Proteins > cAMP-dependent protein kinase catalytic subunit alpha
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cAMP-dependent protein kinase catalytic subunit alpha
A cAMP-dependent protein kinase catalytic subunit alpha that is encoded in the genome of cow. [OMA:P00517, PRO:DNx]
Synonyms
PKA C-alpha;
EC 2.7.11.11
Research
Bioassay Publications (20)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 13 (65.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (29)
Drugs with Inhibition Measurements
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.The Journal of biological chemistry, , Aug-25, Volume: 266, Issue:24, 1991
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.Journal of medicinal chemistry, , Volume: 35, Issue:1, 1992
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.The Journal of biological chemistry, , Aug-25, Volume: 266, Issue:24, 1991
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction.Journal of medicinal chemistry, , Jan-08, Volume: 36, Issue:1, 1993
Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.The Journal of biological chemistry, , Aug-25, Volume: 266, Issue:24, 1991
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity.The Journal of biological chemistry, , Aug-25, Volume: 281, Issue:34, 2006
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.Bioorganic & medicinal chemistry letters, , Jul-21, Volume: 13, Issue:14, 2003
Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction.Journal of medicinal chemistry, , Jan-08, Volume: 36, Issue:1, 1993
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.Journal of medicinal chemistry, , May-17, Volume: 50, Issue:10, 2007
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.Bioorganic & medicinal chemistry, , Feb-15, Volume: 14, Issue:4, 2006
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.The Journal of biological chemistry, , Oct-18, Volume: 271, Issue:42, 1996
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.Bioorganic & medicinal chemistry letters, , Jul-21, Volume: 13, Issue:14, 2003
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.Bioorganic & medicinal chemistry letters, , Nov-03, Volume: 13, Issue:21, 2003
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.The Journal of biological chemistry, , Aug-25, Volume: 266, Issue:24, 1991
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.Journal of medicinal chemistry, , Jun-28, Volume: 50, Issue:13, 2007
A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.Journal of molecular biology, , Mar-30, Volume: 367, Issue:3, 2007