Peptidyl-prolyl cis-trans isomerase FKBP1A

A peptidyl-prolyl cis-trans isomerase FKBP1A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62942]

Synonyms

PPIase FKBP1A;
EC 5.2.1.8;
12 kDa FK506-binding protein;
12 kDa FKBP;
FKBP-12;
Calstabin-1;
FK506-binding protein 1A;
FKBP-1A;
Immunophilin FKBP12;
Rotamase

Research

Bioassay Publications (23)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (4.35)	18.7374
1990's	10 (43.48)	18.2507
2000's	6 (26.09)	29.6817
2010's	3 (13.04)	24.3611
2020's	3 (13.04)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cycloheximide	Homo sapiens (human)	IC50	3.6000	1	1
cycloheximide	Homo sapiens (human)	Ki	3.4000	1	1
3-(3-pyridyl)-1-propyl-(2s)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate	Homo sapiens (human)	IC50	1.2400	1	1
3-(3-pyridyl)-1-propyl-(2s)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate	Homo sapiens (human)	Ki	0.0050	3	3
tacrolimus	Homo sapiens (human)	IC50	7.8618	5	5
tacrolimus	Homo sapiens (human)	Ki	0.0004	1	1
biricodar	Homo sapiens (human)	IC50	0.0170	1	1
l 683590	Homo sapiens (human)	IC50	0.0021	2	2
cyclosporine	Homo sapiens (human)	Ki	0.0200	1	1
sirolimus	Homo sapiens (human)	IC50	0.0042	6	6
sirolimus	Homo sapiens (human)	Ki	1.3505	4	4
timcodar	Homo sapiens (human)	IC50	100.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
thiabendazole	Homo sapiens (human)	Kd	60.0000	1	1
tacrolimus	Homo sapiens (human)	EC50	0.0009	1	1
N-(2-fluorophenyl)-2-[2-(4-thiazolyl)-1-benzimidazolyl]acetamide	Homo sapiens (human)	Kd	4,000.0000	1	1
l 683590	Homo sapiens (human)	EC50	0.0016	2	2
sirolimus	Homo sapiens (human)	EC50	0.0364	1	1
bastadin 5	Homo sapiens (human)	EC50	2.2000	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
peptidyl-prolyl cis-trans isomerase activity	molecular function	Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]
transforming growth factor beta receptor binding	molecular function	Binding to a transforming growth factor beta receptor. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
macrolide binding	molecular function	Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. [GOC:jl, ISBN:0198506732]
FK506 binding	molecular function	Binding to a 23-membered macrolide lactone FK506. [GOC:jl]
channel regulator activity	molecular function	Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:mah]
signaling receptor inhibitor activity	molecular function	Binds to and modulates the activity of a signaling receptor. [GOC:ceb]
type I transforming growth factor beta receptor binding	molecular function	Binding to a type I transforming growth factor beta receptor. [GOC:BHF, GOC:mah]
transmembrane transporter binding	molecular function	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
I-SMAD binding	molecular function	Binding to an inhibitory SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]
activin receptor binding	molecular function	Binding to an activin receptor. [GOC:BHF, GOC:vk]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
terminal cisterna	cellular component	The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release. [GOC:mtg_muscle]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
sarcoplasmic reticulum	cellular component	A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]
Z disc	cellular component	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194]
cytoplasmic side of membrane	cellular component	The side of a membrane that faces the cytoplasm. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
sarcoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the sarcoplasmic reticulum. [GOC:rph]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
ryanodine receptor complex	cellular component	A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom. [GOC:ame, PMID:22822064]

Involved In

This protein is involved in 21 target(s):

Target	Category	Definition
protein peptidyl-prolyl isomerization	biological process	The modification of a protein by cis-trans isomerization of a proline residue. [GOC:krc, PMID:16959570]
heart morphogenesis	biological process	The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:dph, GOC:isa_complete]
protein folding	biological process	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb]
'de novo' protein folding	biological process	The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. [GOC:mb]
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	biological process	Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:mtg_muscle]
protein maturation by protein folding	biological process	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. [GOC:isa_complete]
negative regulation of transforming growth factor beta receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]
positive regulation of protein binding	biological process	Any process that activates or increases the frequency, rate or extent of protein binding. [GOC:mah]
regulation of protein localization	biological process	Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. [GOC:dph, GOC:mah, GOC:tb]
negative regulation of activin receptor signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway. [GOC:BHF, GOC:rl]
protein refolding	biological process	The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. [GOC:mb]
T cell activation	biological process	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
positive regulation of canonical NF-kappaB signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
regulation of immune response	biological process	Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]
ventricular cardiac muscle tissue morphogenesis	biological process	The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. [GOC:devbiol]
regulation of ryanodine-sensitive calcium-release channel activity	biological process	Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. [GOC:BHF, GOC:dph, GOC:tb]
heart trabecula formation	biological process	The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
supramolecular fiber organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. [GOC:pr]
regulation of amyloid precursor protein catabolic process	biological process	Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793]
amyloid fibril formation	biological process	The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159]