Proteins > Steryl-sulfatase
Page last updated: 2024-08-07 15:48:04

Steryl-sulfatase

A steryl-sulfatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08842]

Synonyms

EC 3.1.6.2;
Arylsulfatase C;
ASC;
Estrone sulfatase;
Steroid sulfatase;
Steryl-sulfate sulfohydrolase

Research

Bioassay Publications (51)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (11.76)18.2507
2000's28 (54.90)29.6817
2010's12 (23.53)24.3611
2020's5 (9.80)2.80

Compounds (17)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
acetazolamideHomo sapiens (human)IC505.012512
letrozoleHomo sapiens (human)IC500.000911
pioglitazoneHomo sapiens (human)IC500.800011
estroneHomo sapiens (human)IC5051.000011
17-methylestradiolHomo sapiens (human)IC5019.600011
acetoxyestroneHomo sapiens (human)IC5050.000011
estrone-3-o-sulfamateHomo sapiens (human)IC500.75384344
estrone-3-o-sulfamateHomo sapiens (human)Ki0.620044
estrone sulfateHomo sapiens (human)IC507.600022
estrone sulfateHomo sapiens (human)Ki60.000011
irosustatHomo sapiens (human)IC500.07552223
vorozoleHomo sapiens (human)IC5010.000011
estradiol-3-o-sulfamateHomo sapiens (human)IC500.016011
2-methoxyestradiol-3,17-o,o-bis(sulfamate)Homo sapiens (human)IC500.039022
2-meoemateHomo sapiens (human)IC500.042011
4-methylcoumarin 7-o-sulfamateHomo sapiens (human)IC504.76711314
kw 2581Homo sapiens (human)IC500.004011
2-ethylestradiol sulfamateHomo sapiens (human)IC501.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
dehydroepiandrosterone sulfateHomo sapiens (human)Km10.350022
estrone-3-o-sulfamateHomo sapiens (human)Km95.000011
estrone sulfateHomo sapiens (human)Km12.266733
4-methylcoumarin 7-o-sulfamateHomo sapiens (human)Km275.000011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
steryl-sulfatase activitymolecular functionCatalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. [EC:3.1.6.2]
sulfuric ester hydrolase activitymolecular functionCatalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. [GOC:ai]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
arylsulfatase activitymolecular functionCatalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. [EC:3.1.6.1]

Located In

This protein is located in 9 target(s):

TargetCategoryDefinition
lysosomecellular componentA small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
endosomecellular componentA vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum lumencellular componentThe volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
intracellular membrane-bounded organellecellular componentOrganized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 3 target(s):

TargetCategoryDefinition
steroid catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:go_curators]
female pregnancybiological processThe set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. [ISBN:0192800825]
epidermis developmentbiological processThe process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:go_curators, UBERON:0001003]