A neutrophil collagenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22894]
EC 3.4.24.34;
Matrix metalloproteinase-8;
MMP-8;
PMNL collagenase;
PMNL-CL
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (12.50) | 18.2507 |
| 2000's | 17 (42.50) | 29.6817 |
| 2010's | 14 (35.00) | 24.3611 |
| 2020's | 4 (10.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| nafamostat | Homo sapiens (human) | IC50 | 420.0000 | 1 | 1 |
| tiludronic acid | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| zoledronic acid | Homo sapiens (human) | IC50 | 17.6000 | 1 | 1 |
| piloty's acid | Homo sapiens (human) | Ki | 55.9100 | 3 | 10 |
| marimastat | Homo sapiens (human) | IC50 | 2.0013 | 5 | 5 |
| n-(2-isobutyl-3-(n'-hydroxycarbonylamido)propanoyl)-o-methyltyrosinemethylamide | Homo sapiens (human) | Ki | 0.0007 | 1 | 1 |
| ilomastat | Homo sapiens (human) | IC50 | 0.0054 | 2 | 2 |
| ilomastat | Homo sapiens (human) | Ki | 0.0002 | 2 | 2 |
| 3-((benzyl)(methylaminocarbonyl)methylaminocarbonyl)n-hydroxy-5-methylhexanamide | Homo sapiens (human) | IC50 | 0.0000 | 1 | 1 |
| 3-((benzyl)(methylaminocarbonyl)methylaminocarbonyl)n-hydroxy-5-methylhexanamide | Homo sapiens (human) | Ki | 0.0020 | 1 | 1 |
| 2-(4-aminophenyl)benzothiazole | Homo sapiens (human) | IC50 | 88.0000 | 1 | 1 |
| cgs 27023a | Homo sapiens (human) | IC50 | 0.0105 | 2 | 2 |
| prinomastat | Homo sapiens (human) | IC50 | 0.0005 | 2 | 2 |
| 2-[(4-phenylphenyl)sulfonylamino]pentanedioic acid | Homo sapiens (human) | IC50 | 1.0240 | 1 | 1 |
| rs-130830 | Homo sapiens (human) | IC50 | 0.0001 | 4 | 4 |
| rs-130830 | Homo sapiens (human) | Ki | 0.1369 | 1 | 6 |
| batimastat | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| ik 682 | Homo sapiens (human) | Ki | 0.2570 | 2 | 2 |
| (11c)cgs 25966 | Homo sapiens (human) | Ki | 0.0160 | 3 | 3 |
| ro 32-3555 | Homo sapiens (human) | Ki | 0.0040 | 1 | 1 |
| sb 3ct compound | Homo sapiens (human) | Ki | 2.1000 | 1 | 1 |
| pd 166793 | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| pd 166793 | Homo sapiens (human) | Ki | 0.0044 | 1 | 1 |
| sc 78080 | Homo sapiens (human) | IC50 | 0.0017 | 2 | 2 |
| arp-100 | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide | Homo sapiens (human) | IC50 | 0.0016 | 2 | 2 |
| bms-566394 | Homo sapiens (human) | IC50 | 4.0007 | 1 | 2 |
| bms-566394 | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| grassystatin a | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| tetracycline | Homo sapiens (human) | IC50 | 180.0000 | 1 | 1 |
| 2-[(4-chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one | Homo sapiens (human) | IC50 | 70.0000 | 2 | 2 |
| 2-[(4-methoxyphenyl)methylthio]-6-methyl-1H-pyrimidin-4-one | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 4-[[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acid methyl ester | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] |
| metalloendopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] |
| serine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] |
| peptidase activity | molecular function | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| tumor necrosis factor binding | molecular function | Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. [GOC:jl, http://lookwayup.com/] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| specific granule lumen | cellular component | The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549] |
| collagen-containing extracellular matrix | cellular component | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617] |
| tertiary granule lumen | cellular component | Any membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| extracellular matrix disassembly | biological process | A process that results in the breakdown of the extracellular matrix. [GOC:jid] |
| collagen catabolic process | biological process | The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194] |
| positive regulation of tumor necrosis factor production | biological process | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120] |
| endodermal cell differentiation | biological process | The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. [CL:0000223, GOC:yaf, PMID:17624332] |
| cellular response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah] |
| positive regulation of neuroinflammatory response | biological process | Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc] |
| positive regulation of tumor necrosis factor-mediated signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807] |
| extracellular matrix organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah] |