Transient receptor potential cation channel subfamily V member 2

A transient receptor potential cation channel TRPV2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9Y5S1]

TrpV2;
Osm-9-like TRP channel 2;
OTRPC2;
Vanilloid receptor-like protein 1;
VRL-1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cannabinol	Homo sapiens (human)	IC50	15.7000	1	1
cannabichromene	Homo sapiens (human)	IC50	6.5000	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	IC50	0.8000	1	1
tranilast	Homo sapiens (human)	IC50	10.0000	1	1
cannabigerol	Homo sapiens (human)	IC50	1.5000	1	1
cannabidivarin	Homo sapiens (human)	IC50	31.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cannabinol	Homo sapiens (human)	EC50	19.0000	1	1
(6ar-trans)-isomer of tetrahydrocannabivarin 9	Homo sapiens (human)	EC50	4.1000	1	1
cannabigerol	Homo sapiens (human)	EC50	1.7000	1	1
cannabidivarin	Homo sapiens (human)	EC50	7.3000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-aminoethoxydiphenyl borate	Homo sapiens (human)	Activity	10.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
monoatomic ion channel activity	molecular function	Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
monoatomic cation channel activity	molecular function	Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient. [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
calcium channel activity	molecular function	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
monoatomic ion transmembrane transporter activity	molecular function	Enables the transfer of an ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]

This protein is located in 6 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
growth cone membrane	cellular component	The portion of the plasma membrane surrounding a growth cone. [GOC:mah]
melanosome	cellular component	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301]
axonal growth cone	cellular component	The migrating motile tip of a growing nerve cell axon. [GOC:jl, NIF_Subcellular:sao203987954]
cell body	cellular component	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 6 target(s):

Target	Category	Definition
sensory perception	biological process	The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai, GOC:dph]
positive regulation of axon extension	biological process	Any process that activates or increases the frequency, rate or extent of axon extension. [GOC:go_curators]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
positive regulation of calcium ion import	biological process	Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. [GOC:BHF]
positive regulation of cold-induced thermogenesis	biological process	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
calcium ion import across plasma membrane	biological process	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]