A matrilysin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09237]
EC 3.4.24.23;
Matrin;
Matrix metalloproteinase-7;
MMP-7;
Pump-1 protease;
Uterine metalloproteinase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 18 (54.55) | 29.6817 |
| 2010's | 8 (24.24) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,3-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| protocatechuic acid | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| gallic acid | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| beta-resorcylic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| veratric acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| methyl gallate | Homo sapiens (human) | IC50 | 26.5000 | 1 | 2 |
| 3,4,5-trimethoxybenzoic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 9.3143 | 2 | 7 |
| marimastat | Homo sapiens (human) | IC50 | 2.0090 | 5 | 5 |
| n-(2-isobutyl-3-(n'-hydroxycarbonylamido)propanoyl)-o-methyltyrosinemethylamide | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| ilomastat | Homo sapiens (human) | IC50 | 0.0190 | 2 | 2 |
| bb3497 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 3-((benzyl)(methylaminocarbonyl)methylaminocarbonyl)n-hydroxy-5-methylhexanamide | Homo sapiens (human) | IC50 | 0.0083 | 1 | 1 |
| prinomastat | Homo sapiens (human) | IC50 | 0.0723 | 3 | 3 |
| prinomastat | Homo sapiens (human) | Ki | 0.0540 | 1 | 1 |
| isoliquiritigenin | Homo sapiens (human) | IC50 | 0.0080 | 1 | 1 |
| rs-130830 | Homo sapiens (human) | IC50 | 0.9325 | 4 | 4 |
| rs-130830 | Homo sapiens (human) | Ki | 1.2000 | 1 | 1 |
| tmi-1 | Homo sapiens (human) | IC50 | 0.0130 | 1 | 6 |
| batimastat | Homo sapiens (human) | IC50 | 3.5012 | 2 | 2 |
| ik 682 | Homo sapiens (human) | Ki | 0.2590 | 3 | 3 |
| epigallocatechin-3-o-(3''-o-methyl)-gallate | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| ro 32-3555 | Homo sapiens (human) | IC50 | 0.0185 | 1 | 1 |
| abt-770 | Homo sapiens (human) | IC50 | 10.0000 | 3 | 3 |
| sb 3ct compound | Homo sapiens (human) | Ki | 88.7500 | 4 | 4 |
| pd 166793 | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| sc 78080 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| sc 78080 | Homo sapiens (human) | Ki | 7.0000 | 1 | 1 |
| arp-100 | Homo sapiens (human) | IC50 | 50.0000 | 3 | 3 |
| s 3304 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide | Homo sapiens (human) | IC50 | 6.0555 | 1 | 2 |
| bms-566394 | Homo sapiens (human) | IC50 | 4.0007 | 1 | 2 |
| bms-566394 | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| incb3619 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| grassystatin a | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| minocycline | Homo sapiens (human) | IC50 | 125.0000 | 1 | 1 |
| guanosine diphosphate | Homo sapiens (human) | IC50 | 125.2600 | 1 | 5 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] |
| metalloendopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] |
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| metallopeptidase activity | molecular function | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular matrix | cellular component | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| antibacterial peptide secretion | biological process | The regulated release of an antibacterial peptide from a cell or a tissue. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] |
| antibacterial peptide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of an antibacterial peptide. [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] |
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| extracellular matrix disassembly | biological process | A process that results in the breakdown of the extracellular matrix. [GOC:jid] |
| positive regulation of cell migration | biological process | Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators] |
| collagen catabolic process | biological process | The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194] |
| regulation of cell population proliferation | biological process | Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl] |
| defense response to Gram-negative bacterium | biological process | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. [GOC:ai] |
| defense response to Gram-positive bacterium | biological process | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai] |
| extracellular matrix organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah] |