Page last updated: 2024-08-07 17:22:02
Carbonic anhydrase 4
A carbonic anhydrase 4 that is encoded in the genome of cow. [OMA:Q95323, PRO:DNx]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase IV;
Carbonic anhydrase IV;
CA-IV
Research
Bioassay Publications (33)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 30 (90.91) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (39)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| acetazolamide | Bos taurus (cattle) | IC50 | 0.0700 | 2 | 2 |
| acetazolamide | Bos taurus (cattle) | Ki | 0.1642 | 21 | 34 |
| celecoxib | Bos taurus (cattle) | IC50 | 16.8152 | 3 | 6 |
| celecoxib | Bos taurus (cattle) | Ki | 0.2900 | 2 | 2 |
| diclofenac | Bos taurus (cattle) | IC50 | 100.0000 | 2 | 4 |
| dichlorphenamide | Bos taurus (cattle) | IC50 | 0.3800 | 2 | 2 |
| dichlorphenamide | Bos taurus (cattle) | Ki | 0.4575 | 16 | 22 |
| ethoxzolamide | Bos taurus (cattle) | Ki | 0.0166 | 13 | 19 |
| mafenide | Bos taurus (cattle) | Ki | 399,992,860.8064 | 11 | 14 |
| methazolamide | Bos taurus (cattle) | IC50 | 0.0360 | 2 | 2 |
| methazolamide | Bos taurus (cattle) | Ki | 0.1504 | 20 | 30 |
| sulfanilamide | Bos taurus (cattle) | Ki | 315,773,689.0134 | 13 | 19 |
| sulpiride | Bos taurus (cattle) | IC50 | 0.6200 | 1 | 1 |
| sulfacetamide | Bos taurus (cattle) | Ki | 5.5116 | 2 | 5 |
| carzenide | Bos taurus (cattle) | Ki | 0.0860 | 1 | 1 |
| benzolamide | Bos taurus (cattle) | Ki | 0.0215 | 2 | 6 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Bos taurus (cattle) | Ki | 35,554,000.1244 | 9 | 9 |
| disulphane | Bos taurus (cattle) | Ki | 10,000,700.0558 | 5 | 5 |
| brinzolamide | Bos taurus (cattle) | Ki | 3,483,830.8042 | 9 | 13 |
| piloty's acid | Bos taurus (cattle) | Ki | 44.6860 | 2 | 9 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Bos taurus (cattle) | Ki | 0.1780 | 3 | 3 |
| 2-aminobenzenesulfonamide | Bos taurus (cattle) | Ki | 327,522,500.9825 | 8 | 8 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Bos taurus (cattle) | Ki | 41,539,077.9662 | 10 | 13 |
| aminozolamide | Bos taurus (cattle) | Ki | 3,800,400.0152 | 5 | 5 |
| 6-hydroxyethoxzolamide | Bos taurus (cattle) | Ki | 2,999,360.0120 | 5 | 5 |
| valdecoxib | Bos taurus (cattle) | IC50 | 11.0126 | 3 | 5 |
| valdecoxib | Bos taurus (cattle) | Ki | 0.3400 | 2 | 2 |
| naphthalenesulfonamide | Bos taurus (cattle) | Ki | 0.4380 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Bos taurus (cattle) | Ki | 326,654,671.0215 | 11 | 15 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Bos taurus (cattle) | IC50 | 0.0650 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Bos taurus (cattle) | Ki | 0.0533 | 3 | 3 |
| N1-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide | Bos taurus (cattle) | Ki | 5.2052 | 2 | 5 |
| 2,6-dibromosulfanilamide | Bos taurus (cattle) | Ki | 2.0282 | 2 | 5 |
| sc 560 | Bos taurus (cattle) | IC50 | 100.0000 | 2 | 4 |
| dorzolamide | Bos taurus (cattle) | IC50 | 0.0430 | 1 | 1 |
| dorzolamide | Bos taurus (cattle) | Ki | 1,800,368.0360 | 19 | 25 |
| topiramate | Bos taurus (cattle) | IC50 | 0.0540 | 1 | 1 |
| topiramate | Bos taurus (cattle) | Ki | 0.0713 | 6 | 9 |
| 6-hydroxybenzothiazide-2-sulfonamide | Bos taurus (cattle) | Ki | 2,833,016.6808 | 6 | 6 |
Drugs with Other Measurements
Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.Bioorganic & medicinal chemistry letters, , Apr-22, Volume: 12, Issue:8, 2002
Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties.Bioorganic & medicinal chemistry letters, , Jul-19, Volume: 9, Issue:14, 1999
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.Journal of enzyme inhibition, , Volume: 16, Issue:4, 2001
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.Bioorganic & medicinal chemistry letters, , Apr-22, Volume: 12, Issue:8, 2002
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.Bioorganic & medicinal chemistry letters, , Apr-22, Volume: 12, Issue:8, 2002
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties.Bioorganic & medicinal chemistry letters, , Apr-03, Volume: 10, Issue:7, 2000
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999