A DNA polymerase beta that is encoded in the genome of human. [PRO:CNA]
EC 2.7.7.7;
EC 4.2.99.-
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| digallic acid | Homo sapiens (human) | Ki | 0.3900 | 1 | 1 |
| pamoic acid | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Dillapiole | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| oleanolic acid | Homo sapiens (human) | IC50 | 14.3660 | 5 | 5 |
| zidovudine | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| ursolic acid | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| thymidine 5'-triphosphate | Homo sapiens (human) | IC50 | 1.4000 | 1 | 1 |
| betulinic acid | Homo sapiens (human) | IC50 | 41.1833 | 3 | 3 |
| calanolide a | Homo sapiens (human) | IC50 | 205.0000 | 1 | 1 |
| 2',3'-dideoxythymidine triphosphate | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| 2',3'-dideoxyadenosine triphosphate | Homo sapiens (human) | IC50 | 8.4000 | 1 | 1 |
| zidovudine triphosphate | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| illimaquinone | Homo sapiens (human) | IC50 | 45.2000 | 1 | 1 |
| sitosterol, (3beta)-isomer | Homo sapiens (human) | IC50 | 26.3000 | 1 | 1 |
| TTP | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| aphidicolin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| stigmasterol | Homo sapiens (human) | IC50 | 117.8933 | 3 | 3 |
| lyoniside | Homo sapiens (human) | IC50 | 26.5000 | 1 | 1 |
| corosolic acid | Homo sapiens (human) | IC50 | 12.6000 | 1 | 1 |
| edgeworin | Homo sapiens (human) | IC50 | 35.1550 | 2 | 2 |
| raltegravir | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| GS-443902 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| damaged DNA binding | molecular function | Binding to damaged DNA. [GOC:jl] |
| DNA-directed DNA polymerase activity | molecular function | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. [EC:2.7.7.7, GOC:vw, ISBN:0198547684] |
| DNA-(apurinic or apyrimidinic site) endonuclease activity | molecular function | Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). [Wikipedia:AP_endonuclease] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| microtubule binding | molecular function | Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc] |
| lyase activity | molecular function | Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [ISBN:0198547684] |
| enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| 5'-deoxyribose-5-phosphate lyase activity | molecular function | Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. [PMID:11251121, PMID:16120966] |
| class I DNA-(apurinic or apyrimidinic site) endonuclease activity | molecular function | Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. [PMID:1698278, RHEA:66592] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| microtubule | cellular component | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568] |
| spindle microtubule | cellular component | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. [ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
This protein is involved in 21 target(s):
| Target | Category | Definition |
|---|---|---|
| in utero embryonic development | biological process | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu] |
| DNA-templated DNA replication | biological process | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. [GOC:mah, ISBN:0198506732] |
| DNA repair | biological process | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486] |
| base-excision repair | biological process | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [ISBN:0815316194] |
| base-excision repair, gap-filling | biological process | Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. [ISBN:1550091131] |
| pyrimidine dimer repair | biological process | The repair of UV-induced T-T, C-T and C-C dimers. [ISBN:0815316194] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| DNA damage response | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators] |
| salivary gland morphogenesis | biological process | The process in which the anatomical structures of the salivary gland are generated and organized. [GOC:jid] |
| intrinsic apoptotic signaling pathway in response to DNA damage | biological process | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis] |
| response to gamma radiation | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:tair_curators] |
| somatic hypermutation of immunoglobulin genes | biological process | Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007] |
| response to ethanol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators] |
| lymph node development | biological process | The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. [GOC:add, ISBN:068340007X, ISBN:0781735149] |
| spleen development | biological process | The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. [GOC:add, ISBN:0781735149] |
| homeostasis of number of cells | biological process | Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. [GOC:isa_complete] |
| neuron apoptotic process | biological process | Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. [CL:0000540, GOC:mtg_apoptosis] |
| response to hyperoxia | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. [GOC:kmv] |
| immunoglobulin heavy chain V-D-J recombination | biological process | The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). [GOC:add, ISBN:0781735149] |
| DNA biosynthetic process | biological process | The biosynthetic process resulting in the formation of DNA. [GOC:mah] |
| double-strand break repair via nonhomologous end joining | biological process | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. [GOC:rph, PMID:10827453, PMID:24837021] |