Page last updated: 2024-11-13

5-adamantan-1-yl-n-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide: a tyrosinase inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID57328615
CHEMBL ID2011796
SCHEMBL ID15765967
MeSH IDM000598920

Synonyms (6)

Synonym
CHEMBL2011796 ,
5-adamantan-1-yl-n-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide
WDLDXQVTSRCDMN-UHFFFAOYSA-N
SCHEMBL15765967
bdbm50484883
polyhydroxy benzamide derivative 3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)0.90000.03403.987110.0000AID654750
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID654754Cytotoxicity in mouse B16 cells assessed as cell viability at 10 uM after 72 hrs2012Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.
AID654758Ratio of kojic acid IC50 to compound IC50 for inhibition of melanogenesis in mouse B16 cells2012Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.
AID1063370Antimelanogenic activity in mouse B16 cells after 4 days by spectrophotometry2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
3D-QSAR study of adamantyl N-benzylbenzamides as melanogenesis inhibitors.
AID654750Inhibition of mushroom tyrosinase2012Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.
AID654752Antimelanogenic activity in mouse B16 cells assessed as inhibition of melanogenesis2012Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.11 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (11.11%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]