Page last updated: 2024-08-07 10:09:55
Replicase polyprotein 1ab
[no definition available]
Synonyms
pp1ab;
ORF1ab polyprotein
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
Compounds (137)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| taxifolin | Betacoronavirus England 1 | IC50 | 73.0000 | 1 | 1 |
| amlexanox | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| bronopol | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| carmofur | Betacoronavirus England 1 | IC50 | 1.8200 | 1 | 1 |
| chloroquine | Betacoronavirus England 1 | IC50 | 5.4700 | 1 | 1 |
| chlorpromazine | Betacoronavirus England 1 | IC50 | 11.2400 | 1 | 2 |
| disulfiram | Betacoronavirus England 1 | IC50 | 18.0750 | 2 | 1 |
| ebselen | Betacoronavirus England 1 | IC50 | 5.3350 | 2 | 1 |
| emodin | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 1 |
| fluphenazine | Betacoronavirus England 1 | IC50 | 11.8000 | 1 | 2 |
| 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone | Betacoronavirus England 1 | IC50 | 8.1000 | 1 | 0 |
| 1-(2-naphthalenyl)-2-propen-1-one | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| lansoprazole | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| niclosamide | Betacoronavirus England 1 | IC50 | 50.0000 | 1 | 1 |
| masoprocol | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| promethazine | Betacoronavirus England 1 | IC50 | 13.6450 | 1 | 2 |
| thiram | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| proflavine | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| thiohexam | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| tetramethylthiuram monosulfide | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| captan | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| protocatechualdehyde | Betacoronavirus England 1 | IC50 | 239.0000 | 1 | 1 |
| apomorphine hydrochloride, anhydrous | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| 6-chrysenamine | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| bonafton | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| 4-chloro-7-nitrobenzofurazan | Betacoronavirus England 1 | IC50 | 141.0000 | 1 | 1 |
| 4-biphenylylacetic acid ethyl ester | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| benserazide hydrochloride | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| razoxane | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| carbidopa | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| exifone | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| oltipraz | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| caracemide | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| nelfinavir | Betacoronavirus England 1 | IC50 | 41.5000 | 1 | 1 |
| epigallocatechin gallate | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| sanguinarine chloride | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| vanitiolide | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| sennoside A | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| pyrrolidine dithiocarbamic acid | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| 2-amino-5-nitropyridine | Betacoronavirus England 1 | IC50 | 137.0000 | 1 | 1 |
| 1-(4-nitrophenyl)piperazine | Betacoronavirus England 1 | IC50 | 71.6000 | 1 | 1 |
| 6,6'-dithiodinicotinic acid | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| omega-(4-iodophenyl)pentadecanoic acid | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| levofloxacin | Betacoronavirus England 1 | IC50 | 7.6000 | 1 | 0 |
| 2,4,6-triiodoresorcinol | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| ampelopsin | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| tanshinone ii a | Betacoronavirus England 1 | IC50 | 0.8000 | 1 | 1 |
| 1-methylpropyl-2-imidazolyl disulfide | Betacoronavirus England 1 | IC50 | 16.5333 | 2 | 2 |
| silver sulfadiazine | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| delavirdine mesylate | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| hematoxylin | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| 1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide | Betacoronavirus England 1 | IC50 | 0.3700 | 1 | 1 |
| IPA-3 | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| tenatoprazole | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| hirsutanone | Betacoronavirus England 1 | IC50 | 4.1000 | 1 | 1 |
| 3,3',4,5'-tetrahydroxystilbene | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| sch-202676 | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| captax | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1h-pyrrole-2,5-dione | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| succimer | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| ccg 50014 | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| bi-78d3 | Betacoronavirus England 1 | IC50 | 3.8000 | 1 | 0 |
| pr-619 | Betacoronavirus England 1 | IC50 | 2.3000 | 1 | 0 |
| 5-(4-Chloro-benzenesulfonyl)-pyrimidine-2,4-diamine | Betacoronavirus England 1 | IC50 | 6.0000 | 1 | 1 |
| S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate | Betacoronavirus England 1 | IC50 | 3.0000 | 1 | 1 |
| N-(4-Butan-2-ylphenyl)-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-3-ylethyl]furan-2-carboxamide | Betacoronavirus England 1 | IC50 | 18.1000 | 1 | 2 |
| 4-nitrocatechol | Betacoronavirus England 1 | IC50 | 145.0000 | 1 | 1 |
| ro 106-9920 | Betacoronavirus England 1 | IC50 | 10.1000 | 1 | 0 |
| apigenin | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| amentoflavone | Betacoronavirus England 1 | IC50 | 8.3000 | 1 | 1 |
| baicalein | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| hyperoside | Betacoronavirus England 1 | IC50 | 50.5000 | 1 | 1 |
| myricetin | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| rosmarinic acid | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| savinin | Betacoronavirus England 1 | IC50 | 25.0000 | 1 | 1 |
| bay 11-7082 | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| bay 11-7085 | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| ildamen | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl}-L-leucinamide | Betacoronavirus England 1 | IC50 | 9.0000 | 1 | 1 |
| broussochalcone a | Betacoronavirus England 1 | IC50 | 25.6500 | 1 | 2 |
| rupintrivir | Betacoronavirus England 1 | IC50 | 280.0000 | 2 | 3 |
| rupintrivir | Betacoronavirus England 1 | Ki | 10.0000 | 1 | 2 |
| Ethyl (E,4S)-4-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-3-phenylpropanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate | Betacoronavirus England 1 | Ki | 2.2600 | 1 | 1 |
| 5-Chloro-3-pyridinyl 2-furoate | Betacoronavirus England 1 | IC50 | 0.0600 | 1 | 1 |
| proflavine hemisulfate | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| np 031112 | Betacoronavirus England 1 | IC50 | 7.1833 | 2 | 1 |
| kw 2449 | Betacoronavirus England 1 | IC50 | 3.6000 | 1 | 0 |
| PF-00835231 | Betacoronavirus England 1 | IC50 | 0.0040 | 1 | 1 |
| 5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| rabeprazole sodium | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 0 |
| Benzotriazol-1-yl 1H-indole-5-carboxylate | Betacoronavirus England 1 | Ki | 0.0075 | 1 | 1 |
| 5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate | Betacoronavirus England 1 | IC50 | 0.0630 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-5-carboxylate | Betacoronavirus England 1 | IC50 | 0.3100 | 1 | 1 |
| 5-Chloropyridin-3-yl 1H-indole-2-carboxylate | Betacoronavirus England 1 | IC50 | 0.0650 | 1 | 1 |
| GRL-0617 | Betacoronavirus England 1 | IC50 | 0.6000 | 1 | 1 |
| (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate | Betacoronavirus England 1 | IC50 | 0.0300 | 1 | 1 |
| KOM70144 | Betacoronavirus England 1 | IC50 | 0.5600 | 1 | 1 |
| N-[(1R)-2-(tert-butylamino)-2-oxo-1-(3-pyridinyl)ethyl]-N-(4-tert-butylphenyl)-2-furancarboxamide | Betacoronavirus England 1 | IC50 | 1.5000 | 1 | 1 |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | Betacoronavirus England 1 | IC50 | 0.0500 | 1 | 1 |
| 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | Betacoronavirus England 1 | IC50 | 0.0400 | 1 | 1 |
Drugs with Activation Measurements