gamma-aminobutyric acid has been researched along with Necrosis in 18 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using histamine and the H3 receptor antagonist thioperamide, the roles of histamine receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons." | 7.73 | Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H receptor/cyclic AMP/protein kinase A and H receptor/GABA release pathways. ( Chen, Z; Dai, H; Hu, W; Huang, Y; Leurs, R; Luo, J; Shen, Y; Timmerman, H; Zhang, Z; Zhu, Y, 2006) |
| " L-2-Chloropropionic acid (L-CPA) produces selective neuronal cell necrosis in rat cerebellum when administered orally at 750 mg kg-1 that is mediated in part through activation of N-methyl-D-aspartate (NMDA) receptors." | 7.69 | Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis. ( Dunn, D; Farnworth, M; Gyte, A; Lock, EA; Moore, RB; Simpson, MG; Widdowson, PS; Wyatt, I, 1996) |
| "To induce ALF, C57BL/6NHsd mice were administered GABA, saline, or nothing for 7 d, followed by intraperitoneal administration of 500 μg of tumor necrosis factor α and 20 mg of D-galactosamine." | 3.91 | GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury. ( Hata, T; Hori, T; Nguyen, JH; Rehman, F, 2019) |
| "Using the histamine H3 receptor antagonist clobenpropit, the roles of histamine H3 receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons." | 3.74 | The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. ( Chen, Z; Dai, H; Fu, Q; Hu, W; Leurs, R; Shen, Y; Timmerman, H; Zhang, Z, 2007) |
| "Using histamine and the H3 receptor antagonist thioperamide, the roles of histamine receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons." | 3.73 | Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H receptor/cyclic AMP/protein kinase A and H receptor/GABA release pathways. ( Chen, Z; Dai, H; Hu, W; Huang, Y; Leurs, R; Luo, J; Shen, Y; Timmerman, H; Zhang, Z; Zhu, Y, 2006) |
| " L-2-Chloropropionic acid (L-CPA) produces selective neuronal cell necrosis in rat cerebellum when administered orally at 750 mg kg-1 that is mediated in part through activation of N-methyl-D-aspartate (NMDA) receptors." | 3.69 | Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis. ( Dunn, D; Farnworth, M; Gyte, A; Lock, EA; Moore, RB; Simpson, MG; Widdowson, PS; Wyatt, I, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Ala, M | 1 |
| Mohammad Jafari, R | 1 |
| Nematian, H | 1 |
| Ganjedanesh, MR | 1 |
| Dehpour, AR | 1 |
| Hata, T | 1 |
| Rehman, F | 1 |
| Hori, T | 1 |
| Nguyen, JH | 1 |
| Shim, JK | 1 |
| Ma, Q | 1 |
| Zhang, Z | 3 |
| Podgoreanu, MV | 1 |
| Mackensen, GB | 1 |
| Zhao, M | 1 |
| Destache, CJ | 1 |
| Zhan, G | 1 |
| Liu, H | 1 |
| Zhang, Y | 1 |
| Govindarajan, V | 1 |
| Opere, CA | 1 |
| Desfeux, A | 1 |
| El Ghazi, F | 1 |
| Jégou, S | 1 |
| Legros, H | 1 |
| Marret, S | 1 |
| Laudenbach, V | 1 |
| Gonzalez, BJ | 1 |
| Allen, NJ | 1 |
| Attwell, D | 2 |
| Maus, M | 1 |
| Glowinski, J | 1 |
| Premont, J | 1 |
| Hamann, M | 1 |
| Rossi, DJ | 1 |
| Mohr, C | 1 |
| Andrade, AL | 1 |
| Dai, H | 2 |
| Zhu, Y | 1 |
| Shen, Y | 2 |
| Hu, W | 2 |
| Huang, Y | 1 |
| Luo, J | 1 |
| Timmerman, H | 2 |
| Leurs, R | 2 |
| Chen, Z | 2 |
| Fu, Q | 1 |
| Nakata, N | 1 |
| Kato, H | 1 |
| Kogure, K | 1 |
| Widdowson, PS | 1 |
| Gyte, A | 1 |
| Simpson, MG | 1 |
| Farnworth, M | 1 |
| Dunn, D | 1 |
| Moore, RB | 1 |
| Wyatt, I | 1 |
| Lock, EA | 1 |
| Przedborski, S | 1 |
| Khan, U | 1 |
| Kostic, V | 1 |
| Carlson, E | 1 |
| Epstein, CJ | 1 |
| Sulzer, D | 1 |
| Jevtović-Todorović, V | 2 |
| Todorović, SM | 1 |
| Mennerick, S | 1 |
| Powell, S | 2 |
| Dikranian, K | 1 |
| Benshoff, N | 1 |
| Zorumski, CF | 1 |
| Olney, JW | 2 |
| Igarashi, H | 1 |
| Kwee, IL | 1 |
| Nakada, T | 1 |
| Katayama, Y | 1 |
| Terashi, A | 1 |
| Wozniak, DF | 1 |
| Rieke, GK | 1 |
| Munoz, SJ | 1 |
| Fariello, R | 1 |
| Maddrey, WC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrous Oxide as Treatment for Fibromyalgia[NCT05357066] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-11-12 | Recruiting | ||
| Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial[NCT03365011] | Phase 4 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change of participant-reported tinnitus symptoms 1 week after each intervention.~The Tinnitus Functional Index (TFI) is a 25-question survey assessing tinnitus impact on quality of life. Participants were asked to rate on a scale from 0-10 the degree of unpleasantness, cognitive interference, sleep disturbance, auditory difficulties, interference with relaxation, and emotional distress associated with their tinnitus. Subscores are summed and scaled to a score of 0-100. A score less than 25 indicates mild problems due to tinnitus and little need for intervention, while a score between 25-50 indicates significant problems due to tinnitus with potential need for intervention.~A decrease in TFI score indicates decreased bother due to tinnitus over time, a better outcome. An increase in TFI score indicates increased bother due to tinnitus over time, a worse outcome." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -1.8 |
| Nitrous Oxide | -2.5 |
"Change in participant-reported tinnitus bother after each intervention.~Global Bothersome Scale (GBS) measured participant's self-assessment of tinnitus bother on a 5-point scale ranging from Not bothered, 0 to Extremely bothered, 5.~A change of 0 indicates no change in tinnitus bother over time. A change of -1 indicates somewhat improved tinnitus bother, and a change of positive 1 indicates somewhat worsened tinnitus bother. A change of positive 2 indicates significantly worsened tinnitus bother." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Somewhat improved, -1 | No change, 0 | Somewhat worsened, 1 | Significantly worsened, 2 | |
| Nitrous Oxide | 2 | 34 | 2 | 0 |
| Placebo | 5 | 28 | 5 | 1 |
18 other studies available for gamma-aminobutyric acid and Necrosis
| Article | Year |
|---|---|
Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Graft Survival; Histone Deacetylases; Huma | 2020 |
GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury.
Topics: Aminosalicylic Acids; Animals; Benzenesulfonates; Disease Models, Animal; Galactosamine; gamma-Amino | 2019 |
Effect of pregabalin on cerebral outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats.
Topics: Animals; Behavior, Animal; Cardiopulmonary Bypass; Cerebral Cortex; Circulatory Arrest, Deep Hypothe | 2014 |
Regulation of retinal morphology and posterior segment amino acids by 8-isoprostaglandin E2 in bovine eyes ex vivo.
Topics: Amino Acids; Animals; Apoptosis; Cattle; Dinoprostone; Dose-Response Relationship, Drug; gamma-Amino | 2008 |
Dual effect of glutamate on GABAergic interneuron survival during cerebral cortex development in mice neonates.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bc | 2010 |
Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals.
Topics: Acid Sensing Ion Channels; Acidosis; Animals; Arachidonic Acid; Brain Ischemia; Cations; gamma-Amino | 2002 |
GABA is toxic for mouse striatal neurones through a transporter-mediated process.
Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Death; Cell Survival; Cells, Cultured | 2002 |
The electrical response of cerebellar Purkinje neurons to simulated ischaemia.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Calcium; Cerebellum; Excitatory Amino | 2005 |
Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H receptor/cyclic AMP/protein kinase A and H receptor/GABA release pathways.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Apoptosis; Bicuculline; Cell Surv | 2006 |
The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons.
Topics: Animals; Animals, Newborn; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyc | 2007 |
Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
Topics: Amino Acids; Animals; Brain Ischemia; Disease Models, Animal; Extracellular Space; gamma-Aminobutyri | 1993 |
Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
Topics: Animals; Aspartic Acid; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hydrocarbons, | 1996 |
Increased superoxide dismutase activity improves survival of cultured postnatal midbrain neurons.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Fetus; gamma-Aminobutyric Acid | 1996 |
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus; | 1998 |
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus; | 1998 |
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus; | 1998 |
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin.
Topics: Animals; Brain; Cells, Cultured; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Hippocampus; | 1998 |
1H magnetic resonance spectroscopic imaging of permanent focal cerebral ischemia in rat: longitudinal metabolic changes in ischemic core and rim.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Ischemia; Caudate Nucleus; Circle of Willis; Energy Metabo | 2001 |
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.
Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Inter | 2001 |
Chronic intrastriatal injection of the excitatory amino acid receptor antagonist L-kynurenic acid in rat produces selective neuron sparing lesions.
Topics: Animals; Cholinesterases; Corpus Striatum; gamma-Aminobutyric Acid; Histocytochemistry; Immunohistoc | 1992 |
Submassive hepatic necrosis associated with the use of progabide: a GABA receptor agonist.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; gamma-Aminobutyric Acid; Hum | 1988 |