Page last updated: 2024-08-07 16:00:35
Androgen receptor
An androgen receptor that is encoded in the genome of rat. [OMA:P15207, PRO:DNx]
Synonyms
Dihydrotestosterone receptor;
Nuclear receptor subfamily 3 group C member 4
Research
Bioassay Publications (38)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 16 (42.11) | 29.6817 |
| 2010's | 14 (36.84) | 24.3611 |
| 2020's | 4 (10.53) | 2.80 |
Compounds (159)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| chlordecone | Rattus norvegicus (Norway rat) | IC50 | 12.0226 | 1 | 1 |
| hexachlorocyclohexane | Rattus norvegicus (Norway rat) | IC50 | 40.7380 | 1 | 1 |
| vanillin | Rattus norvegicus (Norway rat) | IC50 | 426.5800 | 1 | 1 |
| 2,4,5-trichlorophenoxyacetic acid | Rattus norvegicus (Norway rat) | IC50 | 457.0880 | 1 | 1 |
| 4-nonylphenol | Rattus norvegicus (Norway rat) | IC50 | 11.4815 | 1 | 1 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| am 251 | Rattus norvegicus (Norway rat) | Ki | 2.2900 | 1 | 1 |
| amiodarone | Rattus norvegicus (Norway rat) | IC50 | 42.2480 | 1 | 0 |
| amiodarone | Rattus norvegicus (Norway rat) | Ki | 28.1650 | 1 | 0 |
| bicalutamide | Rattus norvegicus (Norway rat) | IC50 | 53.9307 | 6 | 6 |
| bicalutamide | Rattus norvegicus (Norway rat) | Ki | 1.5512 | 3 | 5 |
| clomiphene | Rattus norvegicus (Norway rat) | IC50 | 13.4896 | 1 | 1 |
| clotrimazole | Rattus norvegicus (Norway rat) | IC50 | 11.5860 | 1 | 0 |
| clotrimazole | Rattus norvegicus (Norway rat) | Ki | 7.7240 | 1 | 0 |
| dichlorodiphenyl dichloroethylene | Rattus norvegicus (Norway rat) | IC50 | 15.4882 | 1 | 1 |
| ddt | Rattus norvegicus (Norway rat) | IC50 | 18.1970 | 1 | 1 |
| benzophenone | Rattus norvegicus (Norway rat) | IC50 | 128.8250 | 1 | 1 |
| econazole | Rattus norvegicus (Norway rat) | IC50 | 10.1250 | 1 | 0 |
| econazole | Rattus norvegicus (Norway rat) | Ki | 6.7500 | 1 | 0 |
| endosulfan | Rattus norvegicus (Norway rat) | IC50 | 23.4423 | 1 | 1 |
| fluphenazine | Rattus norvegicus (Norway rat) | Ki | 0.8000 | 1 | 1 |
| flutamide | Rattus norvegicus (Norway rat) | IC50 | 13.3900 | 1 | 0 |
| flutamide | Rattus norvegicus (Norway rat) | Ki | 8.9270 | 1 | 0 |
| heptachlor | Rattus norvegicus (Norway rat) | IC50 | 13.4896 | 1 | 1 |
| hexachlorophene | Rattus norvegicus (Norway rat) | IC50 | 4.9753 | 1 | 0 |
| hexachlorophene | Rattus norvegicus (Norway rat) | Ki | 3.3169 | 1 | 0 |
| methoxychlor | Rattus norvegicus (Norway rat) | IC50 | 28.1838 | 1 | 1 |
| miconazole | Rattus norvegicus (Norway rat) | IC50 | 7.0890 | 1 | 0 |
| miconazole | Rattus norvegicus (Norway rat) | Ki | 4.7260 | 1 | 0 |
| nafoxidine | Rattus norvegicus (Norway rat) | IC50 | 12.8825 | 1 | 1 |
| periciazine | Rattus norvegicus (Norway rat) | Ki | 3.0000 | 1 | 1 |
| vorinostat | Rattus norvegicus (Norway rat) | IC50 | 0.1582 | 1 | 1 |
| sulfasalazine | Rattus norvegicus (Norway rat) | IC50 | 43.9510 | 1 | 0 |
| sulfasalazine | Rattus norvegicus (Norway rat) | Ki | 29.3010 | 1 | 0 |
| corticosterone | Rattus norvegicus (Norway rat) | IC50 | 23.4423 | 1 | 1 |
| prednisolone | Rattus norvegicus (Norway rat) | IC50 | 42.6579 | 1 | 1 |
| estriol | Rattus norvegicus (Norway rat) | IC50 | 436.5160 | 1 | 1 |
| norethindrone acetate | Rattus norvegicus (Norway rat) | IC50 | 0.1060 | 1 | 0 |
| norethindrone acetate | Rattus norvegicus (Norway rat) | Ki | 0.0710 | 1 | 0 |
| spironolactone | Rattus norvegicus (Norway rat) | IC50 | 0.4060 | 2 | 1 |
| spironolactone | Rattus norvegicus (Norway rat) | Ki | 0.0906 | 1 | 0 |
| aldosterone | Rattus norvegicus (Norway rat) | IC50 | 42.6579 | 1 | 1 |
| estrone | Rattus norvegicus (Norway rat) | IC50 | 11.6170 | 1 | 0 |
| estrone | Rattus norvegicus (Norway rat) | Ki | 7.7450 | 1 | 0 |
| androsterone | Rattus norvegicus (Norway rat) | IC50 | 40.7380 | 1 | 1 |
| 17-desoxyestradiol | Rattus norvegicus (Norway rat) | IC50 | 41.6869 | 1 | 1 |
| ethinyl estradiol | Rattus norvegicus (Norway rat) | IC50 | 4.8812 | 2 | 1 |
| ethinyl estradiol | Rattus norvegicus (Norway rat) | Ki | 1.0900 | 1 | 0 |
| chlordan | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| testosterone propionate | Rattus norvegicus (Norway rat) | IC50 | 1.9055 | 1 | 1 |
| methyltestosterone | Rattus norvegicus (Norway rat) | IC50 | 0.0111 | 2 | 1 |
| methyltestosterone | Rattus norvegicus (Norway rat) | Ki | 0.0043 | 1 | 0 |
| androstenedione | Rattus norvegicus (Norway rat) | IC50 | 0.6761 | 2 | 2 |
| norethindrone | Rattus norvegicus (Norway rat) | IC50 | 0.0711 | 2 | 1 |
| norethindrone | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 0 |
| norethynodrel | Rattus norvegicus (Norway rat) | IC50 | 1.5488 | 1 | 1 |
| 17-alpha-hydroxyprogesterone | Rattus norvegicus (Norway rat) | IC50 | 0.7390 | 1 | 0 |
| 17-alpha-hydroxyprogesterone | Rattus norvegicus (Norway rat) | Ki | 0.4930 | 1 | 0 |
| medroxyprogesterone acetate | Rattus norvegicus (Norway rat) | IC50 | 0.2790 | 2 | 2 |
| medroxyprogesterone acetate | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 1 | 0 |
| mestranol | Rattus norvegicus (Norway rat) | IC50 | 10.6820 | 1 | 0 |
| mestranol | Rattus norvegicus (Norway rat) | Ki | 7.1210 | 1 | 0 |
| dichlorodiphenyldichloroethane | Rattus norvegicus (Norway rat) | IC50 | 15.4882 | 1 | 1 |
| bisphenol a | Rattus norvegicus (Norway rat) | IC50 | 53.9635 | 2 | 1 |
| bisphenol a | Rattus norvegicus (Norway rat) | Ki | 22.5310 | 1 | 0 |
| p-tert-amylphenol | Rattus norvegicus (Norway rat) | IC50 | 77.6247 | 1 | 1 |
| methylprednisolone | Rattus norvegicus (Norway rat) | IC50 | 26.6800 | 1 | 0 |
| methylprednisolone | Rattus norvegicus (Norway rat) | Ki | 17.7860 | 1 | 0 |
| 2-sec-butylphenol | Rattus norvegicus (Norway rat) | IC50 | 102.3290 | 1 | 1 |
| 4-phenylphenol | Rattus norvegicus (Norway rat) | IC50 | 8.3176 | 1 | 1 |
| propylparaben | Rattus norvegicus (Norway rat) | IC50 | 309.0300 | 1 | 1 |
| butylphen | Rattus norvegicus (Norway rat) | IC50 | 144.5440 | 1 | 1 |
| methylparaben | Rattus norvegicus (Norway rat) | IC50 | 426.5800 | 1 | 1 |
| monobenzone | Rattus norvegicus (Norway rat) | IC50 | 234.4230 | 1 | 1 |
| 3-chlorophenol | Rattus norvegicus (Norway rat) | IC50 | 457.0880 | 1 | 1 |
| 2,4-dihydroxybenzophenone | Rattus norvegicus (Norway rat) | IC50 | 102.3290 | 1 | 1 |
| ethynodiol diacetate | Rattus norvegicus (Norway rat) | IC50 | 3.1000 | 1 | 0 |
| ethynodiol diacetate | Rattus norvegicus (Norway rat) | Ki | 2.0670 | 1 | 0 |
| chlormadinone acetate | Rattus norvegicus (Norway rat) | IC50 | 0.0313 | 1 | 0 |
| chlormadinone acetate | Rattus norvegicus (Norway rat) | Ki | 0.0209 | 1 | 0 |
| fluorometholone | Rattus norvegicus (Norway rat) | IC50 | 1.2850 | 1 | 0 |
| fluorometholone | Rattus norvegicus (Norway rat) | Ki | 0.8570 | 1 | 0 |
| cyproterone acetate | Rattus norvegicus (Norway rat) | IC50 | 6.2260 | 3 | 2 |
| cyproterone acetate | Rattus norvegicus (Norway rat) | Ki | 0.0310 | 1 | 0 |
| nandrolone | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 1 | 0 |
| nandrolone | Rattus norvegicus (Norway rat) | Ki | 0.0021 | 1 | 0 |
| epitestosterone | Rattus norvegicus (Norway rat) | IC50 | 0.0158 | 1 | 1 |
| flavanone | Rattus norvegicus (Norway rat) | IC50 | 54.9541 | 1 | 1 |
| medroxyprogesterone | Rattus norvegicus (Norway rat) | IC50 | 0.1370 | 1 | 0 |
| medroxyprogesterone | Rattus norvegicus (Norway rat) | Ki | 0.0910 | 1 | 0 |
| androstenediol | Rattus norvegicus (Norway rat) | IC50 | 1.3804 | 1 | 1 |
| dihydrotestosterone | Rattus norvegicus (Norway rat) | IC50 | 2.5814 | 9 | 8 |
| dihydrotestosterone | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 6 | 5 |
| flavone | Rattus norvegicus (Norway rat) | IC50 | 77.6247 | 1 | 1 |
| gentian violet | Rattus norvegicus (Norway rat) | IC50 | 5.5700 | 1 | 0 |
| gentian violet | Rattus norvegicus (Norway rat) | Ki | 3.7130 | 1 | 0 |
| 1-naphthylisothiocyanate | Rattus norvegicus (Norway rat) | IC50 | 25.5130 | 1 | 0 |
| 1-naphthylisothiocyanate | Rattus norvegicus (Norway rat) | Ki | 17.0090 | 1 | 0 |
| megestrol acetate | Rattus norvegicus (Norway rat) | IC50 | 0.0300 | 1 | 0 |
| megestrol acetate | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 0 |
| 4-cumylphenol | Rattus norvegicus (Norway rat) | IC50 | 39.8107 | 1 | 1 |
| o,p'-ddt | Rattus norvegicus (Norway rat) | IC50 | 14.7911 | 1 | 1 |
| ethylestrenol | Rattus norvegicus (Norway rat) | IC50 | 0.0270 | 1 | 0 |
| ethylestrenol | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 1 | 0 |
| 4-hydroxybenzophenone | Rattus norvegicus (Norway rat) | IC50 | 181.9700 | 1 | 1 |
| 4-chloro-2-cresol | Rattus norvegicus (Norway rat) | IC50 | 120.2260 | 1 | 1 |
| mesterolone | Rattus norvegicus (Norway rat) | IC50 | 18.2800 | 1 | 1 |
| 4-octylphenol | Rattus norvegicus (Norway rat) | IC50 | 19.0546 | 1 | 1 |
| 2,4,2',4'-tetrachlorobiphenyl | Rattus norvegicus (Norway rat) | IC50 | 16.9824 | 1 | 1 |
| acetophenazine | Rattus norvegicus (Norway rat) | Ki | 0.8000 | 1 | 1 |
| 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane | Rattus norvegicus (Norway rat) | IC50 | 0.1630 | 1 | 1 |
| stanozolol | Rattus norvegicus (Norway rat) | IC50 | 0.0220 | 1 | 0 |
| stanozolol | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 0 |
| ac 45594 | Rattus norvegicus (Norway rat) | IC50 | 14.7911 | 1 | 1 |
| danazol | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 0 |
| danazol | Rattus norvegicus (Norway rat) | Ki | 0.0080 | 1 | 0 |
| bromocriptine | Rattus norvegicus (Norway rat) | IC50 | 2.2810 | 1 | 0 |
| bromocriptine | Rattus norvegicus (Norway rat) | Ki | 1.5210 | 1 | 0 |
| clobetasol propionate | Rattus norvegicus (Norway rat) | IC50 | 3.7750 | 1 | 0 |
| clobetasol propionate | Rattus norvegicus (Norway rat) | Ki | 2.5170 | 1 | 0 |
| promegestone | Rattus norvegicus (Norway rat) | IC50 | 1.3183 | 1 | 1 |
| 2,4'-dichlorobiphenyl | Rattus norvegicus (Norway rat) | IC50 | 16.2181 | 1 | 1 |
| lovastatin | Rattus norvegicus (Norway rat) | IC50 | 30.1640 | 1 | 0 |
| lovastatin | Rattus norvegicus (Norway rat) | Ki | 20.1100 | 1 | 0 |
| mifepristone | Rattus norvegicus (Norway rat) | IC50 | 0.0083 | 1 | 0 |
| mifepristone | Rattus norvegicus (Norway rat) | Ki | 0.0056 | 1 | 0 |
| nitrogenase stabilizing-protective protein, bacteria | Rattus norvegicus (Norway rat) | IC50 | 0.6455 | 2 | 1 |
| nitrogenase stabilizing-protective protein, bacteria | Rattus norvegicus (Norway rat) | Ki | 0.0691 | 8 | 8 |
| finasteride | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol | Rattus norvegicus (Norway rat) | IC50 | 9.3325 | 1 | 1 |
| nelfinavir | Rattus norvegicus (Norway rat) | IC50 | 36.3890 | 1 | 0 |
| nelfinavir | Rattus norvegicus (Norway rat) | Ki | 24.2590 | 1 | 0 |
| taleranol | Rattus norvegicus (Norway rat) | IC50 | 26.9339 | 1 | 2 |
| bisphenol b | Rattus norvegicus (Norway rat) | IC50 | 38.0189 | 1 | 1 |
| alfatradiol | Rattus norvegicus (Norway rat) | IC50 | 75.8578 | 1 | 1 |
| 4,4'-Dihydroxybenzophenone | Rattus norvegicus (Norway rat) | IC50 | 144.5440 | 1 | 1 |
| 6-hydroxyflavone | Rattus norvegicus (Norway rat) | IC50 | 181.9700 | 1 | 1 |
| 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane | Rattus norvegicus (Norway rat) | IC50 | 9.1201 | 1 | 1 |
| equol | Rattus norvegicus (Norway rat) | IC50 | 74.1310 | 1 | 1 |
| 11-hydroxyprogesterone, (11alpha)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.3300 | 1 | 1 |
| androstan-3-ol | Rattus norvegicus (Norway rat) | IC50 | 1.6982 | 1 | 1 |
| 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol | Rattus norvegicus (Norway rat) | IC50 | 38.0189 | 1 | 1 |
| 3,3'-Dihydroxyhexestrol | Rattus norvegicus (Norway rat) | IC50 | 37.1535 | 1 | 1 |
| etienic acid | Rattus norvegicus (Norway rat) | IC50 | 8.9000 | 1 | 1 |
| cp-55,940 | Rattus norvegicus (Norway rat) | Ki | 0.0007 | 1 | 1 |
| 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl | Rattus norvegicus (Norway rat) | IC50 | 16.2181 | 1 | 1 |
| Zearalanone | Rattus norvegicus (Norway rat) | IC50 | 26.3290 | 1 | 2 |
| ru 58841 | Rattus norvegicus (Norway rat) | Ki | 0.0258 | 2 | 2 |
| 4-androstene-3,17-diol | Rattus norvegicus (Norway rat) | IC50 | 0.6310 | 1 | 1 |
| 4'-hydroxyflavanone | Rattus norvegicus (Norway rat) | IC50 | 57.5440 | 1 | 1 |
| triptophenolide | Rattus norvegicus (Norway rat) | IC50 | 0.4670 | 1 | 1 |
| ru 59063 | Rattus norvegicus (Norway rat) | Ki | 0.0022 | 1 | 1 |
| estradiol 3-benzoate | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 0 |
| estradiol 3-benzoate | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 1 | 0 |
| androstane-3,17-dione, (5alpha)-isomer | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene | Rattus norvegicus (Norway rat) | IC50 | 20.4174 | 1 | 1 |
| 2-hydroxyestradiol | Rattus norvegicus (Norway rat) | IC50 | 8.5114 | 1 | 1 |
| mibolerone | Rattus norvegicus (Norway rat) | IC50 | 0.0013 | 2 | 2 |
| mibolerone | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 2 | 2 |
| metribolone | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 3 | 3 |
| (S)-bicalutamide | Rattus norvegicus (Norway rat) | Ki | 0.3645 | 3 | 4 |
| halcinonide | Rattus norvegicus (Norway rat) | IC50 | 0.8850 | 1 | 0 |
| halcinonide | Rattus norvegicus (Norway rat) | Ki | 0.5900 | 1 | 0 |
| tibolone | Rattus norvegicus (Norway rat) | IC50 | 0.1130 | 1 | 0 |
| tibolone | Rattus norvegicus (Norway rat) | Ki | 0.0754 | 1 | 0 |
| fluticasone propionate | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| diethylstilbestrol | Rattus norvegicus (Norway rat) | IC50 | 14.1254 | 1 | 1 |
| chalcone | Rattus norvegicus (Norway rat) | IC50 | 64.5654 | 1 | 1 |
| dieldrin | Rattus norvegicus (Norway rat) | IC50 | 6.8850 | 1 | 0 |
| dieldrin | Rattus norvegicus (Norway rat) | Ki | 4.5900 | 1 | 0 |
| isoeugenol | Rattus norvegicus (Norway rat) | IC50 | 204.1740 | 1 | 1 |
| tamoxifen | Rattus norvegicus (Norway rat) | IC50 | 17.3423 | 2 | 1 |
| tamoxifen | Rattus norvegicus (Norway rat) | Ki | 15.1080 | 1 | 0 |
| 6-hydroxyflavanone | Rattus norvegicus (Norway rat) | IC50 | 18.6209 | 1 | 1 |
| dimethylstilbestrol | Rattus norvegicus (Norway rat) | IC50 | 14.1254 | 1 | 1 |
| epi 001 | Rattus norvegicus (Norway rat) | IC50 | 6.0000 | 1 | 1 |
| am 630 | Rattus norvegicus (Norway rat) | Ki | 0.0312 | 1 | 1 |
| 7,13-bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane | Rattus norvegicus (Norway rat) | IC50 | 14.1600 | 1 | 0 |
| genistein | Rattus norvegicus (Norway rat) | IC50 | 85.1138 | 1 | 1 |
| pulmicort | Rattus norvegicus (Norway rat) | IC50 | 1.1725 | 2 | 1 |
| pulmicort | Rattus norvegicus (Norway rat) | Ki | 1.0900 | 1 | 0 |
| oxymetholone | Rattus norvegicus (Norway rat) | IC50 | 0.2060 | 1 | 0 |
| oxymetholone | Rattus norvegicus (Norway rat) | Ki | 0.1370 | 1 | 0 |
| coumestrol | Rattus norvegicus (Norway rat) | IC50 | 42.6579 | 1 | 1 |
| 7-hydroxyflavone | Rattus norvegicus (Norway rat) | IC50 | 42.6579 | 1 | 1 |
| 4-hydroxyestradiol | Rattus norvegicus (Norway rat) | IC50 | 2.5704 | 1 | 1 |
| 4-hydroxychalcone | Rattus norvegicus (Norway rat) | IC50 | 47.8630 | 1 | 1 |
| 4'-hydroxychalcone | Rattus norvegicus (Norway rat) | IC50 | 57.5440 | 1 | 1 |
| 4,4'-dihydroxystilbene | Rattus norvegicus (Norway rat) | IC50 | 83.1764 | 1 | 1 |
| dorzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0110 | 1 | 1 |
| ethisterone | Rattus norvegicus (Norway rat) | IC50 | 0.0670 | 1 | 0 |
| ethisterone | Rattus norvegicus (Norway rat) | Ki | 0.0440 | 1 | 0 |
| 4-hydroxystilbene | Rattus norvegicus (Norway rat) | IC50 | 41.6869 | 1 | 1 |
| lacidipine | Rattus norvegicus (Norway rat) | IC50 | 3.9180 | 1 | 0 |
| lacidipine | Rattus norvegicus (Norway rat) | Ki | 2.6120 | 1 | 0 |
| 17-n,n-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one | Rattus norvegicus (Norway rat) | IC50 | 2.8000 | 1 | 1 |
| jwh-133 | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 1 | 1 |
| andarine | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 3 | 2 |
| fluticasone furoate | Rattus norvegicus (Norway rat) | IC50 | 1.8800 | 1 | 1 |
| mk 2866 | Rattus norvegicus (Norway rat) | IC50 | 0.0364 | 1 | 1 |
| N-methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| pf-562,271 | Rattus norvegicus (Norway rat) | IC50 | 0.0140 | 1 | 1 |
| mdv 3100 | Rattus norvegicus (Norway rat) | IC50 | 0.8238 | 4 | 4 |
| mdv 3100 | Rattus norvegicus (Norway rat) | Ki | 3.6410 | 2 | 2 |
| apalutamide | Rattus norvegicus (Norway rat) | Ki | 1.4520 | 1 | 1 |
| azd3514 | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dihydrotestosterone | Rattus norvegicus (Norway rat) | EC50 | 0.0019 | 2 | 2 |
| bastadin 5 | Rattus norvegicus (Norway rat) | EC50 | 2.0000 | 1 | 1 |
| bms-564929 | Rattus norvegicus (Norway rat) | EC50 | 0.0078 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| spironolactone | Rattus norvegicus (Norway rat) | Anogenital distance | 1,460.0000 | 1 | 1 |
| mdv 3100 | Rattus norvegicus (Norway rat) | Kapp | 24.0000 | 1 | 1 |
Exploration and Biological Evaluation of Basic Heteromonocyclic Propanamide Derivatives as SARDs for the Treatment of Enzalutamide-Resistant Prostate Cancer.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SFEuropean journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs).Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 16, Issue:21, 2006
(+)-(2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an orally potent and peripherally selective nonsteroidal androgen receptor antagonist.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Aldosterone antagonists. 3. Synthesis and activities of steroidal 7 alpha-(alkoxycarbonyl)-15,16-methylene spirolactones.Journal of medicinal chemistry, , Volume: 33, Issue:2, 1990
[no title available],
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand: synthesis, X-ray analysis, and biological activity.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
[no title available],
Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs).Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.Bioorganic & medicinal chemistry, , Oct-01, Volume: 14, Issue:19, 2006
Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold.Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist.Journal of medicinal chemistry, , Dec-14, Volume: 49, Issue:25, 2006
Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand: synthesis, X-ray analysis, and biological activity.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Discovery of nonsteroidal androgens.Biochemical and biophysical research communications, , Mar-06, Volume: 244, Issue:1, 1998
Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding.Journal of medicinal chemistry, , Volume: 29, Issue:11, 1986
[no title available],
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016
Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.Bioorganic & medicinal chemistry, , Oct-01, Volume: 14, Issue:19, 2006
Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
Discovery of nonsteroidal androgens.Biochemical and biophysical research communications, , Mar-06, Volume: 244, Issue:1, 1998
[no title available],
Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5α-reductase 2 and with cytotoxic activity in cancer cells.Bioorganic & medicinal chemistry, , 03-01, Volume: 25, Issue:5, 2017
Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.Bioorganic & medicinal chemistry letters, , Apr-23, Volume: 11, Issue:8, 2001
Therapeutic Strategies to Target the Androgen Receptor.Journal of medicinal chemistry, , 07-14, Volume: 65, Issue:13, 2022
Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.Journal of medicinal chemistry, , Feb-24, Volume: 48, Issue:4, 2005
Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 18, Issue:20, 2008
Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators.Journal of medicinal chemistry, , Feb-12, Volume: 47, Issue:4, 2004
[no title available],
Exploration and Biological Evaluation of Basic Heteromonocyclic Propanamide Derivatives as SARDs for the Treatment of Enzalutamide-Resistant Prostate Cancer.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents.Bioorganic & medicinal chemistry, , 01-01, Volume: 27, Issue:1, 2019
Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety.Bioorganic & medicinal chemistry, , 10-15, Volume: 27, Issue:20, 2019
Identification of Triptophenolide from ACS medicinal chemistry letters, , Dec-08, Volume: 7, Issue:12, 2016
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016