Proteins > NAD kinase

Page last updated: 2024-08-07 12:47:12

NAD kinase

An NAD kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95544]

Synonyms

EC 2.7.1.23;
Poly(P)/ATP NAD kinase

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (33.33)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
epigallocatechin gallate	Homo sapiens (human)	IC50	0.9600	1	1
epigallocatechin gallate	Homo sapiens (human)	Ki	3.2800	1	1
gallocatechol	Homo sapiens (human)	IC50	100.0000	1	1
benzamide adenine nucleotide	Homo sapiens (human)	IC50	90.0000	1	1
benzamide adenine nucleotide	Homo sapiens (human)	Ki	90.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
epigallocatechin gallate	Homo sapiens (human)	Kd	1.7800	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzamide adenine nucleotide	Homo sapiens (human)	Km	540.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
NAD+ kinase activity	molecular function	Catalysis of the reaction: ATP + NAD+ = ADP + 2 H+ + NADP+. [EC:2.7.1.23, RHEA:18629]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
phosphorylation	biological process	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732]
NAD metabolic process	biological process	The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153]
positive regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]
ATP metabolic process	biological process	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
NADP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH. [GOC:mah]