Ubiquitin carboxyl-terminal hydrolase isozyme L1

A ubiquitin carboxyl-terminal hydrolase isozyme L1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09936]

Synonyms

UCH-L1;
EC 3.4.19.12;
Neuron cytoplasmic protein 9.5;
PGP 9.5;
PGP9.5;
Ubiquitin thioesterase L1

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	2 (50.00)	24.3611
2020's	1 (25.00)	2.80

Compounds (7)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
vitamin k 3	Homo sapiens (human)	IC50	290.0000	1	1
celastrol	Homo sapiens (human)	IC50	31.4000	1	5
4,5,6,7-tetrachloroindan-1,3-dione	Homo sapiens (human)	IC50	75.0000	1	1
acetyl isogambogic acid	Homo sapiens (human)	IC50	17.3200	1	5
degrasyn	Homo sapiens (human)	IC50	3.0000	1	1
vialinin a	Homo sapiens (human)	IC50	22.3000	1	1
ldn 57444	Homo sapiens (human)	IC50	300.0000	2	2

Enables

This protein enables 7 target(s):

Target	Category	Definition
cysteine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
cysteine-type deubiquitinase activity	molecular function	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
omega peptidase activity	molecular function	Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes. [EC:3.4.19.-, PMID:20157488, PMID:9920379]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
alpha-2A adrenergic receptor binding	molecular function	Binding to an alpha-2A adrenergic receptor. [GOC:mah, GOC:nln]
ubiquitin binding	molecular function	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
neuron projection terminus	cellular component	The specialized, terminal region of a neuron projection such as an axon or a dendrite. [GOC:jl]
axon cytoplasm	cellular component	Any cytoplasm that is part of a axon. [GO_REF:0000064, GOC:TermGenie, PMID:18667152]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
male germ cell proliferation	biological process	The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population. [GOC:hjd]
response to ischemia	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd]
axon target recognition	biological process	The process in which an axon recognizes and binds to a set of cells with which it may form stable connections. [ISBN:0878932437]
adult walking behavior	biological process	The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. [GOC:jid, GOC:pr, ISBN:0198606907]
regulation of macroautophagy	biological process	Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc]
protein deubiquitination	biological process	The removal of one or more ubiquitin groups from a protein. [GOC:ai]
axonal transport of mitochondrion	biological process	The directed movement of mitochondria along microtubules in nerve cell axons. [GOC:ai]
eating behavior	biological process	The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. [GOC:jl, GOC:pr, PMID:19361967]
proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators]
negative regulation of MAP kinase activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. [GOC:dph, GOC:go_curators]
positive regulation of glycolytic process	biological process	Any process that activates or increases the frequency, rate or extent of glycolysis. [GOC:go_curators]
neuromuscular process	biological process	Any process pertaining to the functions of the nervous and muscular systems of an organism. [GOC:ai]
muscle cell development	biological process	The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. [CL:0000187, GOC:devbiol]
cellular response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:krc, GOC:mah]