aminolevulinic acid has been researched along with Necrosis in 55 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to verify whether such an association exists by injecting rabbits with 5-aminolevulinic acid and searching for the appearance of cardiac necrosis markers and histological heart alterations, and investigate whether the cardiotoxic activity of 5-aminolevulinic acid may involve peroxidation by seeking the presence of the peroxide marker malondialdehyde." | 7.75 | Plasma cardiac necrosis markers C-troponin I and creatine kinase, associated with increased malondialdehyde levels, induced in rabbits by means of 5-aminolevulinic acid injection. ( Brenna, S; Pinelli, A; Rossoni, G; Trivulzio, S, 2009) |
| "The photodynamic therapy using 5-aminolevulinic acid is one of the new therapeutic modalities for malignant glioma yet." | 7.74 | [Photodynamic therapy mediated with 5-aminolevulinic acid for C6 glioma spheroids]. ( Iwasaki, Y; Kamoshima, Y; Terasaka, S, 2008) |
| "The purpose of this study was to investigate the potential use of 5-aminolevulinic acid (5-ALA, 5-amino-4-oxovaleric acid) induced protoporphyrin IX (PPIX) for photodynamic therapy (PDT) of nasopharyngeal carcinoma (NPC) and its related mechanisms of inducing cell death." | 7.71 | In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Lai, JP; Leunig, A; Stepp, H; Xiang, W, 2002) |
| " The aim of this study was to establish whether this might be applicable for hepatocellular carcinoma using protoporphyrin synthesized in the tissue from administered delta-aminolevulinic acid." | 7.69 | Photosensitization of experimental hepatocellular carcinoma with protoporphyrin synthesized from administered delta-aminolevulinic acid: studies with cultured cells and implanted tumors. ( Anderson, KE; Egger, NG; Gourley, WK; Motamedi, M; Schoenecker, JA; Weinman, SA, 1997) |
| "We conclude from these in vitro and in vivo studies that porphyrin accumulation after administration of delta-aminolevulinic acid in this hepatoma is substantial and time dependent, and delivery of laser light locally can cause tumor photosensitization and necrosis." | 7.69 | Photosensitization of experimental hepatocellular carcinoma with protoporphyrin synthesized from administered delta-aminolevulinic acid: studies with cultured cells and implanted tumors. ( Anderson, KE; Egger, NG; Gourley, WK; Motamedi, M; Schoenecker, JA; Weinman, SA, 1997) |
| "This study utilized two breast cancer cell lines differing only in their expression of heat shock protein 27 (hsp27)." | 5.34 | Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells. ( Carper, SW; Loucks, C; Madsen, SJ; Ziegler, SA, 2007) |
| "One of the most valuable innovations in high-grade glioma surgery is 5-aminolevulinic acid (5-ALA)." | 5.05 | 5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. A Case-Based Update and Literature Review. ( Altieri, R; Barresi, V; Della Pepa, GM; Ius, T; La Rocca, G; Marchese, E; Menna, G; Olivi, A; Sabatino, G, 2020) |
| "Podophyllotoxin -combined ALA-PDT inhibited the proliferation and promoted apoptosis and necrosis more effectively than the single treatment at the same intensity and concentration." | 4.12 | Podophyllotoxin-combined 5-aminolevulinic acid photodynamic therapy significantly promotes HR-HPV-infected cell death. ( Chen, P; Li, C; Li, Q; Li, Z; Wang, J; Wang, Q; Xu, M; Zeng, K, 2022) |
| "In this study, we evaluated the in vitro cytotoxic effect of PDT at 5J/cm(2) and 10J/cm(2) of red light (633 ± 3nm) using 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) with and without DW, on keloid fibroblasts compared to normal skin fibroblasts." | 3.77 | Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy. ( Allan, D; Allan, E; Bayat, A; Colthurst, J; Sebastian, A, 2011) |
| " The aim of this study was to verify whether such an association exists by injecting rabbits with 5-aminolevulinic acid and searching for the appearance of cardiac necrosis markers and histological heart alterations, and investigate whether the cardiotoxic activity of 5-aminolevulinic acid may involve peroxidation by seeking the presence of the peroxide marker malondialdehyde." | 3.75 | Plasma cardiac necrosis markers C-troponin I and creatine kinase, associated with increased malondialdehyde levels, induced in rabbits by means of 5-aminolevulinic acid injection. ( Brenna, S; Pinelli, A; Rossoni, G; Trivulzio, S, 2009) |
| "The photodynamic therapy using 5-aminolevulinic acid is one of the new therapeutic modalities for malignant glioma yet." | 3.74 | [Photodynamic therapy mediated with 5-aminolevulinic acid for C6 glioma spheroids]. ( Iwasaki, Y; Kamoshima, Y; Terasaka, S, 2008) |
| "The purpose of this study was to test the susceptibility of human hepatoblastoma and neuroblastoma cells to photodynamic diagnostics (PDD) and photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) as a photosensitizer." | 3.74 | In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary results. ( Bergmann, F; Johansson, A; Metzger, R; Rolle, U; Stepp, H; Till, H, 2008) |
| "The purpose of this study was to investigate the potential use of 5-aminolevulinic acid (5-ALA, 5-amino-4-oxovaleric acid) induced protoporphyrin IX (PPIX) for photodynamic therapy (PDT) of nasopharyngeal carcinoma (NPC) and its related mechanisms of inducing cell death." | 3.71 | In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Lai, JP; Leunig, A; Stepp, H; Xiang, W, 2002) |
| " The aim of this study was to establish whether this might be applicable for hepatocellular carcinoma using protoporphyrin synthesized in the tissue from administered delta-aminolevulinic acid." | 3.69 | Photosensitization of experimental hepatocellular carcinoma with protoporphyrin synthesized from administered delta-aminolevulinic acid: studies with cultured cells and implanted tumors. ( Anderson, KE; Egger, NG; Gourley, WK; Motamedi, M; Schoenecker, JA; Weinman, SA, 1997) |
| "We conclude from these in vitro and in vivo studies that porphyrin accumulation after administration of delta-aminolevulinic acid in this hepatoma is substantial and time dependent, and delivery of laser light locally can cause tumor photosensitization and necrosis." | 3.69 | Photosensitization of experimental hepatocellular carcinoma with protoporphyrin synthesized from administered delta-aminolevulinic acid: studies with cultured cells and implanted tumors. ( Anderson, KE; Egger, NG; Gourley, WK; Motamedi, M; Schoenecker, JA; Weinman, SA, 1997) |
| "In most cases, glioblastoma are characterized by a constitutive activation of NF-κB." | 1.37 | 5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma. ( Agostinis, P; Coupienne, I; Fettweis, G; Piette, J; Rubio, N, 2011) |
| "Glioblastoma were previously shown to respond to treatments by 5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) mainly by activating a necrotic type of cell death." | 1.37 | 5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma. ( Agostinis, P; Coupienne, I; Fettweis, G; Piette, J; Rubio, N, 2011) |
| "This study utilized two breast cancer cell lines differing only in their expression of heat shock protein 27 (hsp27)." | 1.34 | Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells. ( Carper, SW; Loucks, C; Madsen, SJ; Ziegler, SA, 2007) |
| "Of our own patients suffering from oral squamous cell carcinoma (OSCC), 96% possessed a 5-aminolevulinic acid (ALA)-induced tumor fluorescence." | 1.31 | [Experimental 5-aminolevulinic acid-induced photodynamic therapy (ALA-PDT) of oral carcinomas. Procedures in treatment of solid tumors and elucidation of cell death]. ( Berndt, A; Dahse, R; Hyckel, P; Kosmehl, H; Schleier, P; Zenk, W, 2001) |
| "The effects of reperfusion injury were removed from the experiments either through the administration of free radical scavengers (superoxide dismutase (10 mg kg(-1)) and catalase (7." | 1.31 | The role of reperfusion injury in photodynamic therapy with 5-aminolaevulinic acid--a study on normal rat colon. ( Bown, SG; Curnow, A, 2002) |
| "5-Aminolevulinic acid (ALA) is an attractive photosensitizing agent for photodynamic therapy (PDT) as its photoactive derivative, protoporphyrin IX, is metabolized within 1-2 days, eliminating prolonged skin photosensitivity." | 1.30 | Light dose fractionation to enhance photodynamic therapy using 5-aminolevulinic acid in the normal rat colon. ( Bown, SG; Curnow, A; MacRobert, AJ; McIlroy, BW; Postle-Hacon, MJ, 1999) |
| "5-Aminolevulinic acid (ALA) is an endogenous substance which is converted to protoporphyrin IX (PpIX) in the synthetic pathway to heme." | 1.28 | Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless guinea pigs. ( Bachor, R; Goff, BA; Hasan, T; Kollias, N, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (30.91) | 18.2507 |
| 2000's | 16 (29.09) | 29.6817 |
| 2010's | 16 (29.09) | 24.3611 |
| 2020's | 6 (10.91) | 2.80 |
| Authors | Studies |
|---|---|
| Beika, M | 1 |
| Harada, Y | 1 |
| Minamikawa, T | 1 |
| Yamaoka, Y | 1 |
| Koizumi, N | 1 |
| Murayama, Y | 1 |
| Konishi, H | 1 |
| Shiozaki, A | 1 |
| Fujiwara, H | 1 |
| Otsuji, E | 1 |
| Takamatsu, T | 1 |
| Tanaka, H | 1 |
| Wang, J | 1 |
| Wang, Q | 1 |
| Chen, P | 1 |
| Li, Q | 1 |
| Li, Z | 1 |
| Xu, M | 1 |
| Zeng, K | 1 |
| Li, C | 1 |
| Gubarkova, EV | 1 |
| Feldchtein, FI | 1 |
| Zagaynova, EV | 1 |
| Gamayunov, SV | 1 |
| Sirotkina, MA | 1 |
| Sedova, ES | 1 |
| Kuznetsov, SS | 1 |
| Moiseev, AA | 1 |
| Matveev, LA | 1 |
| Zaitsev, VY | 1 |
| Karashtin, DA | 1 |
| Gelikonov, GV | 1 |
| Pires, L | 1 |
| Vitkin, A | 1 |
| Gladkova, ND | 1 |
| Leviskas, B | 1 |
| Valyi-Nagy, T | 1 |
| Munirathinam, G | 1 |
| Bork, M | 1 |
| Valyi-Nagy, K | 1 |
| Skwor, T | 1 |
| La Rocca, G | 1 |
| Sabatino, G | 1 |
| Menna, G | 1 |
| Altieri, R | 1 |
| Ius, T | 1 |
| Marchese, E | 1 |
| Olivi, A | 1 |
| Barresi, V | 1 |
| Della Pepa, GM | 1 |
| Wang, H | 3 |
| Xiong, L | 1 |
| Xia, Y | 1 |
| Wang, X | 1 |
| Predina, JD | 1 |
| Runge, J | 1 |
| Newton, A | 1 |
| Mison, M | 1 |
| Xia, L | 1 |
| Corbett, C | 1 |
| Shin, M | 1 |
| Sulyok, LF | 1 |
| Durham, A | 1 |
| Nie, S | 1 |
| Singhal, S | 1 |
| Holt, D | 1 |
| Sun, X | 2 |
| Xu, H | 1 |
| Shen, J | 1 |
| Guo, S | 2 |
| Shi, S | 1 |
| Dan, J | 1 |
| Tian, F | 2 |
| Tian, Y | 3 |
| Yamamoto, J | 1 |
| Ogura, S | 1 |
| Shimajiri, S | 1 |
| Nakano, Y | 1 |
| Akiba, D | 1 |
| Kitagawa, T | 1 |
| Ueta, K | 1 |
| Tanaka, T | 1 |
| Nishizawa, S | 1 |
| Yao, J | 1 |
| Yan, M | 1 |
| Wang, W | 1 |
| Gao, W | 1 |
| Tian, Z | 1 |
| Dong, Z | 1 |
| Li, B | 1 |
| Gao, T | 1 |
| Shan, P | 1 |
| Liu, B | 1 |
| Cheng, J | 1 |
| Gao, Q | 1 |
| Zhang, Z | 1 |
| Cao, W | 1 |
| Kamoshima, Y | 1 |
| Terasaka, S | 1 |
| Iwasaki, Y | 1 |
| Bergmann, F | 1 |
| Stepp, H | 2 |
| Metzger, R | 1 |
| Rolle, U | 1 |
| Johansson, A | 1 |
| Till, H | 1 |
| Pinelli, A | 1 |
| Trivulzio, S | 1 |
| Brenna, S | 1 |
| Rossoni, G | 1 |
| Wakui, M | 1 |
| Yokoyama, Y | 1 |
| Shigeto, T | 1 |
| Futagami, M | 1 |
| Mizunuma, H | 1 |
| Park, JH | 1 |
| Moon, YH | 1 |
| Kim, DJ | 1 |
| Kim, SA | 1 |
| Lee, JB | 1 |
| Ahn, SG | 1 |
| Yoon, JH | 1 |
| Coupienne, I | 3 |
| Bontems, S | 1 |
| Dewaele, M | 1 |
| Rubio, N | 2 |
| Habraken, Y | 1 |
| Fulda, S | 1 |
| Agostinis, P | 2 |
| Piette, J | 3 |
| Hefti, M | 1 |
| Kim, CH | 1 |
| Chung, CW | 1 |
| Choi, KH | 1 |
| Yoo, JJ | 1 |
| Kim, DH | 1 |
| Jeong, YI | 1 |
| Kang, DH | 1 |
| Sebastian, A | 1 |
| Allan, E | 1 |
| Allan, D | 1 |
| Colthurst, J | 1 |
| Bayat, A | 1 |
| Fettweis, G | 2 |
| Su, GC | 1 |
| Wei, YH | 1 |
| Wang, HW | 2 |
| Nicolodelli, G | 1 |
| Kurachi, C | 1 |
| Rego, RF | 1 |
| Omairi, T | 1 |
| Bagnato, VS | 1 |
| Diez, B | 1 |
| Ernst, G | 1 |
| Teijo, MJ | 1 |
| Batlle, A | 1 |
| Hajos, S | 1 |
| Fukuda, H | 2 |
| Verwanger, T | 1 |
| Sanovic, R | 1 |
| Aberger, F | 1 |
| Frischauf, AM | 1 |
| Krammer, B | 1 |
| Betz, CS | 1 |
| Lai, JP | 1 |
| Xiang, W | 1 |
| Janda, P | 1 |
| Heinrich, P | 1 |
| Baumgartner, R | 1 |
| Leunig, A | 1 |
| Robinson, DJ | 1 |
| de Bruijn, HS | 1 |
| Star, WM | 2 |
| Sterenborg, HJ | 1 |
| Eljamel, MS | 1 |
| Kirveliene, V | 1 |
| Sadauskaite, A | 1 |
| Kadziauskas, J | 1 |
| Sasnauskiene, S | 1 |
| Juodka, B | 1 |
| Wang, XL | 1 |
| Wang, HS | 1 |
| Xu, SZ | 1 |
| Liao, KH | 1 |
| Hillemanns, P | 1 |
| Smetana, K | 1 |
| Pluskalová, M | 1 |
| Marinov, Y | 1 |
| Hrkal, Z | 1 |
| Wild, PJ | 1 |
| Krieg, RC | 1 |
| Seidl, J | 1 |
| Stoehr, R | 1 |
| Reher, K | 1 |
| Hofmann, C | 1 |
| Louhelainen, J | 1 |
| Rosenthal, A | 1 |
| Hartmann, A | 1 |
| Pilarsky, C | 1 |
| Bosserhoff, AK | 1 |
| Knuechel, R | 1 |
| Angell-Petersen, E | 1 |
| Spetalen, S | 1 |
| Madsen, SJ | 2 |
| Sun, CH | 2 |
| Peng, Q | 2 |
| Carper, SW | 2 |
| Sioud, M | 1 |
| Hirschberg, H | 1 |
| Ziegler, SA | 1 |
| Loucks, C | 1 |
| Grant, WE | 1 |
| Hopper, C | 1 |
| MacRobert, AJ | 7 |
| Speight, PM | 2 |
| Bown, SG | 9 |
| van der Veen, N | 1 |
| van Leengoed, HL | 1 |
| Casas, A | 1 |
| Chueke, F | 1 |
| Paredes, S | 1 |
| Batlle, AM | 1 |
| Rebeiz, N | 1 |
| Arkins, S | 1 |
| Rebeiz, CA | 1 |
| Simon, J | 1 |
| Zachary, JF | 1 |
| Kelley, KW | 1 |
| Loh, CS | 2 |
| Buonaccorsi, G | 1 |
| Krasner, N | 2 |
| Chang, SC | 1 |
| Fromm, D | 1 |
| Kessel, D | 1 |
| Webber, J | 1 |
| Noodt, BB | 1 |
| Berg, K | 1 |
| Stokke, T | 1 |
| Nesland, JM | 1 |
| Kleemann, D | 1 |
| Mentzel, T | 1 |
| Fehr, MK | 1 |
| Tromberg, BJ | 1 |
| Svaasand, LO | 1 |
| Ngo, P | 1 |
| Berns, MW | 2 |
| Tadir, Y | 1 |
| Egger, NG | 1 |
| Schoenecker, JA | 1 |
| Gourley, WK | 1 |
| Motamedi, M | 1 |
| Anderson, KE | 1 |
| Weinman, SA | 1 |
| Curnow, A | 4 |
| McIlroy, BW | 2 |
| Postle-Hacon, MJ | 2 |
| Porter, JB | 1 |
| Chang, CJ | 1 |
| Liaw, LH | 1 |
| Nelson, JS | 1 |
| Krzemien, AA | 1 |
| Van Vugt, DA | 1 |
| Pottier, RH | 1 |
| Dickson, EF | 1 |
| Reid, RL | 1 |
| Haller, JC | 1 |
| Schleier, P | 1 |
| Berndt, A | 2 |
| Dahse, R | 1 |
| Zenk, W | 1 |
| Hyckel, P | 1 |
| Kosmehl, H | 1 |
| Goff, BA | 1 |
| Bachor, R | 1 |
| Kollias, N | 1 |
| Hasan, T | 1 |
| Bedwell, J | 1 |
| Phillips, D | 1 |
| Erkkilä, MT | 1 |
| Reichert, D | 1 |
| Gesperger, J | 1 |
| Kiesel, B | 1 |
| Roetzer, T | 1 |
| Mercea, PA | 1 |
| Drexler, W | 1 |
| Unterhuber, A | 1 |
| Leitgeb, RA | 1 |
| Woehrer, A | 1 |
| Rueck, A | 1 |
| Andreana, M | 1 |
| Widhalm, G | 1 |
2 reviews available for aminolevulinic acid and Necrosis
| Article | Year |
|---|---|
5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. A Case-Based Update and Literature Review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Diagnostic Errors; False Positive | 2020 |
New light on the brain: The role of photosensitizing agents and laser light in the management of invasive intracranial tumors.
Topics: Aminolevulinic Acid; Brain Neoplasms; Clinical Trials as Topic; Dihematoporphyrin Ether; Glioma; Hum | 2003 |
53 other studies available for aminolevulinic acid and Necrosis
| Article | Year |
|---|---|
Accumulation of Uroporphyrin I in Necrotic Tissues of Squamous Cell Carcinoma after Administration of 5-Aminolevulinic Acid.
Topics: Aged; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Chromatography, High | 2021 |
Podophyllotoxin-combined 5-aminolevulinic acid photodynamic therapy significantly promotes HR-HPV-infected cell death.
Topics: Aminolevulinic Acid; Apoptosis; Cell Death; Condylomata Acuminata; Humans; Necrosis; Papillomavirus | 2022 |
Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Angiography; Carcinoma, Basal Cell; Cohort Studies; Fa | 2019 |
Metalloporphyrin Pd(T4) Exhibits Oncolytic Activity and Cumulative Effects with 5-ALA Photodynamic Treatment against C918 Cells.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; | 2020 |
5-aminolaevulinic acid-based photodynamic therapy induces both necrosis and apoptosis of keratinocytes in plantar warts.
Topics: Aminolevulinic Acid; Apoptosis; Humans; Keratinocytes; Necrosis; Photochemotherapy; Photosensitizing | 2020 |
Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Disease M | 2019 |
Real-time detection of intracellular reactive oxygen species and mitochondrial membrane potential in THP-1 macrophages during ultrasonic irradiation for optimal sonodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line; Cell Line, Tumor; Humans; Intracellular Space; Macrophage | 2015 |
5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytotoxicity, | 2015 |
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells.
Topics: Aminolevulinic Acid; Apoptosis; Atherosclerosis; Caspase 3; Caspase 8; Cell Line, Tumor; Foam Cells; | 2016 |
[Photodynamic therapy mediated with 5-aminolevulinic acid for C6 glioma spheroids].
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cryoultramicrotomy; Glioma; In Situ Nick-End Labeling; Micr | 2008 |
In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary results.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Hepatoblastoma; Humans; Models, Anima | 2008 |
Plasma cardiac necrosis markers C-troponin I and creatine kinase, associated with increased malondialdehyde levels, induced in rabbits by means of 5-aminolevulinic acid injection.
Topics: Aminolevulinic Acid; Animals; Biomarkers; Creatine Kinase; Daunorubicin; Injections; Male; Malondial | 2009 |
Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Apoptosis; Cell Division; Cell Line, Tumor; Disease Mo | 2010 |
Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; C | 2010 |
NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Brain Neoplasms; Glioblastoma; Humans; Necrosis; NF-kappa | 2011 |
Comment concerning: Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas, Acta Neurochir DOl 1O.1007/s00701-010-0708-4, Intratumoral heterogeneity and fluorescence intensity in meningioma after 5-ALA pretreatment.
Topics: Aminolevulinic Acid; Chromosome Aberrations; Fluorescence; Genetic Heterogeneity; Humans; Intraopera | 2011 |
Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells.
Topics: Aminolevulinic Acid; Annexin A5; Apoptosis; Cell Line, Tumor; Cholangiocarcinoma; Flow Cytometry; Hu | 2011 |
Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy.
Topics: Adult; Aged; Aminolevulinic Acid; Apoptosis; Blotting, Western; Case-Control Studies; Caspase 3; Cel | 2011 |
5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma.
Topics: Aminolevulinic Acid; Apoptosis; Caspase 8; Cell Line, Tumor; Fas-Associated Death Domain Protein; Gl | 2011 |
RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT.
Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Blotting, Western; Bone Neoplasms; Cell Line, Tumor; Cell | 2011 |
NADH fluorescence as a photobiological metric in 5-aminolevlinic acid (ALA)-photodynamic therapy.
Topics: Aminolevulinic Acid; Caspase 3; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relations | 2011 |
Evidence of 5-aminolevulinic acid (ALA) penetration increase due to microdrilling in soft tissue using femtosecond laser ablation.
Topics: Aminolevulinic Acid; Animals; Laser Therapy; Liver; Male; Microtechnology; Models, Animal; Necrosis; | 2012 |
Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Death; | 2012 |
Gene expression pattern following photodynamic treatment of the carcinoma cell line A-431 analysed by cDNA arrays.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Survival; Enzyme Induction; Gene Expr | 2002 |
In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma; Cell Survival; Dose-Response Relationship, Drug; Drug Scr | 2002 |
Dose and timing of the first light fraction in two-fold illumination schemes for topical ALA-mediated photodynamic therapy of hairless mouse skin.
Topics: Aminolevulinic Acid; Animals; Female; Kinetics; Mice; Mice, Hairless; Necrosis; Photochemotherapy; P | 2003 |
Correlation of death modes of photosensitized cells with intracellular ATP concentration.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Animals; Apoptosis; Carcinoma, Hepatocellular; Glycolys | 2003 |
Topical 5-aminolaevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata.
Topics: Adult; Aged; Aminolevulinic Acid; Apoptosis; Condylomata Acuminata; Epidermis; Feasibility Studies; | 2004 |
The effect of 5-aminolevulinic acid-based photodynamic treatment (PDT) on nucleoli of leukemic granulocytic precursors represented by K562 blastic cells in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Cell Nucleolus; Cell Nucleus; Chromatin; HL-60 Cells; Humans; K562 C | 2004 |
RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Catalysis; Cell C | 2005 |
Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Light; Necrosis; Phot | 2006 |
Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Radiati | 2007 |
Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorescence; Humans; Laser The | 1993 |
In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations.
Topics: Aminolevulinic Acid; Animals; Drug Administration Schedule; Female; Fluorescence; Kinetics; Mammary | 1994 |
Photodynamic action of endogenously synthesized porphyrins from aminolevulinic acid, using a new model for assaying the effectiveness of tumoral cell killing.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Biological Assay; Cell Death; Cell Division; Combined | 1993 |
Induction of tumor necrosis by delta-aminolevulinic acid and 1,10-phenanthroline photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Drug Interactions; Drug Screening Assays, Antitumor; Female; Humans; M | 1996 |
Mucosal ablation using photodynamic therapy for the treatment of dysplasia: an experimental study in the normal rat stomach.
Topics: Aminolevulinic Acid; Animals; Female; Gastric Emptying; Gastric Mucosa; Indoles; Necrosis; Organomet | 1996 |
Photodynamic therapy on rat urinary bladder with intravesical instillation of 5-aminolevulinic acid: light diffusion and histological changes.
Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Necrosis; Photochemotherapy; Pho | 1996 |
Feasibility of photodynamic therapy using endogenous photosensitization for colon cancer.
Topics: Adenocarcinoma; Administration, Oral; Aminolevulinic Acid; Biopsy; Colectomy; Colon, Sigmoid; Follow | 1996 |
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Apoptosis; Cells, Cultured; Colonic Neoplasms; Criceti | 1996 |
Photodynamic therapy on the normal rabbit larynx with phthalocyanine and 5-aminolaevulinic acid induced protoporphyrin IX photosensitisation.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Indoles; Larynx; Male; Microscopy, F | 1996 |
Structural and functional effects of endometrial photodynamic therapy in a rat model.
Topics: Aminolevulinic Acid; Animals; Edema; Embryo Implantation; Endometrium; Female; Fibrosis; Male; Necro | 1996 |
Photosensitization of experimental hepatocellular carcinoma with protoporphyrin synthesized from administered delta-aminolevulinic acid: studies with cultured cells and implanted tumors.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; In Vitro Techniques; Laser Therapy; Liver; | 1997 |
Enhancement of 5-aminolaevulinic acid-induced photodynamic therapy in normal rat colon using hydroxypyridinone iron-chelating agents.
Topics: Aminolevulinic Acid; Animals; Colon; Drug Interactions; Female; Iron Chelating Agents; Mucous Membra | 1998 |
Light dose fractionation to enhance photodynamic therapy using 5-aminolevulinic acid in the normal rat colon.
Topics: Aminolevulinic Acid; Animals; Colon; Female; Necrosis; Photobiology; Photochemotherapy; Photosensiti | 1999 |
In vitro and in vivo photosensitizing capabilities of 5-ALA versus photofrin in vascular endothelial cells.
Topics: Aminolevulinic Acid; Animals; Chickens; Dihematoporphyrin Ether; Endothelium, Vascular; Hemangioma; | 1999 |
Evaluation of novel nonlaser light source for endometrial ablation using 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Endometrium; Female; Laser Therapy; Necrosis; | 1999 |
Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon. Comparison of continuous and fractionated light regimes.
Topics: Aminolevulinic Acid; Animals; Colon; Female; Light; Monitoring, Physiologic; Necrosis; Oxygen; Photo | 2000 |
[Experimental 5-aminolevulinic acid-induced photodynamic therapy (ALA-PDT) of oral carcinomas. Procedures in treatment of solid tumors and elucidation of cell death].
Topics: Aminolevulinic Acid; Animals; Apoptosis; Carcinoma, Squamous Cell; Humans; Mice; Mice, SCID; Mouth N | 2001 |
The role of reperfusion injury in photodynamic therapy with 5-aminolaevulinic acid--a study on normal rat colon.
Topics: Allopurinol; Aminolevulinic Acid; Animals; Catalase; Colon; Female; Necrosis; Photochemotherapy; Rat | 2002 |
Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless guinea pigs.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Guinea Pigs; Light; Necrosis; Photochemothera | 1992 |
Photodynamic therapy of the normal rat stomach: a comparative study between di-sulphonated aluminium phthalocyanine and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Gastric Mucosa; Indoles; Necrosis; O | 1992 |
Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Humans; Levulinic Acids; NAD; Necrosis; N | 2020 |