3.67Immune complex glomerulonephritis in hydralazine-induced SLE. ( Harrington, JT; Levey, AS; Pinn, VW; Shapiro, KS, 1984)
" Hoarseness developed in a 60-year-old man that was secondary to ulcerated lesions, which involved the epiglottis and aryteno-epiglottic folds, with serologic evidence of SLE after he had been treated with hydralazine for six months."3.67Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus. ( Forouhar, FA; Weiser, GA; White, WB, 1984)
"Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported."3.67[The so-called dihydralazine hepatitis. A contribution to the pathogenesis]. ( Jahn, G; Krombholz, B; Machnik, G; Reinhardt, M, 1985)
"A hepatitis with bridging necrosis following dihydralazine therapy has been diagnosed bioptically in 20 cases, preferably in women."3.66[Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases]. ( Roschlau, G, 1983)
"Three patients developed hepatic injury two months, ten months and two years, respectively, after hydralazine therapy for hypertension."3.66Hydralazine-induced hepatitis. ( Ichinoe, A; Itoh, S; Itoh, Y; Tsukada, Y, 1981)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199025 (75.76)18.7374
1990's4 (12.12)18.2507
2000's3 (9.09)29.6817
2010's0 (0.00)24.3611
2020's1 (3.03)2.80

Authors

AuthorsStudies
Larkin, BP1
Saad, S1
Glastras, SJ1
Nguyen, LT1
Hou, M1
Chen, H1
Wang, R1
Pollock, CA1
Therrien, F1
Lemieux, P1
Bélanger, S1
Agharazii, M1
Lebel, M1
Larivière, R1
Mikaelian, I1
Coluccio, D1
Hirkaler, GM1
Downing, JC1
Rasmussen, E1
Todd, J1
Estis, J1
Lu, QA1
Nicklaus, R1
MCQUIGGAN, MC1
OLIVER, WJ1
LITTLER, ER1
CERNY, JC1
Dikow, R1
Kihm, LP1
Zeier, M1
Kapitza, J1
Törnig, J1
Amann, K1
Tiefenbacher, C1
Ritz, E1
Shapiro, KS1
Pinn, VW1
Harrington, JT1
Levey, AS1
Drózdz, M1
Piwowarczyk, B1
Olczyk, K1
Wieczorek, M1
Wróblewska-Adamek, I1
Weiser, GA1
Forouhar, FA1
White, WB1
Jones, GR2
Roschlau, G2
Itoh, S2
Ichinoe, A2
Tsukada, Y2
Itoh, Y1
Balazs, T3
Ferrans, VJ1
El-Hage, A1
Ehrreich, SJ1
Johnson, GL1
Herman, EH1
Atkinson, JC1
West, WL1
Kendrey, G2
László, B2
Feld, LG1
Van Liew, JB1
Brentjens, JR1
Boylan, JW1
Baum, R1
Merkel, R1
Schwarz, M1
Mölleken, K1
Rüger, K1
Yamaba, Y1
Ikeda, K1
Nara, Y1
Tagami, M1
Yamori, Y1
Finseth, F1
Adelberg, MG1
Bartoli, E1
Massarelli, G1
Solinas, A1
Faedda, R1
Chiandussi, L1
Zhang, C1
Hsueh, W1
Hanton, G1
Longeart, L1
Lodola, A1
Baumgarten, R1
Fengler, JD1
Joseph, X1
Hammond, TG1
Mosesson, MW1
Machnik, G2
Bergert, A1
Justus, J1
Kunze, P1
Müller, R1
Reinhardt, M2
Schulz, H1
Stein, G1
Thiele, R1
Mesfin, GM1
Shawaryn, GG1
Higgins, MJ1
Kunze, KD1
Porst, H1
Lohmann, J1
Tschöpel, L1
Krombholz, B1
Jahn, G1
Jasmin, G1
Ho, EC1
Moss, AJ1
Payne, BJ1

Other Studies

33 other studies available for hydralazine and Necrosis

ArticleYear
Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.
    PloS one, 2021, Volume: 16, Issue:3

    Topics: Albuminuria; Animals; Biomarkers; Body Weight; Collagen; Diet, High-Fat; DNA Methylation; Female; Fi

2021
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasenta

2009
Assessment of the toxicity of hydralazine in the rat using an ultrasensitive flow-based cardiac troponin I immunoassay.
    Toxicologic pathology, 2009, Volume: 37, Issue:7

    Topics: Animals; Dose-Response Relationship, Drug; Heart; Hydralazine; Immunoassay; Male; Myocardium; Necros

2009
HEMOLYTIC UREMIC SYNDROME.
    JAMA, 1965, Mar-08, Volume: 191

    Topics: Acute Kidney Injury; Anemia, Hemolytic; Child; Diagnosis; Dialysis; Diarrhea; Drug Therapy; Glomerul

1965
Increased infarct size in uremic rats: reduced ischemia tolerance?
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:6

    Topics: Animals; Body Weight; Coronary Vessels; Heart Ventricles; Hydralazine; Imidazoles; Ischemia; Male; M

2004
Immune complex glomerulonephritis in hydralazine-induced SLE.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1984, Volume: 3, Issue:4

    Topics: Aged; Arteritis; Female; Glomerulonephritis; Humans; Hydralazine; Immune Complex Diseases; Kidney Di

1984
Leukocyte collagenolytic activity in normal and hydrazinophthalazine-treated rats during isoprenaline-induced cardiomyopathy.
    Experimental pathology, 1983, Volume: 23, Issue:4

    Topics: Animals; Cardiomyopathies; Cathepsins; Collagen; Hydralazine; Isoproterenol; Leukocytes; Macrophages

1983
Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus.
    Archives of internal medicine, 1984, Volume: 144, Issue:11

    Topics: Epiglottis; Hoarseness; Humans; Hydralazine; Laryngeal Diseases; Lupus Erythematosus, Systemic; Male

1984
Interference with energy production as a means of causing injury to a human pancreatic carcinoma.
    Oncology, 1983, Volume: 40, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Energy Metabolism;

1983
[Dihydralazine-induced hepatitis with bridging necrosis. A clinico-pathologic survey of 20 cases].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1983, Volume: 127, Issue:5-6

    Topics: Adolescent; Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Huma

1983
Hydralazine-induced hepatitis.
    Hepato-gastroenterology, 1981, Volume: 28, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Hypertension; Liver; Liver Cirr

1981
Study of the mechanism of hydralazine-induced myocardial necrosis in the rat.
    Toxicology and applied pharmacology, 1981, Volume: 59, Issue:3

    Topics: Animals; Calcium; Cardiomyopathies; Dihydrotachysterol; Heart Rate; Hydralazine; Male; Necrosis; Pro

1981
[Morphologic observations in liver damage in patients taking Depressan (dihydralazinum sulfuricum)].
    Morphologiai es igazsagugyi orvosi szemle, 1981, Volume: 21, Issue:4

    Topics: Antihypertensive Agents; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Dihydralazine; Huma

1981
[Acute liver damage in patients treated with a depressant (dihydralazine sulfate)].
    Orvosi hetilap, 1981, Dec-27, Volume: 122, Issue:52

    Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Humans; Hydralaz

1981
Renal lesions and proteinuria in the spontaneously hypertensive rat made normotensive by treatment.
    Kidney international, 1981, Volume: 20, Issue:5

    Topics: Age Factors; Animals; Arteriosclerosis; Blood Pressure; Chlorothiazide; Hydralazine; Hypertension; K

1981
Disturbance to energy production in vivo caused by hormones and sympathomimetics in the S180 sarcoma, with consequent drug-induced necrosis [proceedings].
    Biochemical Society transactions, 1980, Volume: 8, Issue:1

    Topics: Animals; Endotoxins; Energy Metabolism; Epinephrine; Hormones; Hydralazine; Lypressin; Mice; Necrosi

1980
[Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1980, Apr-01, Volume: 35, Issue:7

    Topics: Adult; Ajmaline; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dihydral

1980
Hydralazine-induced liver injury.
    Digestive diseases and sciences, 1980, Volume: 25, Issue:11

    Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Hydralazine; Liver; Liver Function Tests; Male

1980
Nitric oxide deficiency induces myocardial infarction in hypercholesterolaemic stroke-prone spontaneously hypertensive rats.
    Clinical and experimental pharmacology & physiology, 1997, Volume: 24, Issue:5

    Topics: Animals; Blood Pressure; Cerebrovascular Disorders; Coronary Vessels; Enzyme Inhibitors; Fibrosis; H

1997
Prevention of skin flap necrosis by a course of treatment with vasodilator drugs.
    Plastic and reconstructive surgery, 1978, Volume: 61, Issue:5

    Topics: Animals; Guanethidine; Hydralazine; Isoxsuprine; Necrosis; Phenoxybenzamine; Rats; Skin; Skin Transp

1978
Acute hepatitis with bridging necrosis due to hydralazine intake. Report of a case.
    Archives of internal medicine, 1979, Volume: 139, Issue:6

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Female; Humans; Hydralazine; Liver; Middle Ag

1979
PAF-induced bowel necrosis. Effects of vasodilators.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:5

    Topics: Alprostadil; Animals; Hydralazine; Hypotension; Indazoles; Intestinal Diseases; Leukopenia; Male; Me

1991
Cardiotoxicity of hydralazine and minoxidil in the rat. Influence of age.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 71, Issue:2

    Topics: Aging; Animals; Blood Pressure; Heart Diseases; Heart Rate; Hydralazine; Isoproterenol; Minoxidil; M

1991
[Dihydralazine hepatitis. Morphologic and clinical criteria for diagnosis].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1990, Volume: 136, Issue:1-2

    Topics: Acute Disease; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Different

1990
Enhanced myocardial necrosis induced in rats by the combined administration of hydralazine and prenalterol.
    The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:9

    Topics: Adrenergic beta-Antagonists; Animals; Cardiomyopathies; Drug Interactions; Hydralazine; Male; Myocar

1986
Fatal small-bowel necrosis and pulmonary hypertension in sickle cell disease.
    Archives of internal medicine, 1989, Volume: 149, Issue:2

    Topics: Adult; Anemia, Sickle Cell; Humans; Hydralazine; Hypertension, Pulmonary; Hypotension; Infarction; I

1989
[Drug-induced hepatitis after dihydralazine treatment with fatal consequences].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1988, Volume: 134, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Dihydralazine; Female; Humans; Hydralazine; Liver; Mal

1988
Cardiovascular alterations in dogs treated with hydralazine.
    Toxicologic pathology, 1987, Volume: 15, Issue:4

    Topics: Animals; Blood Chemical Analysis; Body Weight; Dogs; Heart; Heart Rate; Hemorrhage; Hydralazine; Mal

1987
[Liver lesions induced by dihydralazine and propranolol].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1985, Volume: 130, Issue:1

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydralazine; Female; Humans; Hydralaz

1985
[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1985, Volume: 45, Issue:6

    Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Therapy, Combinatio

1985
Factors influencing the production of cardiomyopathies by methoxamine and metaraminol.
    Annals of the New York Academy of Sciences, 1969, Jan-31, Volume: 156, Issue:1

    Topics: Adrenalectomy; Adrenergic beta-Antagonists; Animals; Aortic Aneurysm; Blood Pressure; Diet; Edema; F

1969
The syndrome of "mesenteric arteritis" following surgical repair of aortic coarctation. Report of nine cases and review of the literature.
    Pediatrics, 1972, Volume: 49, Issue:1

    Topics: Antihypertensive Agents; Aortic Coarctation; Arteritis; Child; Child, Preschool; Female; Humans; Hyd

1972
Myocardial papillary muscle necrosis induced by hypotensive agents in dogs.
    Toxicology and applied pharmacology, 1971, Volume: 20, Issue:3

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Carboxylic Acids; Dogs; Electrocardiography; Femal

1971