Page last updated: 2024-12-08
scymnol
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
scymnol: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 165531 |
| CHEBI ID | 50106 |
| SCHEMBL ID | 3092941 |
| MeSH ID | M0201052 |
Synonyms (14)
| Synonym |
|---|
| CHEBI:50106 |
| (24r)-5beta-cholestane-3alpha,7alpha,12alpha,24,26,27-hexol |
| scymnol |
| 5beta-scymnol |
| 6785-34-8 |
| 5beta-cholestane-3alpha,7alpha,12alpha,24,26,27-hexol |
| cholestane-3,7,12,24,26,27-hexol, (3alpha,5beta,7alpha,12alpha)- |
| 5-BETA-SCYMNOL |
| (3r,5s,7r,8r,9s,10s,12s,13r,14s,17r)-17-[(2r,5r)-5,7-dihydroxy-6-(hydroxymethyl)heptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triol |
| LMST04030173 |
| SCHEMBL3092941 |
| cholestane-3,7,12,24,26,27-hexol |
| DTXSID10987196 |
| Q27121907 |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " Exposure of healthy male Swiss mice to a toxic overdose of APAP (350 mg/kg, ip) significantly increased serum hepatocellular enzyme activities, decreased hepatocellular glutathione (GSH) levels, and induced severe centrilobular hepatocellular necrosis." | ( Elucidation of the hepatoprotective moiety of 5β-scymnol that suppresses paracetamol toxicity in mice. Carter, F; Hodges, LD; Kalafatis, N; Macrides, TA; Wright, PF, 2016) | 0.69 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (6)
| Class | Description |
|---|---|
| 3alpha-hydroxy steroid | A 3-hydroxy steroid in which the 3-hydroxy substituent is in the alpha-position. |
| 7alpha-hydroxy steroid | A 7-hydroxy steroid in which the hydroxy group at position 7 has an alpha-configuration. |
| 12alpha-hydroxy steroid | |
| 24-hydroxy steroid | |
| 26-hydroxy steroid | Any hydroxy steroid in which a hydroxy group is located at position 26. |
| 27-hydroxy steroid | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Research
Studies (14)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 20.41
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.41) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||