A P-selectin that is encoded in the genome of human. [PRO:WCB, UniProtKB:P16109]
CD62 antigen-like family member P;
Granule membrane protein 140;
GMP-140;
Leukocyte-endothelial cell adhesion molecule 3;
LECAM3;
Platelet activation dependent granule-external membrane protein;
PADGEM
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gallic acid | Homo sapiens (human) | IC50 | 19.1000 | 1 | 1 |
| oxycinchophen | Homo sapiens (human) | IC50 | 6,500.0000 | 1 | 1 |
| 2,3,4-Trihydroxybenzoic acid | Homo sapiens (human) | IC50 | 11.8000 | 1 | 1 |
| sulfoquinovosyl dipalmitoyl glyceride | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| bimosiamose | Homo sapiens (human) | IC50 | 82.5000 | 2 | 2 |
| psi 697 | Homo sapiens (human) | IC50 | 137.5000 | 2 | 2 |
| galactocerebroside | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| lipopolysaccharide binding | molecular function | Binding to a lipopolysaccharide. [PMID:11079463] |
| integrin binding | molecular function | Binding to an integrin. [GOC:ceb] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| heparin binding | molecular function | Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732] |
| sialic acid binding | molecular function | Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria. [GOC:add, ISBN:9780721601465] |
| fucose binding | molecular function | Binding to fucose, the pentose 6-deoxygalactose. [ISBN:0582227089] |
| glycosphingolipid binding | molecular function | Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:jl] |
| calcium-dependent protein binding | molecular function | Binding to a protein or protein complex in the presence of calcium. [GOC:jid, PMID:10485905] |
| oligosaccharide binding | molecular function | Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [GOC:mah] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| platelet dense granule membrane | cellular component | The lipid bilayer surrounding the platelet dense granule. [GOC:mah] |
| platelet alpha granule membrane | cellular component | The lipid bilayer surrounding the platelet alpha granule. [GOC:mah, PMID:8467233] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|---|---|
| positive regulation of leukocyte migration | biological process | Any process that activates or increases the frequency, rate, or extent of leukocyte migration. [GOC:add] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
| leukocyte cell-cell adhesion | biological process | The attachment of a leukocyte to another cell via adhesion molecules. [GOC:go_curators] |
| positive regulation of platelet activation | biological process | Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:dph, GOC:sl, GOC:tb] |
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | biological process | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. [GOC:hb] |
| response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464] |
| regulation of integrin activation | biological process | Any process that modulates the frequency, rate, or extent of integrin activation. [GOC:add] |
| defense response to Gram-negative bacterium | biological process | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. [GOC:ai] |
| leukocyte tethering or rolling | biological process | Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation] |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai] |
| cell-cell adhesion | biological process | The attachment of one cell to another cell via adhesion molecules. [GOC:dos] |
| positive regulation of leukocyte tethering or rolling | biological process | Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] |
| response to cytokine | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:sl] |
| heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | biological process | The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. [ISBN:0198506732] |