Proteins > Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

Page last updated: 2024-08-07 18:43:08

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

A phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16816]

Synonyms

PHK-gamma-M;
EC 2.7.11.19;
Phosphorylase kinase subunit gamma-1;
Serine/threonine-protein kinase PHKG1;
2.7.11.1;
2.7.11.26

Research

Bioassay Publications (9)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (11.11)	18.2507
2000's	4 (44.44)	29.6817
2010's	4 (44.44)	24.3611
2020's	0 (0.00)	2.80

Compounds (76)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
staurosporine	Homo sapiens (human)	IC50	0.0017	3	3
sf 2370	Homo sapiens (human)	IC50	0.0017	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sb 202190	Homo sapiens (human)	Kd	10.0000	1	1
imatinib	Homo sapiens (human)	Kd	10.0000	2	2
staurosporine	Homo sapiens (human)	Kd	0.0006	3	3
gefitinib	Homo sapiens (human)	Kd	3.7000	2	2
lestaurtinib	Homo sapiens (human)	Kd	0.0004	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	2	2
ruboxistaurin	Homo sapiens (human)	Kd	3.3667	3	3
canertinib	Homo sapiens (human)	Kd	10.0000	2	2
birb 796	Homo sapiens (human)	Kd	10.0000	2	2
cyc 202	Homo sapiens (human)	Kd	10.0000	1	1
sb 203580	Homo sapiens (human)	Kd	10.0000	2	2
enzastaurin	Homo sapiens (human)	Kd	4.2000	1	1
erlotinib	Homo sapiens (human)	Kd	10.0000	2	2
lapatinib	Homo sapiens (human)	Kd	10.0000	2	2
sorafenib	Homo sapiens (human)	Kd	10.0000	3	3
pd 173955	Homo sapiens (human)	Kd	10.0000	1	1
s 1033	Homo sapiens (human)	Kd	10.0000	1	1
bms 387032	Homo sapiens (human)	Kd	3.8000	2	2
tandutinib	Homo sapiens (human)	Kd	10.0000	3	3
vx-745	Homo sapiens (human)	Kd	10.0000	2	2
dasatinib	Homo sapiens (human)	Kd	10.0000	2	2
zd 6474	Homo sapiens (human)	Kd	3.1000	3	3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
alvocidib	Homo sapiens (human)	Kd	2.2000	2	2
bosutinib	Homo sapiens (human)	Kd	0.3400	1	1
su 11248	Homo sapiens (human)	Kd	0.0313	5	5
jnj-7706621	Homo sapiens (human)	Kd	10.0000	1	1
vx680	Homo sapiens (human)	Kd	2.2000	2	2
ekb 569	Homo sapiens (human)	Kd	2.5000	2	2
axitinib	Homo sapiens (human)	Kd	10.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	0.6633	3	3
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
cp 724714	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	10.0000	2	2
hki 272	Homo sapiens (human)	Kd	10.0000	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	2	2
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	10.0000	1	1
masitinib	Homo sapiens (human)	Kd	10.0000	1	1
pazopanib	Homo sapiens (human)	Kd	10.0000	2	2
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	0.0830	2	2
bibw 2992	Homo sapiens (human)	Kd	1.3000	1	1
tg100-115	Homo sapiens (human)	Kd	10.0000	1	1
pha 665752	Homo sapiens (human)	Kd	1.9000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	10.0000	1	1
brivanib	Homo sapiens (human)	Kd	10.0000	1	1
at 7519	Homo sapiens (human)	Kd	10.0000	1	1
bi 2536	Homo sapiens (human)	Kd	10.0000	1	1
nvp-ast487	Homo sapiens (human)	Kd	10.0000	2	2
kw 2449	Homo sapiens (human)	Kd	0.2100	1	1
abt 869	Homo sapiens (human)	Kd	10.0000	2	2
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
crizotinib	Homo sapiens (human)	Kd	10.0000	1	1
chir-265	Homo sapiens (human)	Kd	10.0000	2	2
motesanib	Homo sapiens (human)	Kd	10.0000	2	2
mln8054	Homo sapiens (human)	Kd	10.0000	2	2
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	10.0000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	10.0000	2	2
nvp-tae684	Homo sapiens (human)	Kd	0.0170	1	1
fedratinib	Homo sapiens (human)	Kd	0.3300	1	1
gsk690693	Homo sapiens (human)	Kd	10.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	10.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
sgx 523	Homo sapiens (human)	Kd	10.0000	1	1
quizartinib	Homo sapiens (human)	Kd	10.0000	2	2
incb-018424	Homo sapiens (human)	Kd	5.7000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	1.1000	1	1
gsk 1363089	Homo sapiens (human)	Kd	10.0000	1	1
chir 258	Homo sapiens (human)	Kd	0.6400	2	2
nintedanib	Homo sapiens (human)	Kd	0.1400	1	1
pp242	Homo sapiens (human)	Kd	10.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
phosphorylase kinase activity	molecular function	Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. [EC:2.7.11.19]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
tau-protein kinase activity	molecular function	Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
phosphorylase kinase complex	cellular component	An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. [PMID:1370475]

Involved In

This protein is involved in 2 target(s):

Target	Category	Definition
carbohydrate metabolic process	biological process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]
glycogen biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. [ISBN:0198506732]

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