Page last updated: 2024-08-07 12:49:46
Carbonic anhydrase 2
A vertebrate-type carbonic anhydrase 2 that is encoded in the genome of cow. [OMA:P00921, PRO:DNx]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase II;
Carbonic anhydrase II;
CA-II
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (14)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| sulfanilamide | Bos taurus (cattle) | Kd | 5.8800 | 1 | 1 |
| carzenide | Bos taurus (cattle) | Kd | 0.8900 | 1 | 1 |
Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies.Bioorganic chemistry, , Volume: 68, 2016
Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
New aminobenzenesulfonamide-thiourea conjugates: synthesis and carbonic anhydrase inhibition and docking studies.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Sulfamates of methyl triterpenoates are effective and competitive inhibitors of carbonic anhydrase II.European journal of medicinal chemistry, , Oct-30, Volume: 86, 2014
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.Journal of medicinal chemistry, , 05-12, Volume: 59, Issue:9, 2016
Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures (II).Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.Journal of medicinal chemistry, , 05-12, Volume: 59, Issue:9, 2016
Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005