An indolethylamine N-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95050]
Indolamine N-methyltransferase;
EC 2.1.1.49;
EC 2.1.1.96;
Aromatic alkylamine N-methyltransferase;
Amine N-methyltransferase;
Arylamine N-methyltransferase;
Thioether S-methyltransferase;
TEMT
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sinefungin | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| 1,8-diazabicyclo(5.4.0)undec-7-ene | Homo sapiens (human) | IC50 | 25.7000 | 1 | 1 |
| s-adenosylhomocysteine | Homo sapiens (human) | Ki | 2.0000 | 1 | 2 |
| 5'-methylthioadenosine | Homo sapiens (human) | Ki | 700.0000 | 1 | 2 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| thioether S-methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. [EC:2.1.1.96, RHEA:19613] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| amine N-methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. [EC:2.1.1.49] |
| S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity | molecular function | Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine. [EC:2.1.1.49, GOC:pz] |
| N-methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. [GOC:ai] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| amine metabolic process | biological process | The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| methylation | biological process | The process in which a methyl group is covalently attached to a molecule. [GOC:mah] |