5-10-15-20-tetrakis(m-hydroxyphenyl)bacteriochlorin has been researched along with Necrosis* in 2 studies
1 trial(s) available for 5-10-15-20-tetrakis(m-hydroxyphenyl)bacteriochlorin and Necrosis
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[Interstitial photodynamic laser therapy for liver metastases: first results of a clinical phase I-study].
Development and evaluation of a new photodynamic treatment technique for the laser therapy of liver malignancies. The combination with new catheter systems enables the use of the photodynamic therapy (PDT) to treat also tumors in parenchymal organs. So far it is mainly used to treat superficial or endoluminal tumors. The presented study is part of a multicenter phase I-study. We treated 5 patients with colorectal liver metastases with the new photosensitizer SQN 400 and following interstitial photodynamic laser treatment. Evaluation of tumors were performed by contrast-enhanced CT scans.. In the contrast enhanced CT scans the development of a complete necrosis within a radius of 1 cm around every single fibre could be shown. Additional the ablation of tumors with the combined use of several fibres is possible. Severe complications or toxicities were not observed.. The photodynamic laser therapy of liver malignancies is a minimal invasive procedure with little side effects which produces sharply defined yet small volumes of necrosis. Topics: Aged; Colorectal Neoplasms; Female; Hematoporphyrin Photoradiation; Humans; Image Enhancement; Injections, Intralesional; Liver; Liver Neoplasms; Male; Middle Aged; Necrosis; Porphyrins; Tomography, X-Ray Computed | 2003 |
1 other study(ies) available for 5-10-15-20-tetrakis(m-hydroxyphenyl)bacteriochlorin and Necrosis
| Article | Year |
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Significantly increased lesion size by using the near-infrared photosensitizer 5,10,15,20-tetrakis (m-hydroxyphenyl)bacteriochlorin in interstitial photodynamic therapy of normal rat liver tissue.
Penetration of tissues by activating light ultimately limits the size of the lesions achievable in interstitial photodynamic therapy. Measurements of the wavelength-dependence of tissue optical properties suggest that substantial improvements may be possible, particularly in pigmented organs such as the liver, by using drugs absorbing at near infrared wavelengths.. In this study, the extent of light induced necrosis with the photosensitive agents Photofrin (activated at 632 nm), meta-tetra(hydroxyphenyl)chlorin (mTHPC) (activated at 652 nm) and 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (mTHPBC) (activated at 740 nm) are compared in normal rat liver. Interstitial irradiation of mTHPBC-sensitized liver tissue resulted in significantly larger necrotic areas than irradiation of Photofrin and mTHPC-sensitised livers.. The results illustrate the advantage of near-infrared photosensitizer activation and point to a specific role for mTHPBC in the interstitial treatment of liver tumours. Topics: Animals; Dihematoporphyrin Ether; Laser Therapy; Liver; Male; Mesoporphyrins; Necrosis; Photochemotherapy; Photosensitizing Agents; Porphyrins; Random Allocation; Rats; Rats, Wistar | 2000 |