Potassium channel subfamily K member 2

A potassium channel subfamily K member 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95069]

Synonyms

Outward rectifying potassium channel protein TREK-1;
TREK-1 K(+) channel subunit;
Two pore domain potassium channel TREK-1;
Two pore potassium channel TPKC1

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (34)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amlodipine	Homo sapiens (human)	IC50	0.4000	1	1
carvedilol	Homo sapiens (human)	IC50	10.9500	2	2
chlorpromazine	Homo sapiens (human)	IC50	2.7000	1	1
fluphenazine	Homo sapiens (human)	IC50	4.7000	1	1
fluoxetine	Homo sapiens (human)	IC50	16.5000	2	2
haloperidol	Homo sapiens (human)	IC50	5.5000	1	1
lidocaine	Homo sapiens (human)	IC50	193.5000	2	2
loxapine	Homo sapiens (human)	IC50	20.0000	1	1
mexiletine	Homo sapiens (human)	IC50	173.0000	1	1
norfluoxetine	Homo sapiens (human)	IC50	9.0000	1	1
propafenone	Homo sapiens (human)	IC50	7.6000	1	1
pimozide	Homo sapiens (human)	IC50	1.8000	1	1
sipatrigine	Homo sapiens (human)	IC50	4.0000	1	1
quinine	Homo sapiens (human)	IC50	3.8500	1	1
flupenthixol	Homo sapiens (human)	IC50	2.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-aminopyridine	Homo sapiens (human)	EC50	2,750.0000	1	1
theophylline	Homo sapiens (human)	EC50	486.0000	1	1
amlodipine	Homo sapiens (human)	EC50	0.4300	1	1
bupivacaine	Homo sapiens (human)	EC50	113.0000	1	1
caffeine	Homo sapiens (human)	EC50	377.0000	1	1
flufenamic acid	Homo sapiens (human)	EC50	100.0000	1	1
fluphenazine	Homo sapiens (human)	EC50	4.7000	1	1
fluspirilene	Homo sapiens (human)	EC50	0.2320	1	1
glyburide	Homo sapiens (human)	EC50	64.0000	1	1
loxapine	Homo sapiens (human)	EC50	19.7000	1	1
nifedipine	Homo sapiens (human)	EC50	8.1800	1	1
riluzole	Homo sapiens (human)	EC50	139.4000	1	1
tolbutamide	Homo sapiens (human)	EC50	784.0000	1	1
pimozide	Homo sapiens (human)	EC50	0.3540	1	1
penfluridol	Homo sapiens (human)	EC50	0.1870	1	1
haloperidol decanoate	Homo sapiens (human)	EC50	5.5000	1	1
niguldipine	Homo sapiens (human)	EC50	0.7500	1	1
mibefradil	Homo sapiens (human)	EC50	0.5000	1	1
sipatrigine	Homo sapiens (human)	EC50	4.0000	1	1
opromazine	Homo sapiens (human)	EC50	2.7000	1	1
flunarizine	Homo sapiens (human)	EC50	2.4800	1	1
fluoxetine	Homo sapiens (human)	EC50	19.0000	1	1
7,10,13,16-docosatetraenylethanolamide	Homo sapiens (human)	EC50	5.1000	1	1
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid	Homo sapiens (human)	EC50	3.0000	1	1

Enables

This protein enables 2 target(s):

Target	Category	Definition
outward rectifier potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah]
potassium ion leak channel activity	molecular function	Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. [GOC:mtg_transport, ISBN:0815340729]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
calyx of Held	cellular component	The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805]
astrocyte projection	cellular component	A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. [NIF_Subcellular:sao1630537580]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated potassium channel complex	cellular component	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
cardiac ventricle development	biological process	The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. [GOC:mtg_heart]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
memory	biological process	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). [GOC:curators, ISBN:0582227089]
response to mechanical stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:hb]
response to axon injury	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
negative regulation of cardiac muscle cell proliferation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
cochlea development	biological process	The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. [GOC:dph, GOC:tb]
positive regulation of cellular response to hypoxia	biological process	Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia. [GOC:TermGenie, GOC:yaf]
negative regulation of DNA biosynthetic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. [GOC:obol]
stabilization of membrane potential	biological process	The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, ISBN:0198506732]